Insecticide for agricultural or horticultural use and method of use thereof

ABSTRACT

Aniline derivatives represented by formula (8): 
     
       
         
         
             
             
         
       
     
     The aniline derivatives can be used as insecticides and/or intermediates in production of insecticides.

TECHNICAL FIELD

The present invention relates to compounds represented by formula (1),insecticides containing the compounds as active ingredients, a methodfor producing the insecticides, and a method for using the insecticides.

BACKGROUND ART

PCT Japanese Translation Patent Publication No. 11-511442 disclosessalicylic compounds similar to compounds of the present invention.However, compounds represented by formula (1) of the present inventiondo not have a salicylic skeleton, and the compounds disclosed in theabove publication are clearly outside the scope of claims of the presentinvention.

Publication No. WO2003-22806 discloses compounds as productionintermediates similar to the compounds of the present invention, but itdoes not disclose an activity to insects. Also, the compounds disclosedin the publication are clearly outside the scope of claims of thepresent invention.

J. Org. Chem. 142 (1966) discloses compounds as production intermediatessimilar to the compounds of the present invention, but it does notdisclose an activity to insects. Also, the compounds disclosed in thepublication are clearly outside the scope of claims of the presentinvention.

J. Am. Chem. Soc. 6382 (2000) discloses compounds as productionintermediates similar to the compounds of the present invention, but itdoes not disclose an activity to insects. Also, the compounds disclosedin the publication are clearly outside the scope of claims of thepresent invention.

DISCLOSURE OF INVENTION

An object of the present invention is to provide insecticides havinghigh effectiveness.

As a result of intensive research for achieving the object, theinventors found that the compounds of the present invention are novelcompounds not disclosed in any document and have an excellentinsecticidal effect, and the compounds can be used as new insecticides.It is also found that intermediates in production of the compounds ofthe present invention are not disclosed in any document and are usefulproduction intermediates. The present invention has been achieved basedon these findings.

The present invention provides compounds represented by the followingformulae:

[1] Compounds represented by formula (1)

wherein A₁, A₂, A₃, and A₄ independently represent a carbon atom, anitrogen atom, or an oxidized nitrogen atom; R₁ represents a C1-C6 alkylgroup which may be substituted, a phenyl group which may be substituted,or a heterocyclic group which may be substituted; R₂ and R₃independently represent a hydrogen atom, a C1-C4 alkyl group which maybe substituted, or a C1-C4 alkylcarbonyl group which may be substituted;G₁, G₂, and G₃ independently represent an oxygen atom or a sulfur atom;Xs may be the same or different and each represent a hydrogen atom, ahalogen atom, a C1-C4 alkyl group which may be substituted, or an aminogroup which may be substituted; n represents an integer of 0 to 4; Qrepresents a phenyl group which may be substituted, a naphthyl groupwhich may be substituted, a tetrahydronaphthyl group which may besubstituted, or a heterocyclic group which may be substituted.

[2] Compounds represented by formula (1) wherein A₁, A₂, A₃, and A₄independently represent a carbon atom, a nitrogen atom, or an oxidizednitrogen atom; R₁ represents the following:

a C1-C6 alkyl group,a C1-C6 haloalkyl group,a C2-C6 alkenyl group,a C2-C6 haloalkenyl group,a C2-C6 alkynyl group,a C2-C6 haloalkynyl group,a C3-C6 cycloalkyl group,a C3-C6 halocycloalkyl group,a phenyl group,a substituted phenyl group having one or more substituents which may bethe same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a cyano group, anitro group, a hydroxyl group, a pentafluorosulfanyl group, a C1-C4alkylcarbonyl group, a C1-C4 haloalkylcarbonyl group, a C1-C4alkylcarbonyloxy group, and a C1-C4 alkoxycarbonyl group,a naphthyl group,a substituted naphthyl group having one or more substituents which maybe the same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a cyano group, anitro group, a hydroxyl group, a pentafluorosulfanyl group, a C1-C4alkylcarbonyl group, a C1-C4 haloalkylcarbonyl group, a C1-C4alkylcarbonyloxy group, and a C1-C4 alkoxycarbonyl group,a heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a tetrahydrofuryl group, a thienyl group, a tetrahydrothienylgroup, a tetrahydropyranyl group, an oxazolyl group, an isoxazolylgroup, an oxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group),a substituted heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a tetrahydrofuryl group, a thienyl group, a tetrahydrothienylgroup, a tetrahydropyranyl group, an oxazolyl group, an isoxazolylgroup, an oxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group) having one or moresubstituents which may be the same or different and which are selectedfrom a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, aC3-C8 cycloalkyl group, a C3-C8 halocycloalkyl group, a C1-C6 alkoxygroup, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a cyano group, a nitro group, a hydroxyl group,a pentafluorosulfanyl group, a C1-C4 alkylcarbonyl group, a C1-C4haloalkylcarbonyl group, a C1-C4 alkylcarbonyloxy group, and a C1-C4alkoxycarbonyl group,

-E₁-Z₁—R₄

(wherein E₁ represents a C1-C4 alkylene group, a C2-C4 alkynylene group,a C3-C4 alkynylene group, a C1-C4 haloalkylene group, a C2-C4haloalkenylene group, or a C3-C4 haloalkynylene group; R₄ represents ahydrogen atom, a C1-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6alkynyl group, a C1-C6 haloalkyl group, a C2-C6 haloalkenyl group, aC2-C6 haloalkynyl group,a C3-C8 cycloalkyl group,a C3-C8 halocycloalkyl group,a phenyl group,a substituted phenyl group having one or more substituents which may bethe same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a cyano group, anitro group, a hydroxyl group, a pentafluorosulfanyl group, a C1-C4alkylcarbonyl group, a C1-C4 haloalkylcarbonyl group, a C1-C4alkylcarbonyloxy group, and a C1-C4 alkoxycarbonyl group,a naphthyl group,a substituted naphthyl group having one or more substituents which maybe the same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a cyano group, anitro group, a hydroxyl group, a pentafluorosulfanyl group, a C1-C4alkylcarbonyl group, a C1-C4 haloalkylcarbonyl group, a C1-C4alkylcarbonyloxy group, and a C1-C4 alkoxycarbonyl group,a heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a tetrahydrofuryl group, a thienyl group, a tetrahydrothienylgroup, a tetrahydropyranyl group, an oxazolyl group, an isoxazolylgroup, an oxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group), ora substituted heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a tetrahydrofuryl group, a thienyl group, a tetrahydrothienylgroup, a tetrahydropyranyl group, an oxazolyl group, an isoxazolylgroup, an oxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group) having one or moresubstituents which may be the same or different and which are selectedfrom a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, aC3-C8 cycloalkyl group, a C3-C8 halocycloalkyl group, a C1-C6 alkoxygroup, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a cyano group, a nitro group, a hydroxyl group,a pentafluorosulfanyl group, a C1-C4 alkylcarbonyl group, a C1-C4haloalkylcarbonyl group, a C1-C4 alkylcarbonyloxy group, and a C1-C4alkoxycarbonyl group), andZ₁ represents —O—, —S—, —SO—, —SO₂—, —C(═O)—, —C(═O)O—, —OC(═O)—,—N(R₅)—, —C(═O)N(R₅)—, or —N(R₅)C(═O)— (R₅ represents a hydrogen atom, aC1-C4 alkyl group, a C1-C4 alkylcarbonyl group, a C1-C4haloalkylcarbonyl group, or a C1-C4 alkoxycarbonyl group)), or -E₂-R₆(wherein E₂ represents a C1-C4 alkylene group, a C2-C4 alkenylene group,a C3-C4 alkynylene group, a C1-C4 haloalkylene group, a C2-C4haloalkenylene group, or a C3-C4 haloalkynylene group, and R₆ representsa C3-C8 cycloalkyl group, a C3-C8 halocycloalkyl group,a cyano group,a nitro group,a hydroxyl group,a phenyl group,a substituted phenyl group having one or more substituents which may bethe same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a cyano group, anitro group, a hydroxyl group, a pentafluorosulfanyl group, a C1-C4alkylcarbonyl group, a C1-C4 haloalkylcarbonyl group, a C1-C4alkylcarbonyloxy group, and a C1-C4 alkoxycarbonyl group,a naphthyl group,a substituted naphthyl group having one or more substituents which maybe the same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a cyano group, anitro group, a hydroxyl group, a pentafluorosulfanyl group, a C1-C4alkylcarbonyl group, a C1-C4 haloalkylcarbonyl group, a C1-C4alkylcarbonyloxy group, and a C1-C4 alkoxycarbonyl group,a heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a tetrahydrofuryl group, a thienyl group, a tetrahydrothienylgroup, a tetrahydropyranyl group, an oxazolyl group, an isoxazolylgroup, an oxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group), ora substituted heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a tetrahydrofuryl group, a thienyl group, a tetrahydrothienylgroup, a tetrahydropyranyl group, an oxazolyl group, an isoxazolylgroup, an oxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group) having one or moresubstituents which may be the same or different and which are selectedfrom a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, aC3-C8 cycloalkyl group, a C3-C8 halocycloalkyl group, a C1-C6 alkoxygroup, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a cyano group, a nitro group, a hydroxyl group,a pentafluorosulfanyl group, a C1-C4 alkylcarbonyl group, a C1-C4haloalkylcarbonyl group, a C1-C4 alkylcarbonyloxy group, and a C1-C4alkoxycarbonyl group);R₂ and R₃ independently represent a hydrogen atom, a C1-C4 alkyl group,a C1-C4 alkylcarbonyl group, or a C1-C4 haloalkylcarbonyl group; G₁, G₂,and G₃ independently represent an oxygen atom or a sulfur atom; Xs maybe the same or different and each represent a hydrogen atom, a halogenatom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C1-C4 alkoxygroup, a C1-C4 haloalkoxy group, a C1-C4 alkylthio group, a C1-C4haloalkylthio group, a C1-C4 alkylsulfinyl group, a C1-C4haloalkylsulfinyl group, a C1-C4 alkylsulfonyl group, a C1-C4haloalkylsulfonyl group, a cyano group, a nitro group, an amino group,or an amino group which may be substituted by a C1-C4 alkyl group;n represents an integer of 0 to 4;Q represents a phenyl group,a substituted phenyl group having one or more substituents which may bethe same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 haloalkyl group which may be substituted by at least onehydroxyl group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, aC1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6haloalkylsulfonyloxy group, a C1-C4 alkylcarbonyl group, a C1-C4haloalkylcarbonyl group, a cyano group, a nitro group, a hydroxyl group,a pentafluorosulfanyl group, a phenyl group, a substituted phenyl group(which may have the same or different substituents selected from ahalogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8cycloalkyl group, a C3-C8 halocycloalkyl group, a C1-C6 alkoxy group, aC1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthiogroup, a C1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, aC1-C6 alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6haloalkylsulfonyloxy, a cyano group, a nitro group, a hydroxyl group,and a pentafluorosulfanyl group), a thienyl group, and a substitutedthienyl group (which may have the same or different substituentsselected from a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkylgroup, a C3-C8 cycloalkyl group, a C3-C8 halocycloalkyl group, a C1-C6alkoxy group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a C1-C6 haloalkylsulfonyloxy, a cyano group, anitro group, a hydroxyl group, and a pentafluorosulfanyl group),a naphthyl group,a substituted naphthyl group having one or more substituents which maybe the same or different and which are selected from a halogen atom, aC1-C6 alkyl group, a C1-C6 haloalkyl group, a C3-C8 cycloalkyl group, aC3-C8 halocycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 haloalkyl group which may be substituted by at least onehydroxyl group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, aC1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a cyano group, anitro group, a hydroxyl group, and a pentafluorosulfanyl group,a heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a thienyl group, an oxazolyl group, an isoxazolyl group, anoxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group),a substituted heterocyclic group (which represents a pyridyl group, apyridine-N-oxide group, a pyrimidinyl group, a pyridazyl group, a furylgroup, a thienyl group, an oxazolyl group, an isoxazolyl group, anoxadiazolyl group, a thiazolyl group, an isothiazolyl group, athiadiazolyl group, a pyrrole group, an imidazolyl group, a triazolylgroup, a pyrazolyl group, or a tetrazolyl group) having one or moresubstituents which may be the same or different and which are selectedfrom a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, aC1-C6 alkoxy group, a C1-C6 haloalkoxy group, a C1-C6 haloalkyl groupwhich may be substituted by at least one hydroxyl group, a C1-C6alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkylsulfinylgroup, a C1-C6 haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, aC1-C6 haloalkylsulfonyl group, a cyano group, a nitro group, a hydroxylgroup, and a pentafluorosulfanyl group,a tetrahydronaphthyl group, ora substituted tetrahydronaphthyl group having one or more substituentswhich may be the same or different and which are selected from a halogenatom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6 alkoxygroup, a C1-C6 haloalkoxy group, a C1-C6 haloalkyl group which may besubstituted by at least one hydroxyl group, a C1-C6 alkylthio group, aC1-C6 haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a cyano group, a nitro group, a hydroxyl group,and a pentafluorosulfanyl group (excluding a case (1) in which Qrepresents 3,4-dichlorophenyl when R1 represents a methyl group, a case(2) in which Q represents an unsubstituted phenyl group when R1represents an ethyl group, and a case (3) in which Q represents anunsubstituted pyridyl group when R1 represents an unsubstituted phenylgroup).

[3] Compounds represented by formula (2)

wherein A₁, A₂, A₃, A₄, R₁, R₂, R₃, G₁, G₂, G₃, X, and n each representthe same as in formula [1], and Hal represents a halogen atom.

[4] Compounds represented by formula (3)

wherein A₁, A₂, A₃, A₄, R₃, G₃, X, n and Q each represent the same as informula [1].

[5] Compounds represented by formula (4)

wherein A₁, A₂, A₃, A₄, R₂, R₃, G₃, X, and n each represent the same asin formula [1], and Q represents a group represented by formula (1-2) or(1-3):

(wherein Y₁, Y₂, Y₄, and Y₅ may be the same or different and eachrepresent a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C1-C6haloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group, a C1-C6alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkylsulfinylgroup, a C1-C6 haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, apentafluorosulfanyl group, a cyano group, or a nitro group, and Y₃represents a C1-C6 haloalkyl group, a C1-C6 haloalkoxy group, a C1-C6haloalkyl group which may be substituted by at least one hydroxyl group,a C1-C6 haloalkylthio group, a C1-C6 haloalkylsulfinyl group, a C1-C6haloalkylsulfonyl group, or a pentafluorosulfanyl group, but only one ofY₁ and Y₅ represents a hydrogen atom)

(wherein Y₆, Y₇, and Y₉ may be the same or different and each representa hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkylgroup, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group, a C1-C6 alkylthiogroup, a C1-C6 haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, apentafluorosulfanyl group, a cyano group, or a nitro group, and Y₈represents a C1-C6 haloalkyl group, a C1-C6 haloalkoxy group, a C1-C6haloalkyl group which may be substituted by at least one hydroxyl group,a C1-C6 haloalkylthio group, a C1-C6 haloalkylsulfinyl group, a C1-C6haloalkylsulfonyl group, or a pentafluorosulfanyl group, but only one ofY₆ and Y₉ represents a hydrogen atom).

[6] A method for producing the above-described compounds in [1]comprising reacting the compounds represented in [3] by formula (2) withcompounds represented by formula (5):

wherein R₃ and Q each represent the same as in [1].

[7] A method for producing the above-described compounds in [1]comprising reacting the compounds represented in [4] by formula (3) withcompounds represented by formula (6):

H-G₂-R₁  (6)

wherein R₁ and G₂ each represent the same as in [1].

[8] A method for producing the above-described compounds in [1]comprising reacting the compounds represented in [5] by formula (4) withcompounds represented by formula (7):

wherein R₁, G₁, and G₂ each represent the same as in [1].

[9] Aniline derivatives represented by formula (8):

wherein R₇ represents a C1-C6 haloalkyl group, Y₁₀, Y₁₁, Y₁₂, and Y₁₃may be the same or different and each represent a hydrogen atom, ahalogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6alkoxy group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, apentafluorosulfanyl group, a cyano group, or a nitro group, and R₈ andR₉ independently represent a hydrogen atom, a C1-C4 alkyl group, am-nitrobenzoyl group, or a substituted m-nitrobenzoyl group, and mrepresents 0, 1, or 2.

[10] Aniline derivatives represented by formula (9):

wherein R₁₀ represents a C1-C6 haloalkyl group which may be substitutedby at least one hydroxyl group, Y₁₄, Y₁₅, Y₁₆, and Y₁₇ may be the sameor different and each represent a hydrogen atom, a halogen atom, a C1-C6alkyl group, a C1-C6 haloalkyl group, a C1-C6 alkoxy group, a C1-C6haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group,a C1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a pentafluorosulfanyl group, a cyano group, or anitro group, and R₁₁ and R₁₂ independently represent a hydrogen atom, aC1-C4 alkyl group, a m-nitrobenzoyl group, or a substitutedm-nitrobenzoyl group.

[11] An insecticide comprising any one of the compounds in [1] or [2] asan active ingredient.

[12] A method for using a chemical comprising treating a useful crop orsoil with an effective amount of any one of the compounds [1] or [2],for protecting the useful crop from harmful organisms.

[13] A method for preventing pests comprising using the compound [1] or[2] and at least one insecticide and/or fungicide in combination.

The compounds of the present invention exhibit an excellent preventiveeffect as insecticides in low dosages, and also exhibit an excellentpreventive effect when being used in combination with anotherinsecticide, an acaricide, a nematocide, a fungicide, a herbicide, aplant growth regulator, or a biological pesticide.

BEST MODE FOR CARRYING OUT THE INVENTION

In the definitions of formula (1) of the present invention, the term“halogen atom” means a fluorine atom, a chlorine, atom, a bromine atom,or an iodine atom. The characters “n-”, “i-”, “s-”, and “t-” mean“normal”, “iso”, “secondary”, and “tertiary”; respectively. With respectto the expression “Ca-Cb (a and b each represent an integer of 1 ormore)”, for example, “C1-C6” means that the number of carbon atoms is 1to 6, “C3-C8” means that the number of carbon atoms is 3 to 8, and“C1-C4” means that the number of carbon atoms is 1 to 4.

In the definitions of the formulae such as formula (1) of the presentinvention, the used terms have the following meanings:

The term “an alkyl group which may be substituted” means a straight,branched or cyclic alkyl group which may be substituted by the same ordifferent groups selected from a hydrogen atom, a halogen atom, ahydroxyl group, a cyano group, a nitro group, a C1-C6 alkoxy group, aC1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthiogroup, a C1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, aC1-C6 alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a C1-C6alkoxycarbonyl group, a C1-C6 haloalkoxycarbonyl group, a C1-C6alkylcarbonyloxy, a C1-C6 haloalkylcarbonyloxy group, an amino group, aC1-C6 alkylamino group, a di-C1-C6 alkylamino group, a phenyl groupwhich may be substituted, a phenylcarbonyl group which may besubstituted, a phenylamino group which may be substituted, and aheterocyclic group which may be substituted.

The term “an alkylcarbonyl group which may be substituted” means astraight, branched or cyclic alkylcarbonyl group which may besubstituted by the same or different groups selected from a hydrogenatom, a halogen atom, a hydroxyl group, a cyano group, a nitro group, aC1-C6 alkoxy group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, aC1-C6 haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6haloalkylcarbonyl group, a C1-C6 alkoxycarbonyl group, a C1-C6haloalkoxycarbonyl group, a C1-C6 alkylcarbonyloxy, a C1-C6haloalkylcarbonyloxy group, an amino group, a C1-C6 alkylamino group, adi-C1-C6 alkylamino group, a phenyl group which may be substituted, aphenylcarbonyl group which may be substituted, a phenylamino group whichmay be substituted, and a heterocyclic group which may be substituted.

The term “a phenyl group which may be substituted” means a phenyl groupwhich may be substituted by the same or different groups selected from ahydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a nitrogroup, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group, a C1-C6 alkylthiogroup, a C1-C6 haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6haloalkylcarbonyl group, a C1-C6 alkoxycarbonyl group, a C1-C6haloalkoxycarbonyl group, a C1-C6 alkylcarbonyloxy, a C1-C6haloalkylcarbonyloxy group, an amino group, a C1-C6 alkylamino group, adi-C1-C6 alkylamino group, a phenyl group which may be substituted, aphenylcarbonyl group which may be substituted, a phenylamino group whichmay be substituted, and a heterocyclic group which may be substituted.

The term “a naphthyl group which may be substituted” means a naphthylgroup which may be substituted by the same or different groups selectedfrom a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, anitro group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group, a C1-C6alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkylsulfinylgroup, a C1-C6 haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, aC1-C6 haloalkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6haloalkylcarbonyl group, a C1-C6 alkoxycarbonyl group, a C1-C6haloalkoxycarbonyl group, a C1-C6 alkylcarbonyloxy, a C1-C6haloalkylcarbonyloxy group, an amino group, a C1-C6 alkylamino group, adi-C1-C6 alkylamino group, a phenyl group which may be substituted, aphenylcarbonyl group which may be substituted, a phenylamino group whichmay be substituted, and a heterocyclic group which may be substituted.

The term “a tetrahydronaphthyl group which may be substituted” means atetrahydronaphthyl group which may be substituted by the same ordifferent groups selected from a hydrogen atom, a halogen atom, ahydroxyl group, a cyano group, a nitro group, a C1-C6 alkoxy group, aC1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthiogroup, a C1-C6 alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, aC1-C6 alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a C1-C6alkoxycarbonyl group, a C1-C6 haloalkoxycarbonyl group, a C1-C6alkylcarbonyloxy, a C1-C6 haloalkylcarbonyloxy group, an amino group, aC1-C6 alkylamino group, a di-C1-C6 alkylamino group, a phenyl groupwhich may be substituted, a phenylcarbonyl group which may besubstituted, a phenylamino group which may be substituted, and aheterocyclic group which may be substituted.

The term “a heterocyclic group which may be substituted” means aheterocyclic group which may be substituted by the same or differentgroups selected from a hydrogen atom, a halogen atom, a hydroxyl group,a cyano group, a nitro group, a C1-C6 alkoxy group, a C1-C6 haloalkoxygroup, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6alkylsulfinyl group, a C1-C6 haloalkylsulfinyl group, a C1-C6alkylsulfonyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a C1-C6alkoxycarbonyl group, a C1-C6 haloalkoxycarbonyl group, a C1-C6alkylcarbonyloxy, a C1-C6 haloalkylcarbonyloxy group, an amino group, aC1-C6 alkylamino group, a di-C1-C6 alkylamino group, a phenyl groupwhich may be substituted, a phenylcarbonyl group which may besubstituted, a phenylamino group which may be substituted, and aheterocyclic group which may be substituted.

The term “a C1-C6 alkyl group” means a straight or branched alkyl grouphaving 1 to 6 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl,n-butyl, s-butyl, t-butyl, n-pentyl, 2-pentyl, neopentyl,4-methyl-2-pentyl, n-hexyl, or 3-methyl-n-pentyl. The term “a C1-C6haloalkyl group” means a straight or branched alkyl group having 1 to 6carbon atoms and substituted by one or more halogen atoms which may bethe same or different, such as trifluoromethyl, pentafluoroethyl,heptafluoro-n-propyl, heptafluoro-i-propyl, 2,2-difluoroethyl,2,2-dichloroethyl, 1,3-difluoro-2-propyl, 1,3-dichloro-2-propyl,1-chloro-3-fluoro-2-propyl, 1,1,1-trifluoro-2-propyl,2,2,2-trifluoroethyl, 2,2,2-trichloroethyl, 2,2,2-tribromoethyl,3,3,3-trifluoro-n-propyl, 4,4,4-trifluoro-n-butyl,1,1,1,3,3,3-hexafluoro-2-propyl,1,1,1,3,3,3-hexafluoro-2-chloro-2-propyl,1,1,1,3,3,3-hexafluoro-2-bromo-2-propyl,1,1,2,3,3,3-hexafluoro-2-chloro-n-propyl,1,1,2,3,3,3-hexafluoro-2-bromo-n-propyl,1,1,2,3,3,3-hexafluoro-1-bromo-2-propyl, 2,2,3,3,3-pentafluoro-n-propyl,3,3,4,4,4-pentafluoro-2-butyl, nonafluoro-n-butyl, nonafluoro-2-butyl,2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl,3-fluoro-n-propyl, 3-chloro-n-propyl, or 3-bromo-n-propyl.

The term “a C2-C6 alkenyl group” means an alkenyl group having 2 to 6carbon atoms and a double bond in its carbon chain, such as vinyl,allyl, 2-butenyl, or 3-butenyl. The term “a C2-C6 haloalkenyl group”means a straight or branched alkenyl group having 2 to 6 carbon atomsand a double bond in its carbon chain and substituted by one or morehalogen atoms which may be the same or different, such as3,3-difluoro-2-propenyl, 3,3-dichloro-2-propenyl,3,3-dibromo-2-propenyl, 2,3-dibromo-2-propenyl, 4,4-difluoro-3-butenyl,or 3,4,4-tribromo-3-butenyl.

The term “a C2-C6 alkynyl group” means an alkynyl group having 2 to 6carbon atoms and a triple bond in its carbon chain, such as propargyl,1-butyne-3-yl, or 1-butyne-3-methyl-3-yl. The term “a C2-C6 haloalkenylgroup” means a straight or branched alkyenyl group having 2 to 6 carbonatoms and a triple bond in its carbon chain and substituted by one ormore halogen atoms which may be the same or different.

The term “a C3-C8 cycloalkyl group” means a cycloalkyl group having 3 to8 carbon atoms and a Cyclic structure, such as cyclopropyl, cyclobutyl,cyclopentyl, 2-methylcyclopentyl, 3-methylcyclopentyl, cyclohexyl,2-methylcyclohexyl, 3-methylcyclohexyl, or 4-methylcyclohexyl. The term“a C3-C8 halocycloalkyl group” means a cycloalkyl group having 3 to 8carbon atoms and a cyclic structure and substituted by one or morehalogen atoms which may be the same or different, such as2,2,3,3-tetrafluorocyclobutyl, 2-chlorocyclohexyl, or4-chlorocyclohexyl.

The term “a C1-C6 alkoxy group” means a straight or branched alkoxygroup having 1 to 6 carbon atoms, such as methoxy, ethoxy, n-propyloxy,isopropyloxy, n-butoxy, s-butoxy, i-butoxy, or t-butoxy. The term “aC1-C6 haloalkoxy group” means a straight or branched haloalkoxy grouphaving 1 to 6 carbon atoms and substituted by one or more halogen atomswhich may be the same or different, such as trifluoromethoxy,pentafluoroethoxy, heptafluoro-n-propyloxy, heptafluoro-i-propyloxy,1,1,1,3,3,3-hexafluoro-2-propyloxy, 2,2,2-trifluoroethoxy,2-chloroethoxy, or 3-fluoro-n-propyloxy.

The term “a C1-C6 alkylthio group” means a straight or branchedalkylthio group having 1 to 6 carbon atoms, such as methylthio,ethylthio, n-propylthio, i-propylthio, n-butylthio, s-butylthio, ort-butylthio. The term “a C1-C6 haloalkylthio group” means a straight orbranched alkylthio group having 1 to 6 carbon atoms and substituted byone or more halogen atoms which may be the same or different, such astrifluoromethylthio, pentafluoroethylthio, 2,2,2-trifluoroethylthio,heptafluoro-n-propylthio, heptafluoro-i-propylthio,nonafluoro-n-butylthio, or nonafluoro-2-butylthio.

The term “a C1-C6 alkylsulfinyl group” means a straight or branchedalkylsulfinyl group having 1 to 6 carbon atoms, such as methylsulfinyl,ethylsulfinyl, n-propylsulfinyl, i-propylsulfinyl, n-butylsulfinyl,s-butylsulfinyl, or t-butylsulfinyl. The term “a C1-C6 haloalkylsulfinylgroup” means a straight or branched alkylsulfinyl group having 1 to 6carbon atoms and substituted by one or more halogen atoms which may bethe same or different, such as trifluoromethylsulfinyl,pentafluoroethylsulfinyl, 2,2,2-trifluoroethylsulfinyl,heptafluoro-n-propylsulfinyl, heptafluoro-1-propylsulfinyl,nonafluoro-n-butylsulfinyl, or nonafluoro-2-butylsulfinyl.

The term “a C1-C6 alkylsulfonyl group” means a straight or branchedalkylsulfonyl group having 1 to 6 carbon atoms, such as methylsulfonyl,ethylsulfonyl, n-propylsulfonyl, i-propylsulfonyl, n-butylsulfonyl,s-butylsulfonyl, or t-butylsulfonyl. The term “a C1-C6 haloalkylsulfonylgroup” means a straight or branched alkylsulfonyl group having 1 to 6carbon atoms and substituted by one or more halogen atoms which may bethe same or different, such as trifluoromethylsulfonyl,pentafluoroethylsulfonyl, 2,2,2-trifluoroethylsulfonyl,heptafluoro-n-propylsulfonyl, heptafluoro-1-propylsulfonyl,nonafluoro-n-butylsulfonyl, or nonafluoro-2-butylsulfonyl.

The term “a C1-C4 alkylcarbonyl group” means a straight, branched, orcyclic alkylcarbonyl group having 1 to 4 carbon atoms, such as acetyl,propionyl, isopropylcarbonyl, or cyclopropylcarbonyl. The term “a C1-C4haloalkylcarbonyl group” means a straight or branched alkylcarbonylgroup having 1 to 4 carbon atoms and substituted by one or more halogenatoms which may be the same or different, such as trifluoroacetyl,pentafluoropropionyl, trichloroacetyl, chloroacetyl, bromoacetyl, or3-chloropropionyl.

The term “a C1-C4 alkoxycarbonyl group” means a straight or branchedalkoxycarbonyl group having 1 to 4 carbon atoms, such asmethoxycarbonyl, ethoxycarbonyl, or isopropyloxycarbonyl.

The term “a C1-C4 alkylcarbonyloxy group” means a straight or branchedalkylcarbonyloxy group having 1 to 4 carbon atoms, such as acetoxy orpropionyloxy. The term “a C1-C4 alkylsulfonyloxy group” means a straightor branched alkylsulfonyloxy group having 1 to 4 carbon atoms, such asmethylsulfonyloxy. The term “a C1-C4 haloalkylsulfonyloxy group” means astraight or branched alkylsulfonyloxy group having 1 to 4 carbon atomsand substituted by one or more halogen atoms which may be the same ordifferent, such as trifluoromethylsulfonyloxy orpentafluoroethylsulfonyloxy.

The term “a C1-C4 alkylene group” means a straight or branched alkylenegroup having 1 to 4 carbon atoms, such as methylene, ethylene,propylene, dimethylmethylene, or isobutylene. The term “a C2-C4alkenylene group” means a straight or branched alkenylene group having 2to 4 carbon atoms and a double bond in its carbon chain. The term “aC3-C4 alkynylene group” means a straight or branched alkynylene having 3to 4 carbon atoms and a triple bond in its carbon chain. The term “aC1-C4 haloalkylene group” means a straight or branched alkylene grouphaving 1 to 4 carbon atoms and substituted by one or more halogen atomswhich may be the same or different, such as chloromethylene,chloroethylene, dichloromethylene, or difluoromethylene.

The term “a C2-C4 haloalkenylene group” means a straight or branchedalkynylene having 2 to 4 carbon atoms and a double bond in its carbonchain, and substituted by one or more halogen atoms which may be thesame or different. The term “a C3-C4 haloalkynylene group” means astraight or branched alkynylene group having 3 to 4 carbon atoms and atriple bond in its carbon chain, and substituted by one or more halogenatoms which may be the same or different.

The term “a C1-C6 haloalkyl group which may be substituted by one ormore hydroxyl groups” means a straight or branched alkyl group having 1to 6 carbon atoms and one or more hydroxyl groups in its carbon chain,and substituted by one or more halogen atoms which may be the same ordifferent, such as 1,2,2,2-tetrafluoro-1-hydroxyethyl,1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl,1,1,1,3,3,4,4,4-octafluoro-2-hydroxy-2-butyl,1,2,2,3,3,4,4,4-octafluoro-1-hydroxy-n-butyl, or1,3-dichloro-1,1,3,3-tetrafluoro-2-hydroxy-2-propyl.

The term “a substituted m-nitrobenzoyl group” means a m-nitrobenzoylgroup having one or more substituents, such as 2-fluoro-3-nitrobenzoyl,4-fluoro-3-nitrobenzoyl, 2-fluoro-5-nitrobenzoyl, or4-chloro-3-nitrobenzoyl.

The compounds represented by formula (1) of the present invention maycontain at least one asymmetric carbon atom or asymmetric center andthus have at least two types of optical isomers. The present inventionincludes the optical isomers and mixtures thereof at any proportions.The compounds represented by formula (1) of the present invention maycontain at least two types of geometric isomers derived fromcarbon-carbon double bonds in the structural formulae. The presentinvention also includes the geometric isomers and mixtures thereof atany proportions.

Preferred examples of the substituents or atoms in the compoundsrepresented by the formulae such as formula (1) of the present inventioninclude the following:

Preferably, R₁ is C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6haloalkenyl, a C2-C6 alkynyl, C2-C6 haloalkynyl, C3-C8 cycloalkyl, C3-C8halocycloalkyl, -E₁-Z₁—R₄ (wherein E₁ represents C1-C4 alkylene, C2-C4alkenylene, C3-C4 alkynylene, C1-C4 haloalkylene, C2-C4 haloalkenylene,or C3-C4 haloalkynylene, R₄ represents a hydrogen atom, C1-C6 alkyl,C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, orC2-C6 haloalkynyl, and Z₁ represents —O—, —S—, —SO—, or —SO₂—), or-E₂-R₆ (wherein E₂ represents C1-C4 alkyl, C2-C4 alkenyl, C3-C4 alkynyl,C1-C4 haloalkyl, C2-C4 haloalkenyl, or C3-C4 haloalkynyl, and R₆represents C3-C8 cycloalkyl, C3-C8 halocycloalkyl, cyano, nitro,hydroxyl, phenyl, substituted phenyl having one or more substituentswhich may be the same or different and which are selected from halogen,C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, cyano,nitro, hydroxyl, C1-C4 alkylcarbonyl, C1-C4 haloalkylcarbonyl, C1-C4alkylcarbonyloxy, and C1-C4 alkoxycarbonyl, pyridyl, or substitutedpyridyl having one or more substituents selected from halogen, C1-C6haloalkyl, and C1-C6 haloalkoxy). More preferably, R₁ is C1-C6 alkyl,C1-C6 haloalkyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, -E₁-Z₁—R₄(wherein E₁ represents C1-C4 alkylene or C1-C4 haloalkylene, R₄represents C1-C6 alkyl or C1-C6 haloalkyl, and Z₁ represents —O—, —S—,—SO—, or —SO₂—), or -E₂-R₆ (wherein E₂ represents C1-C4 alkyl, R₆represents C3-C8 cycloalkyl, cyano, substituted phenyl having one ormore substituents which may be the same or different and which areselected from halogen, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6haloalkylthio, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, cyano,and nitro, pyridyl, substituted pyridyl having one or more substituentsselected from halogen, C1-C6 haloalkyl, and C1-C6 haloalkoxy, thienyl,or tetrahydrofuryl).

Preferably, R₂ and R₃ are independently hydrogen or C1-C4 alkyl, andmore preferably hydrogen, methyl, or ethyl.

Preferably, G₁, G₂, and G₃ are independently oxygen or sulfur, and morepreferably oxygen.

Preferably, X is hydrogen, halogen or trifluoromethyl, and morepreferably hydrogen or fluorine.

Preferably, n is 0 or 1.

Preferably, Q is phenyl, substituted phenyl having one or moresubstituents selected from halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6alkoxy, C1-C6 haloalkoxy, C1-C6 haloalkyl which may be substituted byone or more hydroxyl groups, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl,pentafluorosulfanyl, cyano, and nitro, pyridyl, or substituted pyridylhaving one or more substituents selected from halogen, C1-C6 alkyl,C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 haloalkyl whichmay be substituted by one or more hydroxyl groups, C1-C6 alkylthio,C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6alkylsulfonyl, C1-C6 haloalkylsulfonyl, pentafluorosulfanyl, cyano, andnitro. More preferably, Q is substituted phenyl or substituted pyridylrepresented by formula (1-2) or (1-3). In the formula, preferably, Y₁and Y₅ are independently hydrogen, C1-C4 alkyl, halogen, or methylthio,and only one of Y₁ and Y₅ represents a hydrogen atom.

Preferably, Y₂ and Y₄ are each hydrogen.

Preferably, Y₃ is C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 haloalkylwhich may be substituted by one or more hydroxyl groups, C1-C6haloalkylthio, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, orpentafluorosulfanyl. More preferably, Y₃ is C1-C6 haloalkyl, C1-C6haloalkyl which may be substituted by one or more hydroxyl group, C1-C6haloalkylthio, C1-C6 haloalkylsulfinyl, or C1-C6 haloalkylsulfonyl.

Preferably, Y₆ and Y₉ are independently hydrogen, C1-C4 alkyl, halogen,or methylthio, and only one of Y₆ and Y₉ represents a hydrogen atom.

Preferably, Y₇ is hydrogen.

Preferably, Y₈ is C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 haloalkylwhich may be substituted by one or more hydroxyl groups, C1-C6haloalkylthio, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, orpentafluorosulfanyl. More preferably, Y₈ is C1-C6 haloalkyl or C1-C6haloalkoxy.

Preferably, Hal is chlorine.

Preferably, R₇ is C1-C6 haloalkyl, and more preferably R₇ is C1-C6 alkylsubstituted by fluorine, such as pentafluoroethyl, heptafluoro-n-propyl,heptafluoroisopropyl, nonafluoro-n-butyl, or nonafluoro-2-butyl.

Preferably, Y₁₀ and Y₁₃ are independently hydrogen, C1-C4 alkyl,halogen, or methylthio, and only one of Y₁₀ and Y₁₃ represents ahydrogen atom. More preferably, Y₁₀ and Y₁₃ are each chlorine, bromine,or methyl.

Preferably, Y₁₁ and Y₁₂ are each hydrogen.

Preferably, R₈ and R₉ are each hydrogen, C1-C4 alkyl, m-nitrobenzoyl, or2-fluoro-3-nitrobenzoyl, and only one of R₈ and R₉ represent C1-C4alkyl, m-nitrobenzoyl, or 2-fluoro-3-nitrobenzoyl.

Preferably, m is 0, 1, or 2.

Preferably, R₁₀ is 1,2,2,2-tetrafluoro-1-hydroxyethyl,1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl,1,1,1,3,3,4,4,4-octafluoro-2-hydroxy-2-butyl,1,2,2,3,3,4,4,4-octafluoro-1-hydroxy-n-butyl, or1,3-dichloro-1,1,3,3-tetrafluoro-2-hydroxy-2-propyl, and morepreferably, R₁₀ is 1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl.

Preferably, Y₁₄ and Y₁₇ are independently hydrogen, C1-C4 alkyl,halogen, or methylthio, and only one of Y₁₄ and Y₁₇ represents ahydrogen atom. More preferably, none of Y₁₄ and Y₁₇ represents ahydrogen atom.

Preferably, Y₁₅ and Y₁₆ are each hydrogen.

Preferably, R₁₁ and R₁₂ are each hydrogen, C1-C4 alkyl, m-nitrobenzoyl,or 2-fluoro-3-nitrobenzoyl, and only one of R₁₁ and R₁₂ represents C1-C4alkyl, m-nitrobenzoyl, or 2-fluoro-3-nitrobenzoyl.

Representative processes for producing the compounds of the presentinvention will be described below. Although the compounds of the presentinvention can be produced according to the methods, the productionprocesses are not limited to the processes described below.

An embodiment of the representative processes for producing thecompounds of the present invention is Production Method 1 (in theformula, R₁, R₃, G₁, G₂, (X)n, and Q represent the same as describedabove).

Production Method 1

1-(i) Formula (10)→Formula (12)

A m-nitrobenzoyl chloride derivative represented by formula (10) isreacted with an aromatic amine derivative represented by formula (11) inan appropriate solvent to produce a benzamide derivative represented byformula (12). In this step, an appropriate base can also be used. As thesolvent, any solvent which does not significantly inhibit the progressof reaction can be used. Examples of the solvent include aromatichydrocarbons such as benzene, toluene, and xylene; halogenatedhydrocarbons such as dichloromethane, chloroform, and carbontetrachloride; chained or cyclic ethers such as diethyl ether, dioxane,tetrahydrofuran, and 1,2-dimethoxyethane; esters such as ethyl acetateand butyl acetate; ketones such as acetone, methyl isobutyl ketone, andcyclohexanone; amides such as dimethylformamide and dimethylacetamide;nitriles such as acetonitrile; and inert solvents such as1,3-dimethyl-2-imidazolidinone. These solvents can be used alone or in amixture of two ore more kinds. Examples of the base include organicbases such as triethylamine, tri-n-butylamine, pyridine, and4-dimethylaminopyridine; alkali metal hydroxides such as sodiumhydroxide and potassium hydroxide; carbonates such as sodium hydrogencarbonate and potassium carbonate; phosphates such as dipotassiumhydrogen phosphate and trisodium phosphate; alkali metal hydrides suchas sodium hydride; and alkali metal alcoholates such as sodium methoxideand sodium ethoxide. The base may be used in an appropriate amount inthe range of molar equivalents of 0.01 to 5 times the amount of thecompound represented by formula (10). The reaction temperature may beappropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.The m-nitrobenzoyl chloride derivative represented by formula (10) canbe easily produced from a m-nitrobenzoic acid derivative by aconventional method using a halogenating agent. Examples of thehalogenating agent include thionyl chloride, thionyl bromide, phosphorusoxychloride, oxalyl chloride, and phosphorus trichloride. In a processfor producing the compound represented by formula (12) using them-nitrobenzoic acid derivative and the compound represented by formula(11) without using a halogenating agent, 1-hydroxybenzotriazolefunctioning as an additive, and N,N′-dicyclohexyl carbodiimidefunctioning as a condensing agent can be used according to the techniquedisclosed in, for example, Chem. Ber. p. 788 (1970). Other examples ofthe condensing agent include 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and 1,1′-carbonyl-bis-1H-imidazole. Alternatively, thecompound represented by formula (12) can be produced by a mixed acidanhydride technique using a chloroformic acid ester according to thetechnique disclosed in J. Am. Chem. Soc. p. 5012 (1967). Examples of thechloroformic acid ester include isobutyl chloroformate and isopropylchloroformate. Instead of the chloroformic acid ester, diethylacetylchloride or trimethylacetyl chloride can be used. In the technique usingthe condensing agent and the mixed acid anhydride technique, thesolvent, the reaction temperature, and the reaction time are not limitedto those disclosed in the above documents, and an inert solvent whichdoes not inhibit the progress of reaction may be appropriately used.Also, the reaction temperature and the reaction time may beappropriately selected according to the progress of reaction.

1-(ii) Formula (12)→Formula (13)

The benzamide derivative having a nitro group represented by formula(12) can be converted to a benzamide derivative having an amino grouprepresented by formula (13) by reduction reaction. Examples of atechnique for the reduction reaction include a technique usinghydrogenation and a technique using tin(II) chloride (anhydride). In theformer technique, reaction can be performed in a hydrogen atmosphere inthe presence of a catalyst in a proper solvent under normal pressure orhigh pressure. Examples of the catalyst include palladium catalysts suchas palladium-carbon, nickel catalysts such as Raney nickel, cobaltcatalysts, ruthenium catalysts, rhodium catalysts, and platinumcatalysts. Examples of the solvent include water, alcohols such asmethanol and ethanol; aromatic hydrocarbons such as benzene and toluene;chained or cyclic ethers such as ethers, dioxane, and tetrahydrofuran;and esters such as ethyl acetate. The reaction temperature may beappropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours. Asa result, the compound represented by formula (13) can be produced. Inthe latter technique, the conditions are not limited, and the compoundrepresented by formula (13) can be produced under the conditionsdescribed in, for example, Organic Syntheses, Coll. Vol. III, p. 453.

1-(iii) Formula (13)→Formula (14)

The benzamide derivative having a amino group represented by formula(13) is reacted with a compound represented by formula (7) (for example,a chloroformic ester, a chlorothioformic ester, or a chlorodiformicthioester) in a proper solvent to produce a compound represented byformula (14) of the present invention. In this step, an appropriate basecan also be used. As the solvent, any solvent which does notsignificantly inhibit the progress of reaction can be used. Examples ofthe solvent include aromatic hydrocarbons such as benzene, toluene, andxylene; halogenated hydrocarbons such as dichloromethane, chloroform,and carbon tetrachloride; chained or cyclic ethers such as diethylether, dioxane, tetrahydrofuran, and 1,2-dimethoxyethane; esters such asethyl acetate and butyl acetate; ketones such as acetone, methylisobutyl ketone, and cyclohexanone; amides such as dimethylformamide anddimethylacetamide; nitriles such as acetonitrile; and inert solventssuch as 1,3-dimethyl-2-imidazolidinone. These solvents can be used aloneor in a mixture of two ore more kinds. Examples of the base includeorganic bases such as triethylamine, tri-n-butylamine, pyridine, and4-dimethylaminopyridine; alkali metal hydroxides such as sodiumhydroxide and potassium hydroxide; carbonates such as sodium hydrogencarbonate and potassium carbonate; phosphates such as dipotassiumhydrogen phosphate and trisodium phosphate; alkali metal hydrides suchas sodium hydride; and alkali metal alcoholates such as sodium methoxideand sodium ethoxide. The base may be used in an appropriate amount inthe range of molar equivalents of 0.01 to 5 times the amount of thecompound represented by formula (13). The reaction temperature may beappropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

A compound represented by formula (16) of the present invention can beproduced by Production Method 2 (in the formula, R₁, R₃, G₂, (X)n, and Qrepresent the same as described above) using a 3-isocyanatobenzolychloride represented by formula (15) as a starting material, an alcoholrepresented by formula (6), a thiol, and an aromatic amine representedby formula (11) according to the technique disclosed in J. Org. Chem.,p. 142 (1966).

Production Method 2

In this step, a solvent can be used. As the solvent, any solvent otherthan the solvents described in the above document can be used as long asit does not significantly inhibit the progress of reaction. Examples ofthe solvent include aromatic hydrocarbons such as benzene, toluene, andxylene; halogenated hydrocarbons such as dichloromethane, chloroform,and carbon tetrachloride; chained or cyclic ethers such as dioxane,tetrahydrofuran, and 1,2-dimethoxyethane; esters such as ethyl acetateand butyl acetate; ketones such as acetone, methyl isobutyl ketone, andcyclohexanone; amides such as dimethylformamide and dimethylacetamide;nitriles such as acetonitrile; and inert solvents such as1,3-dimethyl-2-imidazolidinone. These solvents can be used alone or in amixture of two ore more kinds. Also, a base may be added foraccelerating the reaction. Examples of the base other than thosedisclosed in the above document include organic bases such astriethylamine, pyridine, and 4-dimethylaminopyridine; and inorganicbases such as potassium carbonate. The base may be used in anappropriate amount in the range of molar equivalents of 0.01 to 5 timesthe amount of the compound represented by formula (15). The reactiontemperature may be appropriately determined in the range of −20° C. tothe reflux temperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

A thioamide compound can be produced from a compound represented byformula (17) using a Lawson reagent according Production Method 3 (inthe formula, R₁, R₂, R₃, G₁, G₂, (X)n, and Q represent the same asdescribed above).

Production Method 3

3-(i) Formula (17)→Formula (18)

The reaction can be performed under the conditions described inSynthesis, p. 463 (1993) and Synthesis, p. 829 (1984), but theconditions such as a solvent are not limited to those described in thesedocuments.

3-(ii) Formula (18)→Formula (19)

A compound represented by formula (19) of the present invention can beproduced using a compound represented by formula (7) (for example, achloroformic ester or a chlorothioformic ester) under the conditionsproperly selected from the reaction conditions described above in thestep 1-(iii) of Production Method 1.

A chloropyridinecarboxylic acid can be used as a starting material. Forexample, a compound represented by formula (23) can be produced from achloropyridinecarboxylic acid represented by formula (20) according toProduction Method 4 (in the formula, R₁, R₂, R₃, Q, G₁, and G₂ representthe same as described above).

Production Method 4

4-(i) Formula (20)→Formula (21)

A compound represented by formula (18) is halogenated in the presence orabsence of an inert solvent and then reacted with an aromatic aminerepresented by formula (11) to produce a compound represented by formula(21). As the solvent usable in the halogenation step, any solvent whichdoes not significantly inhibit the progress of reaction can be used.Examples of the solvent include aromatic hydrocarbons such as benzene,toluene, and xylene; halogenated hydrocarbons such as dichloromethane,chloroform, and carbon tetrachloride; chained or cyclic ethers such asdiethyl ether, dioxane, tetrahydrofuran, and 1,2-dimethoxyethane; esterssuch as ethyl acetate and butyl acetate; ketones such as acetone, methylisobutyl ketone, and cyclohexanone; amides such as dimethylformamide anddimethylacetamide; nitriles such as acetonitrile; and inert solventssuch as 1,3-dimethyl-2-imidazolidinone. These solvents can be used aloneor in a mixture of two ore more kinds. Examples of a halogenating agentinclude thionyl chloride, thionyl bromide, phosphorus oxychloride,oxalyl chloride, and phosphorus trichloride. The amount of thehalogenating agent used may be appropriately determined in the range ofmolar equivalents of 1 to 10 times the amount of the compoundrepresented by formula (20). Also, N,N-dimethylformamide may be added asan auxiliary for accelerating the reaction. The reaction temperature maybe appropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours. Asthe solvent usable in the amidation step, any solvent which does notsignificantly inhibit the progress of reaction can be used. Examples ofthe solvent include aromatic hydrocarbons such as benzene, toluene, andxylene; halogenated hydrocarbons such as dichloromethane, chloroform,and carbon tetrachloride; chained or cyclic ethers such as diethylether, dioxane, tetrahydrofuran, and 1,2-dimethoxyethane; esters such asethyl acetate and butyl acetate; ketones such as acetone, methylisobutyl ketone, and cyclohexanone; amides such as dimethylformamide anddimethylacetamide; nitriles such as acetonitrile; and inert solventssuch as 1,3-dimethyl-2-imidazolidinone. These solvents can be used aloneor in a mixture of two ore more kinds. Also, a base may be added foraccelerating the progress of reaction. Examples of the base includeorganic bases such as triethylamine, pyridine, 4-dimethylaminopyridine;and inorganic bases such as potassium carbonate. The amount of the baseused may be appropriately determined in the range of molar equivalentsof 0.01 to 5 times the amount of the compound represented by formula(11). The reaction temperature may be appropriately determined in therange of −20° C. to the reflux temperature of the solvent used, and thereaction time may be appropriately determined in the range of severalminutes to 96 hours.

A process for producing a compound represented by formula (21) from acompound represented by formula (20) and a compound represented byformula (11) without using a halogenating agent is presented by aprocess according to the technique disclosed in, for example, Chem.Ber., p. 788 (1970) where 1-hydroxybenzotriazole as an additive andN,N′-dicyclohexyl carbodiimide as a condensing agent are used,respectively. Other examples of the condensing agent include1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, and1,1′-carbonyl-bis-1H-imidazole. The compound represented by formula (21)can also be produced by a mixed acid anhydride technique using achloroformic ester according to the technique disclosed in J. Am. Chem.Soc., p. 5012 (1967). Examples of a chloroformic ester include isobutylchloroformate and isopropyl chloroformate. A compound other than achloroformic ester, for example, diethylacetyl chloride ortrimethylacetyl chloride, can also be used. In the technique using thecondensing agent and the mixed acid anhydride technique, the solvent,the reaction temperatures, and the reaction times are not limited tothose disclosed in the above documents, and an inert solvent which doesnot significantly inhibit the progress of reaction may be appropriatelyused. Also, the reaction temperature and the reaction time may beappropriately selected according to the progress of reaction.

4-(ii) Formula (21)→Formula (22)

A compound represented by formula (22) can be produced by amination withammonia according to the conditions described in, for example, J. Org.Chem., p. 280 (1958). The conditions such as the reaction solvent arenot limited to those disclosed in the above document, and an inertsolvent which does not significantly inhibit the progress of reactionmay be appropriately used. Also, the reaction temperature and thereaction time may be appropriately selected according to the progress ofreaction. As an aminating agent, methylamine or ethylamine can be usedinstead of ammonia.

4-(iii) Formula (22)→Formula (23)

A compound represented by formula (23) of the present invention can beproduced by using a compound represented by formula (7) (for example, achloroformic ester or a chlorothioformic ester) under the conditionsappropriately selected from the reaction conditions described above inthe step 1-(iii) of Production Method 1.

Even when another nitrogen-containing aromatic carboxylic acid such as4-chloropyridine-2-carboxlic acid or 6-chloropyridine-2-carboxylic acidis selected as a starting material, the compound of the presentinvention can be produced according to Production Method 4. In the useof the former starting material, a compound represented by formula (1)wherein A₁ is a nitrogen atom, and A₂, A₃, and A₄ are each a carbon atomcan be produced. In the use of the latter starting material, a compoundrepresented by formula (1) wherein A₁, A₂, and A₃ are each a carbonatom, and A₄ is a nitrogen atom can be produced.

The compound represented by formula (23) is reacted with an appropriateoxidizing agent to produce a corresponding pyridine-N-oxide derivativeaccording to the conditions disclosed in, for example, J. Org. Chem., p.8576 (1999). Examples of the oxidizing agent include organic peroxyacids such as m-chloroperoxybenzoic acid; sodium metaperiodate; hydrogenperoxide; ozone; selenium dioxide, chromic acid; dinitrogen tetraoxide;acyl nitrate; iodine; bromine; N-bromosuccinimide; iodosylbenzene; andt-butyl hypochlorite. The solvent used in this step is not limited tothose disclosed in the above document, and any solvent which does notsignificantly inhibit the progress of reaction may be used. The solventscan be used alone or in a mixture of one or more kinds. In particular, apolar solvent is preferred. The reaction temperature may beappropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

A compound represented by formula (27) of the present invention can beproduced from a easily available m-aminobenzoic ester derivativepresented by formula (24) according to Production Method 5 (in theformula, R₁, R₂, R₃, G₁, G₂, (X)n, and Q represent the same as describedabove, and R represents a lower alkyl group).

Production Method 5

5-(i) Formula (24)→Formula (25)

A compound represented by formula (25) can be produced by using acompound represented by formula (7) (for example, a chloroformic esteror a chlorothioformic ester) under the conditions appropriately selectedfrom the reaction conditions described above in the step 1-(iii) ofProduction Method 1.

5-(ii) Formula (25)→Formula (26)

A compound represented formula (26) can be produced by hydrolysis withan alkali metal hydroxide such as sodium hydroxide or potassiumhydroxide, an alkali earth metal hydroxide such as calcium hydroxide, oran inorganic acid such as hydrochloric acid or sulfuric acid accordingto a conventional technique.

5-(iii) Formula (26)→Formula (27)

A compound represented by formula (27) of the present invention can beproduced by condensation reaction under appropriate conditions accordingto the technique described above in the step 4-(i) of Production Method4. Among the techniques described in the step 4-(i), in the techniqueusing a halogenating agent, the compound represented by formula (27) canbe produced through a compound represented by formula (2):

(wherein A₁, A₂, A₃, A₄, G₁, G₂, G₃, (X)n, and Hal each represent thesame as described above). The halogenation step and the amidation stepcan be performed under reaction conditions according to the techniquedescribed above in the step 4-(i).

The compound represented by formula (27) of the present invention can beproduced from a m-aminobenzoic acid ester represented by formula (28)according to Production Method 6 below (in the formula, R₁, R₂, R₃, G₁,G₂, (X)n, and Q each represent the same as described above, R representsa lower alkyl group, and L represents a functional group having leavingability, such as halogen, methanesulfonyloxy, ortrifluoromethanesulfonyloxy).

Production Method 6

6-(i) Formula (28)→Formula (29)

A compound represented formula (29) can be produced by the techniquedescribed above in the step 1-(iii) of Production Method 1 using acompound represented by formula (7) (for example, a chloroformic esteror a chlorothioformic ester) under appropriate conditions.

6-(ii) Formula (29)→Formula (25)

In this step, examples of a compound represented by formula (30) includealkyl halides such as methyl iodide and ethyl iodide; toluenesulfonicesters; methanesulfonic esters; and alkylating agents such as dimethylsulfate. As a solvent, any solvent which does not significantly inhibitthe progress of reaction can be used. Examples of the solvent includearomatic hydrocarbons such as benzene, toluene, and xylene; halogenatedhydrocarbons such as dichloromethane, chloroform, and carbontetrachloride; chained or cyclic ethers such as diethyl ether, dioxane,tetrahydrofuran, and 1,2-dimethoxyethane; esters such as ethyl acetateand butyl acetate; ketones such as acetone, methyl isobutyl ketone, andcyclohexanone; amides such as dimethylformamide and dimethylacetamide;nitriles such as acetonitrile; and inert solvents such as1,3-dimethyl-2-imidazolidinone. These solvents can be used alone or in amixture of two ore more kinds. Also, a base may be added foraccelerating the progress of reaction. Examples of the base includeorganic bases such as triethylamine, pyridine, and4-dimethylaminopyridine; inorganic bases such as potassium carbonate,sodium hydroxide, and potassium hydroxide; and alkali metal hydridessuch as sodium hydride. The amount of the base used may be appropriatelydetermined in the range of molar equivalents of 0.01 to 5 times theamount of the compound represented by formula (29). The reactiontemperature may be appropriately determined in the range of −20° C. tothe reflux temperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

6-(iii) Formula (25)→Formula (27)

A compound represented by formula (27) of the present invention can beproduced by the techniques described above in the steps 5-(ii) and5-(iii) of Production Method 5 under appropriate conditions.

A compound represented by formula (31) of the present invention can beproduced according to Production Method 7 (in the formula, A₁, A₂, A₃,A₄, R₁, R₃, G₂, G₃, and (X)n each represent the same as describedabove).

Production Method 7

In this step, an appropriate solvent may be used. As the solvent, anysolvent which does not significantly inhibit the progress of reactioncan be used. Examples of the solvent include aromatic hydrocarbons suchas benzene, toluene, and xylene; halogenated hydrocarbons such asdichloromethane, chloroform, and carbon tetrachloride; chained or cyclicethers such as diethyl ether, dioxane, tetrahydrofuran, and1,2-dimethoxyethane; esters such as ethyl acetate and butyl acetate;ketones such as acetone, methyl isobutyl ketone, and cyclohexanone;amides such as dimethylformamide and dimethylacetamide; nitriles such asacetonitrile; and inert solvents such as 1,3-dimethyl-2-imidazolidinone.These solvents can be used alone or in a mixture of two ore more kinds.Also, an appropriate base may be used. Examples of the base includeorganic bases such as triethylamine, tri-n-butylamine, pyridine,4-dimethylaminopyridine; alkali metal hydroxides such as sodiumhydroxide and potassium hydroxide; carbonates such as sodium hydrogencarbonate and potassium carbonate; alkali metal hydrides such as sodiumhydride; and alkali metal alcoholates such as sodium methoxide andsodium ethoxide. The amount of the base used may be appropriatelydetermined in the range of molar equivalents of 0.01 to 5 times theamount of the compound represented by formula (6). The reactiontemperature may be appropriately determined in the range of −20° C. tothe reflux temperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

An isocyanate compound represented by formula (3) can be produced byProduction Method 8 (in the formula, A₁, A₂, A₃, A₄, G₃, R₃, (X)n, and Qeach represent the same as described above) using a m-aminobenzamidederivative or a m-aminopyridinecarboxamide derivative represented byformula (32) as a starting material.

Production Method 8

In this step, reaction can be performed by using phosgene according tothe technique described in Organic Syntheses, Coll., Vol. II, p. 453. Anisocyanate compound represented by formula (3) can also be produced byusing a phosgene dimmer, triphosgene, or oxalyl chloride instead ofphosgene. In this step, an appropriate solvent may be used. As thesolvent, any solvent which does not significantly inhibit the progressof reaction can be used. Examples of the solvent include aromatichydrocarbons such as benzene, toluene, and xylene; halogenatedhydrocarbons such as dichloromethane, chloroform, and carbontetrachloride; chained or cyclic ethers such as diethyl ether, dioxane,tetrahydrofuran, and 1,2-dimethoxyethane; esters such as ethyl acetateand butyl acetate; ketones such as acetone, methyl isobutyl ketone, andcyclohexanone; amides such as dimethylformamide and dimethylacetamide;nitriles such as acetonitrile; and inert solvents such as1,3-dimethyl-2-imidazolidinone. These solvents can be used alone or in amixture of two ore more kinds. The reaction temperature may beappropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

An isocyanate compound represented by formula (3) can also be producedby Production Method 9 (in the formula, A₁, A₂, A₃, A₄, G₃, R₃, (X)n,and Q each represent the same as described above) utilizing Curtiusrearrangement reaction with an isophthaloyl chloride derivativerepresented by formula (33) used as a starting material according to thetechnique described in Macromolecules, p. 1046 (1998).

Production Method 9

In this step, an appropriate solvent may be used. As the solvent, anysolvent which does not significantly inhibit the progress of reactioncan be used. Examples of the solvent include aromatic hydrocarbons suchas benzene, toluene, and xylene; halogenated hydrocarbons such asdichloromethane, chloroform, and carbon tetrachloride; chained or cyclicethers such as diethyl ether, dioxane, tetrahydrofuran, and1,2-dimethoxyethane; esters such as ethyl acetate and butyl acetate;ketones such as acetone, methyl isobutyl ketone, and cyclohexanone;amides such as dimethylformamide and dimethylacetamide; nitriles such asacetonitrile; and inert solvents such as 1,3-dimethyl-2-imidazolidinone.These solvents can be used alone or in a mixture of two ore more kinds.The reaction temperature may be appropriately determined in the range of−20° C. to the reflux temperature of the solvent used, and the reactiontime may be appropriately determined in the range of several minutes to96 hours. In producing a compound represented formula (34), ethanol,propanol, or benzyl alcohol can be used as an alcohol. In esterolysis,hydrolysis or catalytic hydrogen reduction can be performed by aconventional technique.

An aniline derivative represented by formula (39) can be produced byusing an aminothiophenol derivative as a starting material accordingProduction Method 10 (in the formula, R₇, Y₁₁, Y₁₂, and m each representthe same as described above, Y₁₀ and Y₁₃ each represent a hydrogen atomor a halogen atom except a case in which both groups are hydrogen atomsas far as this Method is concerned, Y_(10a) and Y_(13a) each represent ahydrogen atom, a halogen atom, or a methyl group as far as this Methodis concerned, and one of Y_(10a) and Y_(13a) necessarily represents amethyl group).

Production Method 10

10-(i) Formula (35)→Formula (37)

A compound represented by formula (38) can be produced by reaction ofaminothiophenol represented by formula (35) with a haloalkyl iodiderepresented by formula (36) according to the method described in J.Fluorine Chem., p. 207 (1994).

Examples of a haloalkyl iodide represented by formula (36) includetrifluoromethyl iodide, pentafluoroethyl iodide, heptafluoro-n-propyliodide, heptafluoroisopropyl iodide, nonafluoro-n-butyl iodide, andnonafluoroisopropyl iodide. The amount of the haloalkyl iodide used maybe appropriately determined in the range of molar equivalents of 1 to 10times the amount of the compound represented formula (35). The solventused in this step is not limited to those described in the abovedocument, and any solvent which does not significantly inhibit theprogress of reaction can be used as the solvent. Examples of the solventinclude aromatic hydrocarbons such as benzene, toluene, and xylene;halogenated hydrocarbons such as dichloromethane, chloroform, and carbontetrachloride; chained or cyclic ethers such as diethyl ether, dioxane,tetrahydrofuran, and 1,2-dimethoxyethane; esters such as ethyl acetateand butyl acetate; ketones such as acetone, methyl isobutyl ketone, andcyclohexanone; amides such as dimethylformamide and dimethylacetamide;nitriles such as acetonitrile; and inert solvents such as1,3-dimethyl-2-imidazolidinone and hexamethylphosphoric triamide. Thesesolvents can be used alone or in a mixture of two ore more kinds. Inparticular, a polar solvent is preferred. The reaction temperature maybe appropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

10-(ii) Formula (37)→Formula (38)

A compound represented by formula (38) can be produced by using anappropriate halogenating agent according to the technique described in,for example, Synth. Commun., p. 1261 (1989). Examples of thehalogenating agent include chlorine, bromine, iodine,N-chlorosuccinimde, N-bromosuccinimide, and N-iodosuccinimide. Theamount of the halogenating agent used may be appropriately determined inthe range of molar equivalents of 1 to 10 times the amount of thecompound represented formula (37). The number of equivalents of thehalogenating agent used can be appropriately determined so that only Y₁₀or Y₁₃ is a halogen atom. In this step, an appropriate solvent may beused. The solvent used is not limited to those described in the abovedocument, and any solvent which does not significantly inhibit theprogress of reaction can be used as the solvent. Examples of the solventinclude aromatic hydrocarbons such as benzene, toluene, and xylene;halogenated hydrocarbons such as dichloromethane, chloroform, and carbontetrachloride; chained or cyclic ethers such as diethyl ether, dioxane,tetrahydrofuran, and 1,2-dimethoxyethane; esters such as ethyl acetateand butyl acetate; ketones such as acetone, methyl isobutyl ketone, andcyclohexanone; amides such as dimethylformamide and dimethylacetamide;nitriles such as acetonitrile; and inert solvents such as1,3-dimethyl-2-imidazolidinone and hexamethylphosphoric triamide. Thesesolvents can be used alone or in a mixture of two ore more kinds. Inparticular, a polar solvent is preferred. The reaction temperature maybe appropriately determined in the range of −20° C. to the refluxtemperature of the solvent used, and the reaction time may beappropriately determined in the range of several minutes to 96 hours.

10-(iii) Formula (38)→Formula (39)

A compound represented by formula (39) can be produced by using anappropriate oxidizing agent according to the technique described in, forexample, Tetrahedron Lett., p. 4955 (1994). Examples of the oxidizingagent include organic peroxy acids such as m-chloroperoxybenzoic acid;sodium metaperiodate; hydrogen peroxide; ozone; selenium dioxide,chromic acid; dinitrogen tetraoxide; acyl nitrate; iodine; bromine;N-bromosuccinimide; iodosylbenzene; and t-butyl hypochlorite. Thesolvent used in this step is not limited to those disclosed in the abovedocument, and any solvent which does not significantly inhibit theprogress of reaction may be used. The solvents can be used alone or in amixture of one or more kinds. In particular, a polar solvent ispreferred. The reaction temperature may be appropriately determined inthe range of −20° C. to the reflux temperature of the solvent used, andthe reaction time may be appropriately determined in the range ofseveral minutes to 96 hours.

10-(iv) Formula (38)→Formula (38-2)

A compound represented by formula (38-2) (wherein R₇, Y₁₁, Y₁₂, and meach represent the same as described above, Y_(10a) and Y_(13a) eachrepresent a hydrogen atom, a halogen atom, or a methyl group as far asthis step is concerned, and one of Y_(10a) and Y_(13a) necessarilyrepresents a methyl group) can be produced from the compound representedby formula (38) using an appropriate methylating agent. This step can beperformed according to the technique described in, for example,Tetrahedron. Lett., p. 6237 (2000).

10-(V) Formula (38-2)→Formula (39-2)

A compound represented by formula (39-2) (wherein R₇, Y₁₁, Y₁₂, and meach represent the same as described above, Y_(10a) and Y_(13a) bothrepresent a methyl group or one of Y_(10a) and Y_(13a) represents amethyl group and the other represents a halogen atom as far as this stepis concerned) can be produced according to the technique descried abovein the step 10-(iii) of Production Method 10.

The compounds represented by formula (1), (3), (4), and (8) can beproduced from aniline derivatives represented by formula (38), (39),(38-2) and (39-2) according to any one Method appropriately selectedfrom Production Methods 1 to 9.

The compound represented by formula (39) can also be produced from anaminothiophenol represented by formula (40) according to ProductionMethod 11 (in the formula, R₇, Y₁₀, Y₁₁, Y₁₂, Y₁₃, and m each representthe same as described above).

Production Method 11

Reaction with a haloalkyl iodide and subsequent oxidation can beperformed according to Production Method 10. The compounds representedby formula (1), (3), (4), and (8) can be produced from anilinederivatives represented by formula (41) and (42) according to any oneMethod appropriately selected from Production Methods 1 to 9.

A compound represented by formula (9) can also be produced from ananiline derivative represented by formula (41) and used as a startingmaterial according to Production Method 12 (in the formula, R₁₀, R₁₁,R₁₂, Y₁₄, Y₁₅, Y₁₆, and Y₁₇ each represent the same as described above).

Production Method 12

A compound represented by formula (9) can be produced by using anappropriate perfluorinated aldehyde or perfluorinated ketone accordingto the technique described in, for example, J. Am. Chem. Soc., p. 2410(1965) and J. Org. Chem., p. 1001 (1965). Examples of the perfluorinatedaldehyde or perfluorinated ketone include hexafluoroacetone andperfluoro-2-butanone. In this step, an appropriate solvent can be used.The solvent used in this step is not limited to those disclosed in theabove documents, and any solvent which does not significantly inhibitthe progress of reaction may be used. The solvents can be used alone orin a mixture of one or more kinds. The reaction temperature may beappropriately determined in the range of −20° C. to 200° C., and thereaction time may be appropriately determined in the range of severalminutes to 96 hours.

The compounds represented by formula (1), (3), and (4) can be producedfrom an aniline derivative represented by formula (9) according to anyone properly selected from Production Methods 1 to 9.

In all the production Methods, the compounds may be isolated from thereaction systems after reactions according to a normal technique.However, the compounds can be optionally purified by an operation suchas recrystallization, column chromatography., distillation, or the like.Alternatively, the compounds may be used in next reaction steps withoutbeing isolated from the reaction systems.

Although typical examples of the compounds represented by formula (1)and used as active ingredients of insecticides of the present inventionare shown in Tables 1 to 5, the present invention is not limited tothese examples.

Although typical examples of the compounds represented by formula (4)are shown in Tables 6 to 8, the present invention is not limited tothese examples.

In the tables, “n-” denotes normal, “Me” denotes a methyl group, “Et”denotes an ethyl group; “n-Pr” denotes a normal propyl group, “i-Pr,denotes an isopropyl group, “n-Bu” denotes a normal butyl group, “i-Bu”denotes an isobutyl group, “s-Bu” denotes a secondary butyl group,“t-Bu” denotes a tertiary butyl group, “H” denotes a hydrogen atom, “O”denotes an oxygen atom, “S” denotes a sulfur atom, “C” denotes a carbonatom, “N” denotes a nitrogen atom, “F” denotes a fluorine atom, “Cl”denotes a chlorine atom, “Br” denotes a bromine atom, “I” denotes aniodine atom, “CF₃” denotes a trifluoromethy group, “MeO” denotes amethoxy group, “NH₂” denotes an amino group, “MeNH” denotes amethylamino group, and “Me₂N” denotes a dimethylamino group.

TABLE 1 (1-A)

Compound No. R₁ Q 1 Me 2-methyl-4-heptafluoroisopropylphenyl 2 Et2-methyl-4-heptafluoroisopropylphenyl 3 i-Pr2-methyl-4-heptafluoroisopropylphenyl 4 n-Bu2-methyl-4-heptafluoroisopropylphenyl 5 i-Bu2-methyl-4-heptafluoroisopropylphenyl 6 s-Bu2-methyl-4-heptafluoroisopropylphenyl 7 t-Bu2-methyl-4-heptafluoroisopropylphenyl 8 neopentyl2-methyl-4-heptafluoroisopropylphenyl 9 3,3-dimethyl-n-butyl2-methyl-4-heptafluoroisopropylphenyl 10 2-ethyl-n-hexyl2-methyl-4-heptafluoroisopropylphenyl 11 vinyl2-methyl-4-heptafluoroisopropylphenyl 12 allyl2-methyl-4-heptafluoroisopropylphenyl 13 2-isopropyl-5-methylcyclohexyl2-methyl-4-heptafluoroisopropylphenyl 14 benzyl2-methyl-4-heptafluoroisopropylphenyl 15 3-cyanobenzyl2-methyl-4-heptafluoroisopropylphenyl 16 4-cyanobenzyl2-methyl-4-heptafluoroisopropylphenyl 17 2-methoxyethyl2-methyl-4-heptafluoroisopropylphenyl 18 chloromethyl2-methyl-4-heptafluoroisopropylphenyl 19 2-chloroethyl2-methyl-4-heptafluoroisopropylphenyl 20 2,2,2-trichloroethyl2-methyl-4-heptafluoroisopropylphenyl 21 1,2,2,2-tetrachloroethyl2-methyl-4-heptafluoroisopropylphenyl 221,1-dimethyl-2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl23 3-trifluoromethylphenyl 2-methyl-4-heptafluoroisopropylphenyl 244-methylphenyl 2-methyl-4-heptafluoroisopropylphenyl 25 4-chlorophenyl2-methyl-4-heptafluoroisopropylphenyl 26 cyclobutyl2-methyl-4-heptafluoroisopropylphenyl 27 cyclopentyl2-methyl-4-heptafluoroisopropylphenyl 28 2-cyanoethyl2-methyl-4-heptafluoroisopropylphenyl 29 2-(ethylthio)ethyl2-methyl-4-heptafluoroisopropylphenyl 30 2-(ethylsulfinyl)ethyl2-methyl-4-heptafluoroisopropylphenyl 31 2-(ethylsulfonyl)ethyl2-methyl-4-heptafluoroisopropylphenyl 32 2-fluoroethyl2-methyl-4-heptafluoroisopropylphenyl 33 2,2-difluoroethyl2-methyl-4-heptafluoroisopropylphenyl 34 2,2,2-trifluoroethyl2-methyl-4-heptafluoroisopropylphenyl 35 1,3-difluoro-2-propyl2-methyl-4-heptafluoroisopropylphenyl 36 1-chloro-3-fluoro-2-propyl2-methyl-4-heptafluoroisopropylphenyl 371-methyl-2,2,2-trifluoro-2-propyl 2-methyl-4-heptafluoroisopropylphenyl38 3,3,3-trifluoro-n-propyl 2-methyl-4-heptafluoroisopropylphenyl 393,3,4,4,4-pentafluoro-2-butyl 2-methyl-4-heptafluoroisopropylphenyl 404,4,4-trifluoro-n-butyl 2-methyl-4-heptafluoroisopropylphenyl 412,2,3,3-tetrafluorocyclobutyl 2-methyl-4-heptafluoroisopropylphenyl 422,2-dichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 431,3-dichloro-2-propyl 2-methyl-4-heptafluoroisopropylphenyl 443-chloro-n-propyl 2-methyl-4-heptafluoroisopropylphenyl 453,3,3-trichloro-n-propyl 2-methyl-4-heptafluoroisopropylphenyl 462-bromoethyl 2-methyl-4-heptafluoroisopropylphenyl 472,2,2-tribromoethyl 2-methyl-4-heptafluoroisopropylphenyl 48 2-iodoethyl2-methyl-4-heptafluoroisopropylphenyl 49 tetrahydrofuran-3-yl2-methyl-4-heptafluoroisopropylphenyl 50 (furan-2-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 51 (furan-3-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 52 (tetrahydrofuran-2-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 53 (tetrahydrofuran-3-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 54 (thiophen-2-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 55 (thiophen-3-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 56 (pyridin-2-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 57 (pyridin-3-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 58 (6-chloropyridin-3-yl)methyl2-methyl-4-heptafluoroisopropylphenyl 59 Me2,6-dimethyl-4-heptafluoroisopropylphenyl 60 Et2,6-dimethyl-4-heptafluoroisopropylphenyl 61 n-Pr2,6-dimethyl-4-heptafluoroisopropylphenyl 62 i-Pr2,6-dimethyl-4-heptafluoroisopropylphenyl 63 n-Bu2,6-dimethyl-4-heptafluoroisopropylphenyl 64 i-Bu2,6-dimethyl-4-heptafluoroisopropylphenyl 65 s-Bu2,6-dimethyl-4-heptafluoroisopropylphenyl 66 t-Bu2,6-dimethyl-4-heptafluoroisopropylphenyl 67 neopentyl2,6-dimethyl-4-heptafluoroisopropylphenyl 68 1,2-dimethyl-n-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 69 1-methyl-n-butyl2,6-dimethyl-4-heptafluoroisopropylphenyl 70 1,3-dimethyl-n-butyl2,6-dimethyl-4-heptafluoroisopropylphenyl 71 3,3-dimethyl-n-butyl2,6-dimethyl-4-heptafluoroisopropylphenyl 72 cyclopentylmethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 73 1-phenylethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 74 2-phenylethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 75 vinyl2,6-dimethyl-4-heptafluoroisopropylphenyl 76 allyl2,6-dimethyl-4-heptafluoroisopropylphenyl 77 propargyl2,6-dimethyl-4-heptafluoroisopropylphenyl 78 cyclobutyl2,6-dimethyl-4-heptafluoroisopropylphenyl 79 cyclopentyl2,6-dimethyl-4-heptafluoroisopropylphenyl 80 cyclohexyl2,6-dimethyl-4-heptafluoroisopropylphenyl 81 benzyl2,6-dimethyl-4-heptanuoroisopropylphenyl 82 4-methylbenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 83 4-trifluoromethylbenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 84 3-cyanobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 85 4-cyanobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 86 2-fluorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 87 3-fluorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 88 4-fluorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 89 2-chlorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 90 3-chlorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 91 4-chlorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 92 4-nitrobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 93 4-methoxycarbonylbenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 94 2-hydroxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 95 2-methoxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 96 2-ethoxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 97 2-isopropyloxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 98 2-benzyloxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 99 3-ethoxy-n-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 100 ethoxycarbonylmethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 101 1-(methoxycarbonyl)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 102 1-(ethoxycarbonyl)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 103 3-oxo-n-butyl2,6-dimethyl-4-heptafluoroisopropylphenyl 104 2-acetoxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 105 cyanomethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 106 2-cyanoethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 107 3-cyano-n-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 108 2-(methylthio)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 109 2-(ethylthio)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 110 2-(isopropylthio)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1111-methyl-2-(methylthio)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl112 2-(ethylsulfinyl)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1132-(ethylsulfonyl)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1143-(methylthio)-n-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1153-(ethylthio)-n-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1162-fluoroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1172,2-difluoroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1182,2,2-trifluoroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1191,3-difluoro-2-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1201-chloro-3-fluoro-2-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1211-methyl-2,2,2-trifluoroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl122 1,1,1,3,3,3-hexafluoro-2-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 123 3,3,3-trifluoro-n-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1242,2,3,3,3-pentafluoro-n-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl125 3,3,4,4,4-pentafluoro-2-butyl2,6-dimethyl-4-heptafluoroisopropylphenyl 126 4,4,4-tifluoro-n-butyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1272,2,3,3-tetrafluorocyclobutyl 2,6-dimethyl-4-heptafluoroisopropylphenyl128 chloromethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 129trichloromethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1302-chloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1312,2-dichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1322,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1331,2,2,2-tetrachloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1341,3-dichloro-2-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1351,1-dimethyl-2,2,2-trichloroethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 136 3-chloro-n-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 137 2-bromoethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 138 2,2,2-tribromoethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 139 3-bromo-n-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 140 2-iodoethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 141 2-(acetylamino)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 142 2-(dimethylamino)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 143 2-(ethylamino)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 144 methylaminocarbonylethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 145 phenyl2,6-dimethyl-4-heptafluoroisopropylphenyl 146 4-methylphenyl2,6-dimethyl-4-heptafluoroisopropylphenyl 147 3-trifluoromethylphenyl2,6-dimethyl-4-heptafluoroisopropylphenyl 148 4-chlorophenyl2,6-dimethyl-4-heptafluoroisopropylphenyl 149 naphthyl2,6-dimethyl-4-heptafluoroisopropylphenyl 150 Pyridine-2-yl2,6-dimethyl-4-heptafluoroisopropylphenyl 151 pyridine-3-yl2,6-dimethyl-4-heptafluoroisopropylphenyl 152 pyridine-4-yl2,6-dimethyl-4-heptafluoroisopropylphenyl 153 tetrahydrofuran-2-yl2,6-dimethyl-4-heptafluoroisopropylphenyl 154 tetrahydrofuran-3-yl2,6-dimethyl-4-heptafluoroisopropylphenyl 155 (furan-2-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 156 (furan-3-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 157(tetrahydrofuran-2-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl158 (tetrahydrofuran-3-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 159 (thiophen-2-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 160 (thiophen-3-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 161 (pyridin-2-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 162 (pyridin-3-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 163(6-chloropyridin-3-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl164 Me 2-methyl-6-isopropyl-4-heptafluoro isopropylphenyl 165 Et2-methyl-6-isopropyl-4-heptafluoro isopropylphenyl 166 i-Pr4-heptafluoroisopropylphenyl 167 i-Pr3-methyl-4-heptafluoroisopropylphenyl 168 i-Pr2-ethyl-4-heptafluoroisopropylphenyl 169 i-Pr2-propyl-4-heptafluoroisopropylphenyl 170 i-Pr3-methoxy-4-heptafluoroisopropylphenyl 171 i-Pr3-chloro-4-heptafluoroisopropylphenyl 172 i-Pr2,3-dimethyl-4-heptafluoroisopropylphenyl 173 i-Pr2,5-dimethyl-4-heptafluoroisopropylphenyl 174 i-Pr2,6-diethyl-4-heptafluoroisopropylphenyl 175 i-Pr2-ethyl-6-methyl-4-heptafluoroisopropylphenyl 176 i-Pr2-methyl-6-isopropyl-4-heptafluoroisopropyl phenyl 177 i-Pr2-methoxy-6-methyl-4-heptafluoroisopropylphenyl 178 i-Pr2-methyl-6-phenyl4-heptafluoroisopropylphenyl 179 i-Pr2-chloro-5-methyl-4-heptafluoroisopropylphenyl 180 i-Pr2-chloro-6-ethyl-4-heptafluoroisopropylphenyl 181 i-Pr2-chloro-6-n-propyl-4-heptafluoroisopropyl phenyl 182 i-Pr2-chloro-5-methoxy-4-heptafluoroisopropylphenyl 183 i-Pr2,3-dimethyl-6-chloro-4-heptafluoroisopropyl phenyl 184 i-Pr2-chloro-3,6-dimethyl-4-heptafluoroisopropyl phenyl 185 i-Pr2-methyl-3-chloromethyl-6-chloro-4-heptafluoro isopropylphenyl 186 i-Pr2-methyl-3-iodo-6-chloro-4-heptafluoro isopropylphenyl 1872,2,2-trichloroethyl 4-heptafluoroisopropylphenyl 1882,2,2-trichloroethyl 3-methyl-4-heptafluoroisopropylphenyl 1892,2,2-trichloroethyl 2-ethyl-4-heptafluoroisopropylphenyl 1902,2,2-trichloroethyl 2-propyl-4-heptafluoroisopropylphenyl 1912,2,2-trichloroethyl 3-methoxy-4-heptafluoroisopropylphenyl 1922,2,2-trichloroethyl 2-chloro-4-heptafluoroisopropylphenyl 1932,2,2-trichloroethyl 3-chloro-4-heptafluoroisopropylphenyl 1942,2,2-trichloroethyl 2,3-dimethyl-4-heptafluoroisopropylphenyl 1952,2,2-trichloroethyl 2,5-dimethyl-4-heptafluoroisopropylphenyl 1962,2,2-trichloroethyl 2,6-diethyl-4-heptafluoroisopropylphenyl 1972,2,2-trichloroethyl 2-ethyl-6-methyl-4-heptafluoroisopropylphenyl 1982,2,2-trichloroethyl 2-methyl-6-isopropyl-4-heptafluoro isopropylphenyl199 2,2,2-trichloroethyl 2-methoxy-6-methyl-4-heptafluoroisopropylphenyl200 2,2,2-trichloroethyl 2-methyl-6-phenyl-4-heptafluoroisopropylphenyl201 2,2,2-trichloroethyl 2-hydroxy-6-methyl-4-heptafluoroisopropylphenyl 202 2,2,2-trichloroethyl2-chloro-5-methyl-4-heptafluoroisopropylphenyl 203 2,2,2-trichloroethyl2-methyl-3-amino-4-heptafluoroisopropylphenyl 204 2,2,2-trichloroethyl2-methyl-3-t-butoxycarbonylamino-4-heptafluoro isopropylphenyl 2052,2,2-trichloroethyl 2-chloro-6-ethyl-4-heptafluoroisopropylphenyl 2062,2,2-trichloroethyl 2-bromo-6-ethyl-4-heptafluoroisopropylphenyl 2072,2,2-trichloroethyl 2-ethyl-6-iodo-4-heptafluoroisopropylphenyl 2082,2,2-trichloroethyl 2-chloro-6-n-propyl-4-heptafluoro isopropylphenyl209 2,2,2-trichloroethyl 2-bromo-6-n-propyl-4-heptafluoroisopropylphenyl 210 2,2,2-trichloroethyl 2-bromo-6-n-butyl-4-heptafluoroisopropylphenyl 211 2,2,2-trichloroethyl2-chloro-5-methoxy-4-heptafluoro isopropylphenyl 2122,2,2-trichloroethyl 2-bromo-6-methylthio-4-heptafluoro isopropylphenyl213 2,2,2-trichloroethyl 2,6-dichloro-4-heptafluoroisopropylphenyl 2142,2,2-trichloroethyl 2,3-dimethyl-6-chloro-4-heptafluoro isopropylphenyl215 2,2,2-trichloroethyl 2-chloro-3,6-dimethyl-4-heptafluoroisopropylphenyl 216 2,2,2-trichloroethyl2-methyl-3-chloromethyl-6-chloro-4-heptafluoro isopropylphenyl 2172,2,2-trichloroethyl 2-methyl-3,6-dichloro-4-heptafluoro isopropylphenyl218 2,2,2-trichloroethyl 2-methyl-3-bromo-6-chloro-4-heptafluoroisopropylphenyl 219 2,2,2-trichloroethyl2-methyl-3-iodo-6-chloro-4-heptafluoro isopropylphenyl 2202,2,2-trichloroethyl 2-methyl-3-amino-6-chloro-4-heptafluoroisopropylphenyl 221 3,3,3-trifluoro-n-propyl2-bromo-6-n-butyl-4-heptafluoro isopropylphenyl 222 i-Pr2-chloro-6-methyl-4-trifluoromethylphenyl 223 i-Pr2,6-dichloro-4-trifluoromethylphenyl 224 i-Pr2-bromo-4,6-bis(trifluoromethyl)phenyl 225 i-Pr2,6-dimethyl-4-heptafluoro-n-propylphenyl 226 i-Pr2,6-dimethyl-4-nonafluoro-n-butylphenyl 227 2,2,2-trichloroethyl4-trifluoromethylphenyl 228 2,2,2-trichloroethyl2-chloro-6-methyl-4-trifluoromethylphenyl 229 2,2,2-trichloroethyl2-bromo-6-chloro-4-trifluoromethylphenyl 230 2,2,2-trichloroethyl2,6-dichloro-4-trifluoromethylphenyl 231 2,2,2-trichloroethyl2-chloro4,6-bistrifluoromethylphenyl 232 2,2,2-trichloroethyl2-bromo-4,6-bistrifluoromethylphenyl 233 2,2,2-trichloroethyl2,6-dimethyl-4-heptafluoro-n-propylphenyl 234 2,2,2-trichloroethyl2,6-dimethyl-4-nonafluoro-n-butylphenyl 235 2,2,2-trichloroethyl2,3,5,6-tetrafluoro-4-trifluoromethylphenyl 236 2,2,2-trichloroethyl2,6-dibromo-4-pentafluoroethylphenyl 237 3,3,3-trifluoro-n-propyl2,6-dibromo-4-pentafluoroethylphenyl 238 3,3,3-trifluoro-n-propyl2-bromo6-chloro-4-trifluoromethylphenyl 239 Et2,4-bis(trifluoromethyl)phenyl 240 i-Pr 2,4-bis(trifluoromethyl)phenyl241 vinyl 2,4-bis(trifluoromethyl)phenyl 242 cyclopentyl2,4-bis(trifluoromethyl)phenyl 243 2-chloroethyl2,4-bis(trifluoromethyl)phenyl 244 2-cyanoethyl2,4-bis(trifluoromethyl)phenyl 245 2,2-difluoroethyl2,4-bis(trifluoromethyl)phenyl 246 2,2-dichloroethyl2,4-bis(trifluoromethyl)phenyl 247 2,2,2-trichloroethyl2,4-bis(trifluoromethyl)phenyl 248 2,2,2-tribromoethyl2,4-bis(trifluoromethyl)phenyl 249 3,3,3-trifluoro-n-propyl2,4-bis(trifluoromethyl)phenyl 250 2,2,3,3,3-pentafluoro-n-propyl2,4-bis(trifluoromethyl)phenyl 251 4-cyanobenzyl2,4-bis(trifluoromethyl)phenyl 252 (6-chloropyridin-3-yl)methyl2,4-bis(trifluoromethyl)phenyl 253 i-Pr2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 254 2,2-difluoroethyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 255 1,3-difluoro-2-propyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 256 2,2,2-trifluoroethyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 257 2,2,2-trichloroethyl2,6-dimethyl-4-(noanfluoro-2-butyl)phenyl 2581-methyl-2,2,2-trifluoroethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl259 3,3,3-trifluoro-n-propyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl260 Et 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 261 vinyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 262 propargyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 263 cyclobutyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 264 cyclopentyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 265 benzyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 266 3-cyanobenzyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 267 4-cyanobenzyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 268 3-chlorobenzyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 269 2-methoxyethyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 270 2-cyanoethyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 271 2-(methylthio)ethyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 272 2-(ethylthio)ethyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2731-methyl-2-(methylthio)ethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl274 2-(ethylsulfinyl)ethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2752-(ethylsulfonyl)ethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2762-fluoroethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2771-chloro-3-fluoro-2-propyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2782,2,3,3,3-pentafluoro-n-propyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl279 3,3,4,4,4-pentafluoro-2-butyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 280 4,4,4-trifluoro-n-butyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2812,2,3,3-tetrafluorocyclobutyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl282 2-chloroethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2832,2-dichloroethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2841,3-dichloro-2-propyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2853-chloro-n-propyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2862-bromoethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2872,2,2-tribromoethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2883-bromo-n-propyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2892-iodoethyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 290tetrahydrofuran-3-yl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 291(furan-2-yl)methyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 292(furan-3-yl)methyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 293(tetrahydrofuran-2-yl)methyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl294 (tetrahydrofuran-3-yl)methyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 295 (thiophen-2-yl)methyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 296 (thiophen-3-yl)methyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 297 (pyridin-2-yl)methyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 298 (pyridin-3-yl)methyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 299(6-chloropyridin-3-yl)methyl 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl300 2,2,2-trichloroethyl 2,6-dichloro-4-(trifluoromethylthio)phenyl 3012,2,2-trichloroethyl 2,6-dichloro-4-(trifluoromethylsulfonyl)phenyl 302Et 2,6-dimethyl-4-pentafluoroethylphenyl 303 i-Pr2,6-dimethyl-4-pentafluoroethylphenyl 304 propargyl2,6-dimethyl-4-pentafluoroethylphenyl 305 cyclobutyl2,6-dimethyl-4-pentafluoroethylphenyl 306 cyclopentyl2,6-dimethyl-4-pentafluoroethylphenyl 307 benzyl2,6-dimethyl-4-pentafluoroethylphenyl 308 3-cyanobenzyl2,6-dimethyl-4-pentafluoroethylphenyl 309 4-cyanobenzyl2,6-dimethyl-4-pentafluoroethylphenyl 310 3-chlorobenzyl2,6-dimethyl-4-pentafluoroethylphenyl 311 2-methoxyethyl2,6-dimethyl-4-pentafluoroethylphenyl 312 2-cyanoethyl2,6-dimethyl-4-pentafluoroethylphenyl 313 2-(methylthio)ethyl2,6-dimethyl-4-pentafluoroethylphenyl 314 2-(ethylthio)ethyl2,6-dimethyl-4-pentafluoroethylphenyl 315 1-methyl2-(methylthio)ethyl2,6-dimethyl-4-pentafluoroethylphenyl 316 2-(ethylsulfinyl)ethyl2,6-dimethyl-4-pentafluoroethylphenyl 317 2-(ethylsulfonyl)ethyl2,6-dimethyl-4-pentafluoroethylphenyl 318 2-fluoroethyl2,6-dimethyl-4-pentafluoroethylphenyl 319 2,2-difluoroethyl2,6-dimethyl-4-pentafluoroethylphenyl 320 2,2,2-trifluoroethyl2,6-dimethyl-4-pentafluoroethylphenyl 321 1,3-difluoro-2-propyl2,6-dimethyl-4-pentafluoroethylphenyl 322 1-chloro-3-fluoro-2-propyl2,6-dimethyl-4-pentafluoroethylphenyl 323 1-methyl-2,2,2-trifluoroethyl2,6-dimethyl-4-pentafluoroethylphenyl 324 3,3,3-trifluoro-n-propyl2,6-dimethyl-4-pentafluoroethylphenyl 325 2,2,3,3,3-pentafluoro-n-propyl2,6-dimethyl-4-pentafluoroethylphenyl 326 3,3,4,4,4-pentafluoro-2-butyl2,6-dimethyl-4-pentafluoroethylphenyl 327 4,4,4-trifluoro-n-butyl2,6-dimethyl-4-pentafluoroethylphenyl 328 2,2,3,3-tetrafluorocyclobutyl2,6-dimethyl-4-pentafluoroethylphenyl 329 2-chloroethyl2,6-dimethyl-4-pentafluoroethylphenyl 330 2,2-dichloroethyl2,6-dimethyl-4-pentafluoroethylphenyl 331 2,2,2-trichloroethyl2,6-dimethyl-4-pentafluoroethylphenyl 332 1,3-dichloro-2-propyl2,6-dimethyl-4-pentafluoroethylphenyl 333 3-chloro-n-propyl2,6-dimethyl-4-pentafluoroethylphenyl 334 2-bromoethyl2,6-dimethyl-4-pentafluoroethylphenyl 335 2,2,2-tribromoethyl2,6-dimethyl-4-pentafluoroethylphenyl 336 3-bromo-n-propyl2,6-dimethyl-4-pentafluoroethylphenyl 337 2-iodoethyl2,6-dimethyl-4-pentafluoroethylphenyl 338 tetrahydrofuran-3-yl2,6-dimethyl-4-pentafluoroethylphenyl 339 (furan-2-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 340 (furan-3-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 341 (tetrahydrofuran-2-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 342 (tetrahydrofuran-3-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 343 (thiophen-2-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 344 (thiophen-3-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 345 (pyridin-2-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 346 (pyridin-3-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 347 (6-chloropyridin-3-yl)methyl2,6-dimethyl-4-pentafluoroethylphenyl 348 Me2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 349 Et2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 350i-Pr 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl351 propargyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 352 cyclobutyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 353cyclopentyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 354 3-cyanobenzyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3554-cyanobenzyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 356 3-chlorobenzyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3572-methoxyethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 358 2-cyanoethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3592-(methylthio)ethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 360 2-(ethylthio)ethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3611-methyl-2-(methylthio)ethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3622-(ethylsulfinyl)ethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 363 2-(ethylsulfonyl)ethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3642-fluoroethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 365 2,2-difluoroethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3662,2,2-trifluoroethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 367 1,3-difluoro-2-propyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3681-chloro-3-fluoro-2-propyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3691-methyl-2,2,2-trifluoroethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3703,3,3-trifluoro-n-propyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 371 2,2,3,3,3-pentafluoro-n-propyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3723,3,4,4,4-pentafluoro-2-butyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3734,4,4-trifluoro-n-butyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 374 2,2,3,3-tetrafluorocyclobutyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3752-chloroethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 376 2,2-dichloroethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3772,2,2-trichloroethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 378 1,3-dichloro-2-propyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3793-chloro-n-propyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 380 2-bromoethyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3812,2,2-tribromoethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 382 3-bromo-n-propyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 3832-iodoethyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 384 tetrahydrofuran-3-yl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 385(furan-2-yl)methyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 386 (furan-3-yl)methyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 387(tetrahydrofuran-2-yl)methyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 388(tetrahydrofuran-3-yl)methyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 389(thiophen-2-yl)methyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 390 (thiophen-3-yl)methyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 391(pyridin-2-yl)methyl 2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro-isopropyl)phenyl 392 (pyridin-3-yl)methyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 393(6-chloropyridin-3-yl)methyl2,6-dimethyl-4-(2-bromo-1,1,2,3,3,3-hexafluoro- isopropyl)phenyl 394 Et2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 395 i-Pr2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 396 vinyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 397 propargyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 398 cyclobutyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 399 cyclopentyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 400 benzyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 401 3-cyanobenzyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 402 4-cyanobenzyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 403 3-chlorobenzyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 404 2-methoxyethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 405 2-cyanoethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 406 2-(methylthio)ethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 407 2-(ethylthio)ethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4081-methyl-2-(methylthio)ethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4092-(ethylsulfinyl)ethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl410 2-(ethylsulfonyl)ethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 411 2-fluoroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 412 2,2-difluoroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 413 2,2,2-trifluoroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4141,3-difluoro-2-propyl 2,6-dichloro4-(heptafluoro-n-propylthio)phenyl 4151-chloro-3-fluoro-2-propyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4161-methyl-2,2,2-trifluoroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4173,3,3-trifluoro-n-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl418 2,2,3,3,3-pentafluoro-n-propyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4193,3,4,4,4-pentafluoro-2-butyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4204,4,4-trifluoro-n-butyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl421 2,2,3,3-tetrafluorocyclobutyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 422 2-chloroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 423 2,2-dichloroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 424 2,2,2-trichloroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4251,3-dichloro-2-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl426 3-chloro-n-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl427 2-bromoethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4282,2,2-tribromoethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4293-bromo-n-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 4302-iodoethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 431tetrahydrofuran-3-yl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 432(furan-2-yl)methyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 433(furan-3-yl)methyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 434(tetrahydrofuran-2-yl)methyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 435(tetrahydrofuran-3-yl)methyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 436(thiophen-2-yl)methyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl437 (thiophen-3-yl)methyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 438 (pyridin-2-yl)methyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 439 (pyridin-3-yl)methyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 440(6-chloropyridin-3-yl)methyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 441 Et2,6-dibromo-4-(trifluoromethylthio)phenyl 442 i-Pr2,6-dibromo-4-(trifluoromethylthio)phenyl 443 vinyl2,6-dibromo-4-(trifluoromethylthio)phenyl 444 propargyl2,6-dibromo-4-(trifluoromethylthio)phenyl 445 cyclobutyl2,6-dibromo-4-(trifluoromethylthio)phenyl 446 cyclopentyl2,6-dibromo-4-(trifluoromethylthio)phenyl 447 benzyl2,6-dibromo-4-(trifluoromethylthio)phenyl 448 3-cyanobenzyl2,6-dibromo-4-(trifluoromethylthio)phenyl 449 4-cyanobenzyl2,6-dibromo-4-(trifluoromethylthio)phenyl 450 3-chlorobenzyl2,6-dibromo-4-(trifluoromethylthio)phenyl 451 2-methoxyethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 452 2-cyanoethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 453 2-(methylthio)ethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 454 2-(ethylthio)ethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 4551-methyl-2-(methylthio)ethyl 2,6-dibromo-4-(trifluoromethylthio)phenyl456 2-(ethylsulfinyl)ethyl 2,6-dibromo-4-(trifluoromethylthio)phenyl 4572-(ethylsulfonyl)ethyl 2,6-dibromo-4-(trifluoromethylthio)phenyl 4582-fluoroethyl 2,6-dibromo-4-(trifluoromethylthio)phenyl 4592,2-difluoroethyl 2,6-dibromo-4-(trifluoromethylthio)phenyl 4602,2,2-trifluoroethyl 2,6-dibromo-4-(trifluoromethylthio)phenyl 4611,3-difluoro-2-propyl 2,6-dibromo-4-(trifluoromethylthio)phenyl 4621-chloro-3-fluoro-2-propyl 2,6-dibromo-4-(trifluoromethylthio)phenyl 4631-methyl-2,2,2-trifluoroethyl 2,6-dibromo-4-(trifluoromethylthio)phenyl464 3,3,3-trifluoro-n-propyl 2,6-dibromo-4-(trifluoromethylthio)phenyl465 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(trifluoromethylthio)phenyl 4663,3,4,4,4-pentafluoro-2-butyl 2,6-dibromo-4-(trifluoromethylthio)phenyl467 4,4,4-trifluoro-n-butyl 2,6-dibromo-4-(trifluoromethylthio)phenyl468 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(trifluoromethylthio)phenyl 469 2-chloroethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 470 2,2-dichloroethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 471 2,2,2-trichloroethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 472 1,3-dichloro-2-propyl2,6-dibromo-4-(trifluoromethylthio)phenyl 473 3-chloro-n-propyl2,6-dibromo-4-(trifluoromethylthio)phenyl 474 2-bromoethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 475 2,2,2-tribromoethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 476 3-bromo-n-propyl2,6-dibromo-4-(trifluoromethylthio)phenyl 477 2-iodoethyl2,6-dibromo-4-(trifluoromethylthio)phenyl 478 tetrahydrofuran-3-yl2,6-dibromo-4-(trifluoromethylthio)phenyl 479 (furan-2-yl)methyl2,6-dibromo-4-(trifluoromethylthio)phenyl 480 (furan-3-yl)methyl2,6-dibromo-4-(trifluoromethylthio)phenyl 481(tetrahydrofuran-2-yl)methyl 2,6-dibromo-4-(trifluoromethylthio)phenyl482 (tetrahydrofuran-3-yl)methyl2,6-dibromo-4-(trifluoromethylthio)phenyl 483 (thiophen-2-yl)methyl2,6-dibromo-4-(trifluoromethylthio)phenyl 484 (thiophen-3-yl)methyl2,6-dibromo-4-(trifluoromethylthio)phenyl 485 (pyridin-2-yl)methyl2,6-dibromo-4-(trifluoromethylthio)phenyl 486 (pyridin-3-yl)methyl2,6-dibromo-4-(trifluoromethylthio)phenyl 487(6-chloropyridin-3-yl)methyl 2,6-dibromo-4-(trifluoromethylthio)phenyl488 Et 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 489 i-Pr2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 490 vinyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 491 propargyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 492 cyclobutyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 493 cyclopentyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 494 benzyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 495 3-cyanobenzyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 496 4-cyanobenzyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 497 3-chlorobenzyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 498 2-methoxyethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 499 2-cyanoethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 500 2-(methylthio)ethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 501 2-(ethylthio)ethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 5021-methyl-2-(methylthio)ethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 503 2-(ethylsulfinyl)ethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 504 2-(ethylsulfonyl)ethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 505 2-fluoroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 506 2,2-difluoroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 507 2,2,2-trifluoroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 508 1,3-difluoro-2-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 5091-chloro-3-fluoro-2-propyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl510 1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 5113,3,3-trifluoro-n-propyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl512 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 5133,3,4,4,4-pentafluoro-2-butyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 5144,4,4-trifluoro-n-butyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl515 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 516 2-chloroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 517 2,2-dichloroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 518 2,2,2-trichloroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 519 1,3-dichloro-2-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 520 3-chloro-n-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 521 2-bromoethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 522 2,2,2-tribromoethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 523 3-bromo-n-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 524 2-iodoethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 525 tetrahydrofuran-3-yl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 526 (furan-2-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 527 (furan-3-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 528(tetrahydrofuran-2-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 529(tetrahydrofuran-3-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 530 (thiophen-2-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 531 (thiophen-3-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 532 (pyridin-2-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 533 (pyridin-3-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 534(6-chloropyridin-3-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 535 Et2,6-dibromo-4-(pentafluoroethylthio)phenyl 536 i-Pr2,6-dibromo-4-(pentafluoroethylthio)phenyl 537 vinyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 538 propargyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 539 cyclobutyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 540 cyclopentyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 541 benzyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 542 3-cyanobenzyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 543 4-cyanobenzyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 544 3-chlorobenzyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 545 2-methoxyethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 546 2-cyanoethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 547 2-(methylthio)ethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 548 2-(ethylthio)ethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 5491-methyl-2-(methylthio)ethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl550 2-(ethylsulfinyl)ethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl551 2-(ethylsulfonyl)ethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl552 2-fluoroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 5532,2-difluoroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 5542,2,2-trifluoroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 5551,3-difluoro-2-propyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 5561-chloro-3-fluoro-2-propyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl557 1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 558 3,3,3-trifluoro-n-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 5592,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 5603,3,4,4,4-pentafluoro-2-butyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl561 4,4,4-trifluoro-n-butyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl562 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 563 2-chloroethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 564 2,2-dichloroethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 565 2,2,2-trichloroethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 566 1,3-dichloro-2-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 567 3-chloro-n-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 568 2-bromoethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 569 2,2,2-tribromoethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 570 3-bromo-n-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 571 2-iodoethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 572 tetrahydrofuran-3-yl2,6-dibromo-4-(pentafluoroethylthio)phenyl 573 (furan-2-yl)methyl2,6-dibromo-4-(pentafluoroethylthio)phenvl 574 (furan-3-yl)methyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 575(tetrahydrofuran-2-yl)methyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl576 (tetrahydrofuran-3-yl)methyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 577 (thiophen-2-yl)methyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 578 (thiophen-3-yl)methyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 579 (pyridin-2-yl)methyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 580 (pyridin-3-yl)methyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 581(6-chloropyridin-3-yl)methyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl582 Et 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 583 i-Pr2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 584 vinyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 585 propargyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 586 cyclobutyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 587 cyclopentyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 588 benzyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 589 3-cyanobenzyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 590 4-cyanobenzyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 591 3-chlorobenzyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 592 2-methoxyethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 593 2-cyanoethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 594 2-(methylthio)ethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 595 2-(ethylthio)ethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 5961-methyl-2-(methylthio)ethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 5972-(ethylsulfinyl)ethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl598 2-(ethylsulfonyl)ethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 599 2-fluoroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 600 2,2-difluoroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 601 2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 602 1,3-difluoro-2-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 6031-chloro-3-fluoro-2-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 6041-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 6053,3,3-trifluoro-n-propyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl606 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 6073,3,4,4,4-pentafluoro-2-butyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 6084,4,4-trifluoro-n-butyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl609 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 610 2-chloroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 611 2,2-dichloroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 612 2,2,2-trichloroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 613 1,3-dichloro-2-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 614 3-chloro-n-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 615 2-bromoethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 616 2,2,2-tribromoethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 617 3-bromo-n-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 618 2-iodoethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 619 tetrahydrofuran-3-yl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 620 (furan-2-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 621 (furan-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 622(tetrahydrofuran-2-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 623(tetrahydrofuran-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 624 (thiophen-2-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 625 (thiophen-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 626 (pyridin-2-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 627 (pyridin-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 628(6-chloropyridin-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 629 Et2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 630 i-Pr2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 631 vinyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 632 propargyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 633 cyclobutyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 634 cyclopentyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 635 benzyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 636 3-cyanobenzyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 637 4-cyanobenzyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 638 3-chlorobenzyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 639 2-methoxyethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 640 2-cyanoethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 641 2-(methylthio)ethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 642 2-(ethylthio)ethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 6431-methyl-2-(methylthio)ethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 6442-(ethylsulfinyl)ethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl645 2-(ethylsulfonyl)ethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 646 2-fluoroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 647 2,2-difluoroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 648 2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 649 1,3-difluoro-2-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 6501-chloro-3-fluoro-2-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 6511-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 6523,3,3-trifluoro-n-propyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl653 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 6543,3,4,4,4-pentafluoro-2-butyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 6554,4,4-trifluoro-n-butyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl656 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 657 2-chloroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 658 2,2-dichloroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 659 2,2,2-trichloroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 660 1,3-dichloro-2-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 661 3-chloro-n-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 662 2-bromoethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 663 2,2,2-tribromoethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 664 3-bromo-n-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 665 2-iodoethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 666 tetrahydrofuran-3-yl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 667 (furan-2-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 668 (furan-3-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 669(tetrahydrofuran-2-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 670(tetrahydrofuran-3-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 671 (thiophen-2-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 672 (thiophen-3-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 673 (pyridin-2-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 674 (pyridin-3-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 675(6-chloropyridin-3-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 676 Et2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 677 i-Pr2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 678 vinyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 679 propargyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 680 cyclobutyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 681 cyclopentyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 682 benzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 683 3-cyanobenzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 684 4-cyanobenzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 685 3-chlorobenzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 686 2-methoxyethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 687 2-cyanoethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 6882-(methylthio)ethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl689 2-(ethylthio)ethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 690 1-methyl-2-(methylthio)ethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 6912-(ethylsulfinyl)ethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 692 2-(ethylsulfonyl)ethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 693 2-fluoroethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 6942,2-difluoroethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl695 2,2,2-trifluoroethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 696 1,3-difluoro-2-propyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 6971-chloro-3-fluoro-2-propyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 698 1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 6993,3,3-trifluoro-n-propyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 700 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 7013,3,4,4,4-pentafluoro-2-butyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 702 4,4,4-trifluoro-n-butyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 7032,2,3,3-tetrafluorocyclobutyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 704 2-chloroethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 705 2,2-dichloroethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 7062,2,2-trichloroethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl707 1,3-dichloro-2-propyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 708 3-chloro-n-propyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 709 2-bromoethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 7102,2,2-tribromoethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl711 3-bromo-n-propyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl712 2-iodoethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 713tetrahydrofuran-3-yl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl714 (furan-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 715 (furan-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 716(tetrahydrofuran-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 717 (tetrahydrofuran-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 718(thiophen-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 719 (thiophen-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 720(pyridin-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl721 (pyridin-3-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 722 (6-chloropyridin-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 723 Et2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 724 i-Pr2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 725 vinyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 726 propargyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 727 cyclobutyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 728 cyclopentyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 729 benzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 730 3-cyanobenzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 731 4-cyanobenzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 732 3-chlorobenzyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 733 2-methoxyethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 734 2-cyanoethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7352-(methylthio)ethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl736 2-(ethylthio)ethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 737 1-methyl-2-(methylthio)ethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7382-(ethylsulfinyl)ethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 739 2-(ethylsulfonyl)ethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 740 2-fluoroethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7412,2-difluoroethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl742 2,2,2-trifluoroethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 743 1,3-difluoro-2-propyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7441-chloro-3-fluoro-2-propyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 745 1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7463,3,3-trifluoro-n-propyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 747 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7483,3,4,4,4-pentafluoro-2-butyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 749 4,4,4-trifluoro-n-butyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7502,2,3,3-tetrafluorocyclobutyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 751 2-chloroethyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 752 2,2-dichloroethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7532,2,2-trichloroethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl754 1,3-dichloro-2-propyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 755 3-chloro-n-propyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 756 2-bromoethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7572,2,2-tribromoethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl758 3-bromo-n-propyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl759 2-iodoethyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 760tetrahydrofuran-3-yl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl761 (furan-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 762 (furan-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 763(tetrahydrofuran-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 764 (tetrahydrofuran-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 765(thiophen-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 766 (thiophen-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 767(pyridin-2-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl768 (pyridin-3-yl)methyl 2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)phenyl 769 (6-chloropyridin-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propyl sulfonyl)phenyl 7702,2,2-trichloroethyl 2-methyl-4-(heptafluoro-n-propylthio)phenyl 771 Et2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 772 i-Pr2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 773 propargyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 774 cyclobutyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 775 cyclopentyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 776 benzyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 777 3-cyanobenzyl2,6-dimethyl-4-(heptafluoro-n-propylthto)phenyl 778 4-cyanobenzyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 779 3-chlorobenzyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 780 2-methoxyethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 781 2-cyanoethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 782 2-(methylthio)ethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 783 2-(ethylthio)ethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 7841-methyl-2-(methylthio)ethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 7852-(ethylsulfinyl)ethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl786 2-(ethylsulfonyl)ethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 787 2-fluoroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 788 2,2-difluoroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 789 2,2,2-trifluoroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 7901,3-difluoro-2-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl791 1-chloro-3-fluoro-2-propyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 7921-methyl-2,2,2-trifluoroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 7933,3,3-trifluoro-n-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl794 2,2,3,3,3-pentafluoro-n-propyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 7953,3,4,4,4-pentafluoro-2-butyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 7964,4,4-trifluoro-n-butyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl797 2,2,3,3-tetrafluorocyclobutyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 798 2-chloroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 799 2,2-dichloroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 800 2,2,2-trichloroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 8011,3-dichloro-2-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl802 3-chloro-n-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl803 2-bromoethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 8042,2,2-tribromoethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 8053-bromo-n-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 8062-iodoethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 807tetrahydrofuran-3-yl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 808(furan-2-yl)methyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 809(furan-3-yl)methyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 810(tetrahydrofuran-2-yl)methyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 811(tetrahydrofuran-3-yl)methyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 812(thiophen-2-yl)methyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl813 (thiophen-3-yl)methyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 814 (pyridin-2-yl)methyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 815 (pyridin-3-yl)methyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 816(6-chloropyridin-3-yl)methyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 8173,3,3-trifluoro-n-propyl2-(n-butyl)-6-chloro-4-heptafluoroisopropylphenyl 8183,3,3-trifluoro-n-propyl 2-(n-butyl)-4-heptafluoroisopropyl-6-iodophenyl819 3,3,3-trifluoro-n-propyl2-bromo-6-(2-butyl)-4-heptafluoroisopropylphenyl 820 i-Pr2-methyl-4-trifluoromethoxyphenyl 821 i-Pr2-trifluoromethyl-4-isopropylphenyl 822 i-Pr3,5-bistrifluoromethylphenyl 823 i-Pr 2,3,4-trifluorophenyl 824 i-Pr2-heptafluoroisopropyl-3,5-dimethylphenyl 825 i-Pr2,4-dichloro-6-methylphenyl 826 i-Pr 2-chloro-4,6-dimethylphenyl 827i-Pr 2,6-dimethyl-4-chlorophenyl 828 i-Pr 2,6-dimethyl-4-bromophenyl 829i-Pr 2,6-dimethyl-4-iodophenyl 830 i-Pr 2,6-dimethyl-4-(phenyl)phenyl831 i-Pr 2,6-dimethyl-4-(2-methylphenyl)phenyl 832 i-Pr2,6-dimethyl-4-(3-methylphenyl)phenyl 833 i-Pr2,6-dimethyl-4-(4-methylphenyl)phenyl 834 i-Pr2,6-dimethyl-4-(2-methoxyphenyl)phenyl 835 i-Pr2,6-dimethyl-4-(3-methoxyphenyl)phenyl 836 i-Pr2,6-dimethyl-4-(4-methoxyphenyl)phenyl 837 i-Pr2,6-dimethyl-4-(4-ethoxyphenyl)phenyl 838 i-Pr2,6-dimethyl-4-(4-methylthiophenyl)phenyl 839 i-Pr2,6-dimethyl-4-(2-fluorophenyl)phenyl 840 i-Pr2,6-dimethyl-4-(3-fluorophenyl)phenyl 841 i-Pr2,6-dimethyl-4-(4-fluorophenyl)phenyl 842 i-Pr2-bromo-4-isopropyl-6-methylphenyl 843 i-Pr2-chloro-4-cyano-6-methylphenyl 844 i-Pr2-chloro-4-trifluoromethoxy-6-methylphenyl 845 i-Pr2-chloro-4-isopropyl-6-trifluoromethylphenyl 846 i-Pr pentafluorophenyl847 2,2,2-trichloroethyl 4-cyclohexylphenyl 848 2,2,2-trichloroethyl2-trifluoromethylphenyl 849 2,2,2-trichloroethyl4-(trifluoromethylthio)phenyl 850 2,2,2-trichloroethyl4-(trifluoromethylsulfonyl)phenyl 851 2,2,2-trichloroethyl4-(heptafluoro-n-propylthio)phenyl 852 2,2,2-trichloroethyl4-(heptafluoro-n-propylsulfinyl)phenyl 853 2,2,2-trichloroethyl4-(heptafluoroisopropylthio)phenyl 854 2,2,2-trichloroethyl2-(n-butyl)-6-chloro-4-heptafluoroisopropylphenyl 8552,2,2-trichloroethyl 2-(n-butyl)-4-heptafluoroisopropyl-6-iodophenyl 8562,2,2-trichloroethyl 2-bromo-6-(2-butyl)-4-heptafluoroisopropylphenyl857 2,2,2-trichloroethyl 2-(2-butyl)-4-heptafluoroisopropylphenyl 8582,2,2-trichloroethyl 2-methyl-4-trifluoromethoxyphenyl 8592,2,2-trichloroethyl 2-methyl-4-(2,2,2-trifluoroethoxy)phenyl 8602,2,2-trichloroethyl 2-methyl-4-(trifluoromethylsulfonyloxy)phenyl 8612,2,2-trichloroethyl 2-methyl-4-chlorophenyl 862 2,2,2-trichloroethyl2-trifluoromethyl-4-isopropylphenyl 863 2,2,2-trichloroethyl2,5-bistrifluoromethylphenyl 864 2,2,2-trichloroethyl3,5-bistrifluoromethylphenyl 865 2,2,2-trichloroethyl2-trifluoromethyl-4-chlorophenyl 866 2,2,2-trichloroethyl2-chloro-6-trifluoromethylphenyl 867 2,2,2-trichloroethyl2-trifluoromethyl-4-iodophenyl 868 2,2,2-trichloroethyl2-trifluoromethoxy-4-bromophenyl 869 2,2,2-trichloroethyl2,3,4-trifluorophenyl 870 2,2,2-trichloroethyl2-heptafluoroisopropyl-3,5-dimethylphenyl 871 2,2,2-trichloroethyl2,5-dimethyl-4-trifluoromethane sulfonyloxyphenyl 8722,2,2-trichloroethyl 2,6-dimethyl-4-(bis(trifluoromethyl)hydroxymethyl)phenyl 873 2,2,2-trichloroethyl2,6-dimethyl-4-(bis(chlorodifluoromethyl) hydroxymethyl)phenyl 8742,2,2-trichloroethyl 2,6-dimethyl-4-cyanothiophenyl 8752,2,2-trichloroethyl 2,6-dimethyl-4-chlorophenyl 8762,2,2-trichloroethyl 2-chloro-4,6-dimethylphenyl 8772,2,2-trichloroethyl 2,6-dimethyl-4-bromophenyl 878 2,2,2-trichloroethyl2,6-dimethyl-4-iodophenyl 879 2,2,2-trichloroethyl2,6-dimethyl-4-(phenyl)phenyl 880 2,2,2-trichloroethyl2,6-dimethyl-4-(2-methylphenyl)phenyl 881 2,2,2-trichloroethyl2,6-dimethyl-4-(3-methylphenyl)phenyl 882 2,2,2-trichloroethyl2,6-dimethyl-4-(4-methylphenyl)phenyl 883 2,2,2-trichloroethyl2,6-dimethyl-4-(2-methoxyphenyl)phenyl 884 2,2,2-trichloroethyl2,6-dimethyl-4-(3-methoxyphenyl)phenyl 885 2,2,2-trichloroethyl2,6-dimethyl-4-(4-methoxyphenyl)phenyl 886 2,2,2-trichloroethyl2,6-dimethyl-4-(4-ethoxyphenyl)phenyl 887 2,2,2-trichloroethyl2,6-dimethyl-4-(4-methylthiophenyl)phenyl 888 2,2,2-trichloroethyl2,6-dimethyl-4-(2-fluorophenyl)phenyl 889 2,2,2-trichloroethyl2,6-dimethyl-4-(3-fluorophenyl)phenyl 890 2,2,2-trichloroethyl2,6-dimethyl-4-(4-fluorophenyl)phenyl 891 2,2,2-trichloroethyl2,6-dimethyl-4-(3,4-difluorophenyl)phenyl 892 2,2,2-trichloroethyl2,6-dimethyl-4-(3-methyl-4-fluorophenyl)phenyl 893 2,2,2-trichloroethyl2,6-dimethyl-4-(furan-3-yl)phenyl 894 2,2,2-trichloroethyl2,6-dimethyl-4-(thiophene-2-yl)phenyl 895 2,2,2-trichloroethyl2,6-dimethyl-4-(thiophene-3-yl)phenyl 896 2,2,2-trichloroethyl2,4-dichloro-6-methylphenyl 897 2,2,2-trichloroethyl2,4-dichloro-6-trifluoromethylphenyl 898 2,2,2-trichloroethyl2,6-dichloro-4-(heptafluoroisopropylthio)phenyl 899 2,2,2-trichloroethyl2,6-dichloro-4-(heptafluoroisopropyl sulfonyl)phenyl 9002,2,2-trichloroethyl 2,6-dichloro-4-pentafluorosulfanylphenyl 9012,2,2-trichloroethyl 2,6-dibromo-4-cyclohexylphenyl 9022,2,2-trichloroethyl 2,4-dibromo-6-trifluoromethylphenyl 9032,2,2-trichloroethyl 2,6-dibromo-4-(nonafluoro-n-butylthio)phenyl 9042,2,2-trichloroethyl 2-chloro-4-hydroxy-6-methylphenyl 9052,2,2-trichloroethyl 2-chloro-4-trifluoromethoxy-6-methylphenyl 9062,2,2-trichloroethyl 2-chloro-4-((2,2,2-trichloroethoxy)carbonyloxy)-6-methylphenyl 907 2,2,2-trichloroethyl 2-chloro-4-cyano-6-methylphenyl908 2,2,2-trichloroethyl 2-chloro-4-iodo-6-methylphenyl 9092,2,2-trichloroethyl 2-bromo-4-isopropyl-6-methylphenyl 9102,2,2-trichloroethyl 2-bromo-4-hydroxy-6-methylphenyl 9112,2,2-trichloroethyl 2-chloro-4-isopropyl-6-trifluoromethylphenyl 9122,2,2-trichloroethyl 2-bromo-4-((2,2,2-trichloroethoxy)carbonyloxy)-6-methylphenyl 913 2,2,2-trichloroethyl2-chloro-4-bromo-6-trifluoromethylphenyl 914 2,2,2-trichloroethyl2-bromo-4-isopropyl-6-trifluoromethylphenyl 915 2,2,2-trichloroethyl2-bromo-4-chloro-6-trifluoromethylphenyl 916 2,2,2-trichloroethylpentafluorophenyl 917 2-chloroethyl 2,6-dimethyl-4-iodophenyl 9183,3,3-trifluoro-n-propyl 2,6-dimethyl-4-(1,1,1,3,3,3-hexafluoro2-hydroxy-2-propyl)phenyl 919 3,3,3-trifluoro-n-propyl2,6-dichloro-4-pentafluorosulfanylphenyl 920 i-Pr2-methyl-4-heptafluoroisopropyl-1-naphthyl 921 i-Pr4-heptafluoroisopropyl-5,6,7,8- tetrahydro-1-naphthyl 922 i-Pr2-chloro-4-heptafluoroisopropyl-5,6,7,8- tetrahydro-1-naphthyl 923 i-Pr1-methyl-3-trifluoromethylpyrazo1-5-yl 924 i-Pr1-methyl-3-trifluoromethyl-4-chloropyrazol-5-yl 925 i-Pr1-methyl-3-trifluoromethyl-4-bromopyrazol-5-yl 926 i-Pr1-methyl-3-trifluoromethyl-4-methoxy carbonylpyrazol-5-yl 927 i-Pr2-chloro-4-methylpyridin-5-yl 928 i-Pr2-bromo4-methyl-6-chloropyridin-3-yl 929 i-Pr2-(1,1,1,3,3,3-hexafluoroisopropyloxy) pyridin-5-yl 930 i-Pr2-(1,1,1,3,3,3-hexafluoroisopropyloxy)- 4-methylpyridin-5-yl 931 i-Pr2-bromo-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 932 i-Pr2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 9332,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropyl-1-naphthyl 9342,2,2-trichloroethyl 4-heptafluoroisopropyl-5,6,7,8-tetrahydro-1-naphthyl 935 2,2,2-trichloroethyl2-chloro-4-heptafluoroisopropyl 5,6,7,8-tetrahydro-1-naphthyl 9362,2,2-trichloroethyl 1-methyl-3-trifluoromethylpyrazol-5-yl 9372,2,2-trichloroethyl 1-methyl-3-trifluoromethyl-4-chloropyrazol-5-yl 9382,2,2-trichloroethyl 1-methyl-3-trifluoromethyl-4-bromopyrazol-5-yl 9392,2,2-trichloroethyl 1-methyl-3-trifluoromethyl-4-methoxycarbonylpyrazol-5-yl 940 2,2,2-trichloroethyl1-(3-chloropyridine-2-yl)-3-bromopyrazol-5-yl 941 2,2,2-trichloroethyl1-(3-chloropyridin-2-yl)-3-bromo- 4-chloropyrazol-5-yl 9422,2,2-trichloroethyl 2-heptafluoroisopropyl-4-methylpyridin-5-yl 9432,2,2-trichloroethyl 2-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-5-yl944 2,2,2-trichloroethyl 2-(1,1,1,3,3,3-hexafluoroisopropyloxy)-4-methylpyridin-5-yl 945 2,2,2-trichloroethyl2-chloro-4-methylpyridin-5-yl 946 2,2,2-trichloroethyl3-chloro-5-trifluoromethylpyridin-2-yl 947 2,2,2-trichloroethyl2-bromo-4-methyl-6-chloropyridin-3-yl 948 2,2,2-trichloroethyl2-bromo-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 9492,2,2-trichloroethyl 2,6-dichloro-4-(trifluoromethylsulfinyl)phenyl 9502,2,2-trichloroethyl 2,6-dibromo-4-(trifluoromethylsulfinyl)phenyl 9512,2,2-trichloroethyl 2,6-dichloro-4-(pentafluoroethylsulfinyl)phenyl 9522,2,2-trichloroethyl 2,6-dibromo-4-(pentafluoroethylsulfinyl)phenyl 9532,2,2-trichloroethyl 2,6-dichloro-4-(pentafluoroethylsulfonyl)phenyl 9542,2,2-trichloroethyl 2,6-dibromo-4-(pentafluoroethylsulfonyl)phenyl 9552,2,2-trichloroethyl 2,6-dichloro-4-(heptafluoro-n-propylsulfinyl)phenyl 956 2,2,2-trichloroethyl2,6-dibromo-4-(heptafluoro-n-propyl sulfinyl)phenyl 9572,2,2-trichloroethyl 2-chloro-6-methyl-4-(nonafluoro-2-butyl)phenyl 9582,2,2-trichloroethyl 2-bromo-6-methyl-4-(nonafluoro-2-butyl)phenyl 9592,2,2-trichloroethyl 2-iodo-6-methyl-4-(nonafluoro-2-butyl)phenyl 9602,2,2-trichloroethyl 2,6-dichloro-4-(nonafluoro-2-butyl)phenyl 9612,2,2-trichloroethyl 2,6-dibromo-4-(nonafluoro-2-butyl)phenyl 9622,2,2-trichloroethyl 2,6-dimethyl-4-pentafluoroethylphenyl 9632,2,2-trichloroethyl 2,6-dichloro-4-pentafluoroethylphenyl 9642,2,2-trichloroethyl 2,6-dimethyl-4-(pentafluoroethylthio) phenyl 9652,2,2-trichloroethyl 2,6-dimethyl-4-(pentafluoroethylsulfinyl) phenyl966 2,2,2-trichloroethyl 2,6-dimethyl-4-(pentafluoroethylsulfonyl)phenyl 967 2,2,2-trichloroethyl 2,6-dichloro-4-(pentafluoroethylthio)phenyl 968 i-Pr 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 969 cyclobutyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl970 cyclopentyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 971 4-cyanobenzyl2-chloro4-methyl-6-(1,1,1,3,3,3-hexafluoro- isopropyloxy)pyridin-3-yl972 2-methoxyethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 973 2-cyanoethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl974 2-(methylthio)ethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 975 2-(ethylthio)ethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl976 1-methyl-2-(methylthio)ethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl977 2-(ethylsulfinyl)ethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 978 2-(ethylsulfonyl)ethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl979 2-fluoroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 980 2,2-difluoroethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl981 2,2,2-trifluoroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 982 1,3-difluoro-2-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl983 1-chloro-3-fluoro-2-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl984 1-methyl-2,2,2-trifluoroethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl985 3,3,3-trifluoro-n-propyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 986 2,2,3,3,3-pentafluoro-n-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl987 3,3,4,4,4-pentafluoro-2-butyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl988 4,4,4-trifluoro-n-butyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 989 2,2,3,3-tetrafluorocyclobutyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl990 2-chloroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 991 2,2-dichloroethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl992 2,2,2-trichloroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 993 1,3-dichloro-2-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl994 3-chloro-n-propyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 995 2-bromoethyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl996 2,2,2-tribromoethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 997 3-bromo-n-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl998 2-iodoethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 999 tetrahydrofuran-3-yl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1000 (furan-2-yl)methyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1001 (furan-3-yl)methyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1002 (tetrahydrofuran-2-yl)methyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1003 (tetrahydrofuran-3-yl)methyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1004 (thiophen-2-yl)methyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1005 (thiophen-3-yl)methyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1006 (pyridin-2-yl)methyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1007 (pyridin-3-yl)methyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1008 (6-chloropyridin-3-yl)methyl2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1009 Et 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1010 i-Pr2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1011 vinyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1012 propargyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1013 cyclobutyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1014 cyclopentyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1015 benzyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1016 3-cyanobenzyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1017 4-cyanobenzyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1018 3-chlorobenzyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1019 2-methoxyethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1020 2-cyanoethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1021 2-(methylthio)ethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1022 2-(ethylthio)ethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1023 1-methyl-2-(methylthio)ethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1024 2-(ethylsulfinyl)ethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1025 2-(ethylsulfonyl)ethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1026 2-fluoroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1027 2,2-difluoroethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1028 2,2,2-trifluoroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1029 1,3-difluoro-2-propyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1030 1-chloro-3-fluoro-2-propyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1031 1-methyl-2,2,2-trifluoroethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1032 3,3,3-trifluoro-n-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1033 2,2,3,3,3-pentafluoro-n-propyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1034 3,3,4,4,4-pentafluoro-2-butyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1035 4,4,4-trifluoro-n-butyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1036 2,2,3,3-tetrafluorocyclobutyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1037 2-chloroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1038 2,2-dichloroethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1039 2,2,2-trichloroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1040 1,3-dichloro-2-propyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1041 3-chloro-n-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1042 2-bromoethyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1043 2,2,2-tribromoethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1044 3-bromo-n-propyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1045 2-iodoethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1046 tetrahydrofuran-3-yl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1047 (furan-2-yl)methyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1048 furan-3-yl)methyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1049 (tetrahydrofuran-2-yl)methyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1050 (tetrahydrofuran-3-yl)methyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1051 (thiophen-2-yl)methyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1052 (thiophen-3-yl)methyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1053 (pyridin-2-yl)methyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1054 (pyridin-3-yl)methyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1055 (6-chloropyridin-3-yl)methyl2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1056 Et 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1057 i-Pr2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1058vinyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1059 propargyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1060cyclobutyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1061 cyclopentyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1062benzyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1063 3-cyanobenzyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10644-cyanobenzyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1065 3-chlorobenzyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10662-methoxyethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1067 2-cyanoethyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10682-(methylthio)ethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1069 2-(ethylthio)ethyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10701-methyl-2-(methylthio)ethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1071 2-(ethylsulfinyl)ethyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10722-(ethylsulfonyl)ethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1073 2-fluoroethyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10742,2-difluoroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1075 2,2,2-trifluoroethyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10761,3-difluoro-2-propyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1077 1-chloro-3-fluoro-2-propyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10781-methyl-2,2,2-trifluoroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1079 3,3,3-trifluoro-n-propyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10802,2,3,3,3-pentafluoro-n-propyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1081 3,3,4,4,4-pentafluoro-2-butyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10824,4,4-trifluoro-n-butyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1083 2,2,3,3-tetrafluorocyclobutyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10842-chloroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1085 2,2-dichloroethyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10862,2,2-trichloroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1087 1,3-dichloro-2-propyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10883-chloro-n-propyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1089 2-bromoethyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10902,2,2-tribromoethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1091 3-bromo-n-propyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 10922-iodoethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1093 tetrahydrofuran-3-yl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1094(furan-2-yl)methyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1095 (furan-3-yl)methyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1096(tetrahydrofuran-2-yl)methyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1097 (tetrahydrofuran-3-yl)methyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1098(thiophen-2-yl)methyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1099 (thiophen-3-yl)methyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1100(pyridin-2-yl)methyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1101 (pyridin-3-yl)methyl2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1102(6-chloropyridin-3-yl)methyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1103 Et 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1104 i-Pr2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1105vinyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl1106 propargyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1107 cyclobutyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1108cyclopentyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1109 benzyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11103-cyanobenzyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1111 4-cyanobenzyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11123-chlorobenzyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1113 2-methoxyethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11142-cyanoethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1115 2-(methylthio)ethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11162-(ethylthio)ethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1117 1-methyl-2-(methylthio)ethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11182-(ethylsulfinyl)ethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1119 2-(ethylsulfonyl)ethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11202-fluoroethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1121 2,2-difluoroethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11222,2,2-trifluoroethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1123 1,3-difluoro-2-propyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11241-chloro-3-fluoro-2-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1125 1-methyl-2,2,2-trifluoroethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11263,3,3-trifluoro-n-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1127 2,2,3,3,3-pentafluoro-n-propyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11283,3,4,4,4-pentafluoro-2-butyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1129 4,4,4-trifluoro-n-butyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11302,2,3,3-tetrafluorocyclobutyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1131 2-chloroethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11322,2-dichloroethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1133 2,2,2-trichloroethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11341,3-dichloro-2-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1135 3-chloron-propyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11362-bromoethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1137 2,2,2-tribromoethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 11383-bromo-n-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1139 2-iodoethyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1140tetrahydrofuran-3-yl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1141 (furan-2-yl)methyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1142(furan-3-yl)methyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1143 (tetrahydrofuran-2-yl)methyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1144(tetrahydrofuran-3-yl)methyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1145 (thiophen-2-yl)methyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1146(thiophen-3-yl)methyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1147 (pyridin-2-yl)methyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1148(pyridin-3-yl)methyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1149 (6-chloropyridin-3-yl)methyl2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoro isopropyloxy)pyridin-3-yl 1150 Et2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1151 i-Pr2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1152 vinyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1153 propargyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1154 cyclobutyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1155 cyclopentyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1156 benzyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11573-cyanobenzyl 2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl1158 4-cyanobenzyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1159 3-chlorobenzyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11602-methoxyethyl 2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl1161 2-cyanoethyl 2-bromo-4-methyl6-(heptafluoro isopropyl)pyridin-3-yl1162 2-(methylthio)ethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1163 2-(ethylthio)ethyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11641-methyl-2-(methylthio)ethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1165 2-(ethylsulfinyl)ethyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11662-(ethylsulfonyl)ethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1167 2-fluoroethyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11682,2-difluoroethyl 2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl1169 2,2,2-trifluoroethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1170 1,3-difluoro-2-propyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11711-chloro-3-fluoro-2-propyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1172 1-methyl-2,2,2-trifluoroethyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11733,3,3-trifluoro-n-propyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1174 2,2,3,3,3-pentafluoro-n-propyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11753,3,4,4,4-pentafluoro-2-butyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1176 4,4,4-trifluoro-n-butyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11772,2,3,3-tetrafluorocyclobutyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1178 2-chloroethyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11792,2-dichloroethyl 2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl1180 2,2,2-trichloroethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1181 1,3-dichloro-2-propyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 11823-chloro-n-propyl 2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl1183 2-bromoethyl 2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl1184 2,2,2-tribromoethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1185 3-bromo-n-propyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1186 2-iodoethyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1187tetrahydrofuran-3-yl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1188 (furan-2-yl)methyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1189(furan-3-yl)methyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1190 (tetrahydrofuran-2-yl)methyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1191(tetrahydrofuran-3-yl)methyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1192 (thiophen-2-yl)methyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1193(thiophen-3-yl)methyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1194 (pyridin-2-yl)methyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1195(pyridin-3-yl)methyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1196 (6-chloropyridin-3-yl)methyl2-bromo-4-methyl-6-(heptafluoro isopropyl)pyridin-3-yl 1197 Et2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1198 i-Pr2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1199 vinyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1200 propargyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1201 cyclobutyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1202 cyclopentyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1203 benzyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1204 3-cyanobenzyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1205 4-cyanobenzyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1206 3-chlorobenzyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1207 2-methoxyethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1208 2-cyanoethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1209 2-(methylthio)ethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1210 2-(ethylthio)ethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12111-methyl-2-(methylthio)ethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12122-(ethylsulfinyl)ethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1213 2-(ethylsulfonyl)ethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1214 2-fluoroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1215 2,2-difluoroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1216 2,2,2-trifluoroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12171,3-difluoro-2-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1218 1-chloro3-fluoro-2-propyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12191-methyl-2,2,2-trifluoroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12203,3,3-trifluoro-n-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1221 2,2,3,3,3-pentafluoro-n-propyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12223,3,4,4,4-pentafluoro-2-butyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12234,4,4-trifluoro-n-butyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1224 2,2,3,3-tetrafluorocyclobutyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1225 2-chloroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1226 2,2-dichloroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1227 2,2,2-trichloroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12281,3-dichloro-2-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1229 3-chloro-n-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1230 2-bromoethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12312,2,2-tribromoethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12323-bromo-n-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 12332-iodoethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1234tetrahydrofuran-3-yl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1235(furan-2-yl)methyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1236(furan-3-yl)methyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1237(tetrahydrofuran-2-yl)methyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1238(tetrahydrofuran-3-yl)methyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1239(thiophen-2-yl)methyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1240 (thiophen-3-yl)methyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1241 (pyridin-2-yl)methyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1242 (pyridin-3-yl)methyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1243(6-chloropyridin-3-yl)methyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1244 Et2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1245 i-Pr2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1246 vinyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1247 propargyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1248 cyclobutyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1249 cyclopentyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1250 benzyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1251 3-cyanobenzyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1252 4-cyanobenzyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1253 3-chlorobenzyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1254 2-methoxyethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1255 2-cyanoethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1256 2-(methylthio)ethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1257 2-(ethylthio)ethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 12581-methyl-2-(methylthio)ethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 12592-(ethylsulfinyl)ethyl 2-bromo-6-methyl-4-heptafluoroisopropylphenyl1260 2-(ethylsulfonyl)ethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1261 2-fluoroethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1262 2,2-difluoroethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1263 2,2,2-trifluoroethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1264 1,3-difluoro-2-propyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 12651-chloro-3-fluoro-2-propyl 2-bromo-6-methyl-4-heptafluoroisopropylphenyl1266 1-methyl-2,2,2-trifluoroethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 12673,3,3-trifluoro-n-propyl 2-bromo-6-methyl-4-heptafluoroisopropylphenyl1268 2,2,3,3,3-pentafluoro-n-propyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 12693,3,4,4,4-pentafluoro-2-butyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 12704,4,4-trifluoro-n-butyl 2-bromo-6-methyl-4-heptafluoroisopropylphenyl1271 2,2,3,3-tetrafluorocyclobutyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1272 2-chloroethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1273 2,2-dichloroethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1274 2,2,2-trichloroethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1275 1,3-dichloro-2-propyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1276 3-chloro-n-propyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1277 2-bromoethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1278 2,2,2-tribromoethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1279 3-bromo-n-propyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1280 2-iodoethyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1281 tetrahydrofuran-3-yl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1282 (furan-2-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1283 (furan-3-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1284(tetrahydrofuran-2-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1285(tetrahydrofuran-3-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1286 (thiophen-2-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1287 (thiophen-3-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1288 (pyridin-2-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1289 (pyridin-3-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1290(6-chloropyridin-3-yl)methyl2-bromo-6-methyl-4-heptafluoroisopropylphenyl 1291 Et2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1292 i-Pr2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1293 vinyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1294 propargyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1295 cyclobutyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1296 cyclopentyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1297 benzyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1298 3-cyanobenzyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1299 4-cyanobenzyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1300 3-chlorobenzyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1301 2-methoxyethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1302 2-cyanoethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1303 2-(methylthio)ethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1304 2-(ethylthio)ethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 13051-methyl-2-(methylthio)ethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1306 2-(ethylsulfinyl)ethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1307 2-(ethylsulfonyl)ethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1308 2-fluoroethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1309 2,2-difluoroethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1310 2,2,2-trifluoroethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1311 1,3-difluoro-2-propyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 13121-chloro-3-fluoro-2-propyl 2-iodo-6-methyl-4-heptafluoroisopropylphenyl1313 1-methyl-2,2,2-trifluoroethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 13143,3,3-trifluoro-n-propyl 2-iodo-6-methyl-4-heptafluoroisopropylphenyl1315 2,2,3,3,3-pentafluoro-n-propyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 13163,3,4,4,4-pentafluoro-2-butyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 13174,4,4-trifluoro-n-butyl 2-iodo-6-methyl-4-heptafluoroisopropylphenyl1318 2,2,3,3-tetrafluorocyclobutyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1319 2-chloroethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1320 2,2-dichloroethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1321 2,2,2-trichloroethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1322 1,3-dichloro-2-propyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1323 3-chloro-n-propyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1324 2-bromoethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1325 2,2,2-tribromoethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1326 3-bromo-n-propyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1327 2-iodoethyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1328 tetrahydrofuran-3-yl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1329 (furan-2-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1330 (furan-3-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1331(tetrahydrofuran-2-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1332(tetrahydrofuran-3-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1333 (thiophen-2-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1334 (thiophen-3-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1335 (pyridin-2-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1336 (pyridin-3-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1337(6-chloropyridin-3-yl)methyl2-iodo-6-methyl-4-heptafluoroisopropylphenyl 1338 Et2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1339 i-Pr2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1340 vinyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1341 propargyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1342 cyclobutyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1343 cyclopentyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1344 benzyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1345 3-cyanobenzyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1346 4-cyanobenzyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1347 3-chlorobenzyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1348 2-methoxyethyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1349 2-cyanoethyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1350 2-(methylthio)ethyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1351 2-(ethylthio)ethyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13521-methyl-2-(methylthio)ethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1353 2-(ethylsulfinyl)ethyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13542-(ethylsulfonyl)ethyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1355 2-fluoroethyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13562,2-difluoroethyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13572,2,2-trifluoroethyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1358 1,3-difluoro-2-propyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1359 1-chloro3-fluoro-2-propyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13601-methyl-2,2,2-trifluoroethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1361 3,3,3-trifluoro-n-propyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13622,2,3,3,3-pentafluoro-n-propyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1363 3,3,4,4,4-pentafluoro-2-butyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13644,4,4-trifluoro-n-butyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1365 2,2,3,3-tetrafluorocyclobutyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1366 2-chloroethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1367 2,2-dichloroethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1368 2,2,2-trichloroethyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13691,3-dichloro-2-propyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1370 3-chloro-n-propyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1371 2-bromoethyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13722,2,2-tribromoethyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13733-bromo-n-propyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 13742-iodoethyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1375tetrahydrofuran-3-yl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1376 (furan-2-yl)methyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1377 (furan-3-yl)methyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1378 (tetrahydrofuran-2-yl)methyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1379 (tetrahydrofuran-3-yl)methyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1380(thiophen-2-yl)methyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1381 (thiophen-3-yl)methyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1382 (pyridin-2-yl)methyl2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl 1383(pyridin-3-yl)methyl 2-iodo-6-n-propyl-4-heptafluoro isopropylphenyl1384 (6-chloropyridin-3-yl)methyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl

TABLE 2 (1-B)

Compound No. X₁ X₂ X₃ X₄ R₁ Q 1385 Me H H H 2,2,2-trichloroethyl2-methyl-4-heptafluoroisopropylphenyl 1386 Me H H H i-Pr2,6-dimethy-4-heptafluoroisopropylphenyl 1387 Me H H H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1388 F HH H Et 2,6-dimethyl-4-heptafluoroisopropylphenyl 1389 F H H H i-Pr2,6-dimethyl-4-heptafluoroisopropylphenyl 1390 F H H H vinyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1391 F H H H propargyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1392 F H H H cyclobutyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1393 F H H H cyclopentyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1394 F H H H benzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1395 F H H H 3-cyanobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1396 F H H H 4-cyanobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1397 F H H H 3-chlorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1398 F H H H 2-methoxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1399 F H H H 2-cyanoethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1400 F H H H2-(methylthio)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1401 F H HH 2-(ethylthi)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1402 F H HH 1-methyl-2-(methylthio)-ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1403 F H H H2-(ethylsulfinyl)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1404 FH H H 2-(ethylsulfonyl)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1405 F H H H 2-fluoroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1406 F H H H 2,2-difluoroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1407 F H H H 2,2,2-trifluoroethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1408 F H H H1,3-difluoro-2-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1409 F HH H 1-chloro-3-fluoro-2-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1410 F H H H 1-methyl-2,2,2-trifluoroethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1411 F H H H3,3,3-trifluoro-n-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1412F H H H 2,2,3,3,3-pentafluoro-n-propyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1413 F H H H3,3,4,4,4-pentafluoro-2-butyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1414 F H H H 4,4,4-trifluoro-n-butyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1415 F H H H2,2,3,3-tetrafluorocyclobutyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1416 F H H H 2-chloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1417 F H H H 2,2-dichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1418 F H H H 2,2,2-trichloroethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1419 F H H H1,3-dichloro-2-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1420 F HH H 3-chloro-n-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1421 F HH H 2-bromoethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1422 F H H H2,2,2-tribromoethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1423 F H HH 3-bromo-n-propyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1424 F H HH 2-idoethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1425 F H H Htetrahydrofuran-3-yl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1426 F HH H (furan-2-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1427 FH H H (furan-3-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1428F H H H (tetrahydrofuran-2-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1429 F H H H(tetrahydrofuran-3-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1430 F H H H (thiophen-2-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1431 F H H H(thiophen-3-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1432 F HH H (pyridin-2-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1433F H H H (pyridin-3-yl)methyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1434 F H H H (6-chloropyridin-3-yl)methyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1435 F H H H Et2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 1436 F H H H i-Pr2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 1437 F H H H vinyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 1438 F H H H propargyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 1439 F H H H cyclobutyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 1440 F H H H cyclopentyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 1441 F H H H benzyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1442 F H H H 3-cyanobenzyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1443 F H H H 4-cyanobenzyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1444 F H H H 3-chlorobenzyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1445 F H H H 2-methoxyethyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1446 F H H H 2-cyanoethyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1447 F H H H2-(methylthio)ethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1448 F H HH 2-(ethylthio)ethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1449 F H HH 1-methyl-2-(methylthio)ethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl1450 F H H H 2-(ethylsulfinyl)ethyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1451 F H H H2-(ethylsulfonyl)ethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1452 F HH H 2-fluoroethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1453 F H H H2,2-difluoroethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1454 F H H H2,2,2-trifluoroethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1455 F H HH 1,3-difluoro-2-propyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1456 FH H H 1-chloro-3-fluoro-2-propyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1457 F H H H1-methyl-2,2,2-trifluoroethyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl1458 F H H H 3,3,3-trifluoro-n-propyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1459 F H H H2,2,3,3,3-pentafluoro-n-propyl 2,6-dimethyl-4-(nonafluoro2-butyl)phenyl1460 F H H H 3,3,4,4,4-pentafluoro-2-butyl2,6-dimethyl-4-(nonafluoro2-butyl)phenyl 1385 Me H H H2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1386 Me H H Hi-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1387 Me H H H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1388 F HH H Et 2,6-dimethyl-4-heptafluoroisopropylphenyl 1389 F H H H i-Pr2,6-dimethyl-4-heptafluoroisopropylphenyl 1390 F H H H vinyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1391 F H H H propargyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1392 F H H H cyclobutyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1393 F H H H cyclopentyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1394 F H H H benzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1395 F H H H 3-cyanobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1396 F H H H 4-cyanobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1397 F H H H 3-chlorobenzyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1398 F H H H 2-methoxyethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1399 F H H H 2-cyanoethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1400 F H H H2-(methylthio)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1401 F H HH 2-(ethylthio)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1402 F HH H 1-methyl-2-(methylthio)ethyl2,6-dimethyl-4-heptafluoroisopropylphenyl 1403 F H H H2-(ethylsulfinyl)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1404 FH H H 2-(ethylsulfonyl)ethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl1481 F H H H (6-chloropyridin-3-yl)methyl2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 1482 F H H H Et2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1483 F H H H i-Pr2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1484 F H H H vinyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1485 F H H H cyclobutyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1486 F H H H cyclopentyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1487 F H H H3-cyanobenzyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1488 F H HH 4-cyanobenzyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1489 F HH H 2-cyanoethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1490 FH H H 2-(methylthio)ethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1491 F H H H2-(ethylthio)ethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1492F H H H 1-methyl-2-(methylthio)ethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1493 F H H H2-(ethylsulfinyl)ethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl1494 F H H H 2-fluoroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1495 F H H H2,2-difluoroethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1496 FH H H 2,2,2-trifluoroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1497 F H H H1,3-difluoro-2-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl1498 F H H H 1-chloro-3-fluoro-2-propyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1499 F H H H1-methyl-2,2,2-trifluoroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1500 F H H H3,3,3-trifluoro-n-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl1501 F H H H 2,2,3,3,3-pentafluoro-n-propyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1502 F H H H4,4,4-trifluoro-n-butyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl1503 F H H H 2,2,3,3-tetrafluorocyclobutyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1504 F H H H2-chloroethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1505 F H HH 2,2-dichloroethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1506F H H H 2,2,2-trichloroethyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1507 F H H H1,3-dichloro-2-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl1508 F H H H 3-chloro-n-propyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1509 F H H H2-bromoethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1510 F H HH 3-bromo-n-propyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1511F H H H 2-iodoethyl 2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1512F H H H (6-chloropyridin-3-yl)methyl2,6-dichloro-4-(heptafluoro-n-propylthio)phenyl 1513 F H H H Et2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1514 F H H H i-Pr2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1515 F H H H vinyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1516 F H H H cyclobutyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1517 F H H H cyclopentyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1518 F H H H 3-cyanobenzyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1519 F H H H 4-cyanobenzyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1520 F H H H 2-cyanoethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1521 F H H H2-(methylthio)ethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1522 FH H H 2-(ethylthio)ethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl1523 F H H H 1-methyl-2-(methylthio)ethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1524 F H H H2-(ethylsulfinyl)ethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl1525 F H H H 2-fluoroethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl1526 F H H H 2,2-difluoroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1527 F H H H2,2,2-trifluoroethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1528F H H H 1,3-difluoro-2-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1529 F H H H1-chloro-3-fluoro-2-propyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl1530 F H H H 1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1531 F H H H3,3,3-trifluoro-n-propyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl1532 F H H H 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1533 F H H H4,4,4-trifluoro-n-butyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl1534 F H H H 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1535 F H H H 2-chloroethyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1536 F H H H2,2-dichloroethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1537 F HH H 2,2,2-trichloroethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl1538 F H H H 1,3-dichloro-2-propyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1539 F H H H3-chloro-n-propyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1540 F HH H 2-bromoethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1541 F HH H 3-bromo-n-propyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1542F H H H 2-iodoethyl 2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1543 FH H H (6-chloropyridin-3-yl)methyl2,6-dibromo-4-(trifluoromethylsulfonyl)phenyl 1544 F H H H Et2,6-dibromo-4-(pentafluoroethylthio)phenyl 1545 F H H H i-Pr2,6-dibromo-4-(pentafluoroethylthio)phenyl 1546 F H H H vinyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1547 F H H H cyclobutyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1548 F H H H cyclopentyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1549 F H H H 3-cyanobenzyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1550 F H H H 4-cyanobenzyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1551 F H H H 2-cyanoethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1552 F H H H2-(methylthio)ethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1553 F HH H 2-(ethylthio)ethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1554 FH H H 1-methyl-2-(methylthio)ethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1555 F H H H2-(ethylsulfinyl)ethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1556 FH H H 2-fluoroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1557 F HH H 2,2-difluoroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1558 FH H H 2,2,2-trifluoroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl1559 F H H H 1,3-difluoro2-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1560 F H H H1-chloro-3-fluoro-2-propyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl1561 F H H H 1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1562 F H H H3,3,3-trifluoro-n-propyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1563F H H H 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1564 F H H H4,4,4-trifluoro-n-butyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1565F H H H 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1566 F H H H 2-chloroethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1567 F H H H2,2-dichloroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1568 F H HH 2,2,2-trichloroethyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl 1569 FH H H 1,3-dichloro-2-propyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl1570 F H H H 3-chloro-n-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1571 F H H H 2-bromoethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1572 F H H H 3-bromo-n-propyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1573 F H H H 2-iodoethyl2,6-dibromo-4-(pentafluoroethylthio)phenyl 1574 F H H H(6-chloropyridin-3-yl)methyl 2,6-dibromo-4-(pentafluoroethylthio)phenyl1575 F H H H Et 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1576 F HH H i-Pr 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1577 F H H Hvinyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1578 F H H Hcyclobutyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1579 F H H Hcyclopentyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1580 F H H H3-cyanobenzyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1581 F H HH 4-cyanobenzyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1582 F HH H 2-cyanoethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1583 F HH H 2-(methylthio)ethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl1584 F H H H 2-(ethylthio)ethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1585 F H H H1-methyl-2-(methylthio)ethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1586 F H H H2-(ethylsulfinyl)ethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl1587 F H H H 2-fluoroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1588 F H H H2,2-difluoroethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1589 FH H H 2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1590 F H H H1,3-difluoro-2-propyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl1591 F H H H 1-chloro-3-fluoro-2-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1592 F H H H1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1593 F H H H3,3,3-trifluoro-n-propyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl1594 F H H H 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1595 F H H H4,4,4-trifluoro-n-butyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl1596 F H H H 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1597 F H H H2-chloroethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1598 F H HH 2,2-dichloroethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1599F H H H 2,2,2-trichloroethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1600 F H H H1,3-dichloro-2-propyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl1601 F H H H 3-chloro-n-propyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1602 F H H H 2-bromoethyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1603 F H H H3-bromo-n-propyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1604 F HH H 2-iodoethyl 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1605 F HH H (6-chloropyridin-3-yl)methyl2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 1606 F H H H Et2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1607 F H H H i-Pr2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1608 F H H H vinyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1609 F H H H cyclobutyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1610 F H H H cyclopentyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1611 F H H H3-cyanobenzyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1612 F H HH 4-cyanobenzyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1613 F HH H 2-cyanoethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1614 F HH H 2-(methylthio)ethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl1615 F H H H 2-(ethylthio)ethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1616 F H H H1-methyl-2-(methylthio)ethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1617 F H H H2-(ethylsulfinyl)ethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl1618 F H H H 2-fluoroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1619 F H H H2,2-difluoroethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1620 FH H H 2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1621 F H H H1,3-difluoro-2-propyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl1622 F H H H 1-chloro-3-fluoro2-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1623 F H H H1-methyl-2,2,2-trifluoroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1624 F H H H3,3,3-trifluoro-n-propyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl1625 F H H H 2,2,3,3,3-pentafluoro-n-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1626 F H H H4,4,4-trifluoro-n-butyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl1627 F H H H 2,2,3,3-tetrafluorocyclobutyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1628 F H H H2-chloroethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1629 F H HH 2,2-dichloroethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1630F H H H 2,2,2-trichloroethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1631 F H H H1,3-dichloro-2-propyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl1632 F H H H 3-chloro-n-propyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1633 F H H H 2-bromoethyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1634 F H H H3-bromo-n-propyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1635 F HH H 2-iodoethyl 2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1636 F HH H (6-chloropyridin-3-yl)methyl2,6-dibromo-4-(heptafluoroisopropylthio)phenyl 1637 F H H H Et2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1638 F H H H i-Pr2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1639 F H H H vinyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1640 F H H H cyclobutyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1641 F H H H cyclopentyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1642 F H H H3-cyanobenzyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1643 F H HH 4-cyanobenzyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1644 F HH H 2-cyanoethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1645 FH H H 2-(methylthio)ethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1646 F H H H2-(ethylthio)ethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1647F H H H 1-methyl-2-(methylthio)ethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1648 F H H H2-(ethylsulfinyl)ethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl1649 F H H H 2-fluoroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1650 F H H H2,2-difluoroethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1651 FH H H 2,2,2-trifluoroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1652 F H H H1,3-difluoro-2-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl1653 F H H H 1-chloro-3-fluoro-2-propyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1654 F H H H1-methyl-2,2,2-trifluoroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1655 F H H H3,3,3-trifluoro-n-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl1656 F H H H 2,2,3,3,3-pentafluoro-n-propyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1657 F H H H4,4,4-trifluoro-n-butyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl1658 F H H H 2,2,3,3-tetrafluorocyclobutyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1659 F H H H2-chloroethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1660 F H HH 2,2-dichloroethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1661F H H H 2,2,2-trichloroethyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1662 F H H H1,3-dichloro-2-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl1663 F H H H 3-chloro-n-propyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1664 F H H H2-bromoethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1665 F H HH 3-bromo-n-propyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1666F H H H 2-iodoethyl 2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1667F H H H (6-chloropyridin-3-yl)methyl2,6-dimethyl-4-(heptafluoro-n-propylthio)phenyl 1668 F H H H2,2,2-trichloroethyl 2,6-dichloro-4-(trifluoromethylsulfinyl)phenyl 1669F H H H 2,2,2-trichloroethyl2,6-dibromo-4-(trifluoromethylsulfinyl)phenyl 1670 F H H H2,2,2-trichloroethyl 2,6-dichloro-4-(pentafluoroethylsulfinyl)phenyl1671 F H H H 2,2,2-trichloroethyl2,6-dibromo-4-(pentafluoroethylsulfinyl)phenyl 1672 F H H H2,2,2-trichloroethyl 2,6-dichloro-4-(pentafluoroethylsulfonyl)phenyl1673 F H H H 2,2,2-trichloroethyl2,6-dibromo-4-(pentafluoroethylsulfonyl)phenyl 1674 F H H H2,2,2-trichloroethyl 2,6-dichloro-4-(heptafluoro-n-propylsulfinyl)phenyl1675 F H H H 2,2,2-trichloroethyl2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)phenyl 1676 F H H H2,2,2-trichloroethyl 2-chloro-6-methyl-4-(nonafluoro-2-butyl)phenyl 1677F H H H 2,2,2-trichloroethyl2-bromo-6-methyl-4-(nonafluoro-2-butyl)phenyl 1678 F H H H2,2,2-trichloroethyl 2-iodo-6-methyl-4-(nonafluoro-2-butyl)phenyl 1679 FH H H 2,2,2-trichloroethyl 2,6-dichloro-4-(nonafluoro-2-butyl)phenyl1680 F H H H 2,2,2-trichloroethyl2,6-dibromo-4-(nonafluoro-2-butyl)phenyl 1681 F H H H Et2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1682 F H H H i-Pr 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1683 F H H H vinyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1684 F H H H cyclobutyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1685 F H H H cyclopentyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1686 F H H H 3-cyanobenzyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1687 F H H H 4-cyanobenzyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1688 F H H H 2-cyanoethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1689 F H H H 2-(methylthio)ethyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1690 F H H H 2-(ethylthio)ethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1691 F H H H1-methyl-2-(methylthio)ethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1692 F H H H 2-(ethylsulfinyl)ethyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1693 F H H H 2-fluoroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1694 F H H H 2,2-difluoroethyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1695 F H H H 2,2,2-trifluoroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1696 F H H H 1,3-difluoro-2-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1697 F H H H 1-chloro-3-fluoro-2-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1698 F H H H 1-methyl-2,2,2-trifluoroethyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1699 F H H H 3,3,3-trifluoro-n-propyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1700 F H H H2,2,3,3,3-pentafluoro-n-propyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1701 F H H H 4,4,4-trifluoro-n-butyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1702 F H H H 2,2,3,3-tetrafluorocyclobutyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1703 F H H H 2-chloroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1704 F H H H 2,2-dichloroethyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1705 F H H H 2,2,2-trichloroethyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1706 F H H H 1,3-dichloro-2-propyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1707 F H H H 3-chloro-n-propyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1708 F H H H 2-bromoethyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1709 F H H H 3-bromo-n-propyl 2-chloro-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1710 F H H H 2-iodoethyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1711 F H H H (6-chloropyridin-3-yl)methyl2-chloro-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1712 F H H H Et 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1713 F H H H i-Pr2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1714 F H H H vinyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1715 F H H H cyclobutyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1716 F H H H cyclopentyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1717 F H H H 3-cyanobenzyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1718 F H H H 4-cyanobenzyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1719 F H H H 2-cyanoethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1720 F H H H 2-(methylthio)ethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1721 F H H H 2-(ethylthio)ethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1722 F H H H 1-methyl-2-(methylthio)ethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1723 F H H H 2-(ethylsulfinyl)ethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1724 F H H H 2-fluoroethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1725 F H H H 2,2-difluoroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1726 F H H H 2,2,2-trifluoroethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1727 F H H H 1,3-difluoro-2-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1728 F H H H1-chloro-3-fluoro-2-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1729 F H H H1-methyl-2,2,2-trifluoroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1730 F H H H3,3,3-trifluoro-n-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1731 F H H H2,2,3,3,3-pentafluoro-n-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1732 F H H H 4,4,4-trifluoro-n-butyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1733 F H H H 2,2,3,3-tetrafluorocyclobutyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1734 F H H H 2-chloroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1735 F H H H 2,2-dichloroethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1736 F H H H 2,2,2-trichloroethyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1737 F H H H 1,3-dichloro-2-propyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1738 F H H H 3-chloro-n-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1739 F H H H 2-bromoethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1740 F H H H 3-bromo-n-propyl 2-bromo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1741 F H H H 2-iodoethyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1742 F H H H (6-chloropyridin-3-yl)methyl2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl1743 F H H H Et 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1744 F H H H i-Pr2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1745F H H H vinyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1746 F H H H cyclobutyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1747F H H H cyclopentyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1748 F H H H 3-cyanobenzyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1749F H H H 4-cyanobenzyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1750 F H H H 2-cyanoethyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1751F H H H 2-(methylthio)ethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1752 F H H H 2-(ethylthio)ethyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1753F H H H 1-methyl-2-(methylthio)ethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1754 F H H H 2-(ethylsulfinyl)ethyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1755F H H H 2-fluoroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1756 F H H H 2,2-difluoroethyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1757F H H H 2,2,2-trifluoroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1758 F H H H 1,3-difluoro-2-propyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1759F H H H 1-chloro-3-fluoro-2-propyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1760 F H H H1-methyl-2,2,2-trifluoroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1761 F H H H3,3,3-trifluoro-n-propyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1762 F H H H2,2,3,3,3-pentafluoro-n-propyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1763 F H H H 4,4,4-trifluoro-n-butyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1764F H H H 2,2,3,3-tetrafluorocyclobutyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1765 F H H H 2-chloroethyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1766F H H H 2,2-dichloroethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1767 F H H H 2,2,2-trichloroethyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1768F H H H 1,3-dichloro-2-propyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1769 F H H H 3-chloro-n-propyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1770F H H H 2-bromoethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1771 F H H H 3-bromo-n-propyl2-iodo-4-methyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1772F H H H 2-iodoethyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1773 F H H H(6-chloropyridin-3-yl)methyl 2-iodo-4-methyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1774 F H H H Et2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1775 FH H H i-Pr 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1776 F H H H vinyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1777 FH H H cyclobutyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1778 F H H H cyclopentyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1779 FH H H 3-cyanobenzyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1780 F H H H 4-cyanobenzyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1781 FH H H 2-cyanoethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1782 F H H H 2-(methylthio)ethyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1783 FH H H 2-(ethylthio)ethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1784 F H H H1-methyl-2-(methylthio)ethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1785 F H H H 2-(ethylsulfinyl)ethyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1786 FH H H 2-fluoroethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1787 F H H H 2,2-difluoroethyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1788 FH H H 2,2,2-trifluoroethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1789 F H H H 1,3-difluoro-2-propyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1790 FH H H 1-chloro-3-fluoro-2-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1791 F H H H1-methyl-2,2,2-trifluoroethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1792 F H H H3,3,3-trifluoro-n-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1793 F H H H2,2,3,3,3-pentafluoro-n-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1794 F H H H 4,4,4-trifluoro-n-butyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1795 FH H H 2,2,3,3-tetrafluorocyclobutyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1796 F H H H 2-chloroethyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1797 FH H H 2,2-dichloroethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1798 F H H H 2,2,2-trichloroethyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1799 FH H H 1,3-dichloro-2-propyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1800 F H H H 3-chloro-n-propyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1801 FH H H 2-bromoethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1802 F H H H 3-bromo-n-propyl2,4-dimethyl-6-(1,1,1,3,3,3- hexafluoroisopropyloxy)pyridin-3-yl 1803 FH H H 2-iodoethyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1804 F H H H(6-chloropyridin-3-yl)methyl 2,4-dimethyl-6-(1,1,1,3,3,3-hexafluoroisopropyloxy)pyridin-3-yl 1805 F H H H Et 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1806 F H H H i-Pr 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1807 F H H H vinyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1808 F H H Hcyclobutyl 2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1809 FH H H cyclopentyl 2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl1810 F H H H 3-cyanobenzyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1811 F H H H 4-cyanobenzyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1812 F H H H2-cyanoethyl 2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1813F H H H 2-(methylthio)ethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1814 F H H H 2-(ethylthio)ethyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1815 F H H H1-methyl-2-(methylthio)ethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1816 F H H H 2-(ethylsulfinyl)ethyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1817 F H H H2-fluoroethyl 2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl1818 F H H H 2,2-difluoroethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1819 F H H H 2,2,2-trifluoroethyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1820 F H H H1,3-difluoro-2-propyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1821 F H H H1-chloro-3-fluoro-2-propyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1822 F H H H1-methyl-2,2,2-trifluoroethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1823 F H H H 3,3,3-trifluoro-n-propyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1824 F H H H2,2,3,3,3-pentafluoro-n-propyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1825 F H H H 4,4,4-trifluoro-n-butyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1826 F H H H2,2,3,3-tetrafluorocyclobutyl 2-bromo--methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1827 F H H H 2-chloroethyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1828 F H H H2,2-dichloroethyl 2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl1829 F H H H 2,2,2-trichloroethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1830 F H H H 1,3-dichloro-2-propyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1831 F H H H3-chloro-n-propyl 2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl1832 F H H H 2-bromoethyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1833 F H H H 3-bromo-n-propyl2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1834 F H H H2-iodoethyl 2-bromo-4-methyl-6- (heptafluoroisopropyl)pyridin-3-yl 1835F H H H (6-chloropyridin-3-yl)methyl 2-bromo-4-methyl-6-(heptafluoroisopropyl)pyridin-3-yl 1836 F H H H Et2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1837 F H H H i-Pr2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1838 F H H H vinyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1839 F H H H cyclobutyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1840 F H H H cyclopentyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1841 F H H H3-cyanobenzyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1842 F H HH 4-cyanobenzyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1843 F HH H 2-cyanoethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1844 F HH H 2-(methylthio)ethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1845 F H H H 2-(ethylthio)ethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1846 F H H H1-methyl-2-(methylthio)ethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1847 F H H H2-(ethylsulfinyl)ethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1848 F H H H 2-fluoroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1849 F H H H2,2-difluoroethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1850 FH H H 2,2,2-trifluoroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1851 F H H H1,3-difluoro-2-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1852 F H H H 1-chloro-3-fluoro-2-propyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1853 F H H H1-methyl-2,2,2-trifluoroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1854 F H H H3,3,3-trifluoro-n-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1855 F H H H 2,2,3,3,3-pentafluoro-n-propyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1856 F H H H4,4,4-trifluoro-n-butyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1857 F H H H 2,2,3,3-tetrafluorocyclobutyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1858 F H H H2-chloroethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1859 F H HH 2,2-dichloroethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1860F H H H 2,2,2-trichloroethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1861 F H H H1,3-dichloro-2-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl1862 F H H H 3-chloro-n-propyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1863 F H H H 2-bromoethyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1864 F H H H3-bromo-n-propyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1865 F HH H 2-iodoethyl 2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1866 F HH H (6-chloropyridin-3-yl)methyl2-chloro-6-methyl-4-heptafluoroisopropylphenyl 1867 F H H H Et2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1868 F H H H i-Pr2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1869 F H H H vinyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1870 F H H H cyclobutyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1871 F H H H cyclopentyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1872 F H H H3-cyanobenzyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1873 F H HH 4-cyanobenzyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1874 F HH H 2-cyanoethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1875 F HH H 2-(methylthio)ethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl1876 F H H H 2-(ethylthio)ethyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1877 F H H H1-methyl-2-(methylthio)ethyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1878 F H H H2-(ethylsulfinyl)ethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl1879 F H H H 2-fluoroethyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1880 F H H H2,2-difluoroethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1881 FH H H 2,2,2-trifluoroethyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1882 F H H H1,3-difluoro-2-propyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl1883 F H H H 1-chloro-3-fluoro-2-propyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1884 F H H H1-methyl-2,2,2-trifluoroethyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1885 F H H H3,3,3-trifluoro-n-propyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl1886 F H H H 2,2,3,3,3-pentafluoro-n-propyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1887 F H H H4,4,4-trifluoro-n-butyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl1888 F H H H 2,2,3,3-tetrafluorocyclobutyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1889 F H H H2-chloroethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1890 F H HH 2,2-dichloroethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1891F H H H 2,2,2-trichloroethyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1892 F H H H1,3-dichloro-2-propyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl1893 F H H H 3-chloro-n-propyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1894 F H H H 2-bromoethyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1895 F H H H3-bromo-n-propyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1896 F HH H 2-iodoethyl 2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1897 F HH H (6-chloropyridin-3-yl)methyl2-iodo-6-n-propyl-4-heptafluoroisopropylphenyl 1898 Cl H H H i-Pr2-methyl-4-heptafluoroisopropylphenyl 1899 Cl H H H 2,2,2-trichloroethyl2-methyl-4-heptafluoroisopropylphenyl 1900 Cl H H H i-Pr2,6-dimethyl-4-heptafluoroisopropylphenyl 1901 Cl H H H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1902 Cl HH H 2,2,2-trichloroethyl 2,4-bistrifluoromethylphenyl 1903 Cl H H H2,2,2-trichloroethyl 2-(1,1,1,3,3,3-hexafluoroisopropyloxy)-4-methylpyridin-5-yl 1904 Br H H H i-Pr2,6-dimethyl-4-heptafluoroisopropylphenyl 1905 Br H H H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1906 F FH H 2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1907 F FH H 2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1908F F F H i-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1909 H Me H Hi-Pr 2-methyl-4-heptafluoroisopropylphenyl 1910 H Me H H2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1911 H Me H Hi-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1912 H Me H H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1913 HMeO H H i-Pr 2-methyl-4-heptafluoroisopropylphenyl 1914 H MeO H H2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1915 H F H Hi-Pr 2-methyl-4-heptafluoroisopropylphenyl 1916 H F H H2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1917 H F H Hi-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1918 H F H H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1919 H ClH H i-Pr 2-methyl-4-heptafluoroisopropylphenyl 1920 H Cl H H2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1921 H Cl H Hi-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1922 H Cl H H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1923 H HMe H 2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1924H H CF₃ H i-Pr 2-methyl-4-heptafluoroisopropylphenyl 1925 H H CF₃ H2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1926 H H CF₃H i-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1927 H H CF₃ H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1928 H HNH₂ H i-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1929 H H Me₂N H2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1930 H HH Me i-Pr 2-methyl-4-heptafluoroisopropylphenyl 1931 H H H Me2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1932 H H H Mei-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1933 H H H Me2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1934 H HH F i-Pr 2-methyl-4-heptafluoroisopropylphenyl 1935 H H H F2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1936 H H H Fi-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1937 H H H F2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1938 H HH Cl i-Pr 2-methyl-4-heptafluoroisopropylphenyl 1939 H H H Cl2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1940 H H H Cli-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1941 H H H Cl2,2,2-trich1oroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl 1942 H HH Br i-Pr 2-methyl-4-heptafluoroisopropylphenyl 1943 H H H Br2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1944 H H H I2,2,2-trichloroethyl 2-methyl-4-heptafluoroisopropylphenyl 1945 H H H Ii-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl 1946 H H H I t-Bu2-methyl-4-heptafluoroisopropylphenyl 1947 H H H I 2,2,2-trichloroethyl2,6-dimethyl-4-heptafluoroisopropylphenyl

TABLE 3 (1-C)

Compound No. X₁ X₂ X₃ X₄ R₁ R₂ R₃ Q 1948 H H H H 2,2,2-trichloroethyl MeH 2,6-dibromo-4-(heptafluoro n-propylthio)phenyl 1949 H H H H2,2,2-trichloroethyl H Me 2-methyl-4-heptafluoroisopropylphenyl 1950 H HH H i-Pr H Me 2,6-dimethyl-4-heptafluoroisopropylphenyl 1951 H H H H2,2,2-trichloroethyl H Me 2,6-dimethyl-4-heptafluoroisopropylphenyl 1952H H H H i-Pr H Me 2-methyl-6-chloro-4-heptafluoroisopropylphenyl 1953 HH H H 2,2,2-trichloroethyl H Me2-methyl-6-chloro-4-heptafluoroisopropylphenyl 1954 H H H H i-Pr H Me2-methyl-6-bromo-4-heptafluoroisopropylphenyl 1955 H H H H2,2,2-trichloroethyl H Me 2-methyl-6-bromo-4-heptafluoroisopropylphenyl1956 H H H H 2,2,2-trichloroethyl H Et2,6-dimethyl-4-heptafluoroisopropylphenyl 1957 H H H H2,2,2-trichloroethyl H i-Pr 2,6-dimethyl-4-heptafluoroisopropylphenyl1958 H H H H 2,2,2-trichloro Me H2,6-dimethyl-4-heptafluoroisopropylphenyl 1959 F H H H2,2,2-trichloroethyl Me H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1960H H MeNH H i-Pr Me H 2,6-dimethyl-4-heptafluoroisopropylphenyl

TABLE 4 (1-D)

Compound No. G₁ G₂ G₃ R₁ Q 1961 O S O Me2,6-dimethyl-4-heptafluoroisopropylphenyl 1962 O S O Et2,6-dimethyl-4-heptafluoroisopropylphenyl 1963 O O S iPr2,6-dimethyl-4-heptafluoroisopropylphenyl 1964 O O S2,2,2-trichloroethyl 2,6-dimethyl-4-heptafluoroisopropylphenyl

TABLE 5 (1-E)

Compound No. A₁ A₂ A₃ A₄ R₁ R₂ Q 1965 N C C C i-Pr H2-methyl-4-heptafluoroisopropylphenyl 1966 N C C C 2,2,2-trichloroethylH 2-methyl-4-heptafluoroisopropylphenyl 1967 N C C C i-Pr H2,6-dimethyl-4-heptafluoroisopropylphenyl 1968 N C C C2,2,2-trichloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1969 NC C C 2-chloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1970 N CC C 2-fluoroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1971 N C CC Et H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1972 N C C C vinyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1973 N C C C cyclobutyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1974 N C C C cyclopentyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1975 N C C C 3-cyanobenzyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1976 N C C C 4-cyanobenzyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1977 N C C C 2-cyanoethyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1978 N C C C2-(methylthio)ethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1979 N CC C 2-(ethylthio)ethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1980N C C C 1-methyl-2-(methylthio)ethyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1981 N C C C2-(ethylsulfinyl)ethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1982N C C C 2-fluoroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1983 NC C C 2,2-difluoroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1984N C C C 2,2,2-trifluoroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl1985 N C C C 1,3-difluoro-2-propyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1986 N C C C1-chloro-3-fluoro-2-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl1987 N C C C 1-methyl-2,2,2-trifluoroethyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1988 N C C C3,3,3-trifluoro-n-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl1989 N C C C 2,2,3,3,3-pentafluoro-n-propyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1990 N C C C4,4,4-trifluoro-n-butyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1991N C C C 2,2,3,3-tetrafluorocyclobutyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1992 N C C C 2,2-dichloroethylH 2,6-dimethyl-4-heptafluoroisopropylphenyl 1993 N C C C1,3-dichloro-2-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1994 NC C C 3-chloro-n-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1995N C C C 2-bromoethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1996 NC C C 3-bromo-n-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1997N C C C 2-iodoethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 1998 N CC C (6-chloropyridin-3-yl)methyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 1999 N C C C Et H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2000 N C C C i-Pr H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2001 N C C C vinyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2002 N C C C cyclobutyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2003 N C C C cyclopentyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2004 N C C C 3-cyanobenzyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2005 N C C C 4-cyanobenzyl H2,6-dimethyl-4-(nonafluoro-2-butyl) 2006 N C C C 2-cyanoethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2007 N C C C2-(methylthio)ethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2008 N CC C 2-(ethylthio)ethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2009N C C C 1-methyl-2-(methylthio)ethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2010 N C C C2-(ethylsulfinyl)ethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2011N C C C 2-fluoroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2012 NC C C 2,2-difluoroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2013N C C C 2,2,2-trifluoroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2014 N C C C 1,3-difluoro-2-propyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2015 N C C C1-chloro-3-fluoro-2-propyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2016 N C C C 1-methyl-2,2,2-trifluoroethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2017 N C C C3,3,3-trifluoro-n-propyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2018 N C C C 2,2,3,3,3-pentafluoro-n-propyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2019 N C C C4,4,4-trifluoro-n-butyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2020N C C C 2,2,3,3-tetrafluorocyclobutyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2021 N C C C 2-chloroethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2022 N C C C 2,2-dichloroethylH 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2023 N C C C2,2,2-trichloroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2024 NC C C 1,3-dichloro-2-propyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2025 N C C C 3-chloro-n-propyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2026 N C C C 2-bromoethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2027 N C C C 3-bromo-n-propylH 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2028 N C C C 2-iodoethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2029 N C C C(6-chloropyridin-3-yl)methyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2030 N C C C Et H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2031 NC C C i-Pr H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2032 N C C Cvinyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2033 N C C Ccyclobutyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2034 N C C Ccyclopentyl H 2,6-dibromo4-(heptafluoro-n-propylthio)phenyl 2035 N C C C3-cyanobenzyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2036 N CC C 4-cyanobenzyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2037N C C C 2-cyanoethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2038 N C C C 2-(methylthio)ethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2039 N C C C2-(ethylthio)ethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2040N C C C 1-methyl-2-(methylthio)ethyl H2,6-dibromo4-(heptafluoro-n-propylthio)phenyl 2041 N C C C2-(ethylsulfinyl)ethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2042 N C C C 2-fluoroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2043 N C C C2,2-difluoroethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2044N C C C 2,2,2-trifluoroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2045 N C C C1,3-difluoro-2-propyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2046 N C C C 1-chloro-3-fluoro-2-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2047 N C C C1-methyl-2,2,2-trifluoroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2048 N C C C3,3,3-trifluoro-n-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2049 N C C C2,2,3,3,3-pentafluoro-n-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2050 N C C C4,4,4-trifluoro-n-butyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2051 N C C C 2,2,3,3-tetrafluorocyclobutyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2052 N C C C2-chloroethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2053 N CC C 2,2-dichloroethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2054 N C C C 2,2,2-trichloroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2055 N C C C1,3-dichloro-2-propyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2056 N C C C 3-chloro-n-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2057 N C C C 2-bromoethylH 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2058 N C C C3-bromo-n-propyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2059 NC C C 2-iodoethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2060N C C C (6-chloropyridin-3-yl)methyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2061 N-oxide C C C i-Pr H2,6-dimethyl-4-heptafluoroisopropylphenyl 2062 N-oxide C C C2,2,2-trichloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2063N-oxide C C C Et H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2064N-oxide C C C vinyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2065N-oxide C C C cyclobutyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2066 N-oxide C C C cyclopentyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2067 N-oxide C C C3-cyanobenzyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2068 N-oxide CC C 4-cyanobenzyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2069N-oxide C C C 2-cyanoethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2070 N-oxide C C C 2-(methylthio)ethyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2071 N-oxide C C C2-(ethylthio)ethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2072N-oxide C C C 1-methyl-2-(methylthio)ethyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2073 N-oxide C C C2-(ethylsulfinyl)ethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2074N-oxide C C C 2-fluoroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2075 N-oxide C C C 2,2-difluoroethyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2076 N-oxide C C C2,2,2-trifluoroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2077N-oxide C C C 1,3-difluoro-2-propyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2078 N-oxide C C C1-chloro-3-fluoro-2-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2079 N-oxide C C C 1-methyl-2,2,2-trifluoroethyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2080 N-oxide C C C3,3,3-trifluoro-n-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2081 N-oxide C C C 2,2,3,3,3-pentafluoro-n-propyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2082 N-oxide C C C4,4,4-trifluoro-n-butyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2083N-oxide C C C 2,2,3,3-tetrafluorocyclobutyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2084 N-oxide C C C2-chloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2085 N-oxide CC C 2,2-dichloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2086N-oxide C C C 1,3-dichloro-2-propyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2087 N-oxide C C C3-chloro-n-propyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2088N-oxide C C C 2-bromoethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2089 N-oxide C C C 3-bromo-n-propyl H2,6-dimethyl-4-heptafluoroisopropylphenyl 2090 N-oxide C C C 2-iodoethylH 2,6-dimethyl-4-heptafluoroisopropylphenyl 2091 N-oxide C C C(6-chloropyridin-3-yl)methyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2092 N-oxide C C C Et H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2093N-oxide C C C i-Pr H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2094N-oxide C C C vinyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2095N-oxide C C C cyclobutyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2096 N-oxide C C C cyclopentyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2097 N-oxide C C C3-cyanobenzyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2098 N-oxide CC C 4-cyanobenzyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2099N-oxide C C C 2-cyanoethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2100 N-oxide C C C 2-(methylthio)ethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2101 N-oxide C C C2-(ethylthio)ethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2102N-oxide C C C 1-methyl-2-(methylthio)ethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2103 N-oxide C C C2-(ethylsulfinyl)ethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2104N-oxide C C C 2-fluoroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2105 N-oxide C C C 2,2-difluoroethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2106 N-oxide C C C2,2,2-trifluoroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2107N-oxide C C C 1,3-difluoro-2-propyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2108 N-oxide C C C1-chloro-3-fluoro-2-propyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2109 N-oxide C C C 1-methyl-2,2,2-trifluoroethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2110 N-oxide C C C3,3,3-trifluoro-n-propyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2111 N-oxide C C C 2,2,3,3,3-pentafluoro-n-propyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2112 N-oxide C C C4,4,4-trifluoro-n-butyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2113N-oxide C C C 2,2,3,3-tetrafluorocyclobutyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2114 N-oxide C C C2-chloroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2115 N-oxide CC C 2,2-dichloroethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2116N-oxide C C C 2,2,2-trichioroethyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2117 N-oxide C C C1,3-dichloro-2-propyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2118N-oxide C C C 3-chloro-n-propyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2119 N-oxide C C C2-bromoethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2120 N-oxide CC C 3-bromo-n-propyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2121N-oxide C C C 2-iodoethyl H 2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl2122 N-oxide C C C (6-chloropyridin-3-yl)methyl H2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 2123 N-oxide C C C Et H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2124 N-oxide C C C i-Pr H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2125 N-oxide C C C vinylH 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2126 N-oxide C C Ccyclobutyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2127 N-oxideC C C cyclopentyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2128N-oxide C C C 3-cyanobenzyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2129 N-oxide C C C4-cyanobenzyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2130N-oxide C C C 2-cyanoethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2131 N-oxide C C C2-(methylthio)ethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2132 N-oxide C C C 2-(ethylthio)ethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2133 N-oxide C C C1-methyl-2-(methylthio)ethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2134 N-oxide C C C2-(ethylsulfinyl)ethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2135 N-oxide C C C 2-fluoroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2136 N-oxide C C C2,2-difluoroethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2137N-oxide C C C 2,2,2-trifluoroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2138 N-oxide C C C1,3-difluoro-2-propyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2139 N-oxide C C C 1-chloro-3-fluoro-2-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2140 N-oxide C C C1-methyl-2,2,2-trifluoroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2141 N-oxide C C C3,3,3-trifluoro-n-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2142 N-oxide C C C2,2,3,3,3-pentafluoro-n-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2143 N-oxide C C C4,4,4-trifluoro-n-butyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2144 N-oxide C C C 2,2,3,3-tetrafluorocyclobutyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2145 N-oxide C C C2-chloroethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2146N-oxide C C C 2,2-dichloroethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2147 N-oxide C C C2,2,2-trichloroethyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl2148 N-oxide C C C 1,3-dichloro-2-propyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2149 N-oxide C C C3-chloro-n-propyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2150N-oxide C C C 2-bromoethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2151 N-oxide C C C3-bromo-n-propyl H 2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2152N-oxide C C C 2-iodoethyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2153 N-oxide C C C(6-chloropyridin-3-yl)methyl H2,6-dibromo-4-(heptafluoro-n-propylthio)phenyl 2154 C N C C i-Pr H2-methyl-4-heptafluoroisopropylphenyl 2155 C N C C 2,2,2-trichloroethylH 2-methyl-4-heptafluoroisopropylphenyl 2156 C N C C i-Pr H2,6-dimethyl-4-heptafluoroisopropylphenyl 2157 C N C C2,2,2-trichloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2158 CC N C i-Pr H 2-methyl-4-heptafluoroisopropylphenyl 2159 C C N C2,2,2-trichloroethyl H 2-methyl-4-heptafluoroisopropylphenyl 2160 C C NC i-Pr H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2161 C C N C2,2,2-trichloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2162 CC C N i-Pr H 2-methyl-4-heptafluoroisopropylphenyl 2163 C C C N2,2,2-trichloroethyl H 2-methyl-4-heptafluoroisopropylphenyl 2164 C C CN i-Pr H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2165 C C C N2,2,2-trichloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2166 CC C N-oxide i-Pr H 2,6-dimethyl-4-heptafluoroisopropylphenyl 2167 C C CN-oxide 2,2,2-trichloroethyl H 2,6-dimethyl-4-heptafluoroisopropylphenyl2168 N C C C 2,2,2-trichloroethyl Me2,6-dimethyl-4-heptafluoroisopropylphenyl

TABLE 6 (4-A)

Compound No. R₃ Y₁ Y₂ Y₃ Y₄ Y₅ I-1 H Me H heptafluoro-n-propyl H Me I-2H H H heptafluoroisopropyl H H I-3 H H Me heptafluoroisopropyl H H I-4 HH MeO heptafluoroisopropyl H H I-5 H H Cl heptafluoroisopropyl H H I-6 HMe H heptafluoroisopropyl H H I-7 H Me H heptafluoroisopropyl H Me I-8 HMe H heptafluoroisopropyl H phenyl I-9 H Me H heptafluoroisopropyl Me HI-10 H Me Me heptafluoroisopropyl H H I-11 H Me Me heptafluoroisopropylH Cl I-12 H Me I heptafluoroisopropyl H Cl I-13 Me Me Hheptafluoroisopropyl H Me I-14 i-Pr Me H heptafluoroisopropyl H Me I-15H Et H heptafluoroisopropyl H H I-16 H Et H heptafluoroisopropyl H MeI-17 H Et H heptafluoroisopropyl H Et I-18 H Et H heptafluoroisopropyl HI I-19 H n-Pr H heptafluoroisopropyl H H I-20 H i-Pr Hheptafluoroisopropyl H Me I-21 H MeO H heptafluoroisopropyl H Me I-22 HCl H heptafluoroisopropyl H Et I-23 H Cl H heptafluoroisopropyl Me HI-24 H Cl H heptafluoroisopropyl MeO H I-25 H Cl Me heptafluoroisopropylH Me I-26 H Br H heptafluoroisopropyl H Me I-27 H Br Hheptafluoroisopropyl H Et I-28 H Br H heptafluoroisopropyl H n-Pr I-29 HBr H heptafluoroisopropyl H n-Bu I-30 H Br Me heptafluoroisopropyl H MeI-31 H I H heptafluoroisopropyl H Me I-32 H I H heptafluoroisopropyl Hn-Pr I-33 H Me H nonafluoro-n-butyl H Me I-34 H Me H nonafluoro-2-butylH Me I-35 H H H trifluoromethylthio H H I-36 H Br H trifluoromethylthioH Br I-37 H H H trifluoromethylsulfonyl H H I-38 H Br Htrifluoromethylsulfonyl H Br I-39 H Me H 2,2,2-trifluoroethoxy H H I-40H H H heptafluoroisopropylthio H H I-41 H Cl H heptafluoroisopropylthioH Cl I-42 H Br H heptafluoroisopropylthio H Br I-43 H Cl Hheptafluoro-n-propylthio H Cl I-44 H Br H heptafluoro-n-propylthio H BrI-45 H Cl H heptafluoroisopropylsulfonyl H Cl I-46 H Br Hnonafluoro-n-butylthio H Br I-47 H Br H pentafluoroethylthio H Br I-48 HBr H heptafluoro-n-propylsulfinyl H Br I-49 Me Me Hheptafluoro-n-propylthio H Me I-50 Me Br H heptafluoro-n-propylthio H Br

TABLE 7 (4-B)

Compound No. X₁ X₂ X₃ X₄ Y₁ Y₃ Y₅ I-51 Me H H H Me heptafluoroisopropylH I-52 Me H H H Me heptafluoroisopropyl Me I-53 H Me H H Meheptafluoroisopropyl H I-54 H Me H H Me heptafluoroisopropyl Me I-55 H HH Me Me heptafluoroisopropyl H I-56 H H H Me Me heptafluoroisopropyl MeI-59 F H H H Me heptafluoroisopropyl Me I-60 F H H H Meheptafluoroisopropylthio Me I-61 H F H H Me heptafluoroisopropyl Me I-62H H H F Me heptafluoroisopropyl H I-63 H H H F Me heptafluoroisopropylMe I-64 Cl H H H Me heptafluoroisopropyl H I-65 Cl H H H Meheptafluoroisopropyl Me I-66 H Cl H H Me heptafluoroisopropyl H I-67 HCl H H Me heptafluoroisopropyl Me I-68 H H H Cl Me heptafluoroisopropylH I-69 H H H Cl Me heptafluoroisopropyl Me I-70 Br H H H Meheptafluoroisopropyl Me I-71 H H H Br Me heptafluoroisopropyl H I-72 H IH H Me heptafluoroisopropyl H I-73 H H H I Me heptafluoroisopropyl HI-74 H H H I Me heptafluoroisopropyl Me I-75 H H CF₃ H Meheptafluoroisopropyl H I-76 H H CF₃ H Me heptafluoroisopropyl Me I-77 HMeO H H Me heptafluoroisopropyl H I-78 H H NH₂ H Me heptafluoroisopropylH I-79 H H NH₂ H Me heptafluoroisopropyl Me I-80 Cl Cl H Cl Meheptafluoroisopropyl H

TABLE 8 (4-C)

Compound No. X₁ X₂ X₃ X₄ Q I-81 H H H H 2-methyl-4-heptafluoroisopropyl-1-naphthyl I-82 H H H H 4-heptafluoroisopropyl-5,6,7,8-tetrahydro-1-naphthyl I-83 H H H H 2-chloro-4-heptafluoroisopropyl-5,6,7,8-tetrahydro-1-naphthyl I-84 H H H H 2-((1,1,1,3,3,3-hexafluoro2-propyloxy)pyridin-5-yl I-85 Cl H H H 2-(1,1,1,3,3,3-hexafluoro-2-propyloxy)-4-methylpyridin-5-yl I-86 H H H H2-bromo-4-methyl-6-(1,1,1,3,3,3- hexafluoro-2-propyloxy)pyridin-3-yl

Table 9 shows the physical properties of the compounds represented byformulae (1) and (4) of the present invention. This table also shows¹H-NMR shift values obtained by using tetramethylsilane as an internalreference material, and chloroform-d as a solvent.

TABLE 9 Compound No. ¹H-NMR (CDCl₃, ppm) 3 δ 1.30 (6H, d, J = 6.3 Hz),2.41 (3H, s), 5.00-5.05 (1H, m), 6.92 (1H, s), 7.40-7.61 (5H, m), 7.93(1H, s), 8.01 (1H, s), 8.21 (1H, d, J = 8.8 Hz) 4 δ 0.96 (3H, t, J = 7.3Hz), 1.38-1.47 (2H, m), 1.63-1.71 (2H, m), 2.41 (3H, s), 4.19 (2H, t, J= 6.6 Hz), 6.83 (1H, s), 7.42-7.62 (5H, m), 7.83 (1H, s), 8.00 (1H, s),8.25 (1H, d, J = 8.5 Hz) 5 δ 0.98 (6H, d, J = 6.8 Hz), 1.94-2.05 (1H,m), 2.42 (3H, s), 3.98 (2H, d, J = 6.6 Hz), 6.81 (1H, s), 7.44-7.52 (3H,m), 7.55-7.61 (2H, m), 7.85 (1H, s), 8.01 (1H, s), 8.25 (1H, d, J = 8.6Hz) 6 δ 0.96 (3H, t, J = 7.6 Hz), 1.29 (3H, d, J = 6.1 Hz), 1.58-1.73(2H, m), 2.42 (3H, s), 4.83-4.92 (1H, m), 6.72 (1H, s), 7.42-7.61 (5H,m), 7.79 (1H, s), 8.01 (1H, s), 8.26 (1H, d, J = 8.5 Hz) 7 δ 1.53 (9H,s), 2.41 (3H, s), 6.66 (1H, s), 7.40-7.59 (5H, m), 7.80 (1H, s), 7.98(1H, d, J = 1.7 Hz), 8.23 (1H, d, J = 8.8 Hz) 8 δ 0.98 (9H, s), 2.41(3H, s), 3.89 (2H, s), 6.94 (1H, s), 7.41-7.50 (3H, m), 7.54-7.57 (1H,m), 7.62 (1H, d, J = 8.1 Hz), 7.86 (1H, s), 8.02 (1H, s), 8.24 (1H, d, J= 8.8 Hz) 9 δ 0.97 (9H, s), 1.62 (2H, t, J = 7.6 Hz), 2.41 (3H, s), 4.25(2H, t, J = 7.6 Hz), 6.79 (1H, br), 7.42-7.51 (3H, m), 7.54-7.57 (1H,m), 7.61 (1H, d), 7.82 (1H, s), 7.99 (1H, s), 8.24 (1H, d, J = 8.5 Hz)10 δ 0.90 (3H, t, J = 7.3 Hz), 0.91 (3H, t, J = 7.3 Hz), 1.26-1.41 (8H,m), 1.55-1.65 (1H, m), 2.40 (3H, s), 4.10 (2H, t, J = 5.4 Hz), 7.01 (1H,s), 7.40-7.50 (3H, m), 7.55 (1H, d, J = 7.8 Hz), 7.62 (1H, d, J = 7.8Hz), 7.91 (1H, s), 8.01 (1H, s), 8.21 (1H, d, J = 8.5 Hz) 11 δ 2.42 (3H,s), 4.55 (1H, dd, J = 1.7 Hz, 6.3 Hz), 4.83 (1H, dd, J = 1.7 Hz, 13.9Hz), 7.29 (1H, dd, J = 6.3 Hz, 13.9 Hz), 7.42-7.50 (3H, m), 7.61-7.63(1H, m), 7.77 (1H, d, J = 7.8 Hz), 8.08 (1H, s), 8.15 (1H, d, J = 7.8Hz), 8.30 (1H, s), 8.92 (1H, br-s) 12 δ 2.42 (3H, s), 4.68-4.70 (2H, m),5.27-5.31 (1H, m), 5.35-5.41 (1H, m), 5.93-6.03 (1H, m), 6.83 (1H, br),7.44-7.52 (3H, m), 7.55-7.63 (2H, m), 7.79 (1H, br), 8.00 (1H, s), 8.26(1H, d, J = 8.8 Hz) 13 δ 0.82 (3H, d, J = 7.1 Hz), 0.84-0.99 (7H, m),1.02-1.12 (2H, m), 1.36-1.42 (1H, m), 1.50-1.59 (1H, m), 1.68-1.72 (2H,m), 1.94-1.99 (1H, m), 2.11 (1H, d, J = 1.7 Hz), 2.42 (3H, s), 4.65-4.72(1H, m), 6.74 (1H, s), 7.42-7.62 (5H, m), 7.80 (1H, s), 8.02 (1H, s),8.25 (1H, d, J = 8.5 Hz) 14 δ 2.38 (3H, s), 5.19 (2H, s), 7.19 (1H, s),7.32-7.61 (10H, m), 7.91 (1H, s), 8.00 (1H, s), 8.18 (1H, d, J = 8.5 Hz)16 δ 2.34 (3H, s), 5.27 (2H, s), 6.96 (1H, br-s), 7.40-7.58 (6H, m),7.63-7.69 (3H, m), 7.79 (1H, s), 8.00 (1H, s), 8.25 (1H, d, J = 8.8 Hz)17 δ 2.33 (3H, s), 3.34 (3H, s), 3.57-3.61 (2H, m), 4.26-4.32 (2H, m),7.13 (1H, s), 7.32-7.42 (3H, m), 7.46-7.53 (2H, m), 7.83 (1H, s), 7.91(1H, d, J = 1.7 Hz), 8.13 (1H, d, J = 8.5 Hz) 18 δ 2.42 (3H, s), 5.83(2H, s), 7.16 (1H, br-s), 7.43-7.52 (3H, m), 7.61 (1H, d, J = 8.1 Hz),7.68 (1H, d, J = 8.1 Hz), 7.82 (1H, s), 8.03 (1H, s), 8.25 (1H, d, J =8.5 Hz) 18 δ 2.42 (3H, s), 5.83 (2H, s), 7.16 (1H, br-s), 7.43-7.52 (3H,m), 7.61 (1H, d, J = 8.1 Hz), 7.68 (1H, d, J = 8.1 Hz), 7.82 (1H, s),8.03 (1H, s), 8.25 (1H, d, J = 8.5 Hz) 19 δ 2.40 (3H, s), 3.74 (2H, t, J= 5.6 Hz), 4.44 (2H, t, J = 5.6 Hz), 7.19 (1H, s), 7.42-7.50 (3H, m),7.55-7.58 (1H, m), 7.63 (1H, d, J = 7.6 Hz), 7.88 (1H, s), 8.01 (1H, s),8.22 (1H, d, J = 8.8 Hz) 20 δ 2.40 (3H, s), 4.83 (2H, s), 7.42-7.49 (3H,m), 7.58-7.61 (1H, m), 7.67-7.69 (2H, m), 7.98 (1H, s), 8.06 (1H, s),8.19 (1H, d, J = 8.5 Hz) 21 δ 2.43 (3H, s), 6.90 (1H, s), 7.22 (1H,br-s), 7.47-7.54 (3H, m), 7.64-7.68 (2H, m), 7.78 (1H, s), 8.06 (1H, s),8.26 (1H, d, J = 8.8 Hz) 22 δ 2.01 (6H, s), 2.42 (3H, s), 6.95 (1H, br),7.44-7.52 (3H, m), 7.57-7.62 (2H, m), 7.80 (1H, s), 8.02 (1H, s), 8.24(1H, d, J = 8.5 Hz) 23 δ 2.41 (3H, s), 7.23-7.29 (1H, m), 7.40-7.55 (7H,m), 7.61-7.64 (1H, m), 7.72 (1H, d, J = 8.3 Hz), 7.78 (1H, s), 8.07 (1H,s), 8.26 (1H, d, J = 8.8 Hz) 24 δ 2.36 (3H, s), 2.40 (3H, s), 7.05-7.09(2H, m), 7.15 (1H, s), 7.20 (2H, d, J = 8.1 Hz), 7.47-7.52 (3H, m),7.60-7.63 (1H, m), 7.66-7.68 (1H, m), 7.79 (1H, s), 8.07 (1H, s), 8.25(1H, d, J = 8.8 Hz) 25 δ 2.41 (3H, s), 7.12-7.17 (2H, m), 7.32-7.38 (2H,m), 7.42-7.48 (3H, m), 7.64 (1H, d, J = 7.8 Hz), 7.82 (1H, d, J = 7.8Hz), 7.99 (1H, d, J = 8.5 Hz), 8.06 (1H, d, J = 8.5 Hz), 8.51 (1H, s),9.52 (1H, s) 59 δ 2.32 (6H, s), 3.79 (3H, s), 6.92 (1H, br-s), 7.34 (2H,s), 7.43 (1H, t, J = 7.8 Hz), 7.52-7.62 (3H, m), 8.00 (1H, s) 60 δ 1.33(3H, t, J = 7.1 Hz), 2.33 (6H, s), 4.24 (2H, q, J = 7.1 Hz), 6.80 (1H,s), 7.35 (2H, s), 7.44 (1H, t, J = 7.8 Hz), 7.46 (1H, s), 7.52-7.61 (2H,m), 8.02 (1H, s) 61 δ 0.99 (3H, t, J = 7.3 Hz), 1.71 (2H, m), 2.34 (6H,s), 4.14 (2H, t, J = 6.9 Hz), 6.79 (1H, s), 7.35 (2H, s), 7.41-7.47 (2H,m), 7.59-7.61 (2H, m), 8.02 (1H, s) 62 δ 1.31 (6H, d, J = 6.3 Hz), 2.33(6H, s), 5.03 (1H, septet, J = 6.3 Hz), 6.74 (1H, s), 7.35 (2H, s), 7.43(1H, t, J = 8.1 Hz), 7.52 (1H, s), 7.56-7.61 (2H, m), 8.03 (1H, s) 63 δ0.96 (3H, t, J = 7.3 Hz), 1.38-1.48 (2H, m), 1.61-1.71 (2H, m), 2.34(6H, s), 4.19 (2H, t, J = 6.9 Hz), 6.76 (1H, s), 7.35 (2H, s), 7.42-7.46(2H, m), 7.58-7.61 (2H, m), 8.02 (1H, s) 64 δ 0.98 (6H, d, J = 6.8 Hz),1.94-2.04 (1H, m), 2.34 (6H, s), 3.97 (2H, d, J = 6.6 Hz), 6.79 (1H, s),7.35 (2H, s), 7.42-7.47 (2H, m), 7.59-7.61 (2H, m), 8.02 (1H, s) 66 δ1.53 (9H, s), 2.34 (6H, s), 6.62 (1H, s), 7.35 (2H, s), 7.38-7.45 (2H,m), 7.51-7.60 (2H, m), 8.02 (1H, s) 67 δ 0.99 (9H, s), 2.34 (6H, s),3.90 (2H, s), 6.79 (1H, s), 7.35 (2H, s), 7.43 (1H, br-s), 7.46 (1H, t,J = 8.1 Hz), 7.59-7.63 (2H, m), 8.03 (1H, s) 68 δ 0.95 (3H, d, J = 6.8Hz), 0.96 (3H, d, J = 6.8 Hz), 1.24 (3H, d, J = 6.3 Hz), 1.81-1.89 (1H,m), 2.34 (6H, s), 4.75 (1H, quint, J = 6.3 Hz), 6.77 (1H, s), 7.35 (2H,s), 7.44 (1H, t, J = 8.1 Hz), 7.54-7.62 (3H, m), 8.05 (1H, s) 69 δ 0.94(3H, t, J = 7.3 Hz), 1.29 (3H, d, J = 6.3 Hz), 1.32-1.45 (2H, m),1.46-1.58 (1H, m), 1.61-1.70 (1H, m), 2.35 (6H, s), 4.93 (1H, sext., J =6.3 Hz), 6.73 (1H, s), 7.35 (2H, s), 7.42-7.47 (1H, m), 7.51 (1H, s),7.56-7.62 (2H, m), 8.05 (1H, s) 70 δ 0.93 (3H, d, J = 6.6 Hz), 0.94 (3H,d, J = 6.6 Hz), 1.29 (3H, d, J = 6.3 Hz), 1.31-1.37 (1H, m), 1.57-1.75(2H, m), 2.34 (6H, s), 4.96-5.05 (1H, m), 6.70 (1H, s), 7.35 (2H, s),7.42-7.46 (2H, m), 7.57-7.61 (2H, m), 8.04 (1H, s) 71 δ 0.97 (9H, s),1.62 (2H, t, J = 7.6 Hz), 2.34 (6H, s), 4.25 (2H, t, J = 7.6 Hz), 6.73(1H, s), 7.35 (2H, s), 7.43-7.47 (2H, m), 7.59-7.61 (2H, m), 8.02 (1H,s) 72 δ 1.27-1.34 (2H, m), 1.50-1.66 (4H, m), 1.74-1.83 (2H, m),2.18-2.32 (1H, m), 2.34 (6H, s), 4.07 (2H, d, J = 7.1 Hz), 6.79 (1H, s),7.35 (2H, s), 7.43-7.51 (2H, m), 7.58-7.62 (2H, m), 8.03 (1H, s) 73 δ1.62 (3H, d, J = 6.6 Hz), 2.33 (6H, s), 5.90 (1H, q, J = 6.6 Hz), 6.82(1H, br-s), 7.28-7.45 (9H, m), 7.56 (1H, d, J = 8.1 Hz), 7.60 (1H, d, J= 7.6 Hz), 8.02 (1H, br-s) 74 δ 2.34 (6H, s), 3.02 (2H, t, J = 7.1 Hz),4.42 (2H, t, J = 7.1 Hz), 6.74 (1H, br-s), 7.23-7.27 (2H, m), 7.31-7.35(5H, m), 7.41-7.47 (2H, m), 7.58-7.62 (2H, m), 7.99 (1H, br-s) 75 δ 2.34(6H, s), 4.58 (1H, dd, J = 2.0 Hz, 6.3 Hz), 4.87 (1H, dd, J = 2.0 Hz,13.9 Hz), 7.00 (1H, s), 7.25 (1H, dd, J = 6.3 Hz, 13.9 Hz), 7.35 (2H,s), 7.47 (1H, t, J = 7.8 Hz), 7.55 (1H, s), 7.63-7.65 (2H, m), 8.03 (1H,s) 76 δ 2.34 (6H, s), 4.68-4.70 (2H, m), 5.26-5.31 (1H, m), 5.35-5.41(1H, m), 5.92-6.02 (1H, m), 6.84 (1H, s), 7.35 (2H, s), 7.42-7.47 (2H,m), 7.60-7.62 (2H, m), 8.02 (1H, s) 77 δ 2.33 (6H, s), 2.53 (1H, t, J =1.4 Hz), 4.79 (2H, d, J = 1.4 Hz), 6.97 (1H, br-s), 7.35 (2H, s), 7.44(1H, t, J = 8.1 Hz), 7.51 (1H, s), 7.59-7.63 (2H, m), 8.02 (1H, s) 78 δ1.60-1.70 (1H, m), 1.78-1.86 (1H, m), 2.07-2.18 (2H, m), 2.33 (6H, s),2.35-2.43 (2H, m), 5.00-5.08 (1H, m), 6.80 (1H, s), 7.35 (2H, s),7.41-7.46 (1H, m), 7.53-7.62 (3H, m), 8.03 (1H, s) 79 δ 1.68-1.80 (6H,m), 1.86-1.94 (2H, m), 2.34 (6H, s), 5.20-5.23 (1H, m), 6.72 (1H, s),7.35 (2H, s), 7.42-7.62 (4H, m), 8.04 (1H, s) 81 δ 2.32 (6H, s), 5.22(2H, s), 6.87 (1H, s), 7.34 (2H, s), 7.36-7.45 (7H, m), 7.57-7.61 (2H,m), 8.01 (1H, s) 82 δ 2.33 (9H, s), 5.18 (2H, s), 6.83 (1H, br-s),7.14-7.20 (3H, m), 7.31 (1H, d, J = 7.8 Hz), 7.35 (2H, s), 7.44 (2H, t,J = 7.8 Hz), 7.52-7.62 (2H, m), 8.01 (1H, br-s) 83 δ 2.34 (6H, s), 5.28(2H, s), 6.90 (1H, br-s), 7.35 (2H, s), 7.43-7.54 (4H, m), 7.61-7.66(4H, m), 8.01 (1H, s) 84 δ 2.34 (6H, s), 5.24 (2H, s), 6.92 (1H, br-s),7.35-7.52 (4H, m), 7.63-7.81 (6H, m), 8.02 (1H, s) 85 δ 2.34 (6H, s),5.27 (2H, s), 6.97 (1H, br-s), 7.35 (2H, s), 7.45-7.52 (4H, m),7.61-7.69 (4H, m), 8.01 (1H, s) 89 δ 2.34 (6H, s), 5.34 (2H, s), 6.90(1H, br), 7.28-7.30 (3H, m), 7.35 (2H, s), 7.39-7.49 (3H, m), 7.59-7.64(2H, m), 8.04 (1H, m) 90 δ 2.33 (6H, s), 5.18 (2H, s), 6.92 (1H, s),7.22-7.34 (5H, m), 7.40-7.47 (3H, m), 7.59-7.63 (2H, m), 8.02 (1H, s) 91δ 2.33 (6H, s), 5.18 (2H, s), 6.86 (1H, s), 7.29-7.38 (6H, m), 7.43-7.47(2H, m), 7.60-7.62 (2H, m), 8.01 (1H, s) 92 δ 2.34 (6H, s), 5.32 (2H,s), 6.92 (1H, br-s), 7.36 (2H, s), 7.42 (1H, s), 7.48 (1H, t, J = 7.8Hz), 7.58 (2H, d, J = 9.0 Hz), 7.62-7.66 (2H, m), 8.01 (1H, s), 8.25(2H, d, J = 9.0 Hz) 93 δ 2.35 (6H, s), 3.93 (3H, s), 5.28 (2H, s), 6.88(1H, br-s), 7.36 (2H, s), 7.41 (1H, s), 7.45-7.49 (4H, m), 7.63 (2H, d,J = 6.8 Hz), 8.02 (1H, s), 8.05 (1H, d, J = 6.8 Hz) 94 δ 2.32 (6H, s),2.62 (1H, br), 3.87 (2H, t, J = 4.4 Hz), 4.29-4.32 (2H, m), 7.26 (1H,s), 7.34 (2H, s), 7.42 (1H, t, J = 8.1 Hz), 7.54-7.61 (2H, m), 7.77 (1H,s), 8.00 (1H, s) 95 δ 2.31 (6H, s), 3.41 (3H, s), 3.64-3.66 (2H, m),4.32-4.35 (2H, m), 7.14 (1H, s), 7.34 (2H, s), 7.40 (1H, t, J = 7.8 Hz),7.55-7.60 (2H, m), 7.67 (1H, s), 8.00 (1H, s) 96 δ 1.23 (3H, t, J = 6.8Hz), 2.29 (6H, s), 3.56 (2H, q, J = 6.8 Hz), 3.67-3.70 (2H, m),4.31-4.34 (2H, m), 7.26 (1H, s), 7.33 (2H, s), 7.38-7.40 (1H, m),7.52-7.60 (2H, m), 7.83 (1H, s), 8.00 (1H, s) 97 δ 1.18 (6H, d, J = 6.1Hz), 2.29 (6H, s), 3.63-3.69 (3H, m), 4.30-4.32 (2H, m), 7.26 (1H, s),7.33 (2H, s), 7.38 (1H, t, J = 7.8 Hz), 7.56-7.60 (2H, m), 7.82 (1H, s),8.00 (1H, s) 98 δ 2.28 (6H, s), 3.70-3.73 (2H, m), 4.33-4.36 (2H, m),4.57 (2H, s), 7.23-7.39 (9H, m), 7.53 (1H, d, J = 7.8 Hz), 7.58 (1H, d,J = 7.8 Hz), 7.87 (1H, s), 7.99 (1H, s) 99 δ 1.20 (3H, t, J = 8.1 Hz),1.95-2.00 (2H, m), 2.35 (6H, s), 3.47-3.57 (4H, m), 4.30 (2H, t, J = 6.6Hz), 6.78 (1H, s), 7.35 (2H, s), 7.46 (2H, t, J = 7.8 Hz), 7.61 (2H, d,J = 7.8 Hz), 8.02 (1H, s) 100 δ 1.30 (3H, t, J = 7.3 Hz), 2.34 (6H, s),4.26 (2H, q, J = 7.3 Hz), 4.72 (2H, s), 7.35 (2H, s), 7.36-7.40 (1H, m),7.52-7.60 (3H, m), 7.77-7.79 (1H, m), 7.90 (1H, br-s) 101 δ 1.56 (3H, d,J = 7.3 Hz), 2.33 (6H, s), 3.79 (3H, s), 5.18 (1H, q, J = 7.3 Hz), 7.21(1H, br), 7.35 (2H, s), 7.41 (1H, t, J = 7.8 Hz), 7.55-7.62 (3H, m),7.98 (1H, s) 102 δ 1.29 (3H, t, J = 6.8 Hz), 1.55 (3H, d, J = 6.8 Hz),2.34 (6H, s), 4.23 (2H, q, J = 6.8 Hz), 5.16 (1H, q, J = 6.8 Hz), 7.24(1H, br), 7.35 (2H, s), 7.41 (1H, t, J = 7.8 Hz), 7.55-7.62 (3H, m),7.96 (1H, s) 103 δ 2.21 (3H, s), 2.34 (6H, s), 2.84 (2H, t, J = 6.1 Hz),4.46 (2H, t, J = 6.1 Hz), 6.91 (1H, br-s), 7.35 (2H, s), 7.43 (1H, t, J= 7.8 Hz), 7.52-7.70 (3H, m), 8.01 (1H, s) 104 δ 2.10 (3H, s), 2.34 (6H,s), 4.33-4.42 (4H, m), 6.97 (1H, br-s), 7.35 (2H, s), 7.45 (1H, t, J =7.8 Hz), 7.57-7.64 (3H, m), 8.01 (1H, s) 106 δ 2.33 (6H, s), 2.78 (2H,t, J = 6.3 Hz), 4.40 (2H, t, J = 6.3 Hz), 7.12 (1H, br), 7.35 (2H, s),7.45 (1H, t, J = 7.8 Hz), 7.60-7.65 (3H, m), 8.01 (1H, s) 108 δ 2.17(3H, s), 2.34 (6H, s), 2.80 (2H, t, J = 6.6 Hz), 4.37 (2H, t, J = 6.6Hz), 6.84 (1H, br-s), 7.35 (2H, s), 7.43-7.52 (2H, m), 7.58-7.63 (2H,m), 8.02 (1H, s) 109 δ 1.25-1.31 (3H, m), 2.33 (6H, s), 2.57-2.64 (2H,m), 2.81-2.85 (2H, m), 4.32-4.38 (2H, m), 6.92 (1H, s), 7.35 (2H, s),7.42-7.49 (1H, m), 7.58-7.63 (3H, m), 8.03 (1H, s) 110 δ 1.28 (6H, d, J= 6.6 Hz), 2.34 (6H, s), 2.84 (2H, t, J = 7.1 Hz), 2.94-3.04 (1H, m),4.34 (2H, t, J = 7.1 Hz), 6.88 (1H, s), 7.35 (2H, s), 7.42-7.49 (1H, m),7.52-7.64 (3H, m), 8.02 (1H, s) 111 δ 1.40 (3H, d, J = 6.1 Hz), 2.17(3H, s), 2.34 (6H, s), 2.67 (1H, dd, J = 6.1 Hz, 13.7 Hz), 2.77 (1H, dd,J = 6.1 Hz, 13.7 Hz), 5.08 (1H, sextett., J = 6.1 Hz), 6.80 (1H, s),7.35 (2H, s), 7.45 (1H, t, J = 7.8 Hz), 7.52 (1H, s), 7.57-7.63 (2H, m),8.04 (1H, s) 112 δ 1.24-1.37 (3H, m), 2.35 (6H, s), 2.26-2.31 (2H, m),2.98-3.06 (2H, m), 4.67-4.76 (2H, m), 7.35 (3H, s), 7.45 (2H, t, J = 7.8Hz), 7.55-7.74 (2H, m), 8.08 (1H, br-s) 113 δ 1.36-1.43 (3H, m), 2.35(6H, s), 3.04-3.10 (2H, m), 3.37 (2H, t, J = 5.9 Hz), 4.68-4.73 (2H, m),7.00 (1H, br-s), 7.35 (2H, s), 7.46 (2H, t, J = 7.8 Hz), 7.55-7.70 (2H,m), 8.02-8.07 (1H, m) 116 δ 2.35 (6H, s), 4.45 (2H, dt, J = 28.3 Hz, 4.0Hz), 4.66 (2H, dt, J = 47.3 Hz, 4.0 Hz), 6.88 (1H, br-s), 7.36 (2H, s),7.46-7.50 (2H, m), 7.59-7.65 (2H, m), 8.02 (1H, s) 117 δ 2.34 (6H, s),4.38 (2H, dt, J = 3.9 Hz, 13.6 Hz), 6.00 (1H, tt, J = 3.9 Hz, 47.3 Hz),7.05 (1H, br-s), 7.35 (2H, s), 7.47 (1H, t, J = 7.8 Hz), 7.57-7.66 (3H,m), 8.01 (1H, s) 118 δ 2.33 (6H, s), 4.57 (2H, q, J = 8.3 Hz), 7.09 (1H,br), 7.35 (2H, s), 7.45-7.50 (2H, m), 7.61-7.66 (2H, m), 8.01 (1H, s)119 δ 2.35 (6H, s), 4.61-4.75 (4H, m), 5.18-5.31 (1H, m), 6.98 (1H,br-s), 7.36 (2H, s), 7.45-7.52 (2H, m), 7.58-7.66 (2H, m), 8.03 (1H, s)120 δ 2.35 (6H, s), 3.75-3.83 (2H, m), 4.46-4.80 (2H, m), 5.19-5.24 (1H,m), 6.97 (1H, br-s), 7.36 (2H, s), 7.36-7.48 (2H, m), 7.60-7.66 (2H, m),8.03 (1H, s) 121 (DMSO-d₆) δ 1.48 (3H, d, J = 6.6 Hz), 2.35 (6H, s),5.35 (1H, septet, J = 6.6 Hz), 7.33 (2H, s), 7.42 (1H, t, J = 7.8 Hz),7.68 (1H, d, J = 7.8 Hz), 7.76 (1H, d, J = 7.8 Hz), 8.11 (1H, s), 8.76(1H, s), 9.26 (1H, s) 122 (CDCl₃ + DMSO-d₆) δ 2.35 (6H, s), 5.87 (1H,septet, J = 6.3 Hz), 7.33 (2H, s), 7.44 (1H, t, J = 8.1 Hz), 7.71-7.78(2H, m), 8.17 (1H, s), 8.97 (1H, s), 10.19 (1H, s) 123 δ 2.34 (6H, s),2.48-2.59 (2H, m), 4.42 (2H, t, J = 6.3 Hz), 6.93 (1H, br- s), 7.35 (2H,s), 7.46 (1H, t, J = 7.8 Hz), 7.57-7.64 (3H, m), 8.01 (1H, br-s) 124 δ2.35 (6H, s), 4.67 (2H, t, J = 13.2 Hz), 6.98 (1H, br-s), 7.29 (2H, s),7.36 (1H, s), 7.50 (1H, t, J = 7.8 Hz), 7.65-7.67 (2H, m), 8.01 (1H, s)125 δ 1.51 (3H, d, J = 6.4 Hz), 2.35 (6H, s), 5.49-5.50 (1H, m), 6.90(1H, br- s), 7.36 (2H, s), 7.44 (1H, br-s), 7.50 (1H, t, J = 7.8 Hz),7.62-7.67 (2H, m), 8.02 (1H, s) 126 δ 1.95-2.05 (2H, m), 2.22-2.27 (2H,m), 2.35 (6H, s), 4.26 (2H, t, J = 6.4 Hz), 6.81 (1H, s), 7.36 (2H, s),7.45-7.49 (2H, m), 7.61-7.63 (2H, m), 8.02 (1H, s) 127 δ 2.35 (6H, s),2.61-2.65 (1H, m), 2.9-3.1 (1H, m), 5.2-5.3 (1H, m), 7.01 (1H, br-s),7.36 (2H, s), 7.45-7.52 (2H, m), 7.62-7.68 (2H, m), 8.01 (1H, s) 128 δ2.34 (6H, s), 5.84 (2H, s), 7.03 (1H, s), 7.36 (2H, s), 7.44-7.52 (2H,m), 7.65-7.67 (2H, m), 8.04 (1H, s) 129 δ 2.36 (6H, s), 7.33 (2H, s),7.40-7.46 (1H, m), 7.65 (1H, d, J = 7.8 Hz), 7.90 (1H, d, J = 7.8 Hz),7.95 (1H, d, J = 1.7 Hz), 8.55 (1H, s), 9.07 (1H, s) 130 δ 2.35 (6H, s),3.74-3.77 (2H, m), 4.44-4.47 (2H, m), 6.87 (1H, br), 7.36 (2H, s),7.43-7.52 (2H, m), 7.59-7.64 (2H, m), 8.02 (1H, s) 131 δ 2.32 (6H, s),4.53 (2H, d, J = 5.9 Hz), 5.90 (1H, t, J = 5.9 Hz), 7.11 (1H, br-s),7.35 (2H, s), 7.45 (1H, t, J = 8.1 Hz), 7.60-7.64 (3H, m), 8.01 (1H,br-s) 132 δ 2.33 (6H, s), 4.84 (2H, s), 7.29 (1H, br), 7.35 (2H, s),7.47 (1H, t, J = 7.8 Hz), 7.58 (1H, s), 7.64-7.66 (2H, m), 8.04 (1H, s)133 δ 2.35 (6H, s), 6.90 (1H, s), 7.17 (1H, br), 7.36 (2H, s), 7.42 (1H,s), 7.50-7.54 (1H, m), 7.66-7.71 (2H, m), 8.06 (1H, s) 134 δ 2.35 (6H,s), 3.83 (4H, d, J = 5.1 Hz), 5.22 (1H, quint, J = 5.1 Hz), 6.93 (1H,s), 7.36 (2H, s), 7.43 (1H, s), 7.48 (1H, t, J = 7.8 Hz), 7.60-7.66 (2H,m), 8.03 (1H, s) 135 δ 2.01 (6H, s), 2.35 (6H, s), 6.88 (1H, br), 7.36(2H, s), 7.43-7.52 (2H, m), 7.58-7.65 (2H, m), 8.03 (1H, s) 136 δ 2.17(2H, quint, J = 6.3 Hz), 2.34 (6H, s), 3.66 (2H, t, J = 6.3 Hz), 4.36(2H, t, J = 6.3 Hz), 6.83 (1H, s), 7.35 (2H, s), 7.43-7.48 (1H, m), 7.52(1H, s), 7.59-7.63 (2H, m), 8.02 (1H, s) 137 δ 2.35 (6H, s), 3.59 (2H,t, J = 5.9 Hz), 4.51 (2H, t, J = 5.9 Hz), 6.86 (1H, br), 7.36 (2H, s),7.43-7.52 (2H, m), 7.60-7.64 (2H, m), 8.02 (1H, s) 138 δ 2.34 (6H, s),5.03 (2H, s), 7.15 (1H, br), 7.35 (2H, s), 7.47-7.54 (2H, m), 7.64-7.69(2H, m), 8.06 (1H, s) 139 δ 2.25 (2H, quint, J = 6.1 Hz), 2.34 (6H, s),3.51 (2H, t, J = 6.1 Hz), 4.35 (2H, t, J = 6.1 Hz), 6.83 (1H, s), 7.35(2H, s), 7.46 (1H, t, J = 8.1 Hz), 7.54 (1H, s), 7.58-7.64 (2H, m), 8.02(1H, s) 140 δ 2.34 (6H, s), 3.34-3.39 (2H, m), 4.42-4.47 (2H, m),6.91-6.99 (1H, br), 7.35 (2H, s), 7.43-7.49 (1H, m), 7.56-7.64 (3H, m),8.03 (1H, s) 141 (DMSO-d₆) δ 1.82 (3H, s), 2.28 (6H, s), 3.33 (2H, q, J= 5.9 Hz), 4.11 (2H, t, J = 5.9 Hz), 7.44 (2H, s), 7.46 (1H, d, J = 7.8Hz), 7.62-7.69 (2H, m), 8.04 (1H, t, J = 5.9 Hz), 8.09 (1H, s), 9.90(1H, s), 9.93 (1H, s) 146 δ 2.34 (6H, s), 2.36 (3H, s), 7.05-7.08 (2H,m), 7.17-7.20 (2H, m), 7.33 (2H, s), 7.43 (1H, t, J = 7.8 Hz), 7.68 (1H,d, J = 7.8 Hz), 7.80 (1H, d, J = 7.8 Hz), 8.17 (1H, s), 8.67 (1H, s),9.29 (1H, s) 147 δ 2.35 (6H, s), 7.33 (2H, s), 7.41-7.57 (5H, m), 7.72(1H, d, J = 7.8 Hz), 7.82 (1H, d, J = 7.8 Hz), 8.18 (1H, s), 9.01 (1H,s), 9.73 (1H, s) 148 δ 2.35 (6H, s), 7.13-7.18 (2H, m), 7.32-7.37 (4H,m), 7.41-7.45 (1H, m), 7.70 (1H, d, J = 7.6 Hz), 7.81 (1H, d, J = 7.6Hz), 8.16 (1H, s), 9.04 (1H, s), 9.69 (1H, s) 149 δ 2.34 (6H, s), 7.32(2H, s), 7.33-7.36 (1H, m), 7.42-7.52 (3H, m), 7.65 (1H, d, J = 2.4 Hz),7.70 (1H, d, J = 7.8 Hz), 7.80-7.88 (4H, m), 8.20 (1H, s), 8.76 (1H, s),9.48 (1H, s) 154 δ 2.08-2.14 (1H, m), 2.18-2.30 (1H, m), 2.35 (6H, s),3.86-4.01 (4H, m), 5.37-5.39 (1H, m), 6.87 (1H, br-s), 7.35 (2H, s),7.46 (2H, t, J = 7.6 Hz), 7.58-7.63 (2H, m), 8.01 (1H, s) 155 δ 2.34(6H, s), 5.18 (2H, s), 6.38 (1H, d, J = 3.2 Hz), 6.48 (1H, d, J = 3.2Hz), 6.83 (1H, br-s), 7.35 (2H, s), 7.43-7.47 (3H, m), 7.57-7.63 (2H,m), 8.01 (1H, s) 156 δ 2.34 (6H, s), 5.10 (2H, s), 6.48 (1H, s), 6.79(1H, br-s), 7.35 (2H, s), 7.39-7.47 (3H, m), 7.53 (1H, s), 7.59-7.63(2H, m), 8.01 (1H, br-s) 157 δ 1.58-1.67 (1H, m), 1.93-1.95 (2H, m),2.01-2.09 (1H, m), 2.34 (6H, s), 3.78-3.93 (2H, m), 4.06-4.23 (2H, m),4.31 (1H, dd, J = 3.2 Hz, 11.2 Hz), 6.95 (1H, br-s), 7.35 (2H, s), 7.45(2H, t, J = 7.8 Hz), 7.50-7.56 (1H, m), 7.63 (1H, d, J = 7.1 Hz), 8.04(1H, s) 158 δ 1.66-1.73 (1H, m), 2.05-2.13 (1H, m), 2.34 (6H, s),2.60-2.70 (1H, m), 3.64-3.68 (1H, m), 3.73-3.79 (1H, m), 3.85-3.92 (2H,m), 4.09-4.15 (2H, m), 6.87 (1H, br-s), 7.35 (2H, s), 7.46 (2H, t, J =7.8 Hz), 7.61-7.66 (2H, m), 8.01 (1H, br-s) 159 δ 2.34 (6H, s), 5.38(2H, s), 6.83 (1H, br-s), 6.98-7.02 (1H, m), 7.16 (1H, d, J = 2.9 Hz),7.34-7.36 (3H, m), 7.43-7.47 (2H, m), 7.59-7.63 (2H, m), 8.01 (1H, s)160 δ 2.34 (6H, s), 5.23 (2H, s), 6.83 (1H, br-s), 7.14 (1H, d, J = 5.1Hz), 7.33-7.37 (4H, m), 7.45 (2H, t, J = 7.8 Hz), 7.61-7.64 (2H, m),8.02 (1H, s) 161 δ 2.32 (6H, s), 5.34 (2H, s), 7.24-7.28 (2H, m), 7.35(2H, s), 7.39 (1H, d, J = 7.8 Hz), 7.43 (1H, d, J = 7.8 Hz), 7.55 (1H,s), 7.61 (2H, t, J = 7.8 Hz), 7.73 (1H, dt, J = 1.7 Hz, 7.8 Hz), 8.03(1H, s), 8.61 (1H, br-s) 162 δ 2.36 (6H, s), 5.36 (2H, s), 6.37 (1H,br-s), 6.70 (1H, s), 7.31-7.39 (4H, m), 7.73-7.82 (4H, m), 8.58-8.61(1H, m), 8.72 (1H, d, J = 2.0 Hz) 163 δ 2.34 (6H, s), 5.22 (2H, s), 6.89(1H, br-s), 7.35-7.49 (5H, m), 7.62 (2H, d, J = 7.3 Hz), 7.72-7.77 (1H,m), 8.00 (1H, br-s), 8.45 (1H, d, J = 2.4 Hz) 164 δ1.23 (6H, d, J = 6.8Hz), 2.34 (3H, s), 3.18 (1H, septet, J = 6.8 Hz), 3.81 (3H, s), 6.84(1H, s), 7.36 (1H, s), 7.42 (1H, s), 7.46 (1H, t, J = 7.8 Hz), 7.56-7.63(3H, m), 8.01 (1H, s) 165 δ1.22 (6H, d, J = 6.8 Hz), 1.33 (3H, t, J =7.3 Hz), 2.33 (3H, s), 3.17 (1H, septet, J = 6.8 Hz), 4.24 (2H, q, J =7.3 Hz), 6.80 (1H, s), 7.35 (1H, s), 7.41 (1H, s), 7.44 (1H, t, J = 7.8Hz), 7.58-7.62 (3H, m), 8.02 (1H, s) 166 δ 1.32 (6H, d, J = 6.1 Hz),5.03 (1H, septet, J = 6.1 Hz), 6.71 (1H, s), 7.40-7.44 (1H, m), 7.54(1H, d, J = 2.0 Hz), 7.56 (1H, d, J = 2.0 Hz), 7.60 (2H, d, J = 8.8 Hz),7.80 (2H, d, J = 8.8 Hz), 7.98 (1H, s), 8.03 (1H, s) 167 δ1.32 (6H, d, J= 6.1 Hz), 2.53 (3H, d, J = 8.8 Hz), 5.04 (1H, septet, J = 6.1 Hz), 6.71(1H, br s), 7.41-7.65 (6H, m), 7.95-7.97 (2H, m) 168 δ 1.32 (6H, d, J =6.1 Hz), 1.33 (3H, t, J = 7.6 Hz), 2.74 (2H, q, J = 7.6 Hz), 5.04 (1H,septet, J = 6.1 Hz), 6.70 (1H, s), 7.43-7.56 (4H, m), 7.60 (1H, d, J =8.1 Hz), 7.86 (1H, s), 8.00 (1H, s), 8.27 (1H, d, J = 8.5 Hz) 169 δ 1.02(3H, t, J = 7.3 Hz), 1.32 (6H, d, J = 6.3 Hz), 1.67-1.77 (2H, m), 2.70(2H, t, J = 7.3 Hz), 5.03 (1H, septet, J = 6.3 Hz), 6.72 (1H, s),7.43-7.60 (5H, m), 7.89 (1H, s), 8.03 (1H, s), 8.29 (1H, d, J = 8.5 Hz)170 δ1.32 (6H, d, J = 6.4 Hz), 3.89 (3H, s), 5.04 (1H, septet, J = 6.4Hz), 6.73 (1H, br s), 7.05-7.08 (1H, m), 7.42-7.46 (1H, m), 7.51-7.58(3H, m), 7.80 (1H, s), 8.00 (1H, s), 8.15 (1H, s) 171 δ1.32 (6H, d, J =6.4 Hz), 5.03 (1H, septet, J = 6.4 Hz), 6.75 (1H, s), 7.28-7.47 (2H, m),7.52-7.58 (2H, m), 7.72-7.75 (1H, m), 7.92 (1H, s), 8.00 (1H, s), 8.37(1H, s) 172 δ1.31 (6H, d, J = 6.3 Hz), 2.30 (3H, s), 2.47 (3H, d, J =5.9 Hz), 5.01-5.09 (1H, m), 6.72 (1H, br-s), 7.40-7.47 (2H, m),7.56-7.60 (2H, m), 7.77 (1H, d, J = 8.6 Hz), 7.83 (1H, br-s), 8.00 (1H,br-s) 173 δ 1.31 (6H, d, J = 6.1 Hz), 2.35 (3H, s), 2.52 (3H, d, J = 9.0Hz), 4.99-5.09 (1H, m), 6.71 (1H, br-s), 7.30 (1H, br-s), 7.44 (1H, t, J= 7.8 Hz), 7.52-7.57 (1H, m), 7.61 (1H, d, J = 7.8 Hz), 7.72 (1H, s),7.98 (1H, s), 8.06 (1H, s) 174 δ 1.23 (6H, t, J = 7.6 Hz), 1.32 (6H, d,J = 6.1 Hz), 2.69 (4H, q, J = 7.6 Hz), 5.03 (1H, septet, J = 6.1 Hz),6.70 (1H, s), 7.38 (2H, s), 7.42-7.47 (2H, m), 7.58-7.62 (2H, m), 8.01(1H, s) 175 δ 1.22 (3H, t, J = 7.6 Hz), 1.31 (6H, d, J = 6.3 Hz), 2.34(3H, s), 2.69 (2H, q, J = 7.6 Hz), 5.03 (1H, septet, J = 6.3 Hz), 6.70(1H, s), 7.37 (2H, s), 7.42-7.47 (2H, m), 7.58-7.61 (2H, m), 8.02 (1H,s) 176 δ1.22 (6H, d, J = 6.8 Hz), 1.31 (6H, d, J = 6.3 Hz), 2.33 (3H,s), 3.17 (1H, septet, J = 6.8 Hz), 5.03 (1H, septet, J = 6.3 Hz), 6.76(1H, s), 7.35 (1H, s), 7.41 (1H, s), 7.44 (1H, t, J = 8.1 Hz), 7.56-7.62(3H, m), 8.03 (1H, s) 177 δ 1.32 (6H, d, J = 6.1 Hz), 2.35 (3H, s), 3.85(3H, s), 5.04 (1H, septet, J = 6.1 Hz), 6.67 (1H, s), 6.96 (1H, s), 7.13(1H, s), 7.44 (1H, t, J = 8.1 Hz), 7.59-7.65 (3H, m), 7.96 (1H, s) 178 δ1.30 (6H, d, J = 6.1 Hz), 2.42 (3H, s), 5.00 (1H, septet, J = 6.1 Hz),6.63 (1H, s), 7.27-7.41 (8H, m), 7.45 (1H, s), 7.53 (1H, s), 7.58 (1H,d, J = 7.8 Hz), 7.74 (1H, s) 179 δ1.31 (6H, d, J = 6.1 Hz), 2.61 (3H, d,J = 6.3 Hz), 5.05 (1H, septet, J = 6.1 Hz), 6.76 (1H, br s), 7.45-7.58(3H, m), 7.70 (1H, d, J = 8.1 Hz), 7.96 (1H, t, J = 1.8 Hz), 8.56-8.58(1H, m), 8.70 (1H, br s) 180 δ 1.24 (3H, t, J = 7.6 Hz), 1.31 (6H, d, J= 6.3 Hz), 2.75 (2H, q, J = 7.6 Hz), 5.03 (1H, septet, J = 6.3 Hz), 6.74(1H, s), 7.42-7.47 (2H, m), 7.57-7.67 (4H, m), 8.02 (1H, s) 181 δ 0.93(3H, t, J = 7.3 Hz), 1.32 (6H, d, J = 6.1 Hz), 1.63-1.71 (2H, m), 2.70(2H, t, J = 7.6 Hz), 5.04 (1H, septet, J = 6.1 Hz), 6.72 (1H, s),7.44-7.48 (2H, m), 7.57-7.63 (3H, m), 7.68 (1H, s), 8.02 (1H, s) 182δ1.32 (6H, d, J = 6.4 Hz), 3.92 (3H, s), 5.06 (1H, septet, J = 6.4 Hz),6.73 (1H, s), 7.46-7.50 (1H, m), 7.55-7.60 (2H, m), 7.69 (1H, d, J = 7.8Hz), 7.96 (1H, s), 8.48 (1H, d, J = 1.2 Hz), 8.58 (1H, s) 183 δ1.31 (6H,d, J = 6.2 Hz), 2.30 (3H, s), 2.44 (3H, d, J = 6.4 Hz), 5.01-5.05 (1H,m), 6.72 (1H, br-s), 7.44-7.48 (2H, m), 7.61-7.62 (2H, m), 7.78 (1H, s),8.03 (1H, br-s) 184 δ 1.32 (6H, d, J = 6.1 Hz), 2.35 (3H, s), 2.58 (3H,d, J = 6.8 Hz), 5.01-5.07 (1H, m), 6.68 (1H, br-s), 7.35 (1H, s), 7.46(1H, t, J = 7.8 Hz), 7.61-7.65 (2H, m), 7.72 (1H, s), 8.01 (1H, s) 185δ1.31 (6H, d, J = 6.4 Hz), 2.49 (3H, s), 4.77 (2H, br-s), 5.06 (1H,sept, J = 6.4 Hz), 6.73 (1H, br-s), 7.44-7.49 (1H, m), 7.55 (1H, s),7.61-7.63 (2H, m), 7.81 (1H, s), 8.05 (1H, br-s) 186 δ1.32 (6H, d, J =6.4 Hz), 2.61 (3H, s), 5.05 (1H, septet), 6.73 (1H, br-s), 7.44-7.48(2H, m), 7.57-7.64 (2H, m), 7.95 (1H, br-s), 8.06 (1H, br-s) 187 δ 4.84(2H, s), 7.28 (1H, br), 7.45 (1H, t, J = 8.1 Hz), 7.59-7.65 (4H, m),7.81 (2H, d, J = 8.5 Hz), 7.99 (1H, s), 8.17 (1H, s) 188 δ 2.53 (3H, d,J = 8.8 Hz), 4.85 (2H, s), 7.15 (1H, br s), 7.45-7.65 (6H, m), 8.00-8.02(2H, m) 189 δ 1.34 (3H, t, J = 7.6 Hz), 2.75 (2H, q, J = 7.6 Hz), 4.85(2H, s), 7.10 (1H, s), 7.47-7.52 (3H, m), 7.59-7.66 (2H, m), 7.87 (1H,s), 8.05 (1H, s), 8.27 (1H, d, J = 8.8 Hz) 190 δ 1.02 (3H, t, J = 7.3Hz), 1.67-1.77 (2H, m), 2.70 (2H, t, J = 7.6 Hz), 4.85 (2H, s), 7.10(1H, br-s), 7.44-7.52 (3H, m), 7.59-7.65 (2H, m), 7.88 (1H, s), 8.07(1H, s), 8.30 (1H, d, J = 8.5 Hz) 191 δ3.89 (3H, s), 4.85 (2H, s), 7.06(1H, dd, J = 8.5 Hz, 2.0 Hz), 7.18 (1H, br s), 7.46-7.54 (2H, m),7.61-7.63 (2H, m), 7.79-7.80 (1H, m), 8.01 (1H, s), 8.10 (1H, s) 192δ4.86 (2H, s), 7.09 (1H, br.), 7.43-7.79 (5H, m), 8.03 (1H, br.), 8.56(1H, br), 8.76 (1H, d, J = 8.8 Hz) 193 δ4.86 (2H, s), 7.16 (1H, br s),7.47-7.74 (5H, m), 7.93 (1H, s), 8.02 (1H, s), 8.23 (1H, s) 194 δ 2.30(3H, s), 2.47 (3H, d, J = 6.0 Hz), 4.85 (2H, s), 7.12 (1H, br- s), 7.42(1H, d, J = 9.0 Hz), 7.49 (1H, t, J = 8.1 Hz), 7.62-7.67 (2H, m),7.78-7.81 (2H, m), 8.03 (1H, br-s) 195 δ 2.35 (3H, s), 2.52 (3H, d, J =8.8 Hz), 4.86 (2H, s), 7.05 (1H, br- s), 7.31 (1H, s), 7.50 (1H, t, J =7.8 Hz), 7.60-7.67 (2H, m), 7.71 (1H, s), 8.03 (1H, s), 8.07 (1H, s) 196δ 1.23 (6H, t, J = 7.6 Hz), 2.70 (4H, q, J = 7.6 Hz), 4.85 (2H, s), 7.03(1H, br), 7.39 (3H, s), 7.50 (1H, t, J = 8.1 Hz), 7.65 (1H, d, J = 8.1Hz), 7.69 (1H, br-s), 8.04 (1H, s) 197 δ 1.23 (3H, t, J = 7.6 Hz), 2.35(3H, s), 2.69 (2H, q, J = 7.6 Hz), 4.85 (2H, s), 7.05 (1H, br), 7.37(2H, s), 7.42 (1H, s), 7.50 (1H, t, J = 7.8 Hz), 7.64-7.66 (2H, m), 8.04(1H, s) 198 δ1.23 (6H, d, J = 6.8 Hz), 2.34 (3H, s), 3.17 (1H, septet, J= 6.8 Hz), 4.85 (2H, s), 7.18 (1H, br-s), 7.36 (1H, s), 7.42 (1H, s),7.49 (1H, t, J = 8.1 Hz), 7.55 (1H, s), 7.65-7.67 (2H, m), 8.05 (1H, s)199 δ 2.36 (3H, s), 3.86 (3H, s), 4.85 (2H, s), 6.96 (1H, s), 7.01 (1H,br), 7.14 (1H, s), 7.49 (1H, t, J = 8.1 Hz), 7.64-7.68 (3H, m), 7.99(1H, s) 200 δ 2.43 (3H, s), 4.83 (2H, s), 6.99 (1H, br), 7.33-7.42 (8H,m), 7.45 (1H, s), 7.54 (1H, s), 7.64 (1H, d, J = 6.3 Hz), 7.78 (1H, s)201 δ 2.47 (3H, s), 4.86 (2H, s), 7.06 (1H, s), 7.11 (1H, br.),7.24-7.27 (1H, m), 7.53 (1H, t, J = 7.3 Hz), 7.66 (2H, t, J = 7.3 Hz),7.95 (1H, s), 8.17 (1H, s), 8.85 (1H, s) 202 δ1.57 (3H, s), 4.86 (2H,s), 7.10 (1H, br s), 7.52 (2H, t, J = 7.8 Hz), 7.63-7.65 (1H, m),7.72-7.74 (1H, m), 8.03 (1H, br-s), 8.57-8.59 (1H, m), 8.70 (1H, br s)203 δ 2.10 (3H, s), 4.84 (2H, s), 7.11 (1H, d, J = 8.8 Hz), 7.18-7.22(2H, m), 7.47 (1H, t, J = 7.8 Hz), 7.61 (1H, d, J = 7.8 Hz), 7.65 (1H,d, J = 7.8 Hz), 7.80 (1H, br-s), 8.00 (1H, br-s) 204 δ1.50 (9H, s), 2.29(3H, s), 4.85 (2H, s), 6.46 (1H, br-s), 7.20 (1H, br-s), 7.45-7.49 (2H,m), 7.50 (1H, d, J = 7.3 Hz), 7.65 (1H, d, J = 7.3 Hz), 7.88 (1H, br-s),7.99 (1H, br-s), 8.19 (1H, d, J = 8.8 Hz) 205 δ 1.26 (3H, t, J = 7.6Hz), 2.76 (2H, q, J = 7.6 Hz), 4.85 (2H, s), 7.06 (1H, br), 7.47-7.53(2H, m), 7.58-7.61 (2H, m), 7.67-7.69 (2H, m), 8.05 (1H, s) 206 δ 1.25(3H, t, J = 7.3 Hz), 2.77 (2H, q, J = 7.3 Hz), 4.85 (2H, s), 7.06 (1H,br), 7.49-7.53 (2H, m), 7.62 (1H, s), 7.68-7.70 (2H, m), 7.74 (1H, s),8.06 (1H, s) 207 δ 1.24 (3H, t, J = 7.3 Hz), 2.77 (2H, q, J = 7.3 Hz),4.86 (2H, s), 7.07 (1H, br), 7.50-7.58 (3H, m), 7.70-7.72 (2H, m), 7.96(1H, s), 8.07 (1H, s) 208 δ 0.93 (3H, t, J = 7.3 Hz), 1.63-1.69 (2H, m),2.70 (2H, t, J = 7.6 Hz), 4.85 (2H, s), 7.10 (1H, s), 7.45 (1H, s),7.49-7.52 (1H, m), 7.53 (1H, s), 7.58-7.69 (3H, m), 8.04 (1H, s) 209 δ0.93 (3H, t, J = 7.3 Hz), 1.61-1.70 (2H, m), 2.71 (2H, t, J = 7.3 Hz),4.85 (2H, s), 7.10 (1H, br-s), 7.48-7.53 (2H, m), 7.63 (1H, s),7.67-7.70 (2H, m), 7.74 (1H, d, J = 2.0 Hz), 8.05 (1H, s) 210 δ 0.90(3H, t, J = 7.3 Hz), 1.28-1.38 (2H, m), 1.56-1.64 (2H, m), 2.73 (2H, t,J = 7.8 Hz), 4.85 (2H, s), 7.06 (1H, br-s), 7.49-7.53 (2H, m), 7.60 (1H,s), 7.67-7.74 (3H, m), 8.04 (1H, s) 211 δ3.93 (3H, s), 4.86 (2H, s),7.13 (1H, br s), 7.53 (1H, t, J = 8 Hz), 7.61-7.65 (2H, m), 7.71 (1H, d,J = 8 Hz), 8.04 (1H, s), 8.48 (1H, d, J = 1.2 Hz), 8.58 (1H, s) 212 δ2.47 (3H, s), 4.85 (2H, s), 7.08 (1H, br-s), 7.40 (1H, s), 7.51 (1H, t,J = 7.8 Hz), 7.63 (1H, s), 7.67-7.71 (3H, m), 8.03 (1H, s) 213 δ4.86(2H, s), 7.06 (1H, br.), 7.52 (1H, t, J = 7.8 Hz), 7.67-7.71 (3H, m),7.67 (2H, s), 8.05 (1H, s) 214 δ 2.26 (3H, s), 2.45 (3H, d, J = 6.4 Hz),4.86 (2H, s), 7.08 (1H, br- s), 7.49-7.53 (2H, m), 7.69-7.75 (3H, m),8.05 (1H, br-s) 215 δ 2.35 (3H, s), 2.58 (3H, d, J = 6.6 Hz), 4.85 (2H,s), 7.08 (1H, br- s), 7.35 (1H, s), 7.51 (1H, t, J = 8.1 Hz), 7.68 (2H,d, J = 8.1 Hz), 7.73 (1H, s), 8.04 (1H, s) 216 δ 2.50 (3H, s), 4.77 (2H,br-s), 4.86 (2H, s), 7.12 (1H, br-s), 7.51-7.56 (2H, m), 7.69 (2H, d, J= 7.3 Hz), 8.84 (1H, s), 8.08 (1H, br-s) 217 δ 2.43 (3H, s), 4.86 (2H,s), 7.12 (1H, br-s), 7.51 (1H, t, J = 7.9 Hz), 7.57 (1H, br-s), 7.69(1H, d, J = 7.9 Hz), 7.76 (1H, br-s), 7.86 (1H, br-s), 8.08 (1H, br-s)218 δ 2.51 (3H, s), 4.86 (2H, s), 7.00 (1H, br-s), 7.50-7.55 (2H, m),7.68-7.70 (2H, m), 7.87 (1H, br-s), 8.08 (1H, br-s) 219 δ 2.62 (3H, s),4.86 (2H, s), 7.00 (1H, br-s), 7.47 (1H, s), 7.52 (1H, t, J = 7.8 Hz),7.68-7.70 (2H, m), 7.89 (1H, br-s), 8.07 (1H, br- s) 220 δ 2.12 (3H, s),4.50 (2H, br-s), 4.86 (2H, s), 7.14 (1H, br-s), 7.29 (1H, br-s), 7.51(1H, t, J = 7.8 Hz), 7.68-7.70 (2H, m), 7.77 (1H, br- s), 8.04 (1H,br-s) 221 δ 0.90 (3H, t, J = 7.3 Hz), 1.28-1.37 (2H, m), 1.55-1.63 (2H,m), 2.48-2.60 (2H, m), 2.73 (2H, t, J = 7.8 Hz), 4.43 (2H, t, J = 6.3Hz), 6.85 (1H, s), 7.46-7.50 (2H, m), 7.60-7.68 (3H, m), 7.73 (1H, d, J= 1.5 Hz), 8.00 (1H, s) 222 δ1.32 (6H, d, J = 6.3 Hz), 2.39 (3H, s),5.04 (1H, septet, J = 6.3 Hz), 6.71 (1H, s), 7.43-7.47 (2H, m),7.57-7.64 (3H, m), 7.73 (1H, s), 8.04 (1H, s) 223 δ 1.32 (6H, d, J = 6.3Hz), 5.03 (1H, septet, J = 6.3 Hz), 7.41 (1H, t, J = 8.1 Hz), 7.63-7.68(1H, m), 7.67 (2H, s), 7.75 (1H, d, J = 7.6 Hz), 8.00 (1H, s), 8.06 (1H,t, J = 1.7 Hz), 8.93 (1H, s) 224 (DMSO-d₆)δ 1.31 (6H, d, J = 6.3 Hz),5.03 (1H, septet, J = 6.3 Hz), 7.41 (1H, t, J = 8.1 Hz), 7.64 (1H, d, J= 8.1 Hz), 7.79 (1H, d, J = 8.1 Hz), 7.93 (1H, s), 8.00 (1H, s), 8.15(1H, s), 8.26 (1H, s), 9.36 (1H, s) 225 δ 1.31 (6H, d, J = 6.3 Hz), 2.34(6H, s), 5.03 (1H, septet, J = 6.3 Hz), 6.73 (1H, s), 7.33 (2H, s), 7.44(1H, t, J = 7.8 Hz), 7.53-7.62 (3H, m), 8.05 (1H, s) 226 δ 1.31 (6H, d,J = 6.3 Hz), 2.33 (6H, s), 5.02 (1H, septet, J = 6.3 Hz), 6.75 (1H, s),7.33 (2H, s), 7.43 (1H, t, J = 7.8 Hz), 7.52-7.61 (3H, m), 8.04 (1H, s)227 δ 4.84 (2H, s), 7.24 (1H, s), 7.45 (1H, t, J = 7.8 Hz), 7.59-7.62(4H, m), 7.77 (2H, d, J = 8.8 Hz), 7.99 (1H, s), 8.16 (1H, s) 228 δ 2.39(3H, s), 4.85 (2H, s), 7.11 (1H, br-s), 7.47-7.52 (2H, m), 7.58 (1H, s),7.67-7.70 (2H, m), 7.73 (1H, s), 8.06 (1H, s) 229 (DMSO-d₆) δ 4.86 (2H,s), 7.45 (1H, t, J = 7.8 Hz), 7.72 (1H, s), 7.73 (1H, d, J = 7.8 Hz),7.83-7.84 (2H, m), 8.14 (1H, s), 9.27 (1H, s), 9.34 (1H, s) 230(DMSO-d6) δ 4.86 (2H, s), 7.44 (1H, t, J = 8.1 Hz), 7.67 (1H, s), 7.68(1H, s), 7.71-7.74 (1H, m), 7.85 (1H, d, J = 7.3 Hz), 8.15 (1H, s), 9.31(1H, s), 9.41 (1H, br-s) 231 (DMSO-d₆) δ 4.96 (2H, s), 7.51 (1H, t, J =7.8 Hz), 7.65-7.73 (2H, m), 8.13 (1H, s), 8.15 (1H, s), 8.49 (1H, s),10.41 (1H, s), 10.58 (1H, s) 232 (DMSO-d₆) δ 4.86 (2H, s), 7.45 (1H, t,J = 7.8 Hz), 7.70 (1H, d, J = 7.8 Hz), 7.88 (1H, d, J = 7.8 Hz), 7.94(1H, s), 8.08 (1H, s), 8.16 (1H, s), 9.33 (1H, s), 9.42 (1H, s) 233 δ2.34 (6H, s), 4.85 (2H, s), 7.10 (1H, br), 7.34 (2H, s), 7.47-7.51 (2H,m), 7.65-7.68 (2H, m), 8.06 (1H, s) 234 δ 2.34 (6H, s), 4.85 (2H, s),7.10 (1H, br), 7.35 (2H, s), 7.47-7.52 (2H, m), 7.65-7.68 (2H, m), 8.05(1H, s) 235 δ 4.84 (2H, s), 7.17 (1H, br-s), 7.49 (1H, t, J = 7.8 Hz),7.63 (1H, d, J = 7.8 Hz), 7.67 (1H, d, J = 7.8 Hz), 7.94 (1H, s), 8.07(1H, s) 236 δ 4.85 (2H, s), 7.14 (1H, s), 7.51 (1H, t, J = 7.8 Hz),7.68-7.73 (2H, m), 7.83 (1H, s), 7.86 (2H, s), 8.07 (1H, s) 237 δ2.48-2.60 (2H, m), 4.43 (2H, t, J = 6.3 Hz), 6.90 (1H, s), 7.48 (1H, t,J = 7.8 Hz), 7.63-7.69 (2H, m), 7.86 (3H, s), 8.03 (1H, s) 238 (DMSO-d₆)δ 2.50-2.61 (2H, m), 4.41 (2H, t, J = 6.3 Hz), 7.43 (1H, t, J = 7.8 Hz),7.70 (1H, d, J = 7.8 Hz), 7.71 (1H, s), 7.80-7.84 (2H, m), 8.06 (1H, s),8.82 (1H, s), 9.26 (1H, s) 239 δ 1.34 (3H, t, J = 7.3 Hz), 4.26 (2H, q,J = 7.3 Hz), 6.77 (1H, br-s), 7.46-7.53 (2H, m), 7.70 (1H, brd, J = 7.3Hz), 7.86-7.94 (3H, m), 8.39 (1H, s), 8.71 (1H, d, J = 8.8 Hz) 240 δ1.32 (6H, d, J = 6.3 Hz), 5.06 (1H, septet, J = 6.3 Hz), 6.74 (1H, s),7.45-7.52 (2H, m), 7.70 (1H, d, J = 7.3 Hz), 7.86-7.94 (3H, m), 8.40(1H, s), 8.71 (1H, d, J = 8.8 Hz) 241 δ 4.58 (1H, dd, J = 2.0 Hz, 5.8Hz), 4.85 (1H, dd, J = 2.0 Hz, 4.2 Hz), 7.06 (1H, br-s), 7.30 (1H, d, J= 6.4 Hz), 7.49-7.57 (2H, m), 7.74 (1H, d, J = 7.8 Hz), 7.87 (1H, d, J =7.8 Hz), 7.91 (1H, s), 7.99 (1H, s), 8.40 (1H, s), 8.71 (1H, d, J = 8.8Hz) 242 δ1.62-1.70 (2H, m), 1.71-1.87 (4H, m), 1.89-1.96 (2H, m),5.22-5.26 (1H, m), 6.72 (1H, s), 7.45-7.51 (2H, m), 7.70 (1H, brd, J =7.3 Hz), 7.86-7.93 (3H, m), 8.34 (1H, s), 8.70 (1H, d, J = 8.8 Hz) 243 δ3.76 (2H, t, J = 5.4 Hz), 4.47 (2H, t, J = 5.4 Hz), 6.97 (1H, br-s),7.47-7.56 (2H, m), 7.69 (1H, d, J = 7.8 Hz), 7.86-7.91 (2H, m), 7.97(1H, s), 8.39 (1H, s), 8.71 (1H, d, J = 8.8 Hz) 244 δ 2.82 (2H, t, J =6.3 Hz), 4.41 (2H, t, J = 6.3 Hz), 7.46 (1H, t, J = 7.8 Hz), 7.54-7.57(1H, m), 7.81 (1H, d, J = 8.3 Hz), 7.88 (1H, d, J = 8.8 Hz), 7.91 (1H,s), 8.10 (1H, s), 8.56-8.63 (2H, m), 9.55 (1H, br-s) 245 δ4.40 (2H, dt,J = 3.9 Hz, 14.1 Hz), 6.04 (1H, tt, J = 3.9 Hz, 55.3 Hz), 7.43-7.48 (1H,m), 7.55 (1H, d, J = 7.8 Hz), 7.80 (1H, d, J = 7.3 Hz), 7.86 (1H, d, J =8.8 Hz), 7.91 (1H, s), 8.07 (1H, s), 8.53 (1H, s), 8.64 (1H, d, J = 8.8Hz), 9.42 (1H, s) 246 δ4.56 (2H, d, J = 5.9 Hz), 5.92 (1H, t, J = 5.9Hz), 6.97 (1H, br-s), 7.49-7.57 (2H, m), 7.69 (1H, d, J = 7.3 Hz),7.87-7.92 (2H, m), 7.98 (1H, s), 8.39 (1H, s), 8.71 (1H, d, J = 8.8 Hz)247 δ 4.86 (2H, s), 7.15 (1H, br-s), 7.50-7.59 (2H, m), 7.72 (1H, d, J =7.8 Hz), 7.86-7.92 (2H, m), 8.02 (1H, s), 8.40 (1H, s), 8.71 (1H, d, J =8.8 Hz) 248 δ5.05 (2H, s), 7.09 (1H, br-s), 7.51-7.59 (2H, m), 7.73 (1H,d, J = 7.8 Hz), 7.88 (1H, d, J = 8.3 Hz), 7.92 (1H, s), 8.03 (1H, s),8.39 (1H, s), 8.72 (1H, d, J = 8.8 Hz) 249 δ 2.49-2.60 (2H, m), 4.44(2H, t, J = 6.3 Hz), 6.86 (1H, br-s), 7.48-7.56 (2H, m), 7.69 (1H, d, J= 6.3 Hz), 7.88 (1H, d, J = 8.8 Hz), 7.92 (1H, s), 7.96 (1H, s), 8.39(1H, s), 8.71 (1H, d, J = 8.8 Hz) 250 δ4.68 (2H, t, J = 13.2 Hz), 708(1H, br-s), 7.50-7.59 (2H, m), 7.70 (1H, br-d, J = 7.3 Hz), 7.87-7.92(2H, m), 8.00 (1H, s), 8.39 (1H, s), 8.71 (1H, d, J = 8.7 Hz) 251 δ5.29(2H, s), 6.92 (1H, br-s), 7.47-7.55 (4H, m), 7.65-7.70 (3H, m), 7.87(1H, d, J = 8.8 Hz), 7.92 (1H, s), 7.97 (1H, s), 8.38 (1H, br-s), 8.71(1H, d, J = 8.8 Hz) 252 δ5.23 (2H, s), 6.82 (1H, br-s), 7.37 (1H, d, J =8.3 Hz), 7.50-7.53 (2H, m), 7.6 (1H, m), 7.75 (1H, dd, J = 2.4 Hz, 8.3Hz), 7.87-7.96 (3H, m), 8.38 (1H, br-s), 8.47 (1H, d, J = 2.4 Hz), 8.72(1H, d, J = 8.3 Hz) 253 δ 1.31 (6H, d, J = 6.3 Hz), 2.33 (6H, s), 5.02(1H, septet, J = 6.3 Hz), 6.75 (1H, br-s), 7.33 (2H, s), 7.43 (1H, t, J= 7.8 Hz), 7.54-7.61 (3H, m), 8.04 (1H, s) 254 δ 2.34 (6H, s), 4.39 (2H,dt, J = 3.9 Hz, 13.6 Hz), 6.01 (1H, tt, J = 3.9 Hz, 54.6 Hz), 6.98 (1H,s), 7.34 (2H, s), 7.46-7.50 (2H, m), 7.60-7.66 (2H, m), 8.02 (1H, s) 255δ 2.34 (6H, s), 4.61-4.66 (2H, m), 4.71-4.77 (2H, m), 5.18-5.30 (1H, m),7.12 (1H, s), 7.34 (2H, s), 7.45-7.50 (1H, m), 7.52-7.66 (2H, m),7.76-7.84 (1H, m), 8.04 (1H, s) 256 δ 2.34 (6H, s), 4.58 (2H, q, J = 8.3Hz), 7.02 (1H, s), 7.34 (2H, s), 7.45-7.51 (2H, m), 7.62-7.67 (2H, m),8.02 (1H, s) 257 δ 2.34 (6H, s), 4.85 (2H, s), 7.10 (1H, br), 7.34 (2H,s), 7.47-7.51 (2H, m), 7.63-7.67 (2H, m), 8.05 (1H, s) 258 δ1.48 (3H, d,J = 6.8 Hz), 2.34 (6H, s), 5.30-5.36 (1H, m), 6.95 (1H, br- s), 7.30(2H, s), 7.46-7.51 (2H, m), 7.60-7.67 (2H, m), 8.03 (1H, br-s) 259 δ2.35 (6H, s), 2.49-2.59 (2H, m), 4.42 (2H, t, J = 6.3 Hz), 6.85 (1H, br-s), 7.34 (2H, s), 7.45-7.49 (2H, m), 7.60-7.65 (2H, m), 8.02 (1H, br-s)300 δ 4.85 (2H, s), 7.10 (1H, br), 7.50 (1H, t, J = 7.8 Hz), 7.68-7.71(3H, m), 7.72 (2H, s), 8.04 (1H, s) 301 δ 4.85 (2H, s), 7.08 (1H, br),7.51-7.55 (1H, m), 7.69-7.72 (2H, m), 7.84 (1H, s), 8.06 (2H, s), 8.10(1H, s) 331 δ 2.29 (6H, s), 4.85 (2H, s), 7.11-7.19 (3H, m), 7.39 (1H,s), 7.49 (1H, t, J = 7.9 Hz), 7.66-7.73 (2H, m), 8.00 (1H, s) 348 δ 2.35(6H, s), 3.81 (3H, s), 6.80 (1H, br), 7.36 (2H, s), 7.44-7.63 (4H, m),8.02 (1H, s) 377 δ 2.36 (6H, s), 4.85 (2H, s), 7.09 (1H, s), 7.37 (2H,s), 7.44 (1H, s), 7.50 (1H, t, J = 8.3 Hz), 7.67 (2H, d, J = 7.3 Hz),8.05 (1H, s) 424 δ4.85 (2H, s), 7.10 (1H, s), 7.51 (1H, t, J = 7.8 Hz),7.69-7.70 (3H, m), 7.73 (2H, s), 8.05 (1H, s) 464 δ 2.47-2.59 (2H, m),4.41 (2H, t, J = 6.3 Hz), 6.96 (1H, br-s), 7.46 (1H, t, J = 7.8 Hz),7.63-7.67 (2H, m), 7.83 (1H, s), 7.91 (2H, s), 8.00 (1H, s) 471 δ 4.85(2H, s), 7.13 (1H, br-s), 7.50 (1H, t, J = 7.8 Hz), 7.68-7.74 (3H, m),7.92 (2H, s), 8.04 (1H, s) 511 (DMSO-d₆) δ 2.67-2.78 (2H, m), 4.34 (2H,t, J = 5.9 Hz), 7.50 (1H, t, J = 7.8 Hz), 7.68-7.73 (2H, m), 8.13 (1H,s), 8.52 (2H, s), 10.02 (1H, s), 10.77 (1H, s) 518 (DMSO-d₆) δ 4.96 (2H,s), 7.52 (1H, t, J = 7.8 Hz), 7.71-7.75 (2H, m), 8.16 (1H, s), 8.51 (2H,s), 10.42 (1H, s), 10.79 (1H, s) 565 δ4.86 (2H, s), 7.00 (1H, br-s),7.52 (1H, t, J = 8.3 Hz), 7.70-7.73 (3H, m), 7.93 (2H, s), 8.06 (1H, s)605 δ 2.49-2.60 (2H, m), 4.43 (2H, t, J = 6.3 Hz), 6.82 (1H, s), 7.49(1H, t, J = 7.8 Hz), 7.66-7.68 (3H, m), 7.94 (2H, s), 8.01 (1H, s) 612δ4.86 (2H, s), 7.45 (1H, t, J = 7.8 Hz), 7.72 (1H, d, J = 7.8 Hz), 7.94(1H, br-s), 7.93 (2H, s), 8.13 (1H, s), 9.02 (1H, s), 9.17 (1H, s) 659δ4.86 (2H, s), 7.06 (1H, s), 7.51 (1H, t, J = 7.8 Hz), 7.68-7.71 (3H,m), 7.93 (2H, s), 8.06 (1H, s) 706 δ4.84 (2H, s), 7.40 (1H, br-s), 7.48(1H, t, J = 7.8 Hz), 7.67-7.75 (2H, m), 8.00 (1H, s), 8.09 (2H, s), 8.24(1H, s) 770 δ 2.39 (3H, s), 4.86 (2H, s), 7.00 (1H, br-s), 7.48-7.67(5H, m), 7.79 (1H, s), 8.04 (1H, s), 8.24 (1H, d, J = 8.8 Hz) 800 δ 2.31(6H, s), 4.85 (2H, s), 7.11 (1H, br-s), 7.43 (2H, s), 7.47-7.53 (2H, m),7.66 (1H, s), 7.67 (1H, s), 8.05 (1H, s) 817 δ0.89 (3H, t, J = 7.3 Hz),1.24-1.37 (2H, m), 1.55-1.63 (2H, m), 2.47-2.59 (2H, m), 2.70 (2H, t, J= 7.8 Hz), 4.42 (2H, t, J = 5.9 Hz), 6.96 (1H, br-s), 7.43-7.47 (2H, m),7.57 (1H, d, J = 1.5 Hz), 7.62-7.64 (2H, m), 7.74 (1H, s), 8.00 (1H, s)818 δ0.86 (3H, t, J = 7.3 Hz), 1.24-1.33 (2H, m), 1.49-1.57 (2H, m),2.45-2.56 (2H, m), 2.67 (2H, t, J = 7.8 Hz), 4.38 (2H, t, J = 6.3 Hz),7.15 (1H, s), 7.39 (1H, t, J = 7.8 Hz), 7.48 (1H, s), 7.62-7.64 (2H, m),7.88 (1H, s), 7.93 (1H, d, J = 2.0 Hz), 8.01 (1H, s) 819 δ 0.81 (3H, t,J = 7.3 Hz), 1.25 (3H, d, J = 6.8 Hz), 1.53-1.64 (2H, m), 2.49-2.60 (2H,m), 2.92-3.01 (1H, m), 4.43 (2H, t, J = 5.9 Hz), 6.87 (1H, br),7.46-7.51 (2H, m), 7.62-7.67 (3H, m), 7.74 (1H, d, J = 1.5 Hz), 8.01(1H, s) 820 δ1.32 (6H, d, J = 6.3 Hz), 2.36 (3H, s), 5.01-5.07 (1H, m),6.69 (1H, s), 7.11-7.13 (2H, m), 7.44 (1H, t, J = 8.3 Hz), 7.55-7.59(2H, m), 7.68 (1H, br-s), 7.95 (1H, d, J = 8.3 Hz), 7.99 (1H, s) 821 δ1.27 (6H, d, J = 6.8 Hz), 1.31 (6H, d, J = 6.3 Hz), 2.96 (1H, septet, J= 6.8 Hz), 5.05 (1H, septet, J = 6.3 Hz), 6.79 (1H, s), 7.42-7.52 (4H,m), 7.72 (1H, d, J = 7.8 Hz), 7.86 (1H, t, J = 2.0 Hz), 8.14 (1H, s),8.21 (1H, d, J = 8.3 Hz) 822 δ 1.33 (6H, d, J = 6.6 Hz), 5.01-5.09 (1H,m), 6.73 (1H, s), 7.41-7.52 (2H, m), 7.57-7.60 (1H, m), 7.65 (1H, s),8.05 (1H, s), 8.20 (2H, s), 8.35 (1H, s) 823 δ 1.32 (6H, d, J = 6.3 Hz),5.04 (1H, septet, J = 6.3 Hz), 6.70 (1H, br-s), 6.98-7.06 (1H, m), 7.45(1H, t, J = 7.8 Hz), 7.53-7.55 (1H, m), 7.62 (1H, d, J = 8.8 Hz), 7.94(2H, s), 8.07-8.14 (1H, m) 824 δ1.32 (6H, d, J = 6.1 Hz), 2.46 (3H, s),2.54 (3H, d, J = 15 Hz), 5.04 (1H, septet, J = 6.1 Hz), 6.72 (1H, s),7.40-7.44 (2H, m), 7.51-7.56 (3H, m), 7.94 (1H, s), 7.97 (1H, s) 825 δ1.31 (6H, d, J = 6.3 Hz), 2.30 (3H, s), 5.03 (1H, septet, J = 6.3 Hz),6.72 (1H, s), 7.20 (1H, d, J = 2.2 Hz), 7.32 (1H, d, J = 2.2 Hz), 7.43(1H, t, J = 7.8 Hz), 7.59-7.62 (3H, m), 8.00 (1H, s) 826 δ1.31 (6H, d, J= 6.3 Hz), 2.28 (3H, s), 2.31 (3H, s), 5.03 (1H, septet, J = 6.3 Hz),6.71 (1H, br-s), 7.01 (1H, s), 7.13 (1H, s), 7.43 (1H, t, J = 7.8 Hz),7.61-7.63 (3H, m), 7.97 (1H, s) 827 δ 1.31 (6H, d, J = 6.1 Hz), 2.25(6H, s), 5.03 (1H, septet, J = 6.1 Hz), 6.70 (1H, br- s), 7.26 (2H, s),7.38 (1H, br-s), 7.43 (1H, t, J = 7.8 Hz), 7.55-7.61 (2H, m), 8.01 (1H,s) 828 δ 1.31 (6H, d, J = 6.3 Hz), 2.24 (6H, s), 5.02 (1H, septet, J =6.3 Hz), 6.71 (1H, br- s), 7.26 (2H, s), 7.39-7.44 (2H, m), 7.55-7.60(2H, m), 8.00 (1H, s) 829 δ1.31 (6H, d, J = 6.4 Hz), 2.23 (6H, s), 5.03(1H, septet, J = 6.4 Hz), 6.69 (1H, br-s), 7.37 (1H, br-s), 7.43 (1H, t,J = 7.8 Hz), 7.48 (2H, s), 7.55-7.61 (2H, m), 8.01 (1H, br-s) 830 δ1.32(6H, d, J = 6.3 Hz), 2.35 (6H, s), 5.04 (1H, septet, J = 6.3 Hz), 6.72(1H, s), 7.32-7.36 (3H, m), 7.41-7.46 (4H, m), 7.56-7.63 (4H, m), 8.00(1H, s) 831 δ1.32 (6H, d, J = 6 Hz), 2.30 (3H, s), 2.32 (6H, s), 5.04(1H, septet, J = 6 Hz), 6.73 (1H, s), 7.08 (2H, s), 7.22-7.26 (4H, m),7.43-7.48 (2H, m), 7.61-7.63 (2H, m), 8.01 (1H, s) 832 δ1.32 (6H, d, J =6 Hz), 2.31 (6H, s), 2.42 (3H, s), 5.04 (1H, septet, J = 6 Hz), 6.71(1H, s), 7.16 (1H, d, J = 8 Hz), 7.30-7.59 (7H, m), 7.62 (2H, t, J = 8Hz), 8.01 (1H, s) 833 δ1.31 (6H, d, J = 6 Hz), 2.33 (6H, s), 2.49 (3H,s), 5.03 (1H, septet, J = 6 Hz), 6.73 (1H, s), 7.12-7.25 (2H, m), 7.32(2H, s), 7.42-7.52 (4H, m), 7.59-7.63 (2H, m), 7.99 (1H, s) 834 δ1.32(6H, d, J = 6 Hz), 2.32 (6H, s), 3.80 (3H, s), 5.04 (1H, septet, J = 6Hz), 6.73 (1H, s), 6.97 (1H, d, J = 8 Hz), 7.02 (1H, t, J = 7 Hz), 7.27(2H, s), 7.30 (2H, d, J = 7 Hz), 7.34-7.46 (2H, m), 7.60-7.63 (2H, m),7.95 (1H, s) 835 δ1.32 (6H, d, J = 7 Hz), 2.34 (6H, s), 3.87 (3H, s),5.04 (1H, septet, J = 7 Hz), 6.72 (1H, s), 6.88-6.91 (1H, m), 7.11 (1H,t, J = 2 Hz), 7.16 (1H, td, J = 8 Hz, 1 Hz), 7.33-7.37 (3H, m),7.43-7.50 (2H, m), 7.59-7.64 (2H, m), 8.01 (1H, s) 836 δ1.32 (6H, d, J =7 Hz), 2.33 (6H, s), 3.85 (3H, s), 5.04 (1H, septet, J = 7 Hz), 6.73(1H, br-s), 6.96 (2H, d, J = 9 Hz), 7.29 (2H, s), 7.42-7.52 (4H, m),7.60-7.63 (2H, m), 8.00 (1H, s) 837 δ1.32 (6H, d, J = 6 Hz), 1.44 (3H,t, J = 7 Hz), 2.33 (6H, s), 4.08 (2H, q, J = 7 Hz), 5.04 (1H, septet, J= 6 Hz), 6.72 (1H, s), 6.94-6.97 (2H, m), 7.29 (2H, s), 7.42-7.52 (4H,m), 7.61-7.63 (2H, m), 7.99 (1H, s) 838 δ1.31 (6H, d, J = 6 Hz), 2.34(6H, s), 2.53 (3H, s), 5.04 (1H, septet, J = 6 Hz), 6.72 (1H, s),7.31-7.65 (10H, m), 8.00 (1H, s). 839 δ1.31 (6H, d, J = 6.3 Hz), 2.34(6H, s), 5.04 (1H, septet, J = 6.3 Hz), 6.72 (1H, s), 7.12-7.32 (5H, m),7.41-7.48 (3H, m), 7.61-7.63 (2H, m), 7.99 (1H, s) 840 δ1.32 (6H, d, J =7 Hz), 2.34 (6H, s), 5.03 (1H, septet, J = 7 Hz), 6.74 (1H, br s),7.01-7.05 (1H, m), 7.28-7.64 (9H, m), 8.02 (1H, s) 841 δ1.31 (6H, d, J =7 Hz), 2.34 (6H, s), 5.04 (1H, septet, J = 7 Hz), 6.73 (1H, s), 7.11(2H, t, J = 9 Hz), 7.28 (2H, s), 7.42-7.63 (6H, m), 8.01 (1H, s) 842δ1.24 (6H, d, J = 6.8 Hz), 1.31 (6H, d, J = 6.3 Hz), 2.32 (3H, s), 2.86(1H, septet, J = 6.8 Hz), 5.03 (1H, septet, J = 6.3 Hz), 6.74 (1H, s),7.08 (1H, s), 7.33 (1H, d, J = 2.0 Hz), 7.43 (1H, t, J = 7.8 Hz),7.61-7.65 (3H, m), 7.96 (1H, s) 843 δ1.32 (6H, d, J = 6.3 Hz), 2.37 (3H,s), 5.03 (1H, septet, J = 6.3 Hz), 6.74 (1H, s), 7.46 (1H, t, J = 7.8Hz), 7.51-7.57 (2H, m), 7.61-7.65 (2H, m), 7.90 (1H, s), 8.08 (1H, s)844 δ 1.32 (6H, d, J = 6.3 Hz), 2.35 (3H, s), 5.03 (1H, septet, J = 6.3Hz), 6.72 (1H, s), 7.09 (1H, s), 7.21 (1H, d, J = 2.2 Hz), 7.44 (1H, t,J = 8.1 Hz), 7.52-7.61 (3H, m), 8.02 (1H, s) 845 δ 1.29 (6H, d, J = 6.8Hz), 1.31 (6H, d, J = 6.3 Hz), 2.98 (1H, septet, J = 6.8 Hz), 5.04 (1H,septet, J = 6.3 Hz), 6.70 (1H, s), 7.42-7.48 (2H, m), 7.56-7.67 (4H, m),7.92 (1H, s) 846 δ 1.32 (6H, d, J = 6.3 Hz), 5.03 (1H, septet, J = 6.3Hz), 6.75 (1H, br-s), 7.41-7.51 (2H, m), 7.62-7.65 (1H, m), 7.91 (1H,br-s), 8.08 (1H, s) 847 (DMSO-d₆) δ 1.24-1.44 (5H, m), 1.68-1.80 (5H,m), 2.46-2.50 (1H, m), 4.97 (2H, s), 7.19 (2H, d, J = 8.8 Hz), 7.47 (1H,t, J = 7.8 Hz), 7.60-7.70 (4H, m), 8.04 (1H, s), 10.19 (1H, s), 10.37(1H, s) 848 δ 4.84 (2H, s), 7.29 (1H, d, J = 7.8 Hz), 7.35 (1H, br-s),7.48 (1H, t, J = 7.8 Hz), 7.56-7.67 (3H, m), 7.75 (1H, d, J = 7.3 Hz),7.97 (1H, s), 8.23 (1H, s), 8.37 (1H, d, J = 7.8 Hz) 849 δ 4.85 (2H, s),7.12 (1H, br-s), 7.47 (1H, t, J = 7.8 Hz), 7.59-7.67 (4H, m), 7.72-7.75(2H, m), 7.99 (1H, s), 8.03 (1H, s) 850 (DMSO-d₆) δ 4.87 (2H, s), 7.43(1H, t, J = 7.8 Hz), 7.65 (1H, d, J = 7.8 Hz), 7.82 (1H, d, J = 7.8 Hz),7.96 (2H, d, J = 8.8 Hz), 8.07 (1H, s), 8.18-8.22 (2H, m), 9.66 (1H,br), 10.51 (1H, s) 851 δ4.85 (2H, s), 6.67 (1H, br-s), 7.47 (1H, t, J =7.8 Hz), 7.60-7.64 (2H, m), 7.65 (2H, d, J = 8.8 Hz), 7.74 (2H, d, J =8.8 Hz), 7.98 (1H, s), 8.00 (1H, s) 852 δ4.86 (2H, s), 7.09 (1H, br-s),7.48-7.53 (1H, m), 7.61-7.65 (2H, m), 7.81 (2H, d, J = 8.8 Hz), 7.95(2H, d, J = 8.8 Hz), 7.95-8.04 (1H, m), 8.14 (1H, s) 854 δ0.90 (3H, t, J= 7.3 Hz), 1.28-1.38 (2H, m), 1.56-1.65 (2H, m), 2.72 (2H, t, J = 7.8Hz), 4.85 (2H, s), 7.14 (1H, br-s), 7.45 (1H, s), 7.50 (1H, t, J = 7.8Hz), 7.58 (1H, d, J = 1.5 Hz), 7.66-7.68 (3H, m), 8.04 (1H, s) 855 δ0.88 (3H, t, J = 7.3 Hz), 1.24-1.35 (2H, m), 1.52-1.60 (2H, m), 2.70(2H, t, J = 7.8 Hz), 4.84 (2H, s), 7.27 (1H, s), 7.46-7.50 (2H, m),7.67-7.69 (2H, m), 7.76 (1H, s), 7.94 (1H, d, J = 1.5 Hz), 8.06 (1H, s)856 δ 0.81 (3H, t, J = 7.3 Hz), 1.25 (3H, d, J = 5.9 Hz), 1.55-1.65 (2H,m), 2.91-3.01 (1H, m), 4.85 (2H, s), 7.14 (1H, br), 7.50-7.53 (2H, m),7.61-7.77 (4H, m), 8.05 (1H, s) 857 δ0.90 (3H, t, J = 7.3 Hz), 1.31 (3H,d, J = 6.8 Hz), 1.63-1.74 (2H, m), 2.82-2.91 (1H, m), 4.85 (2H, s), 7.22(1H, s), 7.47-7.53 (3H, m), 7.58-7.62 (1H, m), 7.66 (1H, d, J = 8.3 Hz),7.93 (1H, s), 8.05 (1H, s), 8.13-8.15 (1H, m) 858 δ 2.36 (3H, s), 4.85(2H, s), 7.11-7.14 (3H, m), 7.49 (1H, t, J = 8.3 Hz), 7.61-7.69 (3H, m),7.95 (1H, d, J = 8.3 Hz), 8.02 (1H, s) 859 δ 2.31 (3H, s), 4.34 (2H, q,J = 7.8 Hz), 4.84 (2H, s), 6.80-6.86 (2H, m), 7.16 (1H, br-s), 7.47 (1H,t, J = 7.8 Hz), 7.60-7.72 (4H, m), 7.99 (1H, br-s) 860 δ 2.39 (3H, s),4.85 (2H, s), 7.09-8.14 (9H, m) 861 δ 2.31 (3H, s), 4.84 (2H, s), 7.17(1H, br), 7.20-7.23 (2H, m), 7.47 (1H, t, J = 8.1), 7.58-7.67 (3H, m),7.84-7.87 (1H, m), 8.00 (1H, s) 862 δ 1.27 (6H, d, J = 6.8 Hz), 2.97(1H, septet, J = 6.8 Hz), 4.85 (2H, s), 7.18 (1H, br), 7.46-7.51 (3H,m), 7.57 (1H, dd, J = 1.5 Hz, 7.8 Hz), 7.74 (1H, d, J = 7.8 Hz), 7.94(1H, s), 8.14 (1H, s), 8.21 (1H, d, J = 8.3 Hz) 863 δ4.87 (2H, s),7.51-8.01 (8H, m), 8.86 (1H, s) 864 δ 4.87 (2H, s), 7.08 (1H, br.),7.49-7.58 (4H, m), 8.07 (1H, br.), 8.20 (3H, s) 865 δ 4.86 (2H, s), 7.08(1H, br-s), 7.48-7.60 (3H, m), 7.64 (1H, d, J = 2.4 Hz), 7.72 (1H, d, J= 7.3 Hz), 7.98 (1H, s), 8.18 (1H, s), 8.39 (1H, d, J = 8.8 Hz) 866 δ4.85 (2H, s), 7.06 (1H, br), 7.41-7.51 (2H, m), 7.60 (1H, s), 7.65-7.74(4H, m), 7.97 (1H, s) 867 δ4.86 (2H, s), 7.10 (1H, br-s), 7.48-7.57 (2H,m), 7.71 (1H, d, J = 8.3 Hz), 7.90-7.97 (3H, m), 8.19 (1H, br-s), 8.22(1H, d, J = 8.8 Hz) 868 δ 4.85 (2H, s), 7.12 (1H, br-s), 7.46-7.56 (4H,m), 7.71 (1H, d, J = 7.8 Hz), 7.99 (1H, s), 8.14 (1H, s), 8.48 (1H, d, J= 8.8 Hz) 869 δ 4.84 (2H, s), 6.97-7.05 (1H, m), 7.22 (1H, br-s), 7.48(1H, t, J = 7.8 Hz), 7.59 (1H, d, J = 7.8 Hz), 7.69 (1H, d, J = 7.8 Hz),7.96 (1H, s), 7.98 (1H, s), 8.05-8.12 (1H, m) 870 δ 2.46 (3H, s), 2.55(3H, d, J = 14 Hz), 4.86 (2H, s), 7.13 (1H, br s), 7.40 (1H, s),7.46-7.62 (4H, m), 7.88 (1H, s), 7.99 (1H, s) 871 δ 2.34 (3H, s), 2.38(3H, s), 4.85 (2H, s), 6.97-8.03 (8H, m) 872 δ 2.31 (6H, s), 3.99 (1H,s), 4.85 (2H, s), 7.15 (1H, br-s), 7.45-7.51 (4H, m), 7.64-7.66 (2H, m),8.01 (1H, s) 873 δ 2.34 (6H, s), 3.74 (1H, s), 4.85 (2H, s), 7.08 (1H,br-s), 7.48 (1H, s), 7.49 (2H, s), 7.52 (1H, s), 7.65-7.67 (2H, m), 8.04(1H, s) 874 δ 2.30 (6H, s), 4.87 (2H, s), 7.08 (1H, br), 7.49-7.58 (4H,m), 8.07 (1H, br), 8.20 (3H, s) 875 δ 2.25 (6H, s), 4.85 (2H, s), 7.07(1H, br), 7.12 (2H, s), 7.36 (1H, br- s), 7.48 (1H, t, J = 7.8 Hz),7.64-7.66 (2H, m), 8.02 (1H, s) 876 δ 2.28 (3H, s), 2.31 (3H, s), 4.84(2H, s), 7.00 (1H, s), 7.12 (1H, s), 7.18 (1H, br), 7.47 (1H, t, J = 7.8Hz), 7.60 (1H, s), 7.66-7.68 (2H, m), 7.99 (1H, s) 877 δ 2.19 (6H, s),4.82 (2H, s), 7.22 (2H, s), 7.41 (1H, t, J = 8.1 Hz), 7.48 (1H, br),7.61-7.66 (3H, m), 7.99 (1H, s) 878 δ 2.22 (6H, s), 4.84 (2H, s), 7.13(1H, br-s), 7.39 (1H, s), 7.45-7.49 (3H, m), 7.64-7.65 (2H, m), 8.01(1H, br-s) 879 δ 2.35 (6H, s), 4.85 (2H, s), 7.09 (1H, s), 7.32-7.69(11H, m), 8.02 (1H, s) 880 δ 2.30 (3H, s), 2.32 (6H, s), 4.85 (2H, s),7.09 (2H, s), 7.13 (1H, s), 7.21-7.27 (4H, m), 7.46-7.51 (2H, m), 7.68(2H, d, J = 7 Hz), 8.03 (1H, s) 881 δ 2.34 (6H, s), 2.42 (3H, s), 4.85(2H, s), 7.12-7.23 (2H, m), 7.29-7.39 (4H, m), 7.47-7.52 (2H, m), 7.68(2H, d, J = 7 Hz), 8.03 (1H, s) 882 δ 2.34 (6H, s), 2.40 (3H, s), 4.85(2H, s), 7.13 (1H, d, J = 4 Hz), 7.23-7.26 (2H, m), 7.30 (2H, s),7.33-7.50 (4H, m), 7.67 (2H, d, J = 8 Hz), 8.02 (1H, s) 883 δ 2.32 (6H,s), 3.81 (3H, s), 4.85 (2H, s), 6.97-7.04 (2H, m), 7.10 (1H, br s), 7.28(2H, s), 7.30-7.34 (2H, m), 7.42 (1H, s), 7.49 (1H, t, J = 8 Hz),7.66-7.70 (2H, m), 7.99 (1H, s) 884 δ 2.35 (6H, s), 3.88 (3H, s), 4.85(2H, s), 6.89-6.91 (1H, m), 7.10-7.18 (3H, m), 7.33-7.37 (3H, m),7.47-7.52 (2H, m), 7.68 (2H, d, J = 7 Hz), 8.03 (1H, s) 885 δ 2.33 (6H,s), 3.86 (3H, s), 4.85 (2H, s), 6.96 (2H, d, J = 9 Hz), 7.14 (1H, br s),7.30 (2H, s), 7.47-7.53 (4H, m), 7.68 (2H, d, J = 7 Hz), 8.02 (1H, s)886 δ1.44 (3H, t, J = 7 Hz), 2.33 (6H, s), 4.08 (2H, q, J = 7 Hz), 4.85(2H, s), 6.95 (2H, d, J = 9 Hz), 7.13 (1H, s), 7.30 (2H, s), 7.45-7.52(4H, m), 7.68 (2H, d, J = 7 Hz), 8.01 (1H, s) 887 δ 2.33 (6H, s), 2.53(3H, s), 4.84 (2H, s), 7.14 (1H, s), 7.30-7.38 (4H, m), 7.46-7.57 (4H,m), 7.67 (2H, d, J = 6 Hz), 8.02 (1H, s) 888 δ 2.34 (6H, s), 4.85 (2H,s), 7.10-7.34 (6H, m), 7.41-7.52 (3H, m), 7.68 (2H, d, J = 8 Hz), 8.02(1H, s) 889 δ 2.34 (6H, s), 4.85 (2H, s), 7.01-7.06 (1H, m), 7.16 (1H,br s), 7.25-7.50 (8H, m), 7.68 (1H, d, J = 8 Hz), 8.03 (1H, s) 890 δ2.33 (6H, s), 4.85 (2H, s), 7.09-7.15 (3H, m), 7.29 (2H, s), 7.46-7.55(4H, m), 7.67-7.69 (2H, m), 8.03 (1H, s) 891 δ 2.34 (6H, s), 4.85 (2H,s), 7.09 (1H, br s), 7.18-7.30 (4H, m), 7.34-7.51 (3H, m), 7.67-7.69(2H, m), 8.04 (1H, s) 892 δ 2.30 (9H, s), 4.85 (2H, s), 7.05 (1H, t, J =8.8 Hz), 7.14 (1H, br s), 7.28 (2H, s), 7.32-7.51 (4H, m), 7.67-7.69(2H, m), 8.03 (1H, s) 893 δ 2.31 (6H, s), 4.85 (2H, s), 6.69 (1H, s),7.09 (1H, br-s), 7.25 (2H, s), 7.41 (1H, s), 7.47-7.51 (2H, m),7.66-7.68 (2H, m), 7.72 (1H, s), 8.02 (1H, s) 894 δ 2.30 (6H, s), 4.84(2H, s), 7.07-7.09 (1H, m), 7.25 (1H), 7.27-7.29 (1H, m), 7.36 (2H, s),7.36 (2H, s), 7.45-7.50 (2H, m), 7.65-7.67 (2H, m), 8.02 (1H, s) 895 δ2.32 (6H, s), 4.85 (2H, s), 7.18 (1H, s), 7.35-7.50 (7H, m), 7.67 (2H,d, J = 6.8 Hz), 8.02 (1H, s) 896 δ 2.31 (3H, s), 4.85 (2H, s), 7.10 (1H,br), 7.20 (1H, d, J = 2.2 Hz), 7.32 (1H, d, J = 2.2 Hz), 7.49 (1H, t, J= 7.8 Hz), 7.57 (1H, s), 7.66-7.68 (2H, m), 8.02 (1H, s) 897 (DMSO-d₆) δ4.85 (2H, s), 7.44 (1H, t, J = 7.8 Hz), 7.63-7.68 (2H, m), 7.72 (1H, d,J = 2.4 Hz), 7.84 (1H, s), 8.06 (1H, s), 8.80 (1H, s), 9.09 (1H, s) 898δ4.85 (2H, s), 7.00 (1H, br-s), 7.51 (1H, t, J = 8.3 Hz), 7.69-7.72 (5H,m), 8.05 (1H, s) 899 δ4.86 (2H, s), 7.00 (1H, br-s), 7.53 (1H, t, J =7.8 Hz), 7.67-7.73 (2H, m), 7.92 (1H, s), 8.05 (2H, s), 8.11 (1H, s) 900(DMSO-d₆) δ 4.98 (2H, s), 7.52 (1H, t, J = 7.8 Hz), 7.70-7.75 (2H, m),8.17 (1H, s), 8.31 (2H, s), 10.42 (1H, s), 10.63 (1H, s) 901 (DMSO-d₆) δ1.24-1.47 (5H, m), 1.66-1.80 (5H, m), 2.54-2.60 (1H, m), 4.96 (2H, s),7.48 (1H, t, J = 7.8 Hz), 7.60 (2H, s), 7.67-7.71 (2H, m), 8.11 (1H, s),10.24 (1H, s), 10.37 (1H, s) 902 (DMSO-d₆) δ 4.86 (2H, s), 7.44 (1H, t,J = 7.8 Hz), 7.67 (1H, d, J = 7.8 Hz), 7.82 (1H, d, J = 2.0 Hz), 7.85(1H, s), 8.05 (1H, d, J = 2.0 Hz), 8.06 (1H, d, J = 7.8 Hz), 9.04 (1H,s), 9.27 (1H, s) 903 δ4.86 (2H, s), 7.00 (1H, br-s), 7.51 (1H, t, J =7.8 Hz), 7.70 (2H, d, J = 7.8 Hz), 7.75 (1H, s), 7.94 (2H, s), 8.06 (1H,s) 904 δ 2.20 (3H, s), 4.85 (2H, s), 6.60 (1H, d, J = 2.4 Hz), 7.17 (1H,br.), 7.50 (1H, t, J = 7.8 Hz), 7.54 (1H, s), 7.59 (1H, s), 7.69 (1H, d,J = 7.8 Hz), 7.72 (1H, br), 8.03 (1H, s) 905 δ 2.36 (3H, s), 4.85 (2H,s), 7.08 (1H, br-s), 7.10 (1H, s), 7.22-7.23 (1H, m), 7.50 (1H, t, J =8.1 Hz), 7.59 (1H, s), 7.67-7.69 (2H, m), 8.04 (1H, s) 906 δ 2.36 (3H,s), 4.86 (2H, s), 4.88 (2H, s), 7.04 (1H, br.), 7.12 (1H, d, J = 2.4Hz), 7.27 (1H, s), 7.50 (1H, t, J = 7.8 Hz), 7.56 (1H, s), 7.67-7.70(2H, m), 8.02 (1H, s) 907 δ 2.38 (3H, s), 4.85 (2H, s), 7.14 (1H, br),7.49-7.53 (2H, m), 7.62-7.70 (3H, m), 7.85 (1H, s), 8.09 (1H, s) 908 δ2.28 (3H, s), 4.84 (2H, s), 7.11 (1H, br-s), 7.48 (1H, t, J = 7.8 Hz),7.55 (1H, s), 7.59 (1H, s), 7.64-7.68 (3H, m), 8.01 (1H, br-s) 909 δ1.24(6H, d, J = 6.8 Hz), 2.33 (3H, s), 2.86 (1H, septet, J = 6.8 Hz), 4.85(2H, s), 7.09 (1H, s), 7.16 (1H, br), 7.33 (1H, d, J = 2.0 Hz), 7.48(1H, t, J = 7.8 Hz), 7.60 (1H, s), 7.67-7.69 (2H, m), 8.00 (1H, s) 910 δ2.23 (3H, s), 4.86 (2H, s), 6.51 (1H, s), 6.78 (1H, d, J = 2.4 Hz), 7.15(1H, br.), 7.49 (1H, br.), 7.51 (1H, t, J = 7.8), 7.56 (1H, s), 7.71(1H, d, J = 6.8 Hz), 8.05 (1H, s) 911 δ 1.29 (6H, d, J = 7.3 Hz), 2.98(1H, septet, J = 7.3 Hz), 4.85 (2H, s), 7.10 (1H, br), 7.47-7.52 (2H,m), 7.56-7.58 (2H, m), 7.65 (1H, d, J = 7.3 Hz), 7.72 (1H, br), 7.96(1H, s) 912 δ 2.37 (3H, s), 4.85 (2H, s), 4.88 (2H, s), 7.06 (1H, br),7.16 (1H, d, J = 2.4 Hz), 7.43 (1H, d, J = 2.4 Hz), 7.50 (1H, t, = 7.8Hz), 7.56 (1H, s), 7.68 (1H, s), 7.70 (1H, s), 8.03 (1H, s) 913(DMSO-d₆) δ 4.96 (2H, s), 7.49 (1H, t, J = 7.8 Hz), 7.64 (1H, d, J = 7.8Hz), 7.71 (1H, d, J = 7.8 Hz), 8.02 (1H, d, J = 2.0 Hz), 8.10 (1H, s),8.30 (1H, d, J = 2.0 Hz), 10.34 (1H, s), 10.38 (1H, s) 914 (DMSO-d₆) δ1.29 (6H, d, J = 6.8 Hz), 2.99 (1H, septet, J = 6.8 Hz), 4.86 (2H, s),7.42 (1H, t, J = 7.8 Hz), 7.52 (1H, d, J = 1.5 Hz), 7.68 (1H, d, J = 7.8Hz), 7.74 (1H, d, J = 1.5 Hz), 7.85 (1H, d, J = 7.8 Hz), 8.09 (1H, s),9.27 (1H, s), 9.66 (1H, s) 915 δ 4.85 (2H, s), 7.04 (1H, br), 7.47-7.55(2H, m), 7.63-7.70 (3H, m), 7.90 (1H, d, J = 1.5 Hz), 7.99 (1H, s) 916(DMSO-d6) δ 4.86 (2H, s), 7.43 (1H, t, J = 7.8 Hz), 7.70 (1H, d, J = 7.8Hz), 7.84 (1H, d, J = 7.8 Hz), 8.10 (1H, s), 9.46 (1H, br-s), 9.73 (1H,br-s) 917 δ 2.22 (6H, s), 3.79 (2H, t, J = 5.4 Hz), 4.42 (2H, t, J = 5.4Hz), 7.37 (1H, t, J = 7.8 Hz), 7.44 (2H, s), 7.63 (1H, d, J = 7.8 Hz),7.71 (1H, d, J = 7.8 Hz), 8.12 (1H, br-s), 9.37 (1H, s), 9.60 (1H, br-s)918 δ 2.34 (6H, s), 2.53-2.56 (2H, m), 4.43 (2H, t, J = 6.3 Hz), 6.80(1H, br-s), 7.41 (1H, s), 7.47 (2H, s), 7.50 (1H, s), 7.62-7.64 (2H, m),7.9 (1H, s) 919 (DMSO-d₆) δ 2.66-2.78 (2H, m), 4.34 (2H, t, J = 5.9 Hz),7.49 (1H, t, J = 7.8 Hz), 7.66-7.72 (2H, m), 8.12 (1H, s), 8.30 (2H, s),10.00 (1H, s), 10.60 (1H, s) 920 δ 1.32 (6H, d, J = 6.1 Hz), 2.51 (3H,s), 5.01-5.07 (1H, m), 6.72 (1H, br-s), 7.50 (1H, t, J = 7.8 Hz),7.54-7.57 (2H, m), 7.64 (1H, d, J = 8.1 Hz), 7.71 (2H, d, J = 7.3 Hz),7.85 (1H, s), 8.01-8.03 (1H, m), 8.13 (1H, s), 8.45-8.48 (1H, m) 921δ1.32 (6H, d, J = 6.1 Hz), 1.74-1.77 (2H, m), 1.84-1.87 (2H, m), 2.74(2H, t, J = 6.4 Hz), 3.02 (2H, q, J = 6.4 Hz), 5.04 (1H, septet, J = 6.1Hz), 6.73 (1H, br s), 7.42-7.46 (2H, m), 7.52-7.55 (1H, m), 7.62 (1H, brs, J = 8 Hz), 7.76 (1H, br s), 7.96 (1H, br s), 8.03-8.06 (1H, m) 922δ1.31 (6H, d, J = 6.4 Hz), 1.68-1.76 (4H, m), 2.81 (2H, t, J = 5.7 Hz),2.99 (2H, q, J = 6.1 Hz), 5.03 (1H, septet, J = 6.4 Hz), 6.73 (1H,br-s), 7.43-7.47 (2H, m), 7.59-7.64 (3H, m), 8.03 (1H, s) 923 δ1.31 (6H,d, J = 6.4 Hz), 3.83 (3H, s), 5.02 (1H, septet, J = 6.4 Hz), 6.55 (1H,s), 6.78 (1H, br-s), 7.41-7.50 (2H, m), 7.57 (1H, d, J = 7.8 Hz), 8.03(1H, br-s), 8.08 (1H, br-s) 924 δ1.32 (6H, d, J = 6.3 Hz), 3.86 (3H, s),5.04 (1H, septet, J = 6.3 Hz), 6.72 (1H, br-s), 7.45-7.53 (2H, m), 7.63(1H, d, J = 7.3 Hz), 7.80 (1H, br-s), 8.14 (1H, br-s) 925 δ1.32 (6H, d,J = 5.9 Hz), 3.89 (3H, s), 5.04 (1H, septet, J = 5.9 Hz), 6.72 (1H, s),7.47-7.50 (2H, m), 7.70 (1H, d, J = 8.3 Hz), 7.90 (1H, br-s), 8.14 (1H,br-s) 926 δ1.32 (6H, d, J = 6.1 Hz), 3.88 (3H, s), 3.93 (3H, s), 5.04(1H, septet), 6.78 (1H, br- s), 7.47 (1H, br-s), 7.64-7.68 (2H, m), 8.05(1H, br-s), 9.40 (1H, br-s) 927 δ1.33 (6H, d, J = 5.9 Hz), 2.34 (3H, s),5.02 (1H, septet, J = 5.9 Hz), 6.74 (1H, br-s), 7.24 (1H, s), 7.44 (1H,t, J = 7.8 Hz), 7.49-7.52 (1H, m), 7.58-7.60 (1H, m), 7.82 (1H, br-s),8.07 (1H, br-s), 8.71 (1H, s) 928 δ1.31 (6H, d, J = 6.4 Hz), 2.35 (3H,s), 5.01-5.07 (1H, m), 6.74 (1H, br-s), 7.25 (1H, s), 7.46 (1H, t, J =7.8 Hz), 7.58-7.63 (2H, m), 7.68 (1H, br-s), 8.07 (1H, br-s) 929 δ1.32(6H, d, J = 5.9 Hz), 5.03 (1H, septet, J = 5.9 Hz), 6.52 (1H, septet, J= 6.3 Hz), 6.71 (1H, br-s), 6.99 (1H, d, J = 8.8 Hz), 7.43 (1H, t, J =7.8 Hz), 7.51-7.58 (2H, m), 7.92 (1H, br-s), 8.01 (1H, br-s), 8.14 (1H,dd, J = 8.8 Hz, 2.4 Hz), 8.34 (1H, d, J = 2.4 Hz) 930 δ1.32 (6H, d, J =5.9 Hz), 2.33 (3H, s), 5.50 (1H, septet, J = 5.9 Hz), 6.53 (1H, septet,J = 6.4 Hz), 6.74 (1H, br-s), 6.87 (1H, s), 7.43 (1H, t, J = 7.8 Hz),7.54-7.58 (2H, m), 7.64 (1H, br-s), 8.04 (1H, br-s), 8.37 (1H, s) 931δ1.32 (6H, d, J = 6.3 Hz), 5.05 (1H, septet, J = 6.3 Hz), 6.30 (1H,septet, J = 6.3 Hz), 6.69 (1H, br-s), 7.01 (1H, d, J = 8.8 Hz), 7.47(1H, t, J = 7.8 Hz), 7.56 (1H, dd, J = 7.8 Hz, 1.5 Hz), 7.68 (1H, d, J =7.8 Hz), 7.98 (1H, br-s), 8.27 (1H, br-s), 8.82 (1H, d, J = 8.8 Hz) 932δ1.32 (6H, d, J = 6.4 Hz), 2.29 (3H, s), 2.41 (3H, s), 5.04 (1H, septet,J = 6.4 Hz), 6.58 (1H, septet, J = 6.4 Hz), 6.72 (2H, s), 7.37-7.46 (2H,m), 7.53-7.57 (1H, m), 7.60 (1H, d, J = 7.8 Hz), 8.05 (1H, br-s) 933 δ2.49 (3H, s), 4.85 (2H, s), 7.16 (1H, br-s), 7.48-7.57 (3H, s), 7.70(2H, s), 7.76 (1H, d, J = 7.6 Hz), 7.92 (1H, s), 8.00 (1H, dd, J = 3.4Hz, 6.8 Hz), 8.13 (1H, s), 8.47 (1H, dd, J = 3.4 Hz, 6.8 Hz) 934δ1.75-1.79 (2H, m), 1.84-1.87 (2H, m), 2.74 (2H, t, J = 6.4 Hz), 3.02(2H, q, J = 6.4 Hz), 4.85 (2H, s), 7.13 (1H, br s), 7.41-7.51 (2H, m),7.59-7.69 (2H, m), 7.76 (1H, br s), 8.00 (1H, br s), 8.06 (1H, br d, J =8.5 Hz) 935 δ1.65-1.76 (4H, m), 2.81 (2H, t, J = 6.1 Hz), 2.99 (2H, q, J= 6.4 Hz), 4.85 (2H, s), 7.10 (1H, br-s), 7.48-7.52 (2H, m), 7.59 (1H,s), 7.67-7.69 (2H, m), 8.04 (1H, s) 936 δ3.86 (3H, s), 4.85 (2H, s),6.58 (1H, s), 7.10 (1H, br-s), 7.51 (1H, t, J = 7.8 Hz), 7.60 (1H, d, J= 7.8 Hz), 7.65 (1H, d, J = 7.8 Hz), 7.84 (1H, br-s), 8.10 (1H, br-s)937 δ3.85 (3H, s), 4.85 (2H, s), 7.16 (1H, br-s), 7.51 (1H, t, J = 7.9Hz), 7.62 (1H, d, J = 7.9 Hz), 7.68 (1H, d, J = 7.9 Hz), 7.85 (1H,br-s), 8.12 (1H, br-s) 938 δ3.87 (3H, s), 4.85 (2H, s), 7.21 (1H, br-s),7.51 (1H, t, J = 8.3 Hz), 7.61 (1H, d, J = 8.3 Hz), 7.68 (1H, d, J = 8.3Hz), 7.92 (1H, br-s), 8.13 (1H, br-s) 939 δ3.89 (3H, s), 3.94 (3H, s),4.86 (2H, s), 7.20 (1H, br-s), 7.52 (1H, t, J = 7.8 Hz), 7.70-7.73 (2H,m), 8.09 (1H, br-s), 9.44 (1H, s) 940 δ4.87 (2H, s), 7.07-7.11 (2H, m),7.31-7.34 (1H, m), 7.47-7.52 (2H, m), 7.67-7.69 (1H, m), 8.01 (1H, dd, J= 8.0 Hz, 1.4 Hz), 8.19 (1H, br-s), 8.58-8.60 (1H, m), 11.3 (1H, br-s)941 δ4.84 (2H, s), 7.19 (1H, br-s), 7.33 (1H, dd, J = 8.3 Hz, 4.8 Hz),7.44 (1H, t, J = 8.3 Hz), 7.58-7.59 (2H, m), 7.94-7.97 (2H, m), 8.44(1H, dd, J = 4.8 Hz, 1.4 Hz), 9.14 (1H, br-s) 942 δ 2.44 (3H, s), 4.86(2H, s), 7.11 (1H, br-s), 7.52 (1H, t, J = 7.8 Hz), 7.59 (1H, d, J = 2.9Hz), 7.63-7.65 (2H, m), 7.76 (1H, s), 8.09 (1H, s), 9.23 (1H, s) 943δ4.85 (2H, s), 6.52 (1H, septet, J = 6.3 Hz), 6.99 (1H, d, J = 8.8 Hz),7.07 (1H, br-s), 7.48 (1H, t, J = 8.3 Hz), 7.61-7.62 (2H, m), 7.86 (1H,s), 8.02 (1H, s), 8.15 (1H, dd, J = 8.8 Hz, 2.5 Hz), 8.33 (1H, d, J =2.5 Hz) 944 δ 2.35 (3H, s), 4.85 (2H, s), 6.55 (1H, septet, J = 6.4 Hz),6.89 (1H, s), 7.08 (1H, br-s), 7.49 (1H, t, J = 7.8 Hz), 7.59 (1H, s),7.63 (2H, d, J = 8.3 Hz), 8.05 (1H, s), 8.40 (1H, s) 945 δ 2.34 (3H, s),4.85 (2H, s), 7.17 (1H, br-s), 7.22-7.26 (1H, m), 7.49 (1H, t, J = 7.8Hz), 7.60-7.66 (2H, m), 7.75 (1H, br-s), 8.07 (1H, br-s), 8.73 (1H,br-s) 946 δ4.86 (2H, s), 7.13 (1H, br-s), 7.52 (1H, t, J = 8.3 Hz), 7.67(1H, d, J = 8.3 Hz), 7.74 (1H, d, J = 8.3 Hz), 8.02 (1H, s), 8.05 (1H,s), 8.66 (1H, s), 8.70 (1H, br-s) 947 δ 2.36 (3H, s), 5.05 (2H, s), 7.16(1H, br-s), 7.25 (1H, s), 7.51 (1H, t, J = 7.8 Hz), 7.68-7.70 (3H, m),8.08 (1H, br-s) 948 δ4.86 (2H, s), 6.30 (1H, septet, J = 6.4 Hz), 7.00(1H, d, J = 8.8 Hz), 7.04 (1H, br-s), 7.52 (1H, t, J = 7.8 Hz), 7.63(1H, dd, J = 7.8 Hz, 1.5 Hz), 7.70 (1H, d, J = 7.8 Hz), 8.04 (1H, br-s),8.27 (1H, br-s), 8.83 (1H, d, J = 8.8 Hz) 992 δ 2.37 (3H, s), 4.85 (2H,s), 6.33 (1H, septet, J = 5.8 Hz), 6.87 (1H, s), 7.05 (1H, br-s),7.49-7.53 (2H, m), 7.66-7.68 (2H, m), 8.05 (1H, s) 1010 δ1.33 (6H, d, J= 6.4 Hz), 2.37 (3H, s), 5.04 (1H, septet, J = 6.4 Hz), 6.34 (1H,septet, J = 6.4 Hz), 6.72 (1H, br-s), 6.88 (1H, s), 7.45 (1H, t, J = 7.8Hz), 7.58-7.64 (3H, m), 8.05 (1H, s) 1039 δ 2.38 (3H, s), 4.86 (2H, s),6.34 (1H, septet), 6.89 (1H, s), 7.09 (1H, br-s), 7.51 (1H, t, J = 7.8Hz), 7.57 (1H, br-s), 7.66 (1H, br-s), 7.68 (1H, d, J = 7.8 Hz), 8.07(1H, s) 1086 δ 2.37 (3H, s), 4.85 (2H, s), 6.33 (1H, septet, J = 5.8Hz), 6.87 (1H, s), 7.05 (1H, br-s), 7.49-7.53 (2H, m), 7.66-7.68 (2H,m), 8.05 (1H, s) 1104 δ1.32 (6H, d, J = 6.4 Hz), 2.29 (3H, s), 2.41 (3H,s), 5.04 (1H, septet, J = 6.4 Hz), 6.58 (1H, septet, J = 6.4 Hz), 6.72(2H, s), 7.37-7.46 (2H, m), 7.53-7.57 (1H, m), 7.60 (1H, d, J = 7.8 Hz),8.05 (1H, br-s) 1180 δ 2.46 (3H, s), 4.86 (2H, s), 7.11 (1H, s),7.51-7.86 (5H, m), 8.10 (1H, br-s) 1198 δ 1.31 (6H, d, J = 6.3 Hz), 2.40(3H, s), 5.03 (1H, septet, J = 6.3 Hz), 6.72 (1H, s), 7.42-7.47 (2H, m),7.56 (1H, s), 7.60-7.63 (2H, m), 7.74 (1H, s), 8.03 (1H, s) 1227 δ 2.41(3H, s), 4.85 (2H, s), 7.05 (1H, br), 7.44 (1H, s), 7.51 (1H, t, J = 8.1Hz), 7.57 (1H, s), 7.67-7.70 (3H, m), 8.05 (1H, s) 1245 δ 1.31 (6H, d, J= 6.1 Hz), 2.42 (3H, s), 5.04 (1H, septet, J = 6.1 Hz), 6.71 (1H, s),7.45 (1H, d, J = 8.1 Hz), 7.48 (1H, s), 7.61-7.64 (2H, m), 7.72-7.74(2H, m), 8.04 (1H, s) 1274 δ 2.43 (3H, s), 4.86 (2H, s), 7.08 (1H, br),7.48-7.53 (2H, m), 7.68-7.73 (4H, m), 8.06 (1H, s) 1292 δ 1.32 (6H, d, J= 6.3 Hz), 2.42 (3H, s), 5.04 (1H, septet, J = 6.3 Hz), 6.72 (1H, s),7.44-7.52 (2H, m), 7.62-7.66 (3H, m), 7.93 (1H, s), 8.04 (1H, s) 1321 δ2.43 (3H, s), 4.86 (2H, s), 7.08 (1H, br), 7.50-7.54 (2H, m), 7.63 (1H,s), 7.70-7.72 (2H, m), 7.94 (1H, s), 8.08 (1H, s) 1361 δ 0.87 (3H, t, J= 7.3 Hz), 1.53-1.63 (2H, m), 2.44-2.56 (2H, m), 2.64 (2H, t, J = 7.8Hz), 4.38 (2H, t, J = 6.3 Hz), 7.16 (1H, s), 7.38 (1H, t, J = 7.8 Hz),7.48 (1H, s), 7.61-7.64 (2H, m), 7.91-7.94 (2H, m), 8.00 (1H, s) 1368 δ0.93 (3H, t, J = 7.3 Hz), 1.59-1.69 (2H, m), 2.71 (2H, t, J = 7.8 Hz),4.86 (2H, s), 7.11 (1H, br), 7.49-7.54 (2H, m), 7.62 (1H, s), 7.69-7.72(2H, m), 7.96 (1H, d, J = 1.5 Hz), 8.07 (1H, s) 1385 δ 2.35 (3H, s),2.44 (3H, s), 4.86 (2H, s), 6.74 (1H, s), 7.34-7.38 (3H, m), 7.46 (1H,s), 7.52 (1H, d, J = 8.8 Hz), 7.89 (1H, s), 8.35 (1H, d, J = 8.8 Hz)1386 δ 1.32 (6H, d, J = 6.3 Hz), 2.40 (6H, s), 2.41 (3H, s), 5.03 (1H,septet, J = 6.3 Hz), 6.46 (1H, br-s), 7.15 (1H, s), 7.28-7.37 (4H, m),7.95 (1H, d, J = 8.3 Hz) 1387 δ 2.40 (6H, s), 2.45 (3H, s), 4.86 (2H,s), 6.80 (1H, br), 7.16 (1H, s), 7.32-7.42 (4H, m), 7.85 (1H, br) 1388δ1.35 (3H, t, J = 7.3 Hz), 2.36 (6H, s), 4.28 (2H, q, J = 7.3 Hz), 6.91(1H, s), 7.29 (1H, t, J = 8.3 Hz), 7.37 (2H, s), 7.74-7.79 (2H, m), 8.32(1H, br-d, J = 5.9 Hz) 1389 δ1.34 (6H, d, J = 6.3 Hz), 2.36 (6H, s),5.07 (1H, septet, J = 6.3 Hz), 6.86 (1H, br-s), 7.30 (1H, t, J = 8.1Hz), 7.37 (2H, s), 7.72-7.79 (2H, m), 8.32 (1H, br) 1408 δ 2.37 (6H, s),4.70 (4H, dt, J = 2.0 Hz, 46.8 Hz), 5.28 (1H, tt, J = 4.4 Hz, 24.9 Hz),7.08 (1H, br-s), 7.33 (1H, t, J = 8.3 Hz), 7.37 (2H, s), 7.76 (1H, d, J= 12.2 Hz), 7.81 (1H, dt, J = 1.4 Hz, 7.8 Hz), 8.29 (1H, br-s) 1411 δ2.37 (6H, s), 2.51-2.62 (2H, m), 4.46 (2H, t, J = 6.4 Hz), 6.97 (1H, br-s), 7.32 (1H, t, J = 8.3 Hz), 7.37 (2H, s), 7.74-7.82 (2H, m), 8.28 (1H,br-s) 1416 δ 2.37 (6H, s), 3.76-3.79 (2H, m), 4.49 (2H, t, J = 5.4 Hz),7.02 (1H, br), 7.32 (1H, t, J = 7.8 Hz), 7.37 (2H, s), 7.74-7.81 (2H,m), 8.30 (1H, br) 1418 δ 2.37 (6H, s), 4.88 (2H, s), 7.21 (1H, br),7.32-7.37 (3H, m), 7.76-7.85 (2H, m), 8.31 (1H, br) 1421 δ 2.36 (6H, s),3.60 (2H, t, J = 5.9 Hz), 4.54 (2H, t, J = 5.9 Hz), 7.03 (1H, br), 7.32(1H, t, J = 7.8 Hz), 7.37 (2H, s), 7.76-7.81 (2H, m), 8.29 (1H, br) 1435δ1.35 (3H, t, J = 7.3 Hz), 2.36 (6H, s), 4.29 (2H, q, J = 7.3 Hz), 6.89(1H, br-s), 7.30 (1H, t, J = 7.8 Hz), 7.35 (2H, s), 7.74-7.78 (2H, m),8.32 (1H, br-s) 1455 δ 2.33 (6H, s), 4.70 (4H, ddd, J = 48.8 Hz, 2.4 Hz,4.3 Hz), 5.28 (1H, tt, J = 20.0, 4.3 Hz), 7.08 (1H, br-s), 7.32 (1H, d,J = 8.3 Hz), 7.35 (2H, s), 7.75-7.83 (2H, m), 8.29 (1H, br-s) 1458 δ2.36 (6H, s), 2.51-2.62 (2H, m), 4.47 (2H, t, J = 6.3 Hz), 6.95 (1H, br-s), 7.32 (1H, t, J = 7.3 Hz), 7.35 (2H, s), 7.74-7.82 (2H, m), 8.29 (1H,br-s) 1463 δ 2.36 (6H, s), 3.77 (2H, t, J = 5.4 Hz), 4.49 (2H, t, J =5.4 Hz), 7.03 (1H, br), 7.31 (1H, t, J = 8.3 Hz), 7.35 (2H, s),7.76-7.80 (2H, m), 8.29 (1H, br) 1465 δ 2.36 (6H, s), 4.88 (2H, s), 7.18(1H, br), 7.35 (1H, t, J = 8.3 Hz), 7.36 (2H, s), 7.75-7.85 (2H, m),8.31 (1H, br) 1898 δ 1.33 (6H, d, J = 6.3 Hz), 2.37 (3H, s), 5.05 (1H,septet, J = 6.3 Hz), 7.21 (1H, br-s), 7.32 (1H, d, J = 6.6 Hz), 7.39(1H, t, J = 8.1 Hz), 7.46 (1H, s), 7.50-7.53 (2H, m), 8.30-8.36 (2H, m)1899 δ 2.38 (3H, s), 4.87 (2H, s), 7.40-7.51 (5H, m), 7.62 (1H, s),8.27-8.30 (2H, m) 1900 δ 1.34 (6H, d, J = 6.1 Hz), 2.41 (6H, s), 5.05(1H, septet, J = 6.1 Hz), 7.22-7.26 (2H, m), 7.31-7.40 (4H, m), 8.33(1H, dd, J = 1.5 Hz, 8.1 Hz) 1901 δ 2.40 (6H, s), 4.88 (2H, s), 7.29(1H, s), 7.37 (2H, s), 7.38-7.43 (2H, m), 7.50 (1H, s), 8.28 (1H, d, J =6.8 Hz) 1902 δ 4.88 (2H, s), 7.39 (1H, dd, J = 1.5 Hz, 7.3 Hz),7.44-7.51 (2H, m), 7.88-7.92 (2H, m), 8.03 (1H, s), 8.36 (1H, d, J = 8.3Hz), 8.70 (1H, d, J = 8.3 Hz) 1903 δ 2.37 (3H, s), 4.88 (2H, s), 6.55(1H, septet, J = 6.3 Hz), 6.90 (1H, s), 7.32 (1H, s), 7.41-7.48 (3H, m),8.31 (1H, br-s), 8.49 (1H, s) 1904 δ 1.34 (6H, d, J = 6.3 Hz), 2.44 (6H,s), 5.05 (1H, septet, J = 6.3 Hz), 7.13 (1H, s), 7.25-7.28 (2H, m), 7.37(2H, s), 7.41 (1H, t, J = 8.3 Hz), 8.31 (1H, dd, J = 1.5 Hz, 8.3 Hz)1905 δ 2.44 (6H, s), 4.88 (2H, s), 7.15 (1H, br), 7.33-7.37 (3H, m),7.43-7.53 (2H, m), 8.25 (1H, d, J = 8.3 Hz) 1906 δ 2.40 (3H, s), 4.86(2H, s), 7.05-7.10 (2H, m), 7.47 (1H, s), 7.53 (1H, d, J = 8.8 Hz), 7.58(1H, br), 8.22 (1H, br), 8.28 (1H, d, J = 8.8 Hz). 1907 δ 2.40 (6H, s),4.86 (2H, s), 7.00-7.11 (3H, m), 7.37 (2H, s), 8.18 (1H, br) 1908 δ 1.33(6H, d, J = 6.3 Hz), 2.39 (6H, s), 5.04 (1H, septet, J = 6.3 Hz), 6.81(1H, br), 7.30 (1H, br), 7.37 (2H, s), 8.23 (1H, br) 1909 δ 1.33 (6H, d,J = 6.1 Hz), 2.34 (3H, s), 2.42 (3H, s), 5.05 (1H, septet, J = 6.1 Hz),6.46 (1H, br), 7.30 (1H, d, J = 8.1 Hz), 7.45 (1H, s), 7.49 (1H, d, J =8.5 Hz), 7.60 (1H, dd, J = 1.7 Hz, 8.1 Hz), 7.83 (1H, s), 8.27 (1H, d, J= 8.5 Hz), 8.46 (1H, br) 1910 δ 2.39 (3H, s), 2.42 (3H, s), 4.86 (2H,s), 6.77 (1H, br), 7.35 (1H, d, J = 8.1 Hz), 7.46 (1H, s), 7.50 (1H, d,J = 8.8 Hz), 7.65 (1H, dd, J = 2.0 Hz, 8.1 Hz), 7.80 (1H, s), 8.27 (1H,d, J = 8.8 Hz), 8.36 (1H, br) 1911 δ 1.33 (6H, d, J = 6.3 Hz), 2.34 (9H,s), 5.04 (1H, septet, J = 6.3 Hz), 6.48 (1H, br-s), 7.31 (1H, d, J = 7.8Hz), 7.34 (2H, s), 7.55 (1H, s), 7.64 (1H, dd, J = 1.5 Hz, 7.8 Hz), 8.46(1H, s) 1912 δ 2.34 (6H, s), 2.40 (3H, s), 4.86 (2H, s), 6.78 (1H, br),7.34-7.36 (3H, m), 7.50 (1H, s), 7.69 (1H, dd, J = 1.5 Hz, 7.8 Hz), 8.36(1H, s) 1913 δ1.32 (6H, d, J = 6.3 Hz), 2.43 (3H, s), 3.96 (3H, s), 5.05(1H, sept., J = 6.3 Hz), 6.98 (1H, d, J = 8.5 Hz), 7.24 (1H, s), 7.44(1H, s), 7.49 (1H, d, J = 8.5 Hz), 7.71 (1H, dd, J = 2.2 Hz, 8.5 Hz),7.82 (1H, s), 8.25 (1H, d, J = 8.5 Hz), 8.68 (1H, s) 1914 δ 2.43 (3H,s), 4.00 (3H, s), 4.87 (2H, s), 7.02 (1H, d, J = 8.5 Hz), 7.45 (1H, s),7.50 (1H, d, J = 8.5 Hz), 7.54 (1H, s), 7.74-7.79 (2H, m), 8.28 (1H, d,J = 8.5 Hz), 8.66 (1H, s) 1915 δ 1.33 (6H, d, J = 6.3 Hz), 2.42 (3H, s),5.00-5.10 (1H, m), 6.91 (1H, br), 7.20 (1H, dd, J = 8.5 Hz, 10.5 Hz),7.46 (1H, s), 7.49 (1H, d, J = 8.8 Hz), 7.62-7.66 (1H, m), 7.82 (1H, s),8.20 (1H, d, J = 8.8 Hz), 8.71 (1H, d, J = 6.1 Hz) 1916 δ 2.46 (3H, s),4.87 (2H, s), 7.23-7.29 (2H, m), 7.47 (1H, s), 7.51 (1H, d, J = 8.8 Hz),7.68-7.73 (1H, m), 7.78 (1H, s), 8.23 (1H, d, J = 8.5 Hz), 8.68 (1H, d,J = 6.1 Hz) 1917 δ 1.33 (6H, d, J = 6.3 Hz), 2.34 (6H, s), 5.04 (1H,septet, J = 6.3 Hz), 6.91 (1H, s), 7.20 (1H, dd, J = 8.5 Hz, 10.5 Hz),7.35 (2H, s), 7.56 (1H, s), 7.66-7.70 (1H, m), 8.71 (1H, br-d, J = 6.6Hz) 1918 δ 2.34 (6H, s), 4.87 (2H, s), 7.22 (1H, dd, J = 8.8 Hz, 10.5Hz), 7.32 (2H, s), 7.75-7.79 (1H, m), 7.87 (1H, s), 8.56 (1H, s), 8.63(1H, br) 1919 δ1.34 (6H, d, J = 6.3 Hz), 2.43 (3H, s), 5.06 (1H, septet,J = 6.3 Hz), 7.21 (1H, s), 7.46 (1H, s), 7.49-7.52 (2H, m), 7.61 (1H,dd, J = 2.2 Hz, 8.5 Hz), 7.82 (1H, s), 8.24 (1H, d, J = 8.5 Hz), 8.78(1H, d, J = 2.2 Hz) 1920 δ 2.43 (3H, s), 4.88 (2H, s), 7.47 (1H, s),7.50-7.57 (3H, m), 7.66 (1H, dd, J = 2.0 Hz, 8.3 Hz), 7.78 (1H, s), 8.26(1H, d, J = 8.3 Hz), 8.72 (1H, s) 1921 δ 1.34 (6H, d, J = 6.1 Hz), 2.34(6H, s), 5.05 (1H, septet, J = 6.1 Hz), 7.23 (1H, s), 7.35 (2H, s), 7.51(1H, d, J = 8.3 Hz), 7.63-7.69 (2H, m), 8.76 (1H, s) 1922 δ 2.35 (6H,s), 4.88 (2H, s), 7.36 (2H, s), 7.50 (1H, br), 7.53-7.59 (2H, m), 7.70(1H, dd, J = 2.0 Hz, 8.3 Hz), 8.72 (1H, s) 1923 δ 2.35 (6H, s), 2.45(3H, s), 4.84 (2H, s), 7.00 (1H, br), 7.36 (2H, s), 7.41 (1H, s), 7.48(2H, s), 7.83 (1H, s) 1924 δ 1.33 (6H, d, J = 6.1 Hz), 2.46 (3H, s),5.05 (1H, septet, J = 6.1 Hz), 6.89 (1H, br-s), 7.48 (1H, s), 7.51 (1H,d, J = 9.1 Hz), 7.79 (2H, s), 7.89 (1H, s), 8.18 (1H, d, J = 9.1 Hz),8.19 (1H, s) 1925 δ 2.43 (3H, s), 4.86 (2H, s), 7.31 (1H, br-s), 7.49(1H, s), 7.52 (1H, d, J = 8.8 Hz), 7.78 (1H, s), 7.85 (1H, s), 7.94 (1H,s), 8.18 (1H, d, J = 8.8 Hz), 8.24 (1H, s) 1926 δ 1.32 (6H, d, J = 6.1Hz), 2.34 (6H, s), 5.04 (1H, septet, J = 6.1 Hz), 6.87 (1H, s), 7.36(2H, s), 7.50 (1H, s), 7.83 (1H, s), 7.90 (1H, s), 8.20 (1H, s) 1927 δ2.35 (6H, s), 4.86 (2H, s), 7.26 (1H, s), 7.37 (2H, s), 7.48 (1H, s),7.89 (1H, s), 7.97 (1H, s), 8.24 (1H, s) 1928 δ1.31 (6H, d, J = 6.3 Hz),2.33 (6H, s), 3.89 (2H, br.), 4.97-5.04 (1H, m), 6.59 (1H, s), 6.92 (1H,s), 7.02 (1H, s), 7.23-7.26 (1H, m), 7.34 (2H, s), 7.39 (1H, br) 1929 δ2.35 (6H, s), 3.04 (6H, s), 4.84 (2H, s), 6.94 (2H, br), 7.04 (1H, s),7.30 (1H, s), 7.349 (2H, s), 7.404 (1H, s) 1930 δ 1.30 (6H, d, J = 6.3Hz), 2.37 (3H, s), 2.48 (3H, s), 5.02 (1H, septet, J = 6.3 Hz), 6.57(1H, s), 7.20-7.28 (2H, m), 7.44 (2H, s), 7.50 (1H, d, J = 8.3 Hz), 7.76(1H, s), 8.28 (1H, d, J = 9.1 Hz) 1931 δ 2.39 (3H, s), 2.48 (3H, s),4.84 (2H, s), 7.22 (1H, d, J = 8.3 Hz), 7.44-7.54 (3H, m), 7.80 (1H, s),8.13 (1H, d, J = 8.1 Hz), 8.20 (1H, s), 9.04 (1H, s) 1932 δ 1.30 (6H, d,J = 6.1 Hz), 2.39 (6H, s), 2.48 (3H, s), 5.02 (1H, septet, J = 6.1 Hz),6.63 (1H, s), 7.19-7.25 (3H, m), 7.36 (2H, s), 7.81 (1H, s) 1933 δ 2.40(6H, s), 2.50 (3H, s), 4.84 (2H, s), 7.01 (1H, br-s), 7.18 (1H, s),7.24-7.27 (1H, m), 7.31-7.34 (1H, m), 7.37 (2H, s), 7.82 (1H, s) 1934 δ1.31 (6H, d, J = 6.1 Hz), 2.41 (3H, s), 5.04 (1H, septet, J = 6.1 Hz),6.69 (1H, s), 7.16-7.21 (1H, m), 7.46 (1H, s), 7.5 (1H, d, J = 8.8 Hz),7.88 (1H, dd, J = 2.9 Hz, 6.6 Hz), 7.96 (1H, br), 8.40 (1H, d, J = 8.8Hz), 8.57 (1H, d, J = 17.6 Hz) 1935 δ 2.42 (3H, s), 4.84 (2H, s), 7.04(1H, br), 7.20-7.27 (1H, m), 7.46 (1H, s), 7.51 (1H, d, J = 8.5 Hz),7.94 (1H, br), 8.01 (1H, dd, J = 2.9 Hz, 6.6 Hz), 8.40 (1H, d, J = 8.5Hz), 8.57 (1H, br-d, J = 17.6 Hz) 1936 δ 1.31 (6H, d, J = 6.3 Hz), 2.35(6H, s), 5.02 (1H, septet, J = 6.3 Hz), 6.70 (1H, s), 7.19 (1H, dd, J =9.0 Hz, 11.2 Hz), 7.36 (2H, s), 7.83 (1H, dd, J = 2.9 Hz, 6.6 Hz), 7.99(1H, br), 8.01 (1H, d, J = 5.1 Hz) 1937 δ 2.36 (6H, s), 4.84 (2H, s),7.10 (1H, br-s), 7.21-7.26 (1H, m), 7.36 (2H, s), 7.94-8.03 (3H, m) 1938δ 1.31 (6H, d, J = 6.3 Hz), 2.41 (3H, s), 5.03 (1H, septet, J = 6.3 Hz),6.68 (1H, s), 7.40 (1H, d, J = 8.8 Hz), 7.46 (1H, s), 7.51 (1H, d, J =8.5 Hz), 7.67 (1H, d, J = 8.5 Hz), 7.78 (1H, d, J = 2.7 Hz), 8.06 (1H,s), 8.32 (1H, d, J = 8.8 Hz) 1939 δ 2.42 (3H, s), 4.84 (2H, s), 7.38(1H, d, J = 8.8 Hz), 7.45-7.49 (2H, m), 7.72 (1H, d, J = 7.3 Hz), 7.93(1H, s), 8.17 (1H, d, J = 8.5 Hz), 8.52 (1H, s), 9.43 (1H, s) 1940 δ1.31 (6H, d, J = 6.1 Hz), 2.40 (6H, s), 5.03 (1H, septet, J = 6.1 Hz),6.70 (1H, s), 7.36 (2H, s), 7.41 (1H, d, J = 8.8 Hz), 7.63-7.66 (2H, m),7.75 (1H, d, J = 2.7 Hz) 1941 δ 2.40 (6H, s), 4.84 (2H, s), 7.08 (1H,br), 7.37 (2H, s), 7.46 (1H, d, J = 8.8 Hz), 7.64-7.70 (2H, m), 7.82(1H, d, J = 2.7 Hz) 1942 δ1.31 (6H, d, J = 6.3 Hz), 2.41 (3H, s),4.97-5.07 (1H, m), 6.70 (1H, s), 7.45-7.58 (4H, m), 7.72-7.75 (2H, m),8.30 (1H, d, J = 8.8 Hz) 1943 δ 2.44 (3H, s), 4.85 (2H, s), 7.43-7.47(2H, m), 7.54 (1H, d, J = 8.5 Hz), 7.61 (1H, d, J = 8.5 Hz), 7.86 (1H,s), 7.99 (1H, d, J = 8.1 Hz), 9.09 (1H, s), 9.89 (1H, s) 1944 δ 2.43(3H, s), 4.84 (2H, s), 7.36 (1H, s), 7.44 (1H, s), 7.47 (1H, d, J = 8.5Hz), 7.79 (2H, d, J = 8.5 Hz), 8.08 (1H, d, J = 8.5 Hz), 8.62 (1H, s),9.65 (1H, s) 1945 δ 1.31 (6H, d, J = 6.3 Hz), 2.45 (6H, s), 5.03 (1H,septet, J = 6.3 Hz), 6.66 (1H, s), 7.16-7.21 (2H, m), 7.36 (2H, s), 7.76(1H, s), 7.82 (1H, dd, J = 2.7 Hz, 8.8 Hz) 1946 δ1.52 (9H, s), 2.41 (3H,s), 6.58 (1H, s), 7.19 (1H, dd, J = 2.7 Hz, 8.5 Hz), 7.41 (1H, s), 7.45(1H, s), 7.51 (1H, d, J = 7.1 Hz), 7.69 (1H, s), 7.79 (1H, d, J = 8.5Hz), 8.30 (1H, d, J = 8.5 Hz) 1947 δ 2.44 (3H, s), 2.45 (3H, s), 4.83(2H, d, J = 1.7 Hz), 7.00 (1H, br), 7.07-7.27 (2H, m), 7.36 (2H, s),7.74-7.77 (1H, d, J = 10.3 Hz), 7.86 (1H, dd, J = 8.5 Hz, 10.3 Hz) 1948δ3.45 (3H, s), 4.80 (2H, s), 7.53-7.57 (2H, m), 7.68 (1H, s), 7.82 (1H,d, J = 7.8 Hz), 7.93-7.95 (3H, m) 1949 δ 2.30 (3H, s), 3.41 (3H, s),4.77 (2H, s), 6.77 (1H, s), 6.95-7.00 (1H, m), 7.07-7.16 (2H, m),7.29-7.41 (4H, m) 1950 δ 1.26 (6H, d, J = 5.9 Hz), 2.28 (6H, s), 3.33(3H, s), 4.96 (1H, septet, J = 5.9 Hz), 6.47 (1H, s), 6.88 (1H, d, J =7.8 Hz), 7.04 (1H, t, J = 7.8 Hz), 7.21 (2H, s), 7.23-7.47 (2H, m) 1951δ 2.29 (6H, s), 3.34 (3H, s), 4.77 (2H, s), 6.81 (1H, br), 6.99 (1H, d,J = 7.8 Hz), 7.10 (1H, t, J = 7.8 Hz), 7.22 (2H, s), 7.24-7.26 (1H, m),7.42 (1H, s) 1954 δ 1.26 (6H, d, J = 6.3 Hz), 2.34 (3H, s), 3.34 (3H,s), 4.97 (1H, septet, J = 6.3 Hz), 6.46 (1H, s), 6.99 (1H, d, J = 7.8Hz), 7.07 (1H, t, J = 7.8 Hz), 7.28-7.31 (2H, m), 7.40-7.44 (1H, m),7.62 (1H, s) 1955 δ 2.35 (3H, s), 3.36 (3H, s), 4.77 (2H, s), 7.02-7.13(3H, m), 7.29-7.37 (2H, m), 7.44-7.52 (1H, m), 7.62 (1H, s) 1956 δ 1.26(3H, t, J = 7.3 Hz), 2.29 (6H, s), 3.86 (2H, q, J = 7.3 Hz), 4.76 (2H,s), 6.86 (1H, br), 6.92-6.95 (1H, m), 7.08 (1H, t, J = 8.1 Hz), 7.22(2H, s), 7.23-7.30 (1H, m), 7.38 (1H, t, J = 2.0 Hz) 1957 δ 1.46 (6H, d,J = 6.3 Hz), 2.07 (6H, s), 4.77 (2H, s), 5.40 (1H, septet, J = 6.3 Hz),6.78 (1H, br), 6.98 (1H, d, J = 7.8 Hz), 7.14-7.19 (1H, m), 7.17 (2H,s), 7.29 (1H, s), 7.46 (1H, d, J = 7.8 Hz) 1958 δ 2.34 (6H, s), 3.45(3H, s), 4.80 (2H, s), 7.36 (2H, s), 7.50-7.56 (3H, m), 7.78 (1H, d, J =6.1 Hz), 7.90 (1H, s) 1959 (DMSO-d₆) δ 2.32 (6H, s), 3.30 (3H, s), 4.86(2H, s), 6.83 (1H, t, J = 7.4 Hz), 7.40 (1H, t, J = 7.4 Hz), 7.44 (2H,s), 7.67 (1H, t, J = 7.4 Hz), 10.05 (1H, s) 1960 δ1.29 (6H, d, J = 6.3Hz), 2.35 (6H, s), 3.35 (3H, s), 3.38 (3H, s), 4.97-5.03 (1H, m), 7.36(2H, s), 7.58 (1H, s), 7.76 (1H, s), 7.84 (1H, s), 8.56 (1H, s) 1961(DMSO-d₆) δ 2.28 (6H, s), 2.33 (3H, s), 7.44 (2H, s), 7.48 (1H, t, J =7.8 Hz), 7.66-7.75 (2H, m), 8.11 (1H, t, J = 2.0 Hz), 9.96 (1H, s),10.56 (1H, s) 1962 (DMSO-d₆) δ1.34 (3H, t, J = 7.3 Hz), 2.34 (6H, s),2.96 (2H, q, J = 7.3 Hz), 7.33 (2H, s), 7.41 (1H, t, J = 7.8 Hz), 7.67(1H, d, J = 7.8 Hz), 7.83-7.85 (1H, m), 8.11 (1H, d, J = 2.0 Hz), 8.79(1H, s), 9.58 (1H, s) 1963 δ 1.32 (6H, d, J = 6.6 Hz), 2.37 (6H, s),5.00-5.06 (1H, m), 6.69 (1H, s), 7.35-7.65 (5H, m), 8.09 (1H, s), 8.72(1H, s) 1964 δ 2.37 (6H, s), 4.85 (2H, s), 7.07 (1H, br.), 7.39 (2H, s),7.45 (1H, t, J = 8.1 Hz), 7.61-7.68 (2H, m), 8.11 (1H, s), 8.69 (1H, s)1967 δ1.34 (6H, d, J = 6.3 Hz), 2.34 (6H, s), 5.09 (1H, septet, J = 6.3Hz), 7.29 (1H, br-s), 7.35 (2H, s), 7.91 (1H, t, J = 7.8 Hz), 7.97 (1H,d, J = 7.8 Hz), 8.21 (1H, d, J = 7.8 Hz), 9.19 (1H, br-s) 1968 δ 2.35(6H, s), 4.89 (2H, s), 7.36 (2H, s), 7.63 (1H, br-s), 7.97 (1H, dd, J =8.3 Hz, 7.6 Hz), 8.05 (1H, d, J = 7.6 Hz), 8.21 (1H, d, J = 8.3 Hz),9.17 (1H, br-s) 1969 δ 2.35 (6H, s), 3.77-3.80 (2H, m), 4.48-4.52 (2H,m), 7.36 (2H, s), 7.46 (1H, br-s), 7.94 (1H, t, J = 7.8 Hz), 8.02 (1H,dd, J = 7.8 Hz, 1.0 Hz), 8.19 (1H, dd, J = 7.8 Hz, 1.0 Hz), 9.17 (1H,br-s) 2061 δ1.36 (6H, d, J = 6.4 Hz), 2.52 (6H, s), 5.07-5.14 (1H, m),7.36 (2H, s), 7.56 (1H, t, J = 8.2 Hz), 8.15 (1H, dd, J = 8.2 Hz, 1.9Hz), 8.44 (1H, dd, J = 8.2 Hz, 1.9 Hz), 9.45 (1H, br-s), 12.9 (1H, br-s)2062 δ 2.37 (6H, s), 4.91 (2H, s), 7.36 (2H, s), 7.61 (1H, t, J = 8.3Hz), 8.23 (1H, dd, J = 8.3 Hz, 1.9 Hz), 8.45 (1H, dd, J = 8.3 Hz, 1.9Hz), 9.81 (1H, br-s), 12.7 (1H, br-s) 2157 δ 2.36 (6H, s), 4.90 (2H, s),7.38 (2H, s), 7.52-7.60 (2H, m), 8.44 (1H, s), 8.56 (1H, d, J = 5.4 Hz),8.58 (1H, br-s) 2164 δ1.33 (6H, d, J = 5.8 Hz), 2.35 (6H, s), 5.03-5.07(1H, m), 7.06 (1H, s), 7.35 (2H, s), 7.93 (1H, d, J = 2.4 Hz), 7.95 (1H,d, J = 5.9 Hz, 2.4 Hz), 8.49 (1H, d, J = 5.9 Hz), 9.58 (1H, br-s) 2165(DMSO-d₆) δ 2.26 (6H, s), 5.02 (2H, s), 7.43 (2H, s), 7.75 (1H, dd, J =5.4 Hz, 2.0 Hz), 8.31 (1H, d, J = 2.0 Hz), 8.60 (1H, d, J = 5.4 Hz),10.41 (1H, br-s), 10.92 (1H, br-s) 2167 (DMSO-d₆) δ 2.36 (6H, s), 4.90(2H, s), 7.34 (2H, s), 7.94 (1H, dd, J = 7.3 Hz, 3.4 Hz), 8.31 (1H, d, J= 7.3 Hz), 8.60 (1H, d, J = 3.4 Hz), 10.90 (1H, br-s), 13.65 (1H, br-s)2168 (DMSO-d₆) δ 2.30 (6H, s), 3.61 (3H, s), 5.03 (2H, s), 7.47 (2H, s),7.92 (1H, d, J = 7.6 Hz), 7.98 (1H, d, J = 7.6 Hz), 8.08 (1H, t, J = 7.6Hz), 10.18 (1H, s) I-1  δ 2.34 (6H, s), 3.87 (2H, br-s), 6.86-6.89 (1H,m), 7.21-7.30 (3H, m), 7.33 (2H, s), 7.39 (1H, s) I-2  δ 3.87 (2H, br),6.84-7.00 (1H, m), 7.14-7.17 (1H, m), 7.20 (1H, t, J = 2.0 Hz),7.24-7.28 (1H, m), 7.60 (2H, d, J = 8.8 Hz), 7.78 (2H, d, J = 8.8 Hz),7.90 (1H, br-s) I-3  δ 2.51 (3H, d, J = 8.8 Hz), 3.86 (2H, br-s),6.83-8.68 (1H, m), 7.13-7.25 (3H, m), 7.26-7.63 (3H, m), 7.90 (1H, br-s)I-4  δ3.87 (2H, br-s), 3.89 (3H, s), 6.86-6.88 (1H, m), 6.99 (1H, dd, J= 8.6 Hz, 2.0 Hz), 7.15-7.20 (2H, m), 7.27 (1H, t, J = 7.8 Hz), 7.51(1H, d, J = 8.6 Hz), 7.83 (1H, s), 7.93 (1H, s) I-5  δ3.89 (2H, br-s),6.86-6.89 (1H, m), 7.12-7.30 (3H, m), 7.52-7.59 (2H, m), 7.76-7.93 (2H,m) I-6  δ 2.43 (3H, s), 3.83 (2H, br), 6.85-6.88 (1H, m), 7.14-7.17 (1H,m), 7.21-7.29 (2H, m), 7.45 (1H, s), 7.49 (1H, d, J = 8.8 Hz), 7.76 (1H,br), 8.27 (1H, d, J = 8.8 Hz) I-7  δ 2.34 (6H, s), 3.87 (2H, br),6.86-6.89 (1H, m), 7.20-7.35 (6H, m) I-8  δ 2.42 (3H, s), 3.79 (2H,br-s), 6.80 (1H, dd, J = 2.2 Hz, 7.8 Hz), 6.90 (1H, d, J = 7.8 Hz), 7.05(1H, s), 7.15 (1H, t, J = 7.8 Hz), 7.26-7.44 (7H, m), 7.53 (1H, s) I-9 δ 2.33 (3H, s), 2.52 (3H, d, J = 8.8 Hz), 3.89 (2H, br-s), 6.86-6.89(1H, m), 7.14-7.16 (1H, m), 7.22 (1H, s), 7.28-7.30 (2H, m), 7.65 (1H,br-s), 8.11 (1H, s) I-10 δ 2.28 (3H, s), 2.46 (3H, d, J = 6.1 Hz), 3.88(2H, br-s), 6.84-6.89 (1H, m), 7.15-7.19 (1H, m), 7.23-7.29 (2H, m),7.41 (1H, d, J = 9.1 Hz), 7.73 (1H, br-s), 7.81 (1H, d, J = 9.1 Hz) I-12δ 2.60 (3H, s), 3.92 (2H, br-s), 6.89-6.92 (1H, m), 7.24-7.32 (3H, m),7.46 (1H, s), 7.76 (1H, br-s) I-13 δ 2.27 (6H, s), 3.31 (3H, s),6.40-6.43 (1H, m), 6.54-6.58 (1H, m), 6.71 (1H, t, J = 2.0 Hz),6.76-6.86 (1H, m), 7.22 (2H, s) I-14 δ 1.45 (6H, d, J = 6.3 Hz), 2.07(6H, s), 3.53 (2H, br), 5.37 (1H, septet, J = 6.3 Hz), 6.56-6.63 (3H,m), 6.96 (1H, t, J = 7.8 Hz), 7.16 (2H, s) I-15 δ 1.32 (3H, t, J = 7.6Hz), 2.72 (2H, q, J = 7.6 Hz), 3.88 (2H, br), 6.85-6.89 (1H, m),7.13-7.14 (1H, m), 7.22-7.30 (2H, m), 7.46 (1H, s), 7.50 (1H, d, J = 8.8Hz), 7.80 (1H, br-s), 8.29 (1H, d, J = 8.8 Hz) I-16 δ 1.17 (3H, t, J =7.6 Hz), 2.28 (3H, s), 2.65 (2H, q, J = 7.6 Hz), 3.85 (2H, br-s),6.82-6.85 (1H, m), 7.21-7.23 (3H, m), 7.34 (2H, s), 7.64 (1H, s) I-17 δ1.22 (6H, t, J = 7.6 Hz), 2.69 (4H, q, J = 7.6 Hz), 3.86 (2H, br-s),6.86-6.89 (1H, m), 7.15-7.36 (4H, m), 7.38 (2H, s) I-18 δ 1.23 (3H, t, J= 7.3 Hz), 2.76 (2H, q, J = 7.3 Hz), 3.88 (2H, br-s), 6.88-6.91 (1H, m),7.26-7.32 (3H, m), 7.50 (1H, s), 7.53 (1H, s), 7.95 (1H, d, J = 1.5 Hz)I-19 δ 1.00 (3H, t, J = 7.3 Hz), 1.65-1.75 (2H, m), 2.67 (2H, t, J = 7.3Hz), 3.89 (2H, br), 6.84-6.88 (1H, m), 7.11-7.29 (3H, m), 7.43 (1H, s),7.49 (1H, d, J = 8.5 Hz), 7.85 (1H, br-s), 8.27 (1H, d, J = 7.8 Hz) I-20δ1.22 (6H, d, J = 6.8 Hz), 2.32 (3H, s), 3.17 (1H, septet, J = 6.8 Hz),3.87 (2H, br-s), 6.85-6.93 (1H, m), 7.20-7.29 (3H, m), 7.35 (1H, s),7.40-7.45 (2H, m). I-21 δ 2.35 (3H, s), 3.85 (5H, s), 6.85-6.89 (1H, m),6.95 (1H, s), 7.13 (1H, s), 7.23-7.30 (3H, m), 7.62 (1H, s) I-22 δ 1.25(3H, t, J = 7.6 Hz), 2.76 (2H, q, J = 7.6 Hz), 3.88 (2H, br-s),6.87-6.91 (1H, m), 7.24-7.31 (3H, m), 7.47 (1H, s), 7.55 (1H, s), 7.57(1H, s) I-23 δ 2.62 (3H, d, J = 6.4 Hz), 3.91 (2H, br-s), 6.89 (1H, d, J= 8.0 Hz), 7.20-7.32 (4H, m), 7.49 (1H, d, J = 9.0 Hz), 8.58-8.60 (1H,m) I-24 δ3.91 (2H, br-s), 3.92 (3H, s), 6.89-6.92 (1H, m), 7.21-7.33(3H, m), 7.59 (1H, d, J = 1.2 Hz), 8.50 (1H, s), 8.54 (1H, s) I-25 δ2.35 (3H, s), 2.57 (3H, d, J = 6.8 Hz), 3.88 (2H, br-s), 6.88-6.91 (1H,m), 7.25-7.34 (4H, m), 7.67 (1H, s) I-26 δ 2.41 (3H, s), 3.88 (2H,br-s), 6.87-6.91 (1H, m), 7.25-7.31 (3H, m), 7.47 (1H, s), 7.65 (1H, s),7.72 (1H, s) I-27 δ 1.23 (3H, t, J = 7.3 Hz), 2.74 (2H, q, J = 7.3 Hz),3.87 (2H, br-s), 6.86-6.91 (1H, m), 7.25-7.31 (3H, m), 7.50 (1H, s),7.59 (1H, s), 7.73 (1H, d, J = 1.5 Hz) I-28 (DMSO-d₆) δ 0.84 (3H, t, J =7.3 Hz), 1.48-1.58 (2H, m), 2.66 (2H, t, J = 7.3 Hz), 5.36 (2H, br-s),6.77 (1H, dd, J = 1.0 Hz, 7.8 Hz), 7.10-7.19 (3H, m), 7.59 (1H, s), 7.80(1H, s), 10.03 (1H, s) I-29 δ 0.90 (3H, t, J = 7.3 Hz), 1.25-1.37 (2H,m), 1.55-1.63 (2H, m), 2.72 (2H, t, J = 7.8 Hz), 3.89 (2H, br),6.87-6.91 (1H, m), 7.24-7.31 (3H, m), 7.48 (1H, s), 7.55 (1H, s), 7.73(1H, d, J = 1.5 Hz) I-30 δ 2.39 (3H, s), 2.66 (3H, d, J = 6.9 Hz), 7.43(1H, s), 7.75-7.79 (2H, m), 8.33 (1H, d, J = 8.3 Hz), 8.48 (1H, d, J =8.3 Hz), 8.80 (1H, s) I-31 δ 2.41 (3H, s), 3.88 (2H, s), 6.86-6.91 (1H,m), 7.28-7.32 (3H, m), 7.49 (1H, s), 7.58 (1H, s), 7.93 (1H, d, J = 1.2Hz) I-32 δ 0.91 (3H, t, J = 7.3 Hz), 1.58-1.67 (2H, m), 2.69 (2H, t, J =7.8 Hz), 3.88 (2H, br-s), 6.87-6.90 (1H, m), 7.26-7.31 (3H, m), 7.50(1H, s), 7.54 (1H, s), 7.95 (1H, d, J = 2.0 Hz) I-33 δ 2.33 (6H, s),3.87 (2H, br-s), 6.86-6.89 (1H, m), 7.21-7.29 (3H, m), 7.34 (2H, s),7.52 (1H, s) I-34 δ 2.32 (6H, s), 3.86 (2H, br-s), 6.85-6.88 (1H, m),7.20-7.28 (3H, m), 7.33 (2H, s), 7.60 (1H, s) I-35 δ 3.86 (2H, br),6.84-6.87 (1H, m), 7.13-7.28 (3H, m), 7.63-7.64 (2H, m), 7.70-7.74 (2H,m), 7.91 (1H, br-s) I-36 δ 3.99 (2H, br-s), 6.85-6.88 (1H, m), 7.23-7.34(3H, m), 7.91 (2H, s), 8.69 (1H, s) I-37 δ 3.91 (2H, br), 6.88-6.91 (1H,m), 7.15-7.21 (2H, m), 7.29 (1H, t, J = 7.8 Hz), 7.94-7.98 (2H, m), 8.03(2H, d, J = 8.8 Hz), 8.11 (1H, s) I-38 (DMSO-d₆) δ 5.39 (2H, br-s),6.77-6.80 (1H, m), 7.12-7.19 (3H, m), 8.49 (2H, s), 10.53 (1H, s) I-39(DMSO-d₆) δ 2.30 (3H, s), 4.32 (2H, br-s), 4.39 (2H, q, J = 8.3 Hz),6.79-6.86 (3H, m), 7.18-7.27 (2H, m), 7.45 (1H, d, J = 8.8 Hz), 7.56(1H, s), 8.91 (1H, br-s) I-40 δ3.87 (2H, br-s), 6.85-6.88 (1H, m), 7.14(1H, dd, J = 9.3 Hz, 1.0 Hz), 7.19 (1H, t, J = 2.0 Hz), 7.27 (1H, t, J =7.9 Hz), 7.64 (2H, d, J = 8.7 Hz), 7.71 (2H, d, J = 8.7 Hz), 7.86 (1H,s) I-42 δ3.88 (2H, s), 6.90 (1H, d, J = 6.8 Hz), 7.23-7.32 (3H, m), 7.60(1H, s), 7.92 (2H, s) I-43 δ3.89 (2H, br-s), 6.90 (1H, dt, J = 2.5 Hz,6.3 Hz), 7.25-7.32 (3H, m), 7.59 (1H, s), 7.72 (2H, s) I-44 δ3.89 (2H,br-s), 6.90 (1H, dt, J = 2.5 Hz, 6.4 Hz), 7.28-7.30 (3H, m), 7.60 (1H,s), 7.93 (2H, s) I-45 δ3.92 (2H, s), 6.92 (1H, dt, J = 1.5 Hz, 7.3 Hz),7.23-7.30 (3H, m), 7.79 (1H, s), 8.04 (2H, s) I-46 δ3.89 (2H, br-s),6.90 (1H, dd, J = 2.4 Hz, 4.9 Hz), 7.23-7.32 (3H, m), 7.61 (1H, s), 7.93(2H, s) I-47 δ3.88 (2H, br-s), 6.90 (1H, d, J = 6.3 Hz), 7.23-7.32 (3H,m), 7.62 (1H, s), 7.92 (2H, s) I-48 δ6.90-6.94 (1H, m), 7.28-7.33 (3H,m), 7.73 (1H, s), 8.02 (1H, s), 8.25 (1H, s) I-49 δ 2.31 (6H, s), 2.90(3H, s), 6.81 (1H, dd, J = 1.9 Hz, 7.8 Hz), 7.15-7.18 (2H, m), 7.30 (1H,t, J = 7.8 Hz), 7.42 (1H, s), 7.52 (2H, s) I-50 δ 2.91 (3H, s),6.82-6.85 (1H, m), 7.21-7.23 (2H, m), 7.32 (1H, t, J = 7.8 Hz), 7.64(1H, s), 7.93 (2H, s) I-51 δ 2.29 (3H, s), 2.34 (3H, s), 3.82 (2H, br),6.81 (1H, d, J = 8.1 Hz), 6.92 (1H, d, J = 8.1 Hz), 7.11 (1H, t, J = 7.8Hz), 7.41-7.44 (2H, m), 7.50 (1H, d, J = 8.3 Hz), 8.36 (1H, d, J = 8.3Hz) I-53 δ 2.23 (3H, s), 2.39 (3H, s), 3.82 (2H, br), 7.10-7.16 (2H, m),7.24 (1H, d, J = 1.7 Hz), 7.44 (1H, s), 7.49 (1H, d, J = 8.1 Hz), 7.73(1H, s), 8.30 (1H, d, J = 8.8 Hz) I-55 δ 2.34 (3H, s), 2.40 (3H, s),3.70 (2H, br), 6.72 (1H, dd, J = 2.4 Hz, 8.1 Hz), 6.83 (1H, d, J = 2.4Hz), 7.07 (1H, d, J = 8.1 Hz), 7.36 (1H, s), 7.44 (1H, s), 7.50 (1H, d,J = 8.5 Hz), 8.30 (1H, d, J = 8.5 Hz) I-56 δ 2.38 (6H, s), 2.42 (3H, s),3.70 (2H, br), 6.72 (1H, dd, J = 2.4 Hz, 8.1 Hz), 6.89 (1H, d, J = 2.4Hz), 7.05 (1H, s), 7.07 (1H, d, J = 8.1 Hz), 7.36 (2H, s) I-59 δ 2.37(6H, s), 3.90 (2H, br-s), 6.96-7.01 (1H, m), 7.10 (1H, t, J = 7.8 Hz),7.36 (2H, s), 7.43-7.47 (1H, m), 7.86 (1H, d, J = 13.2 Hz) I-60 δ 2.33(6H, s), 6.99 (1H, dt, J = 1.5 Hz, 7.8 Hz), 7.10 (1H, t, J = 7.8 Hz),7.43 (2H, s), 7.46 (1H, d, J = 7.8 Hz), 7.84 (1H, d, J = 13.2 Hz) I-61 δ2.33 (6H, s), 3.93 (2H, s), 7.05-7.14 (1H, m), 7.17-7.21 (1H, m), 7.31(1H, s), 7.35 (2H, s), 7.37-7.40 (1H, m) I-62 δ 2.40 (3H, s), 3.77 (2H,br), 6.79-6.83 (1H, m), 6.97-7.03 (1H, m), 7.44-7.51 (3H, m), 8.42 (1H,d, J = 8.8 Hz), 8.60 (1H, br-d, J = 18.8 Hz) I-63 δ 2.35 (6H, s), 3.74(2H, br-s), 6.77-6.83 (1H, m), 7.01 (1H, dd, J = 8.8 Hz, 11.7 Hz), 7.35(2H, s), 7.42 (1H, dd, J = 2.9 Hz, 6.6 Hz), 8.01 (1H, d, J = 15.6 Hz)I-64 δ 2.38 (3H, s), 4.27 (2H, br), 6.89 (1H, dd, J = 1.5 Hz, 8.1 Hz),7.05 (1H, d, J = 8.8 Hz), 7.18 (1H, t, J = 8.1 Hz), 7.45 (1H, s), 7.51(1H, d, J = 8.1 Hz), 7.60 (1H, s), 8.34 (1H, d, J = 8.8 Hz) I-65 δ 2.40(6H, s), 4.27 (2H, br-s), 6.88 (1H, dd, J = 1.5 Hz, 7.8 Hz), 7.03 (1H,dd, J = 1.5 Hz, 7.8 Hz), 7.16 (1H, t, J = 7.8 Hz), 7.29 (1H, s), 7.36(2H, s) I-66 δ 2.39 (3H, s), 4.27 (2H, br), 7.08 (1H, dd, J = 2.2 Hz,8.3 Hz), 7.32-7.36 (2H, m), 7.45 (1H, s), 7.50 (1H, d, J = 8.5 Hz), 7.68(1H, s), 8.24 (1H, d, J = 8.5 Hz) I-67 δ 2.33 (6H, s), 4.27 (2H, br-s),7.15 (1H, d, J = 8.1 Hz), 7.35-7.38 (5H, m) I-68 δ 2.41 (3H, s), 3.87(2H, br), 6.73 (1H, dd, J = 2.9 Hz, 8.5 Hz), 7.18 (1H, d, J = 2.9 Hz),7.21 (1H, d, J = 8.8 Hz), 7.45 (1H, s), 7.50 (1H, d, J = 8.8 Hz), 8.12(1H, s), 8.34 (1H, d, J = 8.5 Hz) I-69 δ 2.39 (6H, s), 3.85 (2H, br-s),6.72 (1H, dd, J = 2.7 Hz, 8.5 Hz), 7.15 (1H, d, J = 2.7 Hz), 7.22 (1H,d, J = 8.5 Hz), 7.36 (2H, s), 7.66 (1H, s) I-70 δ 2.43 (6H, s), 4.34(2H, br), 6.86 (1H, dd, J = 1.5 Hz, 8.3 Hz), 6.96 (1H, dd, J = 1.5 Hz,8.3 Hz), 7.13 (1H, s), 7.19 (1H, t, J = 8.3 Hz), 7.36 (2H, s) I-71 δ2.41 (3H, s), 3.87 (2H, br), 6.66 (1H, dd, J = 2.9 Hz, 8.5 Hz), 7.03(1H, d, J = 2.9 Hz), 7.38 (1H, d, J = 8.5 Hz), 7.45 (1H, s), 7.50 (1H,d, J = 8.5 Hz), 7.75 (1H, br-s), 8.33 (1H, d, J = 8.5 Hz) I-72 δ 2.40(3H, s), 3.94 (2H, br), 7.05-7.16 (2H, m), 7.36 (1H, dd, J = 2.2 Hz, 8.5Hz), 7.45 (1H, s), 7.50 (1H, d, J = 9.0 Hz), 7.66 (1H, s), 8.24 (1H, d,J = 9.0 Hz) I-73 δ 2.41 (3H, s), 3.88 (2H, br-s), 6.54 (1H, dd, J = 2.9Hz, 8.5 Hz), 6.88 (1H, d, J = 2.9 Hz), 7.37 (1H, s), 7.45 (1H, s), 7.52(1H, d, J = 8.3 Hz), 7.61 (1H, d, J = 8.3 Hz), 8.32 (1H, d, J = 8.5 Hz)I-74 δ 2.44 (6H, s), 3.86 (2H, br-s), 6.52 (1H, dd, J = 2.9 Hz, 8.5 Hz),6.91 (1H, d, J = 2.9 Hz), 7.12 (1H, s), 7.35 (2H, s), 7.62 (1H, d, J =8.5 Hz) I-75 δ 2.38 (3H, s), 4.39 (2H, s), 7.06 (1H, s), 7.40 (1H, d, J= 1.7 Hz), 7.43-7.50 (3H, m), 7.90 (1H, d, J = 9.1 Hz), 8.73 (1H, s)I-76 δ 2.27 (6H, s), 4.09 (2H, br-s), 7.08 (1H, s), 7.33 (2H, s), 7.37(1H, s), 7.43 (1H, s), 7.83 (1H, s) I-77 δ 2.39 (3H, s), 2.93 (3H, s),3.95 (2H, br), 6.84 (1H, d, J = 8.3 Hz), 7.21-7.27 (2H, m), 7.44 (1H,s), 7.48 (1H, d, J = 8.5 Hz), 7.69 (1H, s), 8.28 (1H, d, J = 8.5 Hz)I-79 δ 2.33 (6H, s), 3.76 (4H, br), 6.19 (1H, d, J = 2.0 Hz), 6.60 (2H,d, J = 2.0 Hz), 7.34 (1H, br), 7.52 (2H, s) I-80 δ 2.38 (3H, s), 4.65(2H, s), 7.26 (1H, s), 7.34 (1H, s), 7.47 (1H, s), 7.52 (1H, d, J = 8.5Hz), 8.20 (1H, d, J = 8.5 Hz) I-81 δ 2.50 (3H, s), 3.90 (2H, s),6.91-6.94 (1H, m), 7.27-7.35 (3H, m), 7.48-7.57 (2H, m), 7.70 (1H, s),7.75 (1H, s), 8.01-8.04 (1H, m), 8.45-8.48 (1H, m) I-82 δ1.74-1.78 (2H,m), 1.82-1.88 (2H, m), 2.72 (2H, t, J = 6.0 Hz), 3.01 (2H, q, J = 6.0Hz), 3.88 (2H, br-s), 6.85-6.88 (1H, m), 7.14-7.16 (1H, m), 7.22-7.29(2H, m), 7.42 (1H, d, J = 8.6 Hz), 7.70 (1H, br-s), 8.10 (1H, d, J = 9.0Hz) I-83 δ1.71-1.79 (4H, m), 2.81 (2H, t, J = 6.1 Hz), 2.99 (2H, q, J =6.3 Hz), 3.87 (2H, br-s), 6.87-6.90 (1H, m), 7.24-7.29 (3H, m),7.47-7.52 (2H, m) I-84 δ3.87 (2H, br-s), 6.51 (1H, septet, J = 6.3 Hz),6.85-6.88 (1H, m), 6.99 (1H, d, J = 8.7 Hz), 7.15 (1H, d, J = 7.3 Hz),7.20 (1H, t, J = 2.0 Hz), 7.25-7.29 (1H, m), 7.75 (1H, br-s), 8.15 (1H,dd, J = 8.7 Hz, 2.4 Hz), 8.30 (1H, d, J = 2.4 Hz) I-85 δ 2.37 (3H, s),4.27 (2H, br-s), 6.55 (1H, septet, J = 6.3 Hz), 6.88-6.91 (2H, m), 7.06(1H, dd, J = 7.3 Hz, 1.5 Hz), 7.18 (1H, t, J = 7.3 Hz), 7.37 (1H, br-s),8.50 (1H, br-s) I-86 δ 2.37 (3H, s), 3.88 (2H, br-s), 6.34 (1H, septet,J = 6.3 Hz), 6.88 (1H, s), 6.89-6.91 (1H, m), 7.23-7.31 (3H, m), 7.47(1H, br-s)

The insecticides containing the compounds represented by formula (1) ofthe present invention as active ingredients are suitable for preventinginsect pests such agricultural, horticultural and stored grain insectpests which are noxious to paddy rice, fruit trees, vegetables, othercrops and flowing plants, sanitary pests, or nematodes. For example, theinsecticides have strong insecticidal activity on the following insectpests: Lepidoptera such as cotton caterpillar (Diaphania indica),oriental tea tortrix (Homona magnanima), cabbage webworm (Hellullaundalis), summer fruit tortrix (Adoxophyes orana fasciata), smaller teatortrix (Adoxophyes sp.), apple tortrix (Archips fuscocupreanus), peachfruit moth (Carposina niponensis), Manchurian fruit moth (Grapholitainopinata), oriental fruit moth (Grapholita molesta), soybean pod borer(Leguminivora glycinivorella), mulberry leafroller (Olethreutes mori),citrus leafminer (Phyllocnistis citrella), persimmon fruit moth(Stathmopoda masinissa), tea leafroller (Caloptilia theivora),Caloptilia sp. (Caloptilia zachrysa), apple leafminer (Phyllonorycterringoniella), pear barkminer (Spulerrina astaurota), small citrus dog(Papilio xuthus), common cabbage worm (Pieris rapae crucivora), tabaccobudworm (Heliothis armigera), codling moth (Lapsey resia pomonella),diamondback moth (Plutella xylostella), apple fruit moth (Argyresthiaconjugella), peach fruit moth (Carposina niponensis), rice stem borer(Chilo suppressalis), rice leafroller (Cnaphalocrocis medinalis),tabacco moth (Ephestia elutella), mulberry pyralid (Glyphodes pyloalis),paddy borer (Scirpophaga incertulas), rice skipper (Parnara guttata),rice armyworm (Pseudaletia separata), pink borer (Sesamia inferens),cabbage armyworm (Mamestra brassicae), common cutworm (Spodopteralitura), beet armyworm (Spodoptera exigua), black cutworm (Agrotisipsilon), turnip moth (Agrotis segetum), beet semi-looper (Autographanigrisigna), and cabbage looper (Trichoplusia ni); hemiptera such asaster leafHopper (Macrosteles fascifrons), green rice leafHopper(Nephotettix cincticeps), brown rice planthopper (Nilaparvata lugens),small brown planthopper (Laodelphax striatellus), whitebacked riceplanthopper (Sogatella furcifera), citrus psylla (Diaphorina citri),grape whitefly (Aleurolobus taonabae), silverleaf whitefly (Bermisiaargentifolii), sweetpotato whitefly (Bemisia tabaci), greenHousewhitefly (Trialeurodes vaporariorum), turnip aphid (Lipaphis erysimi),cotton aphid (Aphis gossypii), apple aphid (Aphis Citricola), greenpeach aphid (Myzus persicae), Indian wax scale (Ceroplastes ceriferus),Comstock mealybug (Pseudococcus Comstocki), Japanese mealybug(Planococcus kraunhiae), cottony citrus scale (Pulvinaria aurantii),camphor scale (Pseudaonidia duplex), San Jose scale (Comstockaspisperniciosa), arrowHead scale (Unaspis yanonensis), brownwinged green bug(Plautia Stali), and brown marmorated stink bug (Halyomorpha mista);Coleoptera such as soybean beetle (Anomala rufocuprea), Japanese beetle(Popillia japonica), cigarette beetle (Lasioderma serricorne),powderpost beetle (Lyctusbrunneus), twenty-eight-spotted ladybird(Epilachna vigintioctopunctata), adzuki been weevil (Callosobruchuschinensis), vegetable weevil (Listroderes costirostris), maize weevil(Sitophilus zeamais), boll weevil (Anthonomus gradis gradis), rice waterweevil (Lissorhoptrus oryzophilus), cucurbit leaf beetle (Aulacophorafemoralis), rice leaf beetle (Oulema oryzae), striped flea beetle(Phyllotreta striolata), pine shoot beetle (Tomicus piniperda), Coloradopotato beetle (Leptinotarsa decemlineata), Mexican bean beetle(Epilachna varivestis), corn rootworm (Diabrotica sp.), yellowspottedlongicorn beetle (Psacothea hilaris), and whitespotted longicorn beetle(Anoplophora malasiaca); Diptera such as melon fly (Dacus(Bactrocera)dorsalis), rice leafminer (Agromyza oryzae), onion maggot (Deliaantiqua), seedcorn maggot (Delia platura), soybean pod gall midge(Asphondylia sp.), house fly (Musca domestica), garden pea leafminer(Chromatomyia horticola), legume leafminer (Liriomyza trifolii), bryonyleafminer (Liriomyza bryoniae), and common house mosquito (Culex pipienspipiens); Nematoda such as coffee root-lesion nematode (Pratylenchuscoffeae), root-lesion nematode (Pratylenchus sp.), potato cyst nematode(Globodera rostochiensis), root-knot nematode (Meloidogyne sp.), citrusnematode (Tylemchulus semipenetrans), nematode (Aphelenchus avenae), andchrysanthemum foliar nematode (Aphelenchoides ritzemabosi); Thysanopterasuch as melon thrips (Thrips palmi), western flower thrips(Frankliniella occidentalis), yellow tea thrips (Scirtothrips dorsalis),honeysuckle thrips (Thrips flavus), and onion thrips (Thrips tabaci);Orthoptera such as German cockroach (Blattella germanica), Americancockroach (Periplaneta americana), and rice grasshopper (Oxyayezoensis).

The insecticides containing the compounds represented by formula (1) ofthe present invention as active ingredients have a significantpreventive effect on the above-described insect pests noxious to lowlandcrops, dry field crops, fruit trees, vegetables, other crops, andflowering plants. The effect as the insecticides of the presentinvention can be achieved by treating paddy water, foliages or soil ofpaddy fields, dry fields, fruit trees, vegetables, other crops, orflowering plants before the breeding of noxious insects or at the timeof observation of the breeding of noxious insects at the predictedbreeding season of noxious insects.

The insecticides of the present invention are generally formed intoformulations suitable for use according to a normal method forformulating agricultural/Horticultural pesticides. Namely, a compoundrepresented by formula (1) may be mixed with an appropriate inertcarrier, and if required, an auxiliary at a proper proportion, and theresultant mixture is subjected to dissolution, separation, suspension,mixing, impregnation, adsorption or adhesion to form a suitableformulation such as a suspension, an emulsion, a liquid drug, a wettablepowder, a granule, a dusting powder, or a tablet. As the inert carrierused in the present invention, either a solid or a liquid may be used.Examples of a material usable as the solid carrier include soybeanflour, grain flour, wood flour, bark flour, sawing flour, tobacco stalkflour, walnut sHell flour, bran, cellulose powder, a residue after plantextraction, a synthetic polymer such as a synthetic resin powder, clay(for example, kaoline, bentonite, or acid white clay), talc (forexample, talc or pyrophyllite), silica (for example, diatomite, silicapowder, mica, white carbon (synthetic high-dispersion silicate referredto as “hydrous silicate fine powder” or “hydrous silicate”, someproducts containing calcium silicate as main components)), activatedcarbon, sulfur powder, pumice, calcined diatomite, brick powder, flyash, sand, inorganic mineral powders such as calcium carbonate andcalcium phosphate, chemical fertilizers such as ammonium sulfate,ammonium phosphate, ammonium nitrate, urea, and ammonium chloride, andcompost. These carriers are used alone or in a mixture of at least twokinds.

As a material usable as the liquid carrier, a material having a solventability or a material having no solvent ability but having an ability todisperse an active ingredient compound with the aid of an auxiliary isselected. Typical examples of the liquid carrier are given below, andthese examples can be used alone or in a mixture of two more kinds.Examples of the liquid carrier include water, alcohols (for example,methanol, ethanol, isopropanol, butanol, and ethylene glycol); ketones(for example, acetone, methylethyl ketone, methyl isobutyl ketone,diisobutyl ketone, and cyclohexanone); ethers (for example, diethylether, dioxane, cellosolve, diisopropyl ether, and tetrahydrofuran);aliphatic hydrocarbons (for example, kerosine and mineral oil); aromatichydrocarbons (for example, benzene, toluene, xylene, solvent naphtha,and alkylnaphthalene); halogenated hydrocarbons (for example,dichloromethane, chloroform, carbon tetrachloride, and chlorobenzene);esters (for example, ethyl acetate, butyl acetate, ethyl propionate,diisobutyl phthalate, dibutyl phthalate, and dioctyl phthalate); amides(for example, dimethylformamide, diethylformamide, anddimethylacetamide); and nitriles (for example, acetonitrile).

Typical examples of other auxiliaries are given below, and theseexamples are used alone or in combination according to purposes. Theauxiliary is not necessarily used. For example, a surfactant is used foremulsifying, dispersing, solubilizing and/or wetting the activeingredient compound. Examples of the surfactant include

polyoxyethylene alkyl ether, polyoxyethylene alkyl aryl ether,polyoxyethylene higher fatty acid esters, polyoxyethylene resin acidesters, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitanmonooleate, alkylaryl sulfonate, naphthalenesulfonate, lignin-sulfonate,higher alcohol sulfates. Examples of other auxiliaries used forstabilizing dispersion of the active ingredient compound, and tackifyingand/or bonding the active ingredient compound are given below. Examplesof such auxiliaries include casein, gelatin, starch, methyl cellulose,carboxymethyl cellulose, gum arabic, polyvinyl alcohol, wood turpentine,bran oil, bentonite, xanthan gum, and lignin-sulfonate.

Another auxiliary for improving fluidity of a solid product can also beused. Examples of such an auxiliary include wax, stearates, and alkylphosphates. Also, an auxiliary such as a naphthalenesulfonic acidcondensate or condensed phosphate, can be used as a deflocculant for asuspending product. Furthermore, an auxiliary such as silicone oil canbe used as a defoaming agent.

The compounds represented by formula (1) of the present invention arestable to light, heat and oxidation. However, an appropriate amount ofan antioxidant or an ultraviolet absorber, for example, a phenolderivative such as BHT (2,6-di-t-butyl-4-methyl phenol) or BHA(butylated hydroxyanisole), a bisphenol derivative, an arylamine such asphenyl-α-naphthylamine, phenyl-β-naphthylamine, or a condensate ofphenetidine and acetone, or a benzophenone compound, may be added as astabilizer to produce compositions having a stable effect.

When a compound represented by formula (1) of the present invention isused as an active ingredient, generally, the amount thereof used in adust is 0.5% by weight to 20% by weight, the amount in an emulsion is 5%by weight to 50% by weight, the amount in a wettable powder is 10% byweight to 90% by weight, the amount in a granule is 0.1% by weight to20% by weight, and the amount in a flowable formulation is 10% by weightto 90% by weight. With respect to the amount of the carrier in aformulation, the amount in a dust is 60% by weight to 99% by weight, theamount in an emulsion is 40% by weight to 95% by weight, the amount in awettable powder is 10% by weight to 90% by weight, the amount in agranule is 80% by weight to 99% by weight, and the amount in a flowableformulation is 10% by weight to 90% by weight. With respect to theamount of the auxiliary in a formulation, the amount in a dust is 0.1%by weight to 20% by weight, the amount in an emulsion is 1% by weight to20% by weight, the amount in a wettable powder is 0.1% by weight to 20%by weight, the amount in a granule is 0.1% by weight to 20% by weight,and the amount in a flowable formulation is 0.1% by weight to 20% byweight.

In order to prevent various noxious insects, the compound of the presentinvention is directly used or properly diluted with water or suspendedin water, and an effective amount thereof for preventing pests isapplied to crops in which the breeding of the noxious insects ispredicted, or a place where the breeding of the noxious insects isundesirable. The amount of the compound used depends upon the variousfactors, for example, the purpose, the object insects, the growthconditions of crops, the breeding tendency of insects, weather,environmental conditions, formulations, application methods, applicationplaces, and application times. However, the content of the activeingredient used is generally 0.0001 ppm to 5000 ppm, and preferably 0.01ppm to 1000 ppm. The amount of the active ingredient per 10a isgenerally 1 g to 300 g.

An insecticide containing as an active ingredient the compoundsrepresented by formula (1) of the present invention may be singly usedfor preventing insect pests such agricultural, horticultural or storedgrain insect pests which are noxious to paddy rice, fruit trees,vegetables, other crops and flowering plants, sanitary pests, ornematodes. In order to further obtain an excellent preventive effect onvarious noxious insects which simultaneously occur, at least one ofother insecticides and/or fungicides may be combined with the compoundsrepresented by formula (1) of the present invention.

Examples of such insecticides which can be combined with the compoundsrepresented by formula (1) of the present invention include syntheticpyrethroid insecticides such as allethrin, tetramethrin, resmethrin,phenothrin, furamethrin, permethrin, cypermethrin, deltamethrin,cyhalothrin, cyfluthrin, fenpropathrin, tralomethrin, cycloprothrin,flucythrinate, fluvalinate, acrinathrin, tefluthrin, bifenthrin,empenthrin, beta-cyfluthrin, zeta-cypermethrin, and fenvalerate, andvarious isomers thereof and pyrethrum extracts; organophosphateinsecticides such as DDVP, cyanophos, fenthion, fenitrothion,tetrachlorvinphos, dimethylvinphos, propaphos, methylparathion,temephos, phoxim, acephate, isofenphos, salithion, DEP, EPN, ethion,mecarbam, pyridafenthion, diazinon, pirimiphos-methyl, etrimfos,isoxathion, quinalphos, chlorpyrifos-methyl, chlorpyrifos, phosalone,phosmet, methidathion, oxydeprofos, vamidothion, malathion, phenthoate,dimethoate, formothion, thiometon, ethylthiometon, phorate, terbufos,profenofos, prothiofos, sulprofos, pyraclofos, monocrotophos, naled,fosthiazate, and cadusafos; carbamate insecticides such as NAC, MTMC,MIPC, BPMC, XMC, PHC, MPMC, ethiofencarb, bendiocarb, pirimicarb,carbosulfan, benfuracarb, methomyl, oxamyl, and aldicarb;arylpropylether insecticides such as etofenprox and halfenprox;silylether insecticides such as silafluofen; insecticidal naturalproducts such as nicotine-sulfate, polynactin complex, abamectin,milbemectin, and BT agents; insecticides such as, cartap, thiocyclam,bensultap, diflubenzuron, chlorfluazuron, teflubenzuron, triflumuron,flufenoxuron, flucycloxuron, hexaflumuron, fluazuron, imidacloprid,nitenpyram, acetamiprid, dinotefuran, pymetrozine, fipronil, buprofezin,fenoxycarb, pyriproxyfen, methoprene, hydroprene, kinoprene,diafenthiuron, triazamate, tebufenozide, and endosulfan; acaricides suchas dicofol, chlorobenzilate, bromopropylate, tetradifon, CPCBS, BPPS,chinomethionate, amitraz, benzoximate, hexythiazox, fenbutatin oxide,cyhexatin, dienochlor, clofentezine, pyridaben, fenpyroximate,fenazaquin, and tebufenpyrad; and other insecticides such as novaluron,noviflumuron, emamectin benzoate, clothianidin, thiacloprid,thiamethoxam, flupyrazofos, acequinocyl, bifenazate, chromafenozide,etoxazole, fluacrypyrim, flufenzine, halofenozide, indoxacarb,methoxyfenozide, spirodiclofen, tolfenpyrad, gamma-cyhalothrin,ethiprole, amidoflumet, bistrifluoron, flonicamid, flubrocythrinate,flufenerim, pyridalyl, pyrimidifen, spinosad, and spiromesifen.

Examples of fungicides which can be combined with the compoundsrepresented by formula (1) of the present invention include azolefungicides such as triadimefon, hexaconazole, propiconazole, ipconazole,prochloraz, and triflumizole; pyrimidine fungicides such as pyrifenoxand fenarimol; anilinopyrimidine fungicides such as mepanipyrim andcyprodinil; acylalanine fungicides such as metalaxyl, oxadixyl, andbenalaxyl; benzimidazole fungicides such as thiophanate-methyl andbenomyl; dithiocarbamate fungicids such as mancozeb, propineb, zineb,and metiram; organochlorine fungicides such astetrachloroisophthalonitrile; carboxamide fungicides such as carpropamidand ethaboxam; morpholine fungicides such as dimethomorph; strobilurinfungicides such as azoxystrobin, kresoxim-methyl, metominostrobin,orysastrobin, fluoxastrobin, trifloxystrobin, dimoxystrobin,pyraclostrobin, and picoxystrobin; dicarboxylmide fungicides such asiprodione and procymidone; soil-applied fungicides such as flusulfamide,dazomet, methyl isothiocyanate, and chloropicrin; copper fungicides suchas basic copper chloride, basic copper sulfate, copper nonylphenolsulfonate, oxine-copper, and DBEDC; inorganic fungicides such as sulfurand zinc sulfate; organophosphate fungicides such as edifenphos,tolclofos-methyl, and fosetyl-aluminum; melanin biosynthesis inhibitorssuch as phthalide, tricyclazole, pyroquilon, and diclocymet; antibioticssuch as kasugamycin, validamycin, and polyoxins; fungicidal naturalproducts such as repe seed oil; and other fungicides such asbenthiavalicarb-isopropyl, iprovalicarb, cyflufenamid, fenhexamid,quinoxyfen, spiroxamine, diflumetorim, metrafenone, picobenzamid,proquinazid, silthiofam, oxypoconazole, famoxadone, cyazofamid,fenamidone, furametpyr, zoxamide, boscalid, tiadinil, simeconazole,chlorothalonil, cymoxanil, captan, dithianon, fluazinam, folpet,dichlofluanid,(RS)-N-[2-(1,3-dimethylbutyl)thiophen-3-yl]-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide(penthiopyrad; ISO proposed), oxycarboxin, mepronil, flutolanil,triforine, oxolinic acid, probenazole, acibenzolar-S-methyl,isoprothiolane, ferimzone, diclomezine, pencycuron, fluoroimide,chinomethionate, iminoctadine-triacetate, and iminoctadine-albesilate.

When the compounds represented by formula (1) of the present inventionare combined with at lease one type of other insecticide and/orfungicide, mixed compositions of the compounds represented by formula(1) and other insecticides and/or fungicides may be used, or thecompounds represented by formula (1) may be mixed with otherinsecticides and/or fungicides during agricultural treatment.

Besides the above-described insecticides and fungicides, the compoundsrepresented by formula (1) may be mixed with a herbicide, a fertilizer,an ameliorant, a plant protective such as a plant growth regulator, orresources to form multipurpose compositions having superior efficiencyor compositions from which an additive effect or a synergistic effectcan be expected.

Although representative examples of the present invention will bedescribed below, the present invention is not limited to these examples.

Example 1 (1-1) Production ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-nitrobenzamide

To a solution prepared by adding 20.0 g of2,6-dimethyl-4-heptafluoroisopropylaniline and 11.0 g of pyridine to 100ml of tetrahydrofuran and then stirring the resultant mixture at roomtemperature was dropwise added a solution of 13.0 g of 3-nitrobenzoylchloride in 20 ml of tetrahydrofuran. After the resultant mixture wasstirred at room temperature for 10 hours, ethyl acetate and water wereadded to the reaction solution. Then, a separating operation wasperformed, and an organic layer was separated and then dried withanhydrous magnesium sulfate. The solution was filtered, and then thefiltrate was collected, and the solvent of the filtrate was distilledoff under reduced pressure. The residue was washed with an-hexane-diisopropyl ether solvent mixture to obtain 26.0 g (yield 85%)of the title compound as a white solid.

¹H-NMR (CDCl₃, ppm) δ 2.33 (6H, s), 7.37 (2H, s), 7.68 (1H, s), 7.72(1H, t, J=8.1 Hz), 8.28 (1H, d, J=8.1 Hz), 8.44 (1H, dd, J=1.2 Hz, 8.1Hz), 8.75 (1H, t, J=1.2 Hz)

(1-2) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-aminobenzamide

To a solution prepared by adding 0.90 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-nitrobenzamide and 1.56g of tin chloride anhydride to 25 ml of ethanol and stirring theresultant mixture at room temperature was added 2 ml of conc.hydrochloric acid. The resultant mixture was then stirred under heatingat 60° C. for 1 hour. After the temperature was returned to roomtemperature, the reaction solution was poured into water and thenneutralized with potassium carbonate. Then, ethyl acetate was added tothe reaction solution, and insoluble materials were filtered off. Then,an organic layer was separated and then dried with anhydrous magnesiumsulfate. The solution was filtered, and then the filtrate was collected,and the solvent of the filtrate was distilled off under reducedpressure. The residue was washed with hexane to obtain 0.44 g (yield53%) of the title compound as a white solid.

¹H-NMR (CDCl₃, ppm) δ 2.34 (6H, s), 3.87 (2H, broad), 6.86-6.89 (1H, m),7.20-7.35 (6H, m)

(1-3) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-(2-chloroethoxycarbonylamino)benzamide (Compound No. 130)

To a solution prepared by adding 0.20 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-aminobenzamide and 0.08g of pyridine to 5 ml of tetrahydrofuran and stirring the resultantmixture at room temperature was dropwise added a solution of 0.07 g of2-chloroethyl chloroformate in 1 ml of tetrahydrofuran. After theresultant mixture was stirred for 2 hours, ethyl acetate and water wereadded to the reaction solution. Then, a separating operation wasperformed, and an organic layer was separated and then dried withanhydrous magnesium sulfate. The solution was filtered, and then thefiltrate was collected, and the solvent of the filtrate was distilledoff under reduced pressure. The residue was purified by silica gelcolumn chromatography (eluent; hexane:ethyl acetate=4:1) to obtain 0.23g (yield 91%) of the title compound as a white solid.

¹H-NMR (CDCl₃, ppm) δ 2.35 (6H, s), 3.74-3.77 (2H, m), 4.44-4.47 (2H,m), 6.87 (1H, broad), 7.36 (2H, s), 7.43-7.52 (2H, m), 7.59-7.64 (2H,m), 8.02 (1H, s)

The compounds shown in Table 6 can be produced as productionintermediates useful for producing the compounds represented by formula(1) of the present invention according to the processes described inExamples 1-1 and 1-2.

Example 2

Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-(ethylthiocarbonylamino)benzamide (Compound No. 1962)

To a solution prepared by adding 0.25 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-aminobenzamide producedin (1-2) of Example 1 and 0.06 g of pyridine to 5 ml of tetrahydrofuranand then stirring the resultant mixture at room temperature was dropwiseadded a solution of 0.08 g of ethyl chlorothioformate in 1 ml oftetrahydrofuran. After the resultant mixture was stirred for 2 hours,ethyl acetate and water were added to the reaction solution. Then, aseparating operation was performed, and an organic layer was separatedand then dried with anhydrous magnesium sulfate. The solution wasfiltered, and then the filtrate was collected, and the solvent of thefiltrate was distilled off under reduced pressure. The residue waswashed with hexane to obtain 0.27 g (yield 89%) of the title compound asa white solid.

¹H-NMR (CDCl₃+DMSO-d₆, ppm) δ 1.34 (3H, t, J=7.3 Hz), 2.34 (6H, s), 2.96(2H, q, J=7.3 Hz), 7.33 (2H, s), 7.41 (1H, t, J=7.8 Hz), 7.67 (1H, d,J=7.8 Hz), 7.83-7.85 (1H, m), 8.11 (1H, d, J=2.0 Hz), 8.79 (1H, s), 9.58(1H, s)

Example 3 Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-[(4-cyanobenzyl)oxycarbonylamino]benzamide (Compound No. 85)

To a solution prepared by adding 0.30 g 3-isocyanatobenzoyl chloride to10 ml of ether and then stirring the resultant mixture at 2° C. wasdropwise added, over 5 minutes at a temperature kept at 2° C., asolution of 0.23 g of 4-cyanobenzyl alcohol and 0.32 g oftri-n-butylamine in 5 ml of ether. After the resultant mixture wasstirred at 2° C. for 2 hours, the temperature was returned to roomtemperature, and then a solution of 0.49 g of2,6-dimethyl-4-heptafluoroisopropylaniline in 5 ml of ether was dropwiseadded to the mixture, followed by stirring at room temperature for 8hours. Then, ethyl acetate was added to the reaction solution, and thereaction solution was washed with water twice. Then, an organic layerwas dried with anhydrous magnesium sulfate. The solution was filtered,and then the filtrate was collected, and the solvent of the filtrate wasdistilled off under reduced pressure. The residue was purified by silicagel column chromatography (eluent; hexane:ethyl acetate=2:1 to 1:1) toobtain 0.50 g (yield 40%) of the title compound as an oily material.

¹H-NMR (CDCl, ppm) δ 2.34 (6H, s), 5.27 (2H, s), 6.97 (1H, broad-s),7.35 (2H, s), 7.45-7.52 (4H, m), 7.61-7.69 (4H, m), 8.01 (1H, s)

Similarly, N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-[(6-chloropyridine-3-yl)methoxycarbonylamino]benzamide (Compound No.163) was produced by using 2-chloro-5-hydroxymethylpyridine.

¹H-NMR (CDCl₃, ppm) δ 2.34 (6H,$), 5.22 (2H, s), 6.89 (1H, broad-s),7.35-7.49 (5H, m), 7.62 (2H, d, J=7.3 Hz), 7.72-7.77 (1H, m), 8.00 (1H,broad-s), 8.45 (1H, d, J=2.4 Hz)

N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-[(tetrahydrofuran-3-yl)methoxycarbonylamino]benzamide (Compound No.158) was produced by the same process as described above using3-hydroxymethyltetrahydrofuran except that the solvent was changed totetrahydrofuran.

¹H-NMR (CDCl₃, ppm) δ 1.66-1.73 (1H, m), 2.05-2.13 (1H, m), 2.34 (6H,s), 2.60-2.70 (1H, m), 3.64-3.68 (1H, m), 3.73-3.79 (1H, m), 3.85-3.92(2H, m), 4.09-4.15 (2H, m), 6.87 (1H, broad-s), 7.35 (2H, s), 7.46 (2H,t, J=7.8 Hz), 7.61-7.66 (2H, m), 8.01 (1H, broad-s)

Example 4 (4-1) Production ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-aminobenzthioamide

To 10 ml of toluene were added 0.35 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-aminobenzamide producedin Example (1-2) and 0.19 g of Lawesson's reagent. Then, the resultantmixture was stirred under heating at a reflux temperature for 6 hours.The reaction solution was concentrated under reduced pressure, and thesolvent was distilled off. The residue was purified by silica gel columnchromatography (eluent; hexane:ethyl acetate=3:1) to obtain 0.07 g(yield 20%) of the title compound.

¹H-NMR (CDCl₃, ppm) δ 2.36 (6H, s), 3.87 (2H, broad-s), 6.84-6.87 (1H,m), 7.18-7.24 (2H, m), 7.33 (1H, s), 7.39 (2H, s), 8.56 (1H, broad-s)

(4-2) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-(2,2,2-trichloroethoxycarbonylamino)benzthioamide (Compound No. 1964)

To a solution prepared by adding 0.07 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-aminobenzthioamide and0.03 g of pyridine to 5 ml of tetrahydrofuran and then stirring theresultant mixture at room temperature was dropwise added a solution of0.05 g of 2,2,2-trichloroethyl chloroformate in 1 ml of tetrahydrofuran.After the resultant mixture was stirred 2 hours, ethyl acetate and waterwere added to the reaction solution, and a separating operation wasperformed. Then, an organic layer was separated and dried with anhydrousmagnesium sulfate. The solution was filtered, and then the filtrate wascollected, and the solvent of the filtrate was distilled off underreduced pressure. The residue was purified by silica gel columnchromatography (eluent; hexane:ethyl acetate=4:1) to obtain 0.09 g(yield 90%) of the title compound as a white solid.

¹H-NMR (CDCl₃, ppm) δ 2.37 (6H, s), 4.85 (2H, s), 7.07 (1H, broad), 7.39(2H, s), 7.45 (1H, t, J=8.1 Hz), 7.61-7.68 (2H, m), 8.11 (1H, s), 8.69(1H, s)

Example 5 (5-1) Production ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-chloropyridine-2-carboxamide

First, to a solution prepared by adding 2.36 g of6-chloropyridine-2-carboxylic acid and 5 droplets ofN,N-dimethylformamide to 30 ml of toluene was added 2.14 g of thionylchloride, and then the resultant mixture was stirred under heating at80° C. for 2 hours. Then, the solvent was distilled off under reducedpressure, and the residue was dissolved in 10 ml of tetrahydrofuran. Theresultant solution was added dropwise, at room temperature, to asolution obtained by adding 3.83 g of2,6-dimethyl-4-heptafluoroisopropylaniline and 1.28 g of pyridine to 20ml of tetrahydrofuran, followed by stirring for 5 hours. Then, ethylacetate and water were added to the reaction solution, and a separatingoperation was performed. Then, an organic layer was separated and driedwith anhydrous magnesium sulfate. The solution was filtered, and thenthe filtrate was collected, and the solvent of the filtrate wasdistilled off under reduced pressure. The residue was purified by silicagel column chromatography (eluent; hexane:ethyl acetate=4:1) to obtain3.90 g (yield 67%) of the title compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 2.36 (6H, s), 7.36 (2H, s), 7.56 (1H, dd, J=1.0Hz, 8.1 Hz), 7.88 (1H, dd, J=7.6 Hz, 8.1 Hz), 8.23 (1H, dd, J=1.0 Hz,7.6 Hz), 9.27 (1H, broad-s)

(5-2) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-aminopyridine-2-carboxamide

In a 200 ml autoclave were charged 3.08 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-chloropyridien-2-carboxamide, 30 ml of 28% ammonia water, 0.20 g ofcupper sulfate, and 70 ml of methanol, and the resultant mixture wasstirred under heating at 150° C. for 2 hours. After the mixture wascooled to room temperature, ammonia was distilled off at 60° C. underatmospheric pressure, and methanol was distilled off under reducedpressure. Then, ethyl acetate and water were added to the reactionsolution, and a separating operation was performed. Then, an organiclayer was separated and dried with anhydrous sodium sulfate. Thesolution was filtered, and then the filtrate was collected, and thesolvent of the filtrate was distilled off under reduced pressure. Theresidue was purified by silica gel column chromatography (eluent;hexane:ethyl acetate=3:2 to 2:3) to obtain 2.90 g (yield 98%) of thetitle compound as a oily material.

¹H-NMR (CDCl₃, ppm) δ 2.35 (6H, s), 4.57 (2H, broad-s), 6.69-6.74 (1H,m), 7.34 (2H, s), 7.62-7.66 (2H, m), 9.39 (1H, broad-s)

(5-3) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-(2,2,2-trichloroethoxycarbonylamino)pyridine-2-carboxamide (CompoundNo. 1968)

To a solution prepared by adding 0.15 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-aminopyridine-2-carboxamide and 0.06 g of pyridine to 5 ml oftetrahydrofuran and stirring the resultant mixture at room temperaturewas dropwise added a solution of 0.085 g of 2,2,2-trichloroethylchloroformate in 1 ml of tetrahydrofuran. After the resultant mixturewas stirred for 2 hours, ethyl acetate and water were added to thereaction solution, and a separating operation was performed. Then, anorganic layer was separated and dried with anhydrous magnesium sulfate.The solution was filtered, and then the filtrate was collected, and thesolvent of the filtrate was distilled off under reduced pressure. Theresidue was purified by silica gel column chromatography (eluent;hexane:ethyl acetate=10:1) to obtain 0.13 g (yield 61%) of the titlecompound as a white solid.

¹H-NMR (CDCl₃, ppm) δ 2.35 (6H, s), 4.89 (2H, s), 7.36 (2H, s), 7.63(1H, broad-s), 7.97 (1H, dd, J=7.6 Hz, 8.3 Hz), 8.05 (1H, d, J=7.6 Hz),8.21 (1H, d, J=8.3 Hz), 9.17 (1H, broad-s)

(5-4) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-(2,2,2-trichloroethoxycarbonylamino)pyridine-N-oxide-2-carboxamide(Compound No. 2062)

To 10 ml of benzene was added 0.26 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-(2,2,2-trichloroethoxycarbonylamino)pyridine-2-carboxamide produced inExample 5-3, and then the resultant mixture was stirred. Then, 0.08 g ofm-chloroperbenzoic acid was added to the mixture at room temperature.After the resultant mixture was stirred at 70° C. for 1 hour, 0.2 g ofm-chloroperbenzoic acid was further added to the mixture, followed bystirring at 70° C. for 7 hours. Then, the mixture was diluted with ethylacetate, and an organic layer was washed with a saturated aqueoussolution of sodium hydrogen carbonate three times and dried withanhydrous magnesium sulfate. Then, the solvent was distilled off underreduced pressure. The residue was purified by silica gel columnchromatography (eluent; hexane:ethyl acetate=10:1) to obtain 0.11 g(yield 41%) of the title compound as an amorphous material.

¹H-NMR (CDCl₃, ppm) δ 2.37 (6H, s), 4.91 (2H, s), 7.36 (2H, s), 7.61(1H, t, J=8.3 Hz), 8.23 (1H, dd, J=8.3 Hz, 1.9 Hz), 8.45 (1H, dd, J=8.3Hz, 1.9 Hz), 9.81 (1H, broad-s), 12.70 (1H, broad-s)

(5-5) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-(methylamino)pyridine-2-carboxamide

N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-(methylamino)pyridine-2-carboxamide was produced by usingN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-chloropyridine-2-carboxamide produced in Example 5-1 and a methylamineaqueous solution as reaction materials according to the processdescribed in Example 5-2.

¹H-NMR (DMSO-d₆, ppm) δ 2.30 (6H, s), 2.92 (3H, s), 6.71 (1H, d, J=8.3Hz), 6.85 (1H, d, J=4.9 Hz), 7.22 (1H, d, J=7.0 Hz), 7.44 (2H, s), 7.55(1H, dd, J=7.0 Hz, 8.3 Hz), 10.05 (1H, s)

(5-6) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-[N-(2,2,2-trichloroethoxycarbonyl)-N-methylamino]pyridine-2-carboxamide(Compound No. 2168)

N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-[N-(2,2,2-trichloroethoxycarbonyl)-N-methylamino]pyridine-2-carboxamidewas produced by using N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl6-(methylamino)pyridine-2-carboxamide produced in Example 5-5 as astarting material according to the process described in Example 5-3.

¹H-NMR (DMSO-d₆, ppm) δ 2.30 (6H, s), 3.61 (3H, s), 5.03 (2H, s), 7.47(2H, s), 7.92 (1H, d, J=7.6 Hz), 7.98 (1H, d, J=7.6 Hz), 8.08 (1H, t,J=7.6 Hz), 10.18 (1H, s)

Example 6 (6-1) Production of ethyl3-(2,2,2-trichloroethoxycarbonylamino)benzoate

To a solution prepared by adding 1.0 g of ethyl m-aminobenzoate and 0.72g of pyridine to 10 ml of tetrahydrofuran and stirring the resultantmixture at room temperature was dropwise added a solution of 1.55 g of2,2,2-trichloroethyl chloroformate in 5 ml of tetrahydrofuran. After theresultant mixture was stirred for 2 hours, ethyl acetate and water wereadded to the reaction solution, and a separating operation wasperformed. Then, an organic layer was separated and dried with anhydrousmagnesium sulfate. The solution was filtered, and then the filtrate wascollected, and the solvent of the filtrate was distilled off underreduced pressure. The residue was washed with hexane to obtain 1.89 g(yield 91%) of the title compound.

¹H-NMR (CDCl₃, ppm) δ 1.40 (3H, t, J=7.3 Hz), 4.38 (2H, q, J=7.3 Hz),4.84 (2H, s), 6.96 (1H, broad-s), 7.43 (1H, t, J=7.8 Hz), 7.76-7.82 (2H,m), 7.99 (1H, t, J=2.0 Hz)

(6-2) Production of ethyl3-[N-methyl-N-(2,2,2-trichloroethoxycarbonyl)amino]benzoate

To a suspension of 0.14 g of 60% sodium hydride in 5 ml oftetrahydrofuran was dropwise added a solution of 1.0 g of ethyl3-(2,2,2-trichloroethoxycarbonylamino)benzoate in 5 ml oftetrahydrofuran, and the resultant mixture was stirred at roomtemperature. Then, a solution of 0.45 g of dimethyl sulfate in 5 ml oftetrahydrofuran was dropwise added, and the resultant mixture wasstirred at room temperature for 3 hours. After water was added to themixture, the mixture was subjected to extraction with ethyl acetate, andan organic layer was washed twice with water and dried with anhydrousmagnesium sulfate. Then, the solvent was distilled off under reducedpressure. The residue was purified by silica gel column chromatography(eluent; hexane:ethyl acetate=4:1) to obtain 0.84 g (yield 79%) of thetitle compound as an oily material.

¹H-NMR (CDCl₃, ppm) δ 1.40 (3H, t, J=7.1 Hz), 3.41 (3H, s), 4.39 (2H, q,J=7.1 Hz), 4.77 (2H, s), 7.43-7.52 (2H, m), 7.93-8.01 (2H, m)

(6-3) Production of3-[N-methyl-N-(2,2,2-trichloroethoxycarbonyl)amino]benzoic acid

To 5 ml of ethanol were added 0.5 g of ethyl3-[N-methyl-N-(2,2,2-trichloroethoxycarbonyl)amino]benzoate and a 1Nsodium hydroxide aqueous solution, and the resultant mixture was stirredat room temperature for 1.5 hours. After the reaction solution wascontrolled to pH 3 by dropwise adding 1N hydrochloric acid, ethylacetate was added to the reaction solution, and an organic layer wasseparated. The organic layer was washed with water twice and washed witha saturated saline solution once, and then dried with anhydrousmagnesium sulfate. The solvent was distilled off under reduced pressureto obtain 0.45 g (yield 98%) of the title compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 3.43 (3H, s), 4.79 (2H, s), 7.41-7.60 (2H, m),7.93-8.05 (2H, m)

(6-4) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-[N′-methyl-N′-(2,2,2-trichloroethoxycarbonyl)amino]benzamide (CompoundNo. 1958)

A solution of 0.30 g of3-[N-methyl-N-(2,2,2-trichloroethoxycarbonyl)amino]benzoic acid and 0.07g of N-methylmorpholine in 5 ml of tetrahydrofuran was stirred undercooling at −15° C. A solution of 0.09 g of isopropyl chloroformate in 5ml of tetrahydrofuran was dropwise added to the solution, and then asolution of 0.20 g of 2,6-dimethyl-4-heptafluoroisopropylaniline in 5 mlof tetrahydrofuran was dropwise added to the resultant mixture. Then,the resultant mixture was stirred at −15° C. for 1 hour and at roomtemperature for 24 hours. After the temperature was returned to roomtemperature, ethyl acetate and water were added to the reactionsolution, and a separating operation was performed. Then, an organiclayer was washed with water twice and dried with anhydrous magnesiumsulfate. The solvent was distilled off under reduced pressure. Theresidue was purified by silica gel column chromatography (eluent;hexane:ethyl acetate=4:1 to 2:1) to obtain 0.05 g (yield 5%) of thetitle compound as an oily material.

¹H-NMR (CDCl₃, ppm) δ 2.34 (6H, s), 3.45 (3H, s), 4.80 (2H, s), 7.36(2H, s), 7.50-7.56 (3H, m), 7.78 (1H, d, J=6.1 Hz), 7.90 (1H, s)

Example 7 (7-1) Production ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 2-iodo-5-aminobenzamide

To a solution prepared by adding 0.70 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 3-aminobenzamide producedin Example 1-2 to 8 ml of N,N-dimethylformamide and then stirring theresultant mixture in an iced water bath was dropwise added a solution of0.39 g of N-iodosuccinimide in 2 ml of N,N-dimethylformamide. After thedropwise addition, the temperature was returned to room temperature, andthen mixture was further stirred for 3 hours. Then, ethyl acetate andwater were added to the reaction solution, and a separating operationwas performed. Then, an organic layer was separated and dried withanhydrous magnesium sulfate. The solvent was distilled off under reducedpressure. The residue was purified by silica gel column chromatography(eluent; hexane:ethyl acetate=3:2) to obtain 0.67 g (yield 73%) of thetitle compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 2.44 (6H, s), 3.86 (2H, broad-s), 6.52 (1H, dd,J=2.9 Hz, 8.5 Hz), 6.91 (1H, d, J=2.9 Hz), 7.12 (1H, s), 7.35 (2H, s),7.62 (1H, d, J=8.5 Hz)

(7-2) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl2-iodo-5-(isopropyloxycarbonylamino)benzamide (Compound No. 1945)

To a solution obtained by adding 0.20 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 2-iodo-5-aminobenzamideand 0.06 g of pyridine to 5 ml of tetrahydrofuran and then stirring themixture at room temperature was dropwise added a solution of 0.05 g ofisopropyl chloroformate in 1 ml of tetrahydrofuran. After reaction for 2hours, ethyl acetate and water were added to the reaction solution, anda separating operation was performed. Then, an organic layer wasseparated and dried with anhydrous magnesium sulfate. The solution wasfiltered, and then the filtrate was collected, and the solvent of thefiltrate was distilled off under reduced pressure. The residue waspurified by silica gel column chromatography (eluent; hexane:ethylacetate=4:1) to obtain 0.22 g (yield 96%) of the title compound as asolid.

¹H-NMR (CDCl₃, ppm) δ 1.31 (6H, d, J=6.3 Hz), 2.45 (6H, s), 5.03 (1H,septet, J=6.3 Hz), 6.66 (1H, s), 7.16-7.21 (2H, m), 7.36 (2H, s), 7.76(1H, s), 7.82 (1H, dd, J=2.7 Hz, 8.8 Hz)

Example 8 (8-1) Production ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 2-chloro-3-nitrobenzamide

First, to a solution prepared by adding 2.50 g of2-chloro-3-nitrobenzoic acid and 5 droplets of N,N-dimethylformamide to30 ml of toluene was added 1.62 g of thionyl chloride, and the resultantmixture was stirred under heating at 80° C. for 2 hours. Then, thesolvent was distilled off under reduced pressure, and the residue wasdissolved in 10 ml of tetrahydrofuran. The resultant solution wasdropwise added to a solution of 3.24 g of2,6-dimethyl-4-heptafluoroisopropylaniline and 1.77 g of pyridine in 20ml of tetrahydrofuran at room temperature, and the mixture was stirredfor 5 hours. Then, ethyl acetate and water were added to the reactionsolution, and a separating operation was performed. Then, an organiclayer was separated and dried with anhydrous magnesium sulfate. Thesolution was filtered, and then the filtrate was collected, and thesolvent of the filtrate was distilled off under reduced pressure. Theresidue was purified by silica gel column chromatography (eluent;hexane:ethyl acetate=4:1) to obtain 3.38 g (yield 64%) of the titlecompound as a solid.

¹H-NMR (CDCl₃, ppm) δ 2.42 (6H, s), 7.34 (1H, s), 7.37 (1H, s), 7.55(1H, t, J=7.8 Hz), 7.80 (1H, dd, J=1.5 Hz, 7.8 Hz), 7.86 (1H, dd, J=1.5Hz, 7.8 Hz), 9.58 (1H, s)

(8-2) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl2-fluoro-3-nitrobenzamide

To 25 ml of N,N-dimethylformamide dried with molecular sieve were added2.35 g of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl2-chloro-3-nitrobenzamide and 0.87 g of potassium fluoride(spray-dried), and the resultant mixture was stirred under'heating at150° C. for 3 hours. After the temperature was returned to roomtemperature, ethyl acetate and water were added to the reactionsolution, and a separating operation was performed. Then, an organiclayer was separated, washed with water twice, and dried with anhydrousmagnesium sulfate. The solution was filtered, and then the filtrate wascollected, and the solvent of the filtrate was distilled off underreduced pressure. The residue was purified by silica gel columnchromatography (eluent; hexane:ethyl acetate=4:1) to obtain 1.02 g(yield 45%) of the title compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 2.37 (6H, s), 7.39 (2H, s), 7.48-7.53 (1H, m),7.87 (1H, d, J=11.5 Hz), 8.23-8.28 (1H, m), 8.42-8.46 (1H, m)

(8-3) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl2-fluoro-3-aminobenzamide

The title compound was produced by usingN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 2-fluoro-3-nitrobenzamideproduced in Example 8-2 as a starting material according to the sameprocess as in Example 1-2 (yield 72%).

¹H-NMR (CDCl₃, ppm) δ 2.37 (6H, s), 3.90 (2H, broad-s), 6.96-7.01 (1H,m), 7.10 (1H, t, J=7.8 Hz), 7.36 (2H, s), 7.43-7.47 (1H, m), 7.86 (1H,d, J=13.2 Hz)

(8-4) Production of N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl2-fluoro-3-(isopropyloxycarbonylamino)benzamide (Compound No. 1389)

The title compound was produced by usingN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 2-fluoro-3-aminobenzamideproduced in Example 8-3 as a starting material according to the sameprocess as in Example 7-2 (yield 72%).

¹H-NMR (CDCl₃, ppm) δ 1.34 (6H, d, J=6.3 Hz), 2.36 (6H, s), 5.07 (1H,septet, J=6.3 Hz), 6.86 (1H, broad-s), 7.30 (1H, t, J=8.1 Hz), 7.37 (2H,s), 7.72-7.79 (2H, m), 8.32 (1H, broad)

Example 9 (9-1) Production of3-[(2,2,2-trichloroethoxy)carbonylamino]benzoic acid

To an aqueous solution (200 ml) of 8.22 g of m-aminobenzoic acid and 4.8g of sodium hydroxide was dropwise added 25.0 g of 2,2,2-trichloroethylchloroformate at room temperature. During the dropwise addition, thereaction solution was controlled to pH 10 or more by appropriatelyadding a 1N sodium hydroxide aqueous solution. After the reaction, thesolution was controlled to pH 1 by adding 1N hydrochloric acid, and theprecipitates were collected by filtration. The resultant crude crystalswere dried and then washed with a ethyl acetate/n-hexane mixed solventto obtain 16.2 g (yield 87%) of the title compound as a solid.

¹H-NMR (DMSO-d₆, ppm) δ 4.85 (2H, s), 7.38 (1H, d, J=7.8 Hz), 7.75 (1H,d, J=7.8 Hz), 7.79-7.80 (1H, m), 8.14 (1H, s), 9.02 (1H, s)

(9-2) Production of 3-[(2,2,2-trichloroethoxy)carbonylamino]benzoylchloride

To a toluene solution (10 ml) of 1.0 g of3-[(2,2,2-trichloroethoxy)carbonylamino]benzoic acid produced in Example9-1 was added 2 ml of thionyl chloride, and the resultant mixture wasstirred at 100° C. The solvent was distilled off under reduced pressure,and the residue was dissolved in toluene. The solvent was againdistilled off under reduced pressure to obtain 1.0 g (yield 95%) of thetitle compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 4.86 (2H, s), 7.00 (1H, broad-s), 7.51 (1H, t,J=7.8 Hz), 7.84 (1H, d, J=7.8 Hz), 7.88 (1H, d, J=7.8 Hz), 8.16 (1H, s)

(9-3) Production of N-(2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl3-[(2,2,2-trichloroethoxy)carbonylamino]benzamide (Compound No. 257)

First, to a solution prepared by adding 0.34 g of2,6-dimethyl-4-(nonafluoro-2-butyl)aniline and 0.09 g of pyridine to 5ml of tetrahydrofuran and stirring the resultant mixture at roomtemperature was added 0.33 g of3-[(2,2,2-trichloroethoxy)carbonylamino]benzoyl chloride produced inExample 9-2. After reaction for 5 hours, ethyl acetate and water wereadded to the reaction solution, and a separating operation wasperformed. Then, an organic layer was separated and dried with anhydrousmagnesium sulfate. The solution was filtered, and then the filtrate wascollected, and the solvent of the filtrate was distilled off underreduced pressure. The residue was purified by silica gel columnchromatography (eluent; hexane:ethyl acetate=4:1) to obtain 0.45 g(yield 71%) of the title compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 2.34 (6H, s), 4.85 (2H, s), 7.10 (1H, s), 7.34(2H, s), 7.47-7.51 (2H, m), 7.63-7.67 (2H, m), 8.05 (1H, s)

The following compounds were produced according to the processesdescribed in Examples 9-1 and 9-2.

-   3-(ethoxycarbonylamino)benzoyl chloride-   3-(isopropylpropyloxycarbonylamino)benzoyl chloride-   3-[(cyclobutyloxy)carbonylamino]benzoyl chloride-   3-[(cyclopentyloxy)carbonylamino]benzoyl chloride-   3-[(3-cyanobenzyloxy)carbonylamino]benzoyl chloride-   3-[(4-cyanobenzyloxy)carbonylamino]benzoyl chloride-   3-[(2-cyanoethoxy)carbonylamino]benzoyl chloride-   3-[(2-methylthioethoxy)carbonylamino]benzoyl chloride-   3-[(2-ethylthioethoxy)carbonylamino]benzoyl chloride-   3-[(2-ethylsulfinylethoxy)carbonylamino]benzoyl chloride-   3-[(2-fluoroethoxy)carbonylamino]benzoyl chloride-   3-[(2,2-difluoroethoxy)carbonylamino]benzoyl chloride-   3-[(2,2,2-trifluoroethoxy)carbonylamino]benzoyl chloride-   3-[(1,3-difluoro-2-propyloxy)carbonylamino]benzoyl chloride-   3-[(1-chloro-3-fluoro-2-propyloxy)carbonylamino]benzoyl chloride-   3-[(3,3,3-trifluoro-n-propyloxy)carbonylamino]benzoyl chloride-   3-[(2,2,3,3,3-pentafluoro-n-propyloxy)carbonylamino]benzoyl chloride-   3-[(4,4,4-trifluoro-n-butyloxy)carbonylamino]benzoyl chloride-   3-[(2,2,3,3-tetrafluorocyclobutyloxy)carbonylamino]benzoyl chloride-   3-[(2-chloroethoxy)carbonylamino]benzoyl chloride-   3-[(2,2-dichloroethoxy)carbonylamino]benzoyl chloride-   3-[(1,3-dichloro-2-propyloxy)carbonylamino]benzoyl chloride-   3-[(3-chloro-n-propyloxy)carbonylamino]benzoyl chloride-   3-[(2-bromoethoxy)carbonylamino]benzoyl chloride-   3-[(3-bromo-n-propyloxy)carbonylamino]benzoyl chloride-   3-[(2-iodoethoxy)carbonylamino]benzoyl chloride-   3-[(6-chloropyridine-3-yl)methoxycarbonylamino]benzoyl chloride

Example 10 (10-1) Production of N-(2,4-bistrifluoromethylphenyl)3-isocyanatobenzamide

To a 1,4-dioxane solution (20 ml) of 0.57 g of phosgene dimmer was addeda 1,4-dioxane solution (5 ml) of 2.0 g ofN-(2,4-bistrifluoromethylphenyl) 3-aminobenzamide (produced by using2,4-bistrifluoromethylaniline as a starting material according to theprocess described in Example 1-2), and the resultant mixture was stirredat 60° C. for 3 hours. Then, the solvent was distilled off under reducedpressure, and the residue was dissolved in 10 ml of 1,4-dioxane. Then,the solvent was again distilled off under reduced pressure. The productwas washed with n-hexane and filtered off to obtain 1.54 g (yield 72%)of the title compound.

¹H-NMR (CDCl₃, ppm) δ 7.33-7.36 (1H, m), 7.51 (1H, t, J=7.8 Hz),7.62-7.65 (2H, m), 7.88-7.92 (2H, m), 8.31 (1H, broad-s), 8.70 (1H, d,J=8.8 Hz)

(10-2) Production of N-(2,4-bistrifluoromethylphenyl)3-[(2,2,3,3,3-pentafluoro-n-propyloxy)carbonylamino]benzamide (CompoundNo. 250)

First, to an anhydrous tetrahydrofuran solution (15 ml) of 0.5 g ofN-(2,4-bistrifluoromethylphenyl) 3-isocyanatobenzamide produced inExample 10-1 were added 0.40 g of 2,2,3,3,3-pentafluoro-n-propanol and0.13 g of triethylamine, and the resultant mixture was stirred at roomtemperature for 5 hours. The mixture was diluted with ethyl acetate (20ml), and an organic layer was washed with a 1N sodium hydroxide aqueoussolution and 1N hydrochloric acid. The solvent was distilled off underreduced pressure. The residue was purified by silica gel columnchromatography (eluent; hexane:ethyl acetate=4:1) to obtain 0.49 g(yield 70%) of the title compound.

¹H-NMR (CDCl₃, ppm) δ 4.68 (2H, t, J=13.2 Hz), 7.08 (1H, broad-s),7.50-7.59 (2H, m), 7.70 (1H, broad-s), 7.87-7.92 (2H, m), 8.00 (1H, s),8.39 (1H, s), 8.71 (1H, d, J=8.8 Hz)

Example 11 (11-1) Production ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-(benzyloxycarbonyl)benzamide

A mixture of 3.24 g of benzyl alcohol and 2.85 g of pyridine wasdropwise added to a tetrahydrofuran solution (60 ml) of 6.09 g ofisophthaloyl chloride at room temperature. After the resultant mixturewas stirred for 2 hours, a tetrahydrofuran solution (10 ml) of2,6-dimethyl-4-heptafluoroisopropylaniline was added to the mixture inan ice bath, followed by stirring at room temperature for 2 hours. Thereaction solution was diluted with ethyl acetate (50 ml), and an organiclayer was washed with 1N hydrochloric acid. The solvent was distilledoff under reduced pressure. The residue was purified by silica gelcolumn chromatography (eluent; hexane:ethyl acetate=9:1) to obtain 9.5 g(yield 60%) of the title compound as an amorphous material.

¹H-NMR (CDCl₃, ppm) δ 2.33 (6H, s), 5.41 (2H, s), 7.34-7.48 (7H, m),7.56 (1H, s), 7.61 (1H, t, J=7.8 Hz), 8.17 (1H, t, J=7.8 Hz), 8.28 (1H,d, J=7.8 Hz), 8.57 (1H, s)

(11-2) Production of3-[(2,6-dimethyl-4-heptafluoroisopropylphenyl)aminocarbonyl]benzoic acid

Catalytic hydrogen reduction was performed at normal pressure by using amethanol solution (20 ml) of 2.0 g ofN-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl3-(benzyloxycarbonyl)benzamide produced in Example 11-1 and 0.2 g of 10%palladium-carbon (wet, 50% product) to produce 1.59 g (yield 96%) of thetitle compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 2.36 (6H, s), 7.37 (2H, s), 7.59 (1H, s), 7.67(1H, t, J=7.8 Hz), 8.23 (1H, d, J=7.8 Hz), 8.32 (1H, d, J=7.8 Hz), 8.62(1H, s)

(11-3) Production of N-(2,6-dimethyl-4-heptafluoroisopropylphenyl)3-isocyanatobenzamide

First, to an acetone solution (25 ml) of 1.4 g of-[(2,6-dimethyl-4-heptafluoroisopropylphenyl)aminocarbonyl]benzoic acidproduced in Example 11-2 and 0.38 g of triethylamine was added 0.44 g ofethyl chloroformate in an iced water bath, and the resultant mixture wasstirred at room temperature for 1 hour. Then, an aqueous solution (10ml) of 0.32 g of sodium azide was added to the mixture, followed bystirring at room temperature for 2 hours. The reaction solution waspoured into iced water (150 ml), and the precipitates were extractedwith ethyl acetate (50 ml) and then dried with anhydrous magnesiumsulfate. After anhydrous magnesium sulfate was filtered off, toluene (50ml) was added to the filtrate, and the low-boiling-point solvent wasdistilled off by heating to 110° C. using a Dean and Stark tube. Afterthe end of gas generation was confirmed, the temperature was returned toroom temperature, and then the residual solvent was distilled off underreduced pressure to obtain 1.23 g (yield 88%) of the title compound as asolid.

¹H-NMR (CDCl₃, ppm) δ 2.35 (6H, s), 7.32 (1H, d, J=7.8 Hz), 7.37 (2H,s), 7.39 (1H, s), 7.49 (1H, t, J=7.8 Hz), 7.67 (1H, s), 7.72 (1H, d,J=7.8 Hz)

(11-4) Production of N-(2,6-dimethyl-4-heptafluoroisopropylphenyl)3-[(1-chloro-3-trifluoromethyl-2-propyl)oxycarbonylamino]benzamide(Compound No. 120)

The title compound was produced by usingN-(2,6-dimethyl-4-heptafluoroisopropylphenyl) 3-isocyanatobenzamideproduced in Example 11-3 according to the process described in Example10-2.

¹H-NMR (CDCl₃, ppm) δ 2.35 (6H, s), 3.75-3.83 (2H, m), 4.46-4.80 (2H,m), 5.19-5.24 (1H, m), 6.97 (1H, broad-s), 7.36 (2H, s), 7.36-7.48 (2H,m), 7.60-7.66 (2H, m), 8.03 (1H, s)

The following compounds were produced according to the processesdescribed in Examples 10 and 11.

-   N-2,6-dimethyl-4-(nonafluoro-2-butyl)phenyl 3-isocyanatobenzamide-   N-2,6-dimethyl-4-[(heptafluoro-n-propyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dibromo-4-[(heptafluoro-n-propyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dichloro-4-[(heptafluoro-n-propyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dimethyl-4-[(heptafluoroisopropyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dibromo-4-[(heptafluoroisopropyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dichloro-4-[(heptafluoroisopropyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dimethyl-4-[(nonafluoro-2-butyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dibromo-4-[(nonafluoro-2-butyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dichloro-4-[(nonafluoro-2-butyl)thio]phenyl    3-isocyanatobenzamide-   N-2,6-dimethyl-4-[(heptafluoro-n-propyl)sulfinyl]phenyl    3-isocyanatobenzamide-   N-2,6-dibromo-4-[(heptafluoro-n-propyl)sulfinyl]phenyl    3-isocyanatobenzamide-   N-2,6-dichloro-4-[(heptafluoro-n-propyl)sulfinyl]phenyl    3-isocyanatobenzamide-   N-2,6-dimethyl-4-[(heptafluoro-n-propyl)sulfonyl]phenyl    3-isocyanatobenzamide-   N-2,6-dibromo-4-[(heptafluoro-n-propyl)sulfonyl]phenyl    3-isocyanatobenzamide-   N-2,6-dichloro-4-[(heptafluoro-n-propyl)sulfonyl]phenyl    3-isocyanatobenzamide

Example 12 (12-1) Production of 4-(heptafluoro-n-propylthio)aniline

To an acetonitrile solution (20 ml) of 4-aminothiophenol (1.25 g, 9.98mmol) and triethylamine (1.11 g, 11.0 mmol) was added1-iodoheptafluoro-n-propane (5.91 g, 19.9 mmol), and the resultantmixture was stirred at room temperature for 3 hours. The mixture wasdiluted with ether, and washed with a 1N sodium hydroxide aqueoussolution. Then, the product was purified by silica gel columnchromatography (eluent; hexane:ethyl acetate=4:1) to obtain 1.85 g(yield 63%) of the title compound.

¹H-NMR (CDCl₃, ppm) δ 3.95 (2H, s), 6.66 (2H, d, J=8.8 Hz), 7.40 (2H, d,J=8.8 Hz)

(12-2) Production of 2,6-dibromo-4-(heptafluoro-n-propylthio)aniline

First, to a solution of 0.77 g of 4-(heptafluoro-n-propylthio)anilineproduced in Example 12-1 in 15 ml of N,N-dimethylformamide was added0.98 g of N-bromosuccinimide. After the resultant mixture was stirred at60° C. for 2 hours, ether and water were added to the mixture. Then, anorganic layer was separated, washed with water twice and dried withanhydrous magnesium sulfate. The solvent was distilled off under reducedpressure. The residue was purified by silica gel column chromatography(eluent; hexane:ethyl acetate=9:1) to obtain 1.19 g (yield 100%) of thetitle compound as a red oily material.

¹H-NMR (CDCl₃, ppm) δ4.98 (2H, broad-s), 7.66 (2H, s)

(12-3) Production of N-{2,6-dibromo-4-(heptafluoro-n-propylthio)}phenyl3-nitrobenzamide

To a solution prepared by adding 1.08 g of2,6-dibromo-4-(heptafluoro-n-propylthio)aniline produced in Example 12-2and 0.4 g of pyridine to 20 ml of tetrahydrofuran and stirring theresultant mixture at room temperature was dropwise added a solution of0.55 g of 3-nitrobenzoyl chloride in 20 ml of tetrahydrofuran. After theresultant mixture was stirred at room temperature for 10 hours, ethylacetate and water were added to the reaction solution, and a separatingoperation was performed. Then, an organic layer was separated and driedwith anhydrous magnesium sulfate. The solution was filtered, and thenthe filtrate was collected, and the solvent of the filtrate wasdistilled off under reduced pressure. The residue was purified by silicagel column chromatography (eluent; hexane:ethyl acetate=4:1) to obtain0.86 g (yield 48%) of the title compound as a white solid.

¹H-NMR (CDCl₃, ppm) δ 7.73 (1H, s, J=7.8 Hz, 7.77 (1H, t, J=7.8 Hz),7.96 (2H, s), 8.31 (1H, s), 8.47-8.50 (1H, m), 8.79 (1H, t, J=2.0 Hz)

(12-4) Production of N-{2,6-dibromo-4-(heptafluoro-n-propylthio)}phenyl3-aminobenzamide

To a solution prepared by adding 0.97 g ofN-{2,6-dibromo-4-(heptafluoro-n-propylthio)}phenyl 3-nitrobenzamideproduced in Example 12-3 and 0.95 g of tin(II) chloride (anhydrous) to20 ml of ethanol and stirring the resultant mixture at room temperaturewas added 2 ml of conc. hydrochloric acid, and the resultant mixture wasstirred under heating at 60° C. for 1 hour. After the temperature wasreturned to room temperature, the reaction solution was poured intowater, and the solution was neutralized with potassium carbonate. Then,ethyl acetate was added to the solution, and insoluble materials werefiltered off. Then, an organic layer was separated and dried withanhydrous magnesium sulfate. The solution was filtered, and then thefiltrate was collected, and the solvent of the filtrate was distilledoff under reduced pressure. The residue was washed with hexane to obtain0.75 g (yield 81%) of the title compound as a white solid.

¹H-NMR (CDCl₃, ppm) δ 3.89 (2H, broad-s), 6.90 (1H, dt, J=2.5 Hz, 6.4Hz), 7.28-7.30 (3H, m), 7.60 (1H, s), 7.93 (2H, s)

(12-5) Production of N-{2,6-dibromo-4-(heptafluoro-n-propylthio)}phenyl3-(2,2,2-trichloroethoxycarbonylamino)benzamide (Compound No. 612)

To a solution prepared by adding 0.10 g ofN-{2,6-dibromo-4-(heptafluoro-n-propylthio)}phenyl 3-aminobenzamide and0.02 g of pyridine to 5 ml of tetrahydrofuran and stirring the resultantmixture at room temperature was dropwise added a solution of 0.04 g of2,2,2-trichloroethyl chloroformate in 1 ml of tetrahydrofuran. Afterreaction for 2 hours, ethyl acetate and water were added to the reactionsolution, and a separating operation was performed. Then, an organiclayer was separated and dried with anhydrous magnesium sulfate. Thesolution was filtered, and then the filtrate was collected, and thesolvent of the filtrate was distilled off under reduced pressure. Theresidue was purified by silica gel column chromatography (eluent;hexane:ethyl acetate=4:1.) to obtain 0.11 g (yield 84%) of the titlecompound as a solid.

¹H-NMR (CDCl₃, ppm) δ4.86 (2H, s), 7.45 (1H, t, J=7.8 Hz), 7.72 (1H, d,J=7.8 Hz), 7.93 (2H, s), 7.94 (1H, broad-s), 8.13 (1H, s), 9.02 (1H, s),9.17 (1H, s)

(12-6) Production ofN-{2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)}phenyl 3-nitrobenzamideand N-{2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)}phenyl3-nitrobenzamide

A solution prepared by adding 0.5 g ofN-{2,6-dibromo-4-(heptafluoro-n-propylthio)}phenyl 3-nitrobenzamide to15 ml of chloroform was stirred at room temperature, and 0.5 g ofm-chloroperbenzoic acid was added to the mixture. After the resultantmixture was stirred at room temperature for 1 week, an aqueous solutionof sodium hydrogen sulfite was added to the mixture, followed bystirring. Then, an organic layer was separated and washed with a 1Nsodium hydroxide aqueous solution and saturated saline water. Then, thesolvent was distilled off under reduced pressure. The residue waspurified by silica gel column chromatography (eluent; hexane:ethylacetate=4:1) to obtain 0.21 g ofN-({2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)}phenyl 3-nitrobenzamideand 0.12 g of N-{2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)}phenyl3-nitrobenzamide as solids.

(sulfinyl compound) ¹H-NMR (CDCl₃, ppm) δ 7.76-7.82 (2H, m), 8.06 (1H,s), 8.29 (1H, s), 8.33-8.35 (1H, m), 8.49-8.53 (1H, m), 8.81 (1H, s)

(12-7) Production of 2,6-dimethyl-4-(heptafluoro-n-propylthio)aniline

To 20 ml of DMF were added 3.0 g (1.3 mmol) of2,6-dibromo-4-heptafluoro-n-propylthioaniline, 3.0 g (21.9 mmol) ofpotassium carbonate, 0.75 g (0.65 mmol) of tetrakis(triphenylphosphine)palladium, and 0.17 g (1.3 mmol) of trimethylboroxine, and the resultantmixture was stirred at 135° C. for 6 hours. After the reaction solutionwas cooled to room temperature, insoluble materials were filtered offwith cerite. The filtrate was concentrated under reduced pressure. Theresidue was purified by silica gel column chromatography (eluent;n-hexane:ethyl acetate=12:1 to 4:1) to obtain 1.17 g (yield 55%) of thetitle compound as an oily material.

¹H-NMR (CDCl₃, ppm) δ 2.17 (6H, s), 3.86 (2H, broad-s), 7.22 (2H, s)

The following aniline derivatives can be produced according to theprocesses described in Examples 12-1, 12-2, 12-6, and 12-7.

-   2-methyl-4-(pentafluoroethylthio)aniline-   2-methyl-4-(heptafluoro-n-propylthio)aniline

¹H-NMR (CDCl₃, ppm) δ 2.16 (3H, s), 3.90 (2H, broad-s), 6.65 (1H, d,J=8.3 Hz), 7.28-7.31 (2H, m)

-   2-bromo-4-(heptafluoro-n-propylthio)aniline

¹H-NMR (CDCl₃, ppm) δ 4.44 (2H, broad-s), 6.75 (1H, d, J=8.8 Hz), 7.36(1H, dd, J=2.0 Hz, 8.8 Hz), 7.69 (1H, d, J=2.0 Hz)

-   2-methyl-4-(heptafluoroisopropylthio)aniline-   2-methyl-4-(nonafluoro-n-butylthio)aniline-   2-methyl-4-(pentafluoroethylsulfinyl)aniline-   2-methyl-4-(heptafluoro-n-propylsulfinyl)aniline-   2-methyl-4-(heptafluoroisopropylsulfinyl)aniline-   2-methyl-4-(nonafluoro-n-butylsulfinyl)aniline-   2-methyl-4-(pentafluoroethylsulfonyl)aniline-   2-methyl-4-(heptafluoro-n-propylsulfonyl)aniline-   2-methyl-4-(heptafluoroisopropylsulfonyl)aniline-   2-methyl-4-(nonafluoro-n-butylsulfonyl)aniline-   2,6-dichloro-4-(pentafluoroethylthio)aniline-   2,6-dibromo-4-(pentafluoroethylthio)aniline-   N-{2,6-dibromo-4-(pentafluoroethylthio)}phenyl 3-nitrobenzamide

¹H-NMR (CDCl₃, ppm) δ 7.73 (1H, s), 7.77 (1H, t, J=7.8 Hz), 7.96 (2H,s), 8.32 (1H, d, J=7.8 Hz), 8.47-8.50 (1H, m), 8.80 (1H, t, J=2.0 Hz)

-   2,6-dimethyl-4-(pentafluoroethylthio)aniline-   2,6-dichloro-4-(heptafluoro-n-propylthio)aniline

¹H-NMR (CDCl₃, ppm) δ 4.82 (2H, broad-s), 7.48 (2H, s)

-   N-{2,6-dichloro-4-(heptafluoro-n-propylthio)}phenyl 3-nitrobenzamide

¹H-NMR (CDCl₃, ppm) δ 7.70 (1H, s), 7.76 (2H, s), 7.77 (1H, t, J=7.8Hz), 8.31 (1H, d, J=7.8 Hz), 8.48 (1H, d, J=7.8 Hz), 8.78 (1H, t, J=2.0Hz)

-   2,6-dibromo-4-(heptafluoro-n-propylthio)aniline

¹H-NMR (CDCl₃, ppm) δ 4.93 (2H, broad-s), 7.66 (2H, s)

-   2,6-dimethyl-4-(heptafluoro-n-propylthio)aniline

¹H-NMR (CDCl₃, ppm) δ 2.17 (6H, s), 3.86 (2H, broad-s), 7.22 (2H, s)

-   N-{2,6-dichloro-4-(heptafluoro-n-propylthio)}phenyl    2-chloro-3-nitrobenzamide

¹H-NMR (CDCl₃, ppm) δ 2.39 (6H, s), 7.30 (1H, s), 7.46 (2H, s), 7.57(1H, t, J=7.8 Hz), 7.90 (1H, d, J=7.8 Hz), 7.91 (1H, d, J=7.8 Hz)

-   2-bromo-4-(heptafluoro-n-propyl)thio-6-methylaniline

¹H-NMR (CDCl₃, ppm) δ 2.22 (3H, s), 4.40 (2H, broad-s), 7.27 (1H, s),7.60 (1H, d, J=2.0 Hz)

-   2,6-dichloro-4-(heptafluoroisopropylthio)aniline

¹H-NMR (CDCl₃, ppm) δ 6.40 (2H, s), 7.52 (2H, s)

-   2,6-dibromo-4-(heptafluoroisopropylthio)aniline-   N-{2,6-dichloro-4-(heptafluoroisopropylthio)}phenyl 3-nitrobenzamide

¹H-NMR (CDCl₃, ppm) δ 7.73 (1H, s), 7.76 (1H, t, J=7.8 Hz), 7.95 (2H,s), 8.31 (1H, d, J=7.8 Hz), 8.48 (1H, d, J=7.8 Hz), 8.79 (1H, t, J=1.5Hz)

-   2,6-dimethyl-4-(heptafluoroisopropylthio)aniline-   2,6-dichloro-4-(nonafluoro-n-butylthio)aniline-   2,6-dibromo-4-(nonafluoro-n-butylthio)aniline-   N-{2,6-dichloro-4-(nonafluoro-n-butylthio)}phenyl 3-nitrobenzamide

¹H-NMR (CDCl₃, ppm) δ 7.76 (1H, s), 7.77 (1H, t, J=8.3 Hz), 7.96 (2H,s), 8.32 (1H, d, J=8.3 Hz), 8.48 (1H, d, J=8.3 Hz), 8.80 (1H, t, J=2.0Hz)

-   2,6-dimethyl-4-(nonafluoro-n-butylthio)aniline-   2,6-dichloro-4-(pentafluoroethylsulfinyl)aniline-   2,6-dibromo-4-(pentafluoroethylsulfinyl)aniline-   2,6-dimethyl-4-(pentafluoroethylsulfinyl)aniline-   2,6-dichloro-4-(heptafluoro-n-propylsulfinyl)aniline-   2,6-dibromo-4-(heptafluoro-n-propylsulfinyl)aniline-   N-{2,6-dichloro-4-(heptafluoro-n-propylsulfinyl)}phenyl    3-nitrobenzamide

¹H-NMR (CDCl₃, ppm) δ 7.76-7.82 (2H, m), 8.06 (1H, s), 8.29 (1H, s),8.33-8.35 (1H, m), 8.49-8.53 (1H, m), 8.81 (1H, s)

-   2,6-dimethyl-4-(heptafluoro-n-propylsulfinyl)aniline-   2,6-dichloro-4-(heptafluoroisopropylsulfinyl)aniline-   2,6-dibromo-4-(heptafluoroisopropylsulfinyl)aniline-   2,6-dimethyl-4-(heptafluoroisopropylsulfinyl)aniline-   2,6-dichloro-4-(nonafluoro-n-butylsulfinyl)aniline-   2,6-dibromo-4-(nonafluoro-n-butylsulfinyl)aniline-   2,6-dimethyl-4-(nonafluoro-n-butylsulfinyl)aniline-   2,6-dichloro-4-(pentafluoroethylsulfonyl)aniline-   2,6-dibromo-4-(pentafluoroethylsulfonyl)aniline-   2,6-dimethyl-4-(pentafluoroethylsulfonyl)aniline-   2,6-dichloro-4-(heptafluoro-n-propylsulfonyl)aniline-   2,6-dibromo-4-(heptafluoro-n-propylsulfonyl)aniline-   2,6-dimethyl-4-(heptafluoro-n-propylsulfonyl)aniline-   2,6-dichloro-4-(heptafluoroisopropylsulfonyl)aniline-   N-{2,6-dichloro-4-(heptafluoroisopropylsulfonyl)}phenyl    3-nitrobenzamide

¹H-NMR (CDCl₃, ppm) δ 7.79 (1H, t, J=7.8 Hz), 7.98 (1H, s), 8.07 (2H,s), 8.33 (1H, d, J=7.8 Hz), 8.51 (1H, d, J=7.8 Hz), 8.81 (1H, t, J=2.0Hz)

-   2,6-dibromo-4-(heptafluoroisopropylsulfonyl)aniline-   2,6-dimethyl-4-(heptafluoroisopropylsulfonyl)aniline-   2,6-dichloro-4-(nonafluoro-n-butylsulfonyl)aniline-   2,6-dibromo-4-(nonafluoro-n-butylsulfonyl)aniline-   2,6-dimethyl-4-(nonafluoro-n-butylsulfonyl)aniline

Example 13 (13-1) Production of2,6-dimethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline

A mixture of 2.42 g of 2,6-dimethylaniline, 7.35 g of hexafluoroacetonehydrate, and 0.04 g of p-toluenesulfonic acid monohydrate was stirredunder heating at 100° C. for 5 hours. After the temperature was returnedto room temperature, the mixture was diluted with ethyl acetate andwashed with a 1N sodium hydroxide aqueous solution. Then, the solventwas distilled off under reduced pressure, and the precipitated crudecrystals were washed with a n-hexane-ethyl acetate mixed solvent toobtain 4.47 g (yield 78%) of the title compound as a solid.

¹H-NMR (CDCl₃, ppm) δ 2.20 (6H, s), 3.26 (1H, broad-s), 3.76 (2H,broad-s), 7.25 (2H, s)

(13-2) Production ofN-[2,6-dimethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)]phenyl3-(2,2,2-trichloroethoxycarbonylamino)benzamide (Compound No. 872)

The title compound was produced as an amorphous material by using2,6-dimethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)anilineproduced in Example 13-1 as a starting material according to the processdescribed in Example 9-3 (yield 92%).

¹H-NMR (CDCl₃, ppm) δ 2.31 (6H, s), 3.99 (1H, s), 4.85 (2H, s), 7.15(1H, broad-s), 7.45-7.51 (4H, m), 7.64-7.66 (2H, m), 8.01 (1H, s)

Formulation examples containing the compounds represented by formula (1)of the present invention as active ingredients are shown below, howeverthe present invention is not limited to these examples. In each of theformulation examples, “part(s)” represents “part(s) by weight”.

Formulation Example 1

A mixture of 20 parts of a compound represented by formula (1) of thepresent invention, 10 parts of Sorpol 355S (surfactant produced by TohoCHemical Industry Co., Ltd.), and 70 parts of xylene was uniformlystirred to produce an emulsion.

Formulation Example 2

A mixture of 10 parts of a compound represented by formula (1) of thepresent invention, 2 parts of sodium alkylnaphthalenesulfonate, 1 partof sodium lignin-sulfonate, 5 parts of white Carbon, and 82 parts ofdiatomite was uniformly stirred to produce a wettable powder.

Formulation Example 3

A mixture of 0.3 parts of a compound represented by formula (1) of thepresent invention and 0.3 parts of white carbon was uniformly stirred,and 99.2 parts of clay and 0.2 parts of Driless A (produced by SankyoCo., Ltd.) were added to the mixture. The resultant mixture wasuniformly ground to produce a dust.

Formulation Example 4

A mixture of 2 parts of a compound represented by formula (1) of thepresent invention, 2 parts of white carbon, 2 parts of sodiumlignin-sulfonate, and 94 parts of bentonite was uniformly ground, andthen water was added to the mixture. The resultant mixture was kneaded,granulated and then dried to produce granules.

Formulation Example 5

A mixture of 20 parts of a compound represented by formula (1) of thepresent invention and 5 parts of a 20% aqueous solution of polyvinylalcohol was sufficiently stirred, and then 75 parts of a 0.8% aqueoussolution of xanthane gum was added to the mixture. Then, the resultantmixture was again stirred to produce a flowable agent.

Test examples for making clear that the compounds represented by formula(1) of the present invention have excellent insecticidal activity areshown below, however the present invention is not limited to theseexamples.

Test Example 1 Insecticidal Test for Common Cutworm (Spodoptera Litura)

A cabbage leaf piece was immersed in a solution prepared by diluting atest compound to a predetermined concentration for 30 seconds, and thendried in air. Then, the cabbage leaf piece was placed in a polyethylenecup of 7 cm-size in which 2nd-instar larvae of common cutworm wereplaced. The cup was allowed to stand in a thermostatic chamber at 25° C.Three days after, the numbers of living and dead larvae were counted.The test was carried out in two replications each containing fivelarvae.

As a result, at a concentration of 1000 ppm, a mortality of 70% or morewas exhibited by Compounds Nos. 20, 59, 60, 62, 64, 66, 75, 78, 79, 81,83, 84, 85, 90, 91, 92, 106, 108, 109, 111, 112, 116, 117, 118, 119,120, 121, 123, 124, 125, 126, 127, 130, 131, 132, 134, 135, 136, 137,138, 139, 140, 155, 156, 161, 163, 165, 174, 175, 176, 180, 181, 184,186, 189, 190, 192, 196, 197, 198, 205, 206, 207, 208, 209, 210, 212,213, 215, 216, 217, 218, 219, 220, 221, 224, 225, 228, 229, 230, 231,232, 233, 234, 235, 236, 237, 241, 246, 247, 248, 250, 251, 252, 253,254, 255, 256, 257, 258, 259, 300, 301, 348, 377, 424, 464, 471, 511,518, 565, 605, 612, 659, 706, 770, 800, 817, 818, 819, 854, 855, 856,857, 843, 844, 846, 847, 864, 867, 872, 873, 878, 890, 891, 892, 898,899, 900, 902, 903, 905, 913, 915, 916, 919, 920, 922, 932, 933, 944,948, 992, 1010, 1039, 1086, 1104, 1180, 1198, 1227, 1245, 1274, 1292,1321, 1361, 1368, 1388, 1389, 1408, 1411, 1416, 1418, 1421, 1435, 1455,1458, 1463, 1465, 1903, 1906, 1907, 1922, 1923, 1924, 1925, 1926, 1929,1931, 1932, 1935, 1939, 1941, 1942, 1943, 1944, 1945, 1947, 1948, 1950,1951, 1952, 1953, 1954, 1955, 1956, 1958, 1959, 1963, 1964, 1967, 1968,1969, 2061, 2062, 2164, 2165, and 2168.

Test Example 2 Insecticidal Test for Diamondback Moth (PlutellaXylostella)

A cabbage leaf pieces was immersed in a solution prepared by diluting atest compound to a predetermined concentration for 30 seconds, and thendried in air. Then, the leaf piece was placed in a polyethylene cup of 7cm-size in which 2nd-instar larvae of common cutworm were placed. Thecup was allowed to stand in a thermostatic chamber at 25° C. Three daysafter, the numbers of living and dead larvae were counted. The test wascarried out in two replications each containing five larvae.

As a result, at a concentration of 1000 ppm, a mortality of 70% or morewas exhibited by Compounds Nos. 3, 5, 7, 8, 20, 59, 60, 62, 66, 75, 77,78, 79, 80, 84, 85, 92, 94, 95, 96, 99, 101, 103, 104, 106, 108, 109,110, 111, 112, 113, 116, 117, 118, 119, 120, 121, 123, 126, 127, 130,131, 132, 134, 136, 137, 138, 139, 140, 141, 154, 155, 156, 157, 158,159, 160, 161, 162, 163, 168, 171, 174, 175, 176, 180, 181, 183, 184,186, 190, 192, 196, 197, 198, 201, 203, 204, 205, 206, 207, 208, 209,212, 213, 214, 215, 217, 218, 219, 220, 221, 223, 224, 228, 229, 230,231, 232, 233, 234, 235, 236, 237, 238, 246, 247, 248, 249, 250, 252,253, 254, 255, 256, 257, 258, 259, 300, 301, 348, 377, 424, 464, 471,511, 518, 565, 605, 612, 659, 706, 800, 817, 818, 819, 820, 829, 858,863, 865, 867, 868, 871, 872, 873, 878, 896, 897, 898, 899, 900, 902,908, 913, 915, 919, 920, 922, 930, 932, 933, 936, 939, 941, 942, 943,944, 945, 947, 948, 992, 1010, 1039, 1086, 1104, 1180, 1227, 1245, 1274,1292, 1321, 1361, 1368, 1388, 1389, 1408, 1411, 1416, 1418, 1421, 1435,1455, 1458, 1463, 1465, 1903, 1906, 1907, 1916, 1923, 1926, 1928, 1929,1931, 1933, 1939, 1945, 1947, 1950, 1951, 1952, 1953, 1954, 1955, 1956,1958, 1959, 1963, 1964, 1967, 1968, 1969, 2061, 2062, 2164, 2165, 2167,and 2168.

Test Example 3 Insecticidal Test for Small Brown Planthopper (LaodelphaxStriatellus)

An acetone solution prepared by diluting a test compound to apredetermined concentration was sprayed on rice seedlings, and the riceseedlings were dried in air. Ten small brown planthoppers and anoriginal chemical were used for the test. The rice seedlings wereallowed to stand in a thermostatic chamber at 25° C. Six days after, thenumber of living insects was examined, and three days after, the numberof dead insects was examined. The test was carried out one replicationcontaining ten insects.

As a result, at a concentration of 1000 ppm, a mortality of 70% or morewas exhibited by Compounds Nos. 108, 127, 184, 196, 197, 205, 209, 212,215, 1321, 1361, 1368, 1408, 1411, 1416, 1435, 1455, 1458, 1463, 1958,1959, and 1968.

1-21. (canceled)
 22. An aniline derivative represented by formula (8):

wherein R₇ represents a C1-C6 haloalkyl group, Y₁₀, Y₁₁, Y₁₂, and Y₁₃may be the same or different and each represent a hydrogen atom, ahalogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6alkoxy group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6haloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6haloalkylsulfonyl group, a pentafluorosulfanyl group, a cyano group, ora nitro group, and R₈ and R₉ independently represent a hydrogen atom, aC1-C4 alkyl group, a m-nitrobenzoyl group, or a substitutedm-nitrobenzoyl group, and m represents 0, 1, or 2, excluding thefollowing cases (1) to (3): said case (1) is combination that R₈ and R₉represent a hydrogen atom, Y₁₀ and Y₁₃ are a bromine atom, Y₁₁ and Y₁₂are a hydrogen atom, m is 2 and R₇ is a perfluoro n-butyl group, saidcase (2) is combination that R₈ and R₉ represent a hydrogen atom, Y₁₀and Y₁₁ and Y₁₂ and Y₁₃ are a hydrogen atom, m is 0 and R₇ is aperfluoroethyl group, and said case (3) is combination that R₈ and R₉represent a hydrogen atom, Y₁₀ and Y₁₁ and Y₁₂ and Y₁₃ are a hydrogenatom, m is 0 and R₇ is a perfluoro n-propyl group.